Currently, accumulating pieces of evidence indicate that probiotics, living in the gastrointestinal tract, play an important role in regulating host metabolism. As a tool, probiotics have great potential for treating ...Currently, accumulating pieces of evidence indicate that probiotics, living in the gastrointestinal tract, play an important role in regulating host metabolism. As a tool, probiotics have great potential for treating lipid metabolism diseases. However, the relationship between probiotics and abnormal lipid metabolism is still unclear, and the mechanism of action has been become a focus of microbiome research. Therefore, taking intestinal probiotics as the starting point, this article combs the relationship between probiotics and lipid metabolism. Moreover, we discuss the underlying mechanisms of intestinal probiotics regulating lipid metabolism and summarize the therapeutic strategies for abnormal lipids metabolism. This article provides a reference for the further utilization of probiotics in the field of functional foods(food industry). Meanwhile, it will benefit the clinical diagnosis and treatment of lipid metabolism diseases.展开更多
将含有乳酸杆菌Lactobacillus casei Zhang的悬浮液分组饲喂小鼠,然后分别用E.coliO157和K88攻毒观察发病情况。攻毒4d后取对照组和喂菌组未死亡小鼠的肠内容物,用选择性培养基分离纯化大肠杆菌和乳酸菌,提取分离到菌株的总DNA,进行ERIC...将含有乳酸杆菌Lactobacillus casei Zhang的悬浮液分组饲喂小鼠,然后分别用E.coliO157和K88攻毒观察发病情况。攻毒4d后取对照组和喂菌组未死亡小鼠的肠内容物,用选择性培养基分离纯化大肠杆菌和乳酸菌,提取分离到菌株的总DNA,进行ERIC-PCR扩增分析。发现灌服L.casei Zhang可以降低攻毒后小鼠的死亡率,在停止饲喂乳酸菌的第4d从小鼠肠道内分离到L.casei Zhang,从饲喂组未分离到E.coliO157和K88,喂L.casei Zhang使小鼠肠道中大肠杆菌总数极显著低于对照组。表明所饲喂的乳杆菌可以在小鼠肠道内定殖并对小鼠起到保护作用。展开更多
【目的】评价经鼻高流量吸氧在全麻诱导前行预充氧的有效性及在插管期延长"安全窒息时限"的效果。【方法】随机将80例非困难气道病例纳入全麻面罩组(FM)、全麻面罩复合经鼻高流量吸氧组(FM+HFNCI)、经鼻高流量吸氧组(HFNCI)...【目的】评价经鼻高流量吸氧在全麻诱导前行预充氧的有效性及在插管期延长"安全窒息时限"的效果。【方法】随机将80例非困难气道病例纳入全麻面罩组(FM)、全麻面罩复合经鼻高流量吸氧组(FM+HFNCI)、经鼻高流量吸氧组(HFNCI)以及经鼻高流量吸氧复合鼻咽通气道组(HFNCI+NPA)。麻醉诱导前预充氧阶段,FM及FM+HFNCI组经全麻面罩而HFNCI及HFNCI+NPA组经鼻导管行预充氧;在气管插管期,除FM组外,余患者均接受经鼻高流量氧吹入。记录不同时点血氧分压、血氧饱和度、心率及血压。【结果】预充氧结束时,PaO_2值、SaO_2值在各组间差异无统计学意义(P>0.05)。窒息插管期,PaO_2值在FM组下降明显,而在HFNCI+NPA组上升;FM组ΔPaO_2值最大(均数为-5.4 k Pa),与其余组比较(ΔPaO_2值均数在FM+HFNCI、HFNCI及HFNCI+NPA组分别为-0.5、-0.8、1.4 k Pa)差异有统计学意义(P<0.001)。插管成功时FM、FM+HFNCI、HFNCI、HFNCI+NPA组PaO_2值(均数分别为46.7、48.3、37.7、43.7 k Pa)、SaO_2值(均数分别为99.7%、99.8%、99.4%、99.7%)均远高于各自安全低限值。【结论】HFNCI用于非困难气道病例,麻醉诱导前预充氧有效性高、可能延长"安全窒息时限",提高围插管期安全;为达最佳氧合效果,实施HFNCI时应保证气道通畅。展开更多
文摘糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病最严重的眼部并发症,以不同程度视力下降和视网膜反复出血为特异性表现,严重时可致盲[1]。据研究统计,DR患者占糖尿病患者20.86%[2],是全球首位致盲性眼病。目前,玻璃体切割术(pars plana vitrectomy,PPV)是治疗DR的高新技术,术后易发生并发症,如复发性出血、视网膜脱离和高压眼等[3]。
基金sponsored by the Natural Science Foundation of Zhejiang Province (LQ22C200002)Shenzhen Peacock Talent Programs Research Start-up Grant (802-012677)Shenzhen Key Laboratory Foundation (ZDSYS20200811143757022)。
文摘Currently, accumulating pieces of evidence indicate that probiotics, living in the gastrointestinal tract, play an important role in regulating host metabolism. As a tool, probiotics have great potential for treating lipid metabolism diseases. However, the relationship between probiotics and abnormal lipid metabolism is still unclear, and the mechanism of action has been become a focus of microbiome research. Therefore, taking intestinal probiotics as the starting point, this article combs the relationship between probiotics and lipid metabolism. Moreover, we discuss the underlying mechanisms of intestinal probiotics regulating lipid metabolism and summarize the therapeutic strategies for abnormal lipids metabolism. This article provides a reference for the further utilization of probiotics in the field of functional foods(food industry). Meanwhile, it will benefit the clinical diagnosis and treatment of lipid metabolism diseases.
文摘【目的】评价经鼻高流量吸氧在全麻诱导前行预充氧的有效性及在插管期延长"安全窒息时限"的效果。【方法】随机将80例非困难气道病例纳入全麻面罩组(FM)、全麻面罩复合经鼻高流量吸氧组(FM+HFNCI)、经鼻高流量吸氧组(HFNCI)以及经鼻高流量吸氧复合鼻咽通气道组(HFNCI+NPA)。麻醉诱导前预充氧阶段,FM及FM+HFNCI组经全麻面罩而HFNCI及HFNCI+NPA组经鼻导管行预充氧;在气管插管期,除FM组外,余患者均接受经鼻高流量氧吹入。记录不同时点血氧分压、血氧饱和度、心率及血压。【结果】预充氧结束时,PaO_2值、SaO_2值在各组间差异无统计学意义(P>0.05)。窒息插管期,PaO_2值在FM组下降明显,而在HFNCI+NPA组上升;FM组ΔPaO_2值最大(均数为-5.4 k Pa),与其余组比较(ΔPaO_2值均数在FM+HFNCI、HFNCI及HFNCI+NPA组分别为-0.5、-0.8、1.4 k Pa)差异有统计学意义(P<0.001)。插管成功时FM、FM+HFNCI、HFNCI、HFNCI+NPA组PaO_2值(均数分别为46.7、48.3、37.7、43.7 k Pa)、SaO_2值(均数分别为99.7%、99.8%、99.4%、99.7%)均远高于各自安全低限值。【结论】HFNCI用于非困难气道病例,麻醉诱导前预充氧有效性高、可能延长"安全窒息时限",提高围插管期安全;为达最佳氧合效果,实施HFNCI时应保证气道通畅。
