目的:分析1990—2019年全球异位妊娠疾病负担的区域分布与时间趋势,为异位妊娠的防治提供参考。方法:使用2019年全球疾病负担研究数据,利用伤残调整生命年(disability-adjusted life years,DALYs)评价全球不同地区的异位妊娠负担变化。...目的:分析1990—2019年全球异位妊娠疾病负担的区域分布与时间趋势,为异位妊娠的防治提供参考。方法:使用2019年全球疾病负担研究数据,利用伤残调整生命年(disability-adjusted life years,DALYs)评价全球不同地区的异位妊娠负担变化。通过Spearman相关分析判断异位妊娠年龄标化DALYs率与社会人口指数(sociodemographic index,SDI)的关系。采用Joinpoint回归模型计算1990—2019年异位妊娠标化DALYs率的年度变化百分比和平均年度变化百分比(average annual percentage change,AAPC)。结果:1990—2019年全球异位妊娠年龄标化DALYs率下降了22.23%,从1990年的12.46/10万下降至2019年9.69/10万。非洲的异位妊娠标化DALYs率最高(2019年为42.77/10万)。2019年全球204个国家(不同SDI分区)的异位妊娠标化DALYs率与SDI呈负相关(r=-0.818,P<0.001)。Joinpoint回归分析显示,1990—2019年全球异位妊娠标化DALYs率呈下降趋势,AAPC为-0.93%。1990—2019年,不同SDI地区异位妊娠标化DALYs率均呈下降趋势,其中低SDI地区下降幅度最低(AAPC=-1.07%)。结论:1990—2019年全球异位妊娠疾病负担呈下降趋势,低SDI地区及非洲地区异位妊娠疾病负担较高。展开更多
I am delighted to make this address as the Editor-in-Chief of the Shantou University Medical College Journal(The SUMC Journal)(ISSN 1007-4716).It is with great enthusiasm and a profound sense of responsibility that I ...I am delighted to make this address as the Editor-in-Chief of the Shantou University Medical College Journal(The SUMC Journal)(ISSN 1007-4716).It is with great enthusiasm and a profound sense of responsibility that I extend my warmest greetings to our dedicated authors,esteemed reviewers,and the broader academic community associated with the SUMC Journal.展开更多
Objective:The morphology analysis of whole-mount mouse embryos was observed using an improved paraffin section technique.Methods:Mouse embryos of varying embryonic ages were collected and whole-mount embryo paraffin s...Objective:The morphology analysis of whole-mount mouse embryos was observed using an improved paraffin section technique.Methods:Mouse embryos of varying embryonic ages were collected and whole-mount embryo paraffin sections were prepared using PFA-intravenously injected fixation,prolonged dehydration,and paraffin embedding.Hematoxylin and eosin(H&E)staining and immunohistochemical staining were employed to evaluate the quality of sections,with different tissues being observed labeled by CD34.Results:Following a series of tissue processing and staining procedures,the structure of the whole-mount mouse embryo was well-preserved,and the staining was clear and easily distinguishable.Embryos of different embryonic ages were treated differently,yet the quality of tissue processing remained highly consistent.Conclusion:Tissue processing and staining have been significantly improved,allowing for the easy acquisition of whole-mount mouse embryos of different ages through simplified methods of tissue fixation and dehydration duration.The staining results are clear and stable,providing technical support for the study of mouse embryo development.展开更多
文摘目的:探讨白藜芦醇对糖尿病心脏微血管损伤的作用及机制。方法:分离、培养大鼠心脏微血管内皮细胞,随机分为正常组、甘露醇组、高糖组、高糖+白藜芦醇组及高糖+白藜芦醇+compound C组。采用流式细胞仪检测细胞活性氧水平,试剂盒法检测超氧化物歧化酶活性和丙二醛含量,免疫印迹法检测腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)的活性。结果:与正常组相比,高糖组的活性氧水平和丙二醛含量增高,超氧化物歧化酶活性和p-AMPK/AMPK值降低;与高糖组相比,高糖+白藜芦醇组的活性氧水平和丙二醛含量降低,超氧化物歧化酶活性和p-AMPK/AMPK值升高;与高糖+白藜芦醇组相比,高糖+白藜芦醇+compound C(AMPK抑制剂)组中活性氧水平和丙二醛含量升高,超氧化物歧化酶活性和p-AMPK/AMPK值降低,差异有统计学意义(均P<0.05)。结论:白藜芦醇通过激活AMPK减轻糖尿病心脏微血管损伤。
文摘I am delighted to make this address as the Editor-in-Chief of the Shantou University Medical College Journal(The SUMC Journal)(ISSN 1007-4716).It is with great enthusiasm and a profound sense of responsibility that I extend my warmest greetings to our dedicated authors,esteemed reviewers,and the broader academic community associated with the SUMC Journal.
基金the funding of Department of Education of Guangdong Province,China(Grant No.2020KTSCX036Grant No.2023A1515010544)Health Commission of Guangdong Province(A2023342).
文摘Objective:The morphology analysis of whole-mount mouse embryos was observed using an improved paraffin section technique.Methods:Mouse embryos of varying embryonic ages were collected and whole-mount embryo paraffin sections were prepared using PFA-intravenously injected fixation,prolonged dehydration,and paraffin embedding.Hematoxylin and eosin(H&E)staining and immunohistochemical staining were employed to evaluate the quality of sections,with different tissues being observed labeled by CD34.Results:Following a series of tissue processing and staining procedures,the structure of the whole-mount mouse embryo was well-preserved,and the staining was clear and easily distinguishable.Embryos of different embryonic ages were treated differently,yet the quality of tissue processing remained highly consistent.Conclusion:Tissue processing and staining have been significantly improved,allowing for the easy acquisition of whole-mount mouse embryos of different ages through simplified methods of tissue fixation and dehydration duration.The staining results are clear and stable,providing technical support for the study of mouse embryo development.
