目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正...目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正视力(BCVA)、一阶光栅锐度和(或)二阶纹理敏感度,并分析不同程度弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。结果:弱视组与正常对照组一阶光栅锐度(11.58±6.10 vs 20.27±3.47,P<0.001)、二阶纹理敏感度(0.33±0.16 vs 0.12±0.04,P<0.001)均有明显差异,且轻中度弱视患者与重度弱视患者一阶光栅锐度(12.10±6.23 vs 8.13±3.70,P<0.001)和二阶纹理敏感度(0.32±0.16 vs 0.37±0.17,P<0.05)均有明显差异。结论:单眼屈光参差性弱视患者大脑皮层一阶视觉通路和二阶视觉通路均存在不同程度的损伤,重度弱视患者较轻中度弱视患者损伤更为严重。展开更多
AIM:To evaluate the visual outcomes of standard amblyopic treatment add-on training via perceptual learning in refractive amblyopic children and to identify the risk factors for treatment failure.METHODS:Retrospective...AIM:To evaluate the visual outcomes of standard amblyopic treatment add-on training via perceptual learning in refractive amblyopic children and to identify the risk factors for treatment failure.METHODS:Retrospective charts were reviewed in children with refractive amblyopia who received standard treatment and add-on Cambridge Visual Stimulator(CAM)training.The add-on CAM group that was enrolled had worn full-corrected glasses for at least 2mo before training.A control group received only the standard treatment.Treatment success was defined as best-corrected visual acuity(BCVA)≥20/25.The age,sex,initial BCVA,refractive errors,sessions and duration of training,and final BCVA were recorded.RESULTS:A total of 209 children(129 children in add-on CAM group and 80 children in control group)were enrolled.Seventy-six percent of unilateral and 87%of bilateral amblyopic children achieved treatment success.In children with unilateral or bilateral moderate amblyopia,the duration to reach BCVA≥20/25 was significantly shorter in add-on CAM group than in control group.Poor initial BCVA(P<0.001)and high astigmatism(P=0.007)were risk factors for treatment failure after add-on CAM training.Age,sex,and types of refractive error were not associated with treatment success.CONCLUSION:Add-on CAM training is an effective strategy for visual improvement and can shorten the treatment course when the effect of standard treatment is limited in amblyopic children.展开更多
目的系统评价阿托品压抑疗法与遮盖法治疗小儿弱视的临床疗效。方法检索PubMed、The Cochrane Library、Web of Science、Embase、中国知网、万方、维普及中国生物医学文献数据库所有关于对比阿托品压抑疗法与遮盖法治疗小儿弱视的随机...目的系统评价阿托品压抑疗法与遮盖法治疗小儿弱视的临床疗效。方法检索PubMed、The Cochrane Library、Web of Science、Embase、中国知网、万方、维普及中国生物医学文献数据库所有关于对比阿托品压抑疗法与遮盖法治疗小儿弱视的随机对照试验(RCT)文献,检索时间为2013年1月1日—2023年10月31日,对文献按照纳入标准与排除标准进行筛选和数据录取,采用改良Jadad评分量表评价文献质量,Cochrane手册评价文献偏倚风险,RevMan 5.4软件进行统计分析。结果共纳入12项研究,总样本量1,344例(1,654只眼),其中治疗组671例(826只眼),对照组673例(828只眼)。治疗组在总有效率[OR=3.070,95%CI(2.210,4.250),Z=6.710,P=0.000]、最佳矫正视力[OR=0.180,95%CI(0.160,0.200),Z=19.020,P=0.000]、立体视功能重建有效率[OR=2.940,95%CI(1.810,4.770),Z=4.350,P=0.000]、治疗依从性[OR=7.750,95%CI(3.880,15.470),Z=5.810,P=0.000]方面均高于对照组,在并发症发生率方面低于对照组[OR=0.370,95%CI(0.200,0.690),Z=3.120,P=0.002],差异均有统计学意义。结论阿托品压抑疗法治疗小儿弱视疗效优于遮盖法,且患儿依从性好,并发症少。展开更多
文摘目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正视力(BCVA)、一阶光栅锐度和(或)二阶纹理敏感度,并分析不同程度弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。结果:弱视组与正常对照组一阶光栅锐度(11.58±6.10 vs 20.27±3.47,P<0.001)、二阶纹理敏感度(0.33±0.16 vs 0.12±0.04,P<0.001)均有明显差异,且轻中度弱视患者与重度弱视患者一阶光栅锐度(12.10±6.23 vs 8.13±3.70,P<0.001)和二阶纹理敏感度(0.32±0.16 vs 0.37±0.17,P<0.05)均有明显差异。结论:单眼屈光参差性弱视患者大脑皮层一阶视觉通路和二阶视觉通路均存在不同程度的损伤,重度弱视患者较轻中度弱视患者损伤更为严重。
基金Supported by the Kaohsiung Chang Gung Memorial Hospital and University College of Medicine(No.CMRPG8L1231,No.CMRPG8L1232,Kaohsiung,Taiwan).
文摘AIM:To evaluate the visual outcomes of standard amblyopic treatment add-on training via perceptual learning in refractive amblyopic children and to identify the risk factors for treatment failure.METHODS:Retrospective charts were reviewed in children with refractive amblyopia who received standard treatment and add-on Cambridge Visual Stimulator(CAM)training.The add-on CAM group that was enrolled had worn full-corrected glasses for at least 2mo before training.A control group received only the standard treatment.Treatment success was defined as best-corrected visual acuity(BCVA)≥20/25.The age,sex,initial BCVA,refractive errors,sessions and duration of training,and final BCVA were recorded.RESULTS:A total of 209 children(129 children in add-on CAM group and 80 children in control group)were enrolled.Seventy-six percent of unilateral and 87%of bilateral amblyopic children achieved treatment success.In children with unilateral or bilateral moderate amblyopia,the duration to reach BCVA≥20/25 was significantly shorter in add-on CAM group than in control group.Poor initial BCVA(P<0.001)and high astigmatism(P=0.007)were risk factors for treatment failure after add-on CAM training.Age,sex,and types of refractive error were not associated with treatment success.CONCLUSION:Add-on CAM training is an effective strategy for visual improvement and can shorten the treatment course when the effect of standard treatment is limited in amblyopic children.
