Objective: The analgesic effect of Paeonia Lactiflora has been widely accepted in traditional Chinese medicine. But little is known about the potential mechanism. This study aims to elucidate the effective components ...Objective: The analgesic effect of Paeonia Lactiflora has been widely accepted in traditional Chinese medicine. But little is known about the potential mechanism. This study aims to elucidate the effective components and analgesic mechanism based on network pharmacology. Methods: TCMSP was screened to collect the possible active ingredients and their CAS and SMILES was searched in Pubchem and further be used for reverse molecular docking in Swiss Target Prediction database to obtain potential targets. Pain-related molecules were obtained from GeenCards database, and the predicted targets of Paeonia Lactiflora for pain treatment were selected by Wayne diagram. For mechanism analysis, the protein-protein interactions were constructed by String, the GO analysis and KEGG analysis were conducted in DAVID. Results: Through GO analysis and KEGG analysis, we found that the pain related signaling pathways mainly involved in serotonergic synapse, calcium signaling pathway, inflammatory mediator TRP channels. Using network-based systems biology and molecular docking analyses, we predicted that 11 active ingredients in Paeonia Lactiflora has the analgesic effects with 97 potential targets. PRKCA, CASP3, ALOX15, SLC6A4, PRKCG, ALOX5, PRKCB, ALOX12, EGFR, ADRB2, RYR3, RYR1, NOS2, PTAFR, PRKCQ, and PRKCD were involved in the analgesic effects of Paeonia Lactiflora. Conclusion: Paeonia Lactiflora may alleviate pain through inflammatory mediator regulation of TRP channels, Ca2+ signaling pathway and 5-HT receptor. PRKCA, PRKCB, PRKCD,PRKCQ, and PRKCG may be new targets for pain treatment.展开更多
Objective:To systematically study the clinical effects of combined treatment with Dang gui si ni tang(DGSN)and western medicine(WM)on diabetic peripheral neuropathy.Methods:Seven databases,including Chinese National K...Objective:To systematically study the clinical effects of combined treatment with Dang gui si ni tang(DGSN)and western medicine(WM)on diabetic peripheral neuropathy.Methods:Seven databases,including Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical Database(CBM),Wanfang full-text database,VIP Database for Chinese Technical Periodicals,MEDLINE,PubMed,Embase,were retrieved.Related references about randomized controlled trials on the combination of DGSN and WM on diabetic peripheral neuropathy published during January 2012 up to now(recent 5 years)were reviewed.Related grey literatures were also reviewed according to the selected articles.RevMan5.3 software was used to analyze the publish bias,and to compare the total clinical effects of the combination of DGSN and WM with WM alone.Results:Ultimately,19 randomized controlled trials with 1690 patients were incorporated.The results of meta-analysis showed that combined treatment of diabetic peripheral neuropathy with DGSN and WM showed better general efficacy compared with control group,with a statistically significant difference(P<0.05).The results of study showed homogeneity(P=0.94>0.05).The general efficacy of combined treatment with DGSN and WM was significantly higher than that of control group(P<0.00001,OR=3.98,95%CI:3.01~5.27).Conclusion:Compared with treatment with WM alone,combined treatment of diabetic peripheral neuropathy with DGSN and WM is more effective.Meanwhile,due to the limited literature samples and low quality of literatures,large samples and high quality of multi-center randomized controlled double-blind trials are needed to verify these results.展开更多
Objective:To evaluate the clinical efficacy of Xiaoaiping injection(XAPI)combined with cisplatin plus gemcitabine(regimen of GP)for patients with non-small cell lung cancer(NSCLC).Methods:A literature search was condu...Objective:To evaluate the clinical efficacy of Xiaoaiping injection(XAPI)combined with cisplatin plus gemcitabine(regimen of GP)for patients with non-small cell lung cancer(NSCLC).Methods:A literature search was conducted for collecting the randomized controlled trials(RCTs)on NSCLC treated by Xiaoaiping injection and GP in the Cochrane Library,PubMed,Embase,Chinese National Knowledge Infrastructure(CNKI),China Biology Medicine(CBM),China Science and Technology Journal Database(VIP)and the Wanfang Database from inception to December,2018.The quality of the RCTs was evaluated by the Cochrane risk of bias assessment tool,and data analysis were performed with Review Manager 5.3.Results:A total of 7 randomized controlled trials with 534 patients were incorporated.The results showed that there is no statistical significance in total effective rate[OR=1.39,95%CI(0.97,1.98),P=0.07]and gastrointestinal reactions rate[OR=0.44,95%CI(0.16,1.23),P=0.12]between GP alone and XAPI combined with GP.In comparison with GP alone,the XAPI combined with GP was associated with the lower effects on the decrease rate of hemoglobin[OR=0.49,95%CI(0.26,0.92),P=0.03],leukocyte[OR=0.40,95%CI(0.21,0.74),P=0.004]and platelet[OR=0.43,95%CI(0.22,0.87),P=0.02].However,performance status[OR=3.78,95%CI(2.24,6.38),P<0.0001]of patients in XAPI plus GP group is better than GP alone group.Conclusion:The combination of XAPI and GP has certain curative effect for patients with NSCLC compared with only receiving GP.However,more well-designedand multicenter RCTs should be performed to verify this result because of the quality of enrolled RCTs.展开更多
Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliograp...Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliographic database of Chinese medicine were searched by computer to collect randomized controlled trials of Urinary Kallidinogenase's treatment of acute cerebral infarction.The time limit was set up until September 2019.At the same time,the references and grey literature in the literature were manually screened.Two independent researchers were screened,evaluated and extracted according to inclusion and exclusion criteria.Meta-analysis was carried out by RevMan 5.3 software.Results:A total of 17 randomized controlled trials involving 2,066 patients,including 1,033 in the experimental group,and 1,033 in the control group.meta-analysis results showed that compared with the conventional treatment,Urinary Kallidinogenase had better effect in the treatment of acute cerebral infarction[OR=3.26,95%CI(2.56,4.16),P<0.00001];the national institule of Health Stroke Scale of the Urinary Kallidinogenase group was significantly better than that of the control group.Urinary Kallidinogenase group activity of daily living scale was better than the control group[OR=21.33,95%CI(6.64,36.01),P=0.004];a total of 7 articles reported adverse reactions,including 19 cases in the trial group and 21 cases in the control group,the main adverse reactions were blood pressure drop,other symptoms were chest tightness,facial redness,dizziness fever,nausea and vomiting,arrhythmia,and no other serious adverse reactions.It can recover itself.Conclusion:the available evidence shows that Urinary Kallidinogenase can effectively improve the symptoms of neurological deficits and improve the ability of daily living in patients with acute cerebral infarction,and is safe.However,the quality of the study is limited.展开更多
Objective:To explore the relationship between mental nurses'discrimination against mental patients and the cognitive level of ethical atmosphere.Methods:Convenience sampling was adopted,147 psychiatric nurses from...Objective:To explore the relationship between mental nurses'discrimination against mental patients and the cognitive level of ethical atmosphere.Methods:Convenience sampling was adopted,147 psychiatric nurses from two psychiatric hospitals in guangdong province were selected as research subjects from march to May 2019.A discrimination against mental patients scale(DAMPS)and a ethical Climate Questionnaire(ECQ)were investigated.Results:The total score of ECQ was(87.33±10.99);the score of DAMPS was(1.94±0.60).The cognitive level of ethical atmosphere of psychiatric nurses was negatively correlated with the attitude of discriminating against psychopaths;Gender,marital status,department category,whether they are psychiatric nurses,whether they accept ethical knowledge,and the cognitive level of ethical atmosphere are the influencing factors of the attitude of psychiatric nurses to discriminate against psychiatric patients(R2=0.476,P<0.05).Conclusion:There was a negative correlation between the ethical cognition level of psychiatric nurses and the attitude of discriminating against psychopaths.Hospitals should pay attention to the improvement of the ethical atmosphere of psychiatric nurses and strengthen their ethical education.展开更多
Objective:To investigate the efficacy of the Shengxuebao Mixture in treating anemia after concurrent chemoradiotherapy for cervical cancer.Methods:The patients who met the criteria were randomly divided into the study...Objective:To investigate the efficacy of the Shengxuebao Mixture in treating anemia after concurrent chemoradiotherapy for cervical cancer.Methods:The patients who met the criteria were randomly divided into the study group(n=30)and the control group(n=30).The study group was treated with Shengxuebao Mixture(15 ml once,three times a day)for 30 days,and the control group was treated with ferrous succinate tablets(0.1 g,twice a day),folic acid tablets(5 mg,three times a day),and vitamin B12 tablets(25μg,once a day)for 30 days.Observed the hemoglobin level,erythropoietin level,TCM syndrome score,karnofsky performance status score before and after treatment in the two groups,compared the relevant data and clinical efficacy between the two groups and observed the adverse drug reactions at the same time.Results:The age,pathological type,stage,baseline hemoglobin level,erythropoietin level,TCM syndrome score,and karnofsky performance status score were comparable between the two groups(P>0.05).The hemoglobin level of the two groups after treatment was higher than before treatment(P<0.05).After treatment,the hemoglobin level in the study group was significantly higher than that in the control group(P<0.05),and the number of effective cases in the study group was more than that in the control group,and the effective rate in the study group was higher than that in the control group(P<0.05).The erythropoietin level of the two groups after treatment was lower than before treatment(P<0.05).After treatment,the erythropoietin level in the study group was significantly lower than that in the control group(P<0.05).The TCM syndrome score of the study group decreased significantly after treatment(P<0.05),but there was no significant change in the control group(P>0.05).After treatment,the TCM syndrome score of the study group was significantly lower than that of the control group(P<0.05),and the number of effective cases in the study group was more than that in the control group,and the effective rate in the study group was higher than that in the control group(P<0.05).There was no significant change in the karnofsky performance status score of the study group after treatment(P>0.05),but the karnofsky performance status score of the control group decreased significantly(P<0.05).After treatment,the karnofsky performance status score of the study group was higher than that of the control group(P<0.05),and the number of effective cases in the study group was more than that of the control group,and the effective rate was higher than that of the control group(P<0.05).And there were no obvious adverse reactions in this study.Conclusion:To some extent,this study showed that the Shengxuebao Mixture has a definite effect in treating anemia after concurrent chemoradiotherapy for cervical cancer,can promote the use of erythropoietin,improve TCM syndromes and stabilize the quality of life of patients.展开更多
Objective:Observe the advantages and characteristics of Acupuncture therapy and Point Thread Embedding therapy in the treatment of simple obesity and to select the superior treatment schemes.Methods:on the basis of sy...Objective:Observe the advantages and characteristics of Acupuncture therapy and Point Thread Embedding therapy in the treatment of simple obesity and to select the superior treatment schemes.Methods:on the basis of syndrome differentiation,acupuncture and Point Thread Embedding therapy were adopted respectively for 3 courses of treatment.Observe the changes of body weight and abdomen/waist/hip circumference in different stages of treatment and evaluate the curative effect.Results:Both acupuncture and Point Thread Embedding could lessen the weight and the abdomen/waist/hip circumference of simple obesity.Acupuncture and Point Thread Embedding can not only reduce body weight,but also improve clinical symptoms of simple obesity.The effect rate of clinical symptoms is better than that of weight(P<0.05);The efficiency of Point Thread Embedding group is better than that of Acupuncture group(P<0.05).There was no significant weight loss from the second course of treatment especially in acupuncture group(P>0.05).Conclusion:Acupuncture and Point Thread Embedding in the treatment of simple obesity focus more on the adjustment of body shape and constitution of obese patients;Compare with acupuncture treatment,point thread embedding group had a slower onset time and a longer duration of curative effect while acupuncture group had a faster onset time but a shorter duration.When the body weight is reduced to 5kg,the plateau stage occurs.Point Thread Embedding therapy is easier to be popularized and applied in clinic Because of its convenient and stable therapeutic effect.展开更多
Peripheral vascular disease with increasing prevalence rate is one among many conditions where a dependable cure is still elusive.Peripheral arterial disease(PAD),of which is a common form that results from atheroscle...Peripheral vascular disease with increasing prevalence rate is one among many conditions where a dependable cure is still elusive.Peripheral arterial disease(PAD),of which is a common form that results from atherosclerosis of arteries leading to reduced blood flow to the extremities.Commonly affecting the lower extremity,PAD presents with pain during ambulation,which is known as“intermittent claudication”which later manifests into“rest pain”.Due to the cry of the dying nerves,the pain is so severe that even common analgesics fail to relieve it.It is observed that the pathogenesis and clinical manifestation of PAD has striking similarities with“gambhira vatarakta”which is characterised by burning sensation,severe pain,excessive sweating,thirst,suppuration and tenderness.Keeping this view in mind the patients diagnosed with vatarakta were selected for jalauka avacharana(Leech therapy)followed by manjishtadi kshara basti(Decoction enema prepared by adding several drugs).This protocol showed remarkable results in relieving pain and ultimately vyadhi upashaya.展开更多
Objective:To investigate the clinical efficacy and safety of Banxia Xiexin decoction and omeprazole in the treatment of gastroesophageal reflux disease(GERD).Methods:EMbase,Cochrane,PubMed,CNKI,Wan Fang and VIP databa...Objective:To investigate the clinical efficacy and safety of Banxia Xiexin decoction and omeprazole in the treatment of gastroesophageal reflux disease(GERD).Methods:EMbase,Cochrane,PubMed,CNKI,Wan Fang and VIP database were searched from inception to November 2018 according to the search strategy.Eligible randomized controlled clinical trials related to the efficacy of omeprazole compared with Banxia Xiexin decoction in the treatment of GERD were included according to the inclusion and exclusion criteria.Total effective rate,pathological improvement rate,total symptom score,acid reflux symptoms,heartburn symptoms,improvement of post-sternal pain symptoms,and incidence of adverse reactions were evaluated.Data analysis was performed with RevMan5.3 software provided by Cochrane Collaboration.Results:A total of 15 studies were enrolled,including 1,532 patients.Meta-analysis results showed that the total effective rate of Banxia Xiexinfang was higher than that of omeprazole in the treatment of GERD(odds ratio(OR)=3.99,95%confidence intervals(CI)(2.58,6.15),P<0.00001).Pathological improvement under endoscopy was not obvious(OR=1.98,95%CI(0.94,4.19),P=0.07)between the two groups.The total symptom score improved significantly,indicating that Banxia Xiexin decoction has an objective advantage over omeprazole in the treatment of GERD(standardised mean difference(SMD)=?2.56,95%CI(?3.86,?1.26),P=0.0001),The incidence of adverse reactions in patients treated with Banxia Xiexin decoction is lower than omeprazole group(OR=0.09,95%CI(0.02,0.39),P=0.001].In addition,total effective rate of Banxia Xiexin decoction combined with omeprazole was higher than omeprazole alone(OR=6.31,95%CI(2.86,13.92),P<0.00001).Conclusion:Banxia Xiexin decoction is superior to omeprazole in total effective rate,total symptom score and adverse reaction rate in the treatment of GERD.The clinical efficacy of Banxia Xiexin decoction combined with omeprazole is better than that of omeprazole alone.However,due to the low quality of the included literatures,large-scale and high-quality RCTs are still needed for further confirmation.展开更多
Objective:To explore the clinical drug use of Professor Liu Shangyi,a master of Chinese medicine,in the treatment of thyroid cancer based on the ancient and modern medical record cloud platform v1.5.7 software.Methods...Objective:To explore the clinical drug use of Professor Liu Shangyi,a master of Chinese medicine,in the treatment of thyroid cancer based on the ancient and modern medical record cloud platform v1.5.7 software.Methods:From January 01,2018 to April 01,2019,the information input system of Professor Liu Shangyi,traditional Chinese Medicine Hospital of Guizhou Province,was screened.The data mining and analysis module was used to explore the clinical drug use of Professor Liu Shangyi in the treatment of thyroid cancer.Results:A total of 207 medical cases were recorded in this study,with 207 prescriptions,involving 129 kinds of herbs.The five most frequently used herbs are Ezhu(Curcumae Rhizoma),Biejia(Trionycis Carapax),Maozhuacao(Ranunculi Ternati Radix),Donglingcao(Rabdosia rubescens)and Chaojiezi(Sinapis Semen).Most of the drugs are warm and cold;most of the five flavors are sweet and bitter;most of the Meridian tropism are lung and liver;and the main efficacy are clearing away heat and toxic materials,eliminating phlegm and resolving hard mass.The most frequent correlation analysis of traditional Chinese medicines(TCM)are Bie Jia(Trionycis Carapax)-Ezhu(Curcumae Rhizoma),Donglingcao(Rabdosia rubescens)-Ezhu(Curcumae Rhizoma).Conclusion:Professor Liu Shangyi often use clearing away heat and toxic materials,resolving phlegm and disperse knot combined with tonifying liver and kidney in order to help fostering vital Qi and dispeling evil in clinical treatment of thyroid cancer.展开更多
Oral lichen planus(OLPS),a common oral mucosa disease,not only affects the patients’daily life,but also has a certain risk of cancerization.In traditional Chinese medicine,“phlegm”and“heat”can cause many various ...Oral lichen planus(OLPS),a common oral mucosa disease,not only affects the patients’daily life,but also has a certain risk of cancerization.In traditional Chinese medicine,“phlegm”and“heat”can cause many various illnesses.Professor Bo Zhang holds the point that the pathogenesis of OLPS is related to phlegm-heat amassment.He treated the patient in the case report with traditional Chinese medicine which was based on the principle of clearing phlegm and heat,and got a good curative effect.He treats OLPS with his own unique experience,which is taking clearing phlegm-heat and coordinating spleen-stomach as the main method,taking strengthening vital Qi to eliminate pathogenic factor as the supplement,and applying Wendan Decoction flexiblly.In order to provide a reference and guidance for clinicians,we report the typical case of OLPS.展开更多
Objective:To systematically evaluate the cllinical efficacy of Duhuo Jisheng decoction(DHJSD)combined with non-surgical therapy on lumbar disc herniation(LDH).Methods:China Science and Technology Journal Database(VIP)...Objective:To systematically evaluate the cllinical efficacy of Duhuo Jisheng decoction(DHJSD)combined with non-surgical therapy on lumbar disc herniation(LDH).Methods:China Science and Technology Journal Database(VIP),Chinese National Knowledge Infrastructure(CNKI),WanFang Data,PubMed were searched and eligible randomized controlled clinical trials(RCTs)were included.Two reviewers evaluated the quality of the included RCTs and extracted data independently.Then,data analysis was performed with RevMetn 4.2 software.Results:A total of 18 RCTs were enrolled,including 1682 patients.Meta-analysis results showed that the overall response rate of DHJSD combined with non-operative therapy group(treatment group)in the treatment of LDH was better than that of the non-operative therapy group(control group)[OR=4.29,95%CI(3.19,5.76),P<0.001].JOA score of the treatment group was significantly higher than that of control group[OR=3.96,95%CI(3.4,4.52),P<0.001].VAS score was dramatically lower in the treatment group than the control group[OR=-1.58,95%CI(-1.97,-1.18),P<0.001].Conclusion:The clinical efficacy of DHJSD combined with non-surgical therapy is better than that of non-surgical therapy alone.However,due to the low quality of the included literatures,large-scale and high-quality RCTs are still needed for further confirmation.展开更多
Etiology and pathogenesis of vitiligo has not been interpreted perfectly.Epidemiologic evidence about falling level of copper and zinc in blood serum increasing the risk of vitiligo remains contradictory.We investigat...Etiology and pathogenesis of vitiligo has not been interpreted perfectly.Epidemiologic evidence about falling level of copper and zinc in blood serum increasing the risk of vitiligo remains contradictory.We investigated the association between blood serum copper and zinc with vitiligo via performing a meta-analysis.Results indicates there was a significant lower level of copper and zinc in patients with vitiligo compared with healthy population((Z=3.55,P=0.000;SMDCu=?0.84,95%CI,?1.30 to?0.38)and(Z=5.40,P=0.000;SMDZn=?1.01,95%CI,?1.38 to?0.64),respectively).Meanwhile,no statistical evidence for publication bias in the end outcome.Conclusion from our finding offers a meaningful insight into lower level of copper and zinc in serum confer risk to vitiligo.展开更多
This paper reviews the published literature according to the Arksey and O’Malley’framework in order to determine the factors that influencing factors of nursing interns'belongingness in clinical nursing.Five inf...This paper reviews the published literature according to the Arksey and O’Malley’framework in order to determine the factors that influencing factors of nursing interns'belongingness in clinical nursing.Five influencing factors were extracted from 11 included studies:nursing students themselves,clinical teacher,clinical placement environment,relationships with patients and their families.展开更多
Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology ...Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.展开更多
Objective:To guide the pregnancy and delivery of patients with abnormal uterus through analyzing the delivery outcomes of them.Methods:A total of 32 pregnant cases with abnormal uterus were collected in the North Chin...Objective:To guide the pregnancy and delivery of patients with abnormal uterus through analyzing the delivery outcomes of them.Methods:A total of 32 pregnant cases with abnormal uterus were collected in the North China University of Science and Technology Affiliated Hospital from 2011 to 2018.7615 cases with normal uterus who visited the hospital and delivered during the same period were also collected.The rate of abnormal fetal position,premature rupture of membranes,premature delivery,postpartum complications,and caesarean section,were compared between the two groups by the χ^2 test through SPSS.P values less than 0.05 were considered statistically significant.Results:There were significant differences in abnormal fetal position,premature rupture of membranes,premature delivery and spontaneous birth rate between the two groups(P<0.05),but there was no significant difference in the incidence of postpartum hemorrhage between the two groups(P>0.05).In the cause of cesarean section,there was significant difference in abnormal fetal position and scarred uterus(P<0.05),but no significant difference in placenta previa and other causes(P>0.05).Conclusion:Abnormal fetal position,premature rupture of membranes and premature delivery are more likely to occur in pregnant women with abnormal uterus than in normal ones.The rate of cesarean section in patients with abnormal uterus is significantly higher than that of normal uterus,due to the main reason of abnormal fetal position.Abnormal uterus is a high-risk factor for pregnant women,and patients with abnormal uterus should be strengthened the management of pregnancy and relaxed the indications of cesarean section.展开更多
Professor Jia Chunsheng is one of the sixth of old traditional Chinese medicine experts,and often instructs students in ordinary clinics to attach importance to learning and clinical practices of classic works.Now Pro...Professor Jia Chunsheng is one of the sixth of old traditional Chinese medicine experts,and often instructs students in ordinary clinics to attach importance to learning and clinical practices of classic works.Now Professor Jia Chunsheng selects a poet-Song to Elucidate Mysteries in the Guidelines of Acupuncture Classic by Dou Hanqing in the Jin and Yuan Dynasties,and requires the students to read carefully,investigate deeply,and apply at times;Moreover,Professor Jia Chunsheng discusses the"important factors to achieve good clinical therapeutic effects by acupuncture"contained in the Song to Elucidate Mysteries,in many aspects of understanding acupoint characteristics,defining clearly acupoint compatibility,selecting appropriate needling manipulation,how to determine needling depth,how to determine needling direction,how to determine needle retention time,and how to select acupuncture&moxibustion method,etc.Now they are discussed as follows,to discover and spread Dou's acupuncture technique and to increase clinical therapeutic effects.展开更多
Currently,the influence of change in the intestinal flora on the human body has become a popular topic for clinical research.Several studies show that the nutritional balance,physiological metabolism,immune protection...Currently,the influence of change in the intestinal flora on the human body has become a popular topic for clinical research.Several studies show that the nutritional balance,physiological metabolism,immune protection,and even the occurrence and development of various chronic diseases are related to the change in intestinal flora.This chapter focuses on the changes in the intestinal microflora in pregnant women and the impact on the health of their offspring in order to provide some theoretical basis for clinical guidance.展开更多
Background:Robotic surgery is a complex innovation intervention.Recently,the number of robotic surgery case reports is increasing,but there is unclear on its reporting and methodological quality.Methods:The PubMed dat...Background:Robotic surgery is a complex innovation intervention.Recently,the number of robotic surgery case reports is increasing,but there is unclear on its reporting and methodological quality.Methods:The PubMed database will be searched with high-specificity search strategy from Jan 1,2012 to Aug 1,2018 to identify relevant records.Microsoft Excel 2016 will be used to generate random number and to select 100 robotic surgery case reports according our eligibility criteria.A data extraction form will be used to extract relevant information including first author,year of publication,journal,etc.The CARE guideline and JBI checklist will be used to separately assess the reporting and methodological quality of included studies.The data extraction and assessment of quality will be completed by independent two authors and any disagreement will be resolved through discussion or consulting the third author.Stratified analyses will be conducted based on extracted information.Review Manager 5.3 software will be used to present the results of stratified analyses with Inverse-Variance random-effect model.Results:The study is ongoing and will be submitted to a peerreviewed journal.Conclusion:The present study will summarize evidence on the reporting and methodological quality of robotic surgery case reports,and provide reference for future case reports but not limited to robotic surgery.Ethics and dissemination:Ethical approval is not required because this study will not include any confidential personal data and interventions on the patients.The results of this study will be published in a peerreviewed publication.展开更多
Background:To explore diagnostic value and clinical significance of preoperative neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)combined with serum carbohydrate antigen(CA),including CA125,CA1...Background:To explore diagnostic value and clinical significance of preoperative neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)combined with serum carbohydrate antigen(CA),including CA125,CA153 and CA199,in endometrial cancer(EC).Methods:The clinical data of 135 patients who underwent endometrial pathology examination in our hospital from January 2014 to June 2019 were retrospectively analyzed,including 65 cases of EC,40 cases of proliferative endometrial lesions and 50 cases of normal endometrium.Blood routine analyzer and electrochemical luminescence method were used to detect 5 parameters of NLR,PLR,CA125,CA153 and CA199 in these patients.The study explored the relationship between the five indicators and different levels of endometrial lesions,and analyzed their relationship with clinical pathological characteristics of EC patients.The diagnostic efficacy of NLR,PLR,CA,NLR combined CA,PLR combined CA was evaluated by receiver operating curve(ROC)combined with logistic regression equation.Results:The expression of the five parameters was different in different levels of endometrial lesions,and the expression level increased with the increase of endometrial lesion level.The difference among the three groups was statistically significant(P<0.05).CA125 level was related to International Federation of Gynecology and Obstetrics(FIGO)stage,lymph node metastasis and ki-67 index.CA153 level was related to ki-67 index.CA199 was related to FIGO stage,tissue differentiation and lymph node metastasis.NLR was related to FIGO stage,pathological type,tissue differentiation,myometrial invasion and lymph node metastasis.PLR was correlated with tissue differentiation,and the differences were statistically significant(P<0.05).The diagnosis of NLR combined with CA was the largest area under ROC curve(0.940),and its accuracy,sensitivity and specificity were higher than those of individual parameters and NLR combined with CA.Conclusion:NLR,PLR,CA125,CA153 and CA199 were highly expressed in EC and were correlated with clinical pathological data of EC patients respectively.NLR and PLR combined with CA could significantly improve the diagnostic efficiency of EC,providing clinical reference value for EC screening,therapeutic effect evaluation and disease progression evaluation.展开更多
基金the National Natural Science Foundation of China (Grant No. 81874404).
文摘Objective: The analgesic effect of Paeonia Lactiflora has been widely accepted in traditional Chinese medicine. But little is known about the potential mechanism. This study aims to elucidate the effective components and analgesic mechanism based on network pharmacology. Methods: TCMSP was screened to collect the possible active ingredients and their CAS and SMILES was searched in Pubchem and further be used for reverse molecular docking in Swiss Target Prediction database to obtain potential targets. Pain-related molecules were obtained from GeenCards database, and the predicted targets of Paeonia Lactiflora for pain treatment were selected by Wayne diagram. For mechanism analysis, the protein-protein interactions were constructed by String, the GO analysis and KEGG analysis were conducted in DAVID. Results: Through GO analysis and KEGG analysis, we found that the pain related signaling pathways mainly involved in serotonergic synapse, calcium signaling pathway, inflammatory mediator TRP channels. Using network-based systems biology and molecular docking analyses, we predicted that 11 active ingredients in Paeonia Lactiflora has the analgesic effects with 97 potential targets. PRKCA, CASP3, ALOX15, SLC6A4, PRKCG, ALOX5, PRKCB, ALOX12, EGFR, ADRB2, RYR3, RYR1, NOS2, PTAFR, PRKCQ, and PRKCD were involved in the analgesic effects of Paeonia Lactiflora. Conclusion: Paeonia Lactiflora may alleviate pain through inflammatory mediator regulation of TRP channels, Ca2+ signaling pathway and 5-HT receptor. PRKCA, PRKCB, PRKCD,PRKCQ, and PRKCG may be new targets for pain treatment.
文摘Objective:To systematically study the clinical effects of combined treatment with Dang gui si ni tang(DGSN)and western medicine(WM)on diabetic peripheral neuropathy.Methods:Seven databases,including Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical Database(CBM),Wanfang full-text database,VIP Database for Chinese Technical Periodicals,MEDLINE,PubMed,Embase,were retrieved.Related references about randomized controlled trials on the combination of DGSN and WM on diabetic peripheral neuropathy published during January 2012 up to now(recent 5 years)were reviewed.Related grey literatures were also reviewed according to the selected articles.RevMan5.3 software was used to analyze the publish bias,and to compare the total clinical effects of the combination of DGSN and WM with WM alone.Results:Ultimately,19 randomized controlled trials with 1690 patients were incorporated.The results of meta-analysis showed that combined treatment of diabetic peripheral neuropathy with DGSN and WM showed better general efficacy compared with control group,with a statistically significant difference(P<0.05).The results of study showed homogeneity(P=0.94>0.05).The general efficacy of combined treatment with DGSN and WM was significantly higher than that of control group(P<0.00001,OR=3.98,95%CI:3.01~5.27).Conclusion:Compared with treatment with WM alone,combined treatment of diabetic peripheral neuropathy with DGSN and WM is more effective.Meanwhile,due to the limited literature samples and low quality of literatures,large samples and high quality of multi-center randomized controlled double-blind trials are needed to verify these results.
文摘Objective:To evaluate the clinical efficacy of Xiaoaiping injection(XAPI)combined with cisplatin plus gemcitabine(regimen of GP)for patients with non-small cell lung cancer(NSCLC).Methods:A literature search was conducted for collecting the randomized controlled trials(RCTs)on NSCLC treated by Xiaoaiping injection and GP in the Cochrane Library,PubMed,Embase,Chinese National Knowledge Infrastructure(CNKI),China Biology Medicine(CBM),China Science and Technology Journal Database(VIP)and the Wanfang Database from inception to December,2018.The quality of the RCTs was evaluated by the Cochrane risk of bias assessment tool,and data analysis were performed with Review Manager 5.3.Results:A total of 7 randomized controlled trials with 534 patients were incorporated.The results showed that there is no statistical significance in total effective rate[OR=1.39,95%CI(0.97,1.98),P=0.07]and gastrointestinal reactions rate[OR=0.44,95%CI(0.16,1.23),P=0.12]between GP alone and XAPI combined with GP.In comparison with GP alone,the XAPI combined with GP was associated with the lower effects on the decrease rate of hemoglobin[OR=0.49,95%CI(0.26,0.92),P=0.03],leukocyte[OR=0.40,95%CI(0.21,0.74),P=0.004]and platelet[OR=0.43,95%CI(0.22,0.87),P=0.02].However,performance status[OR=3.78,95%CI(2.24,6.38),P<0.0001]of patients in XAPI plus GP group is better than GP alone group.Conclusion:The combination of XAPI and GP has certain curative effect for patients with NSCLC compared with only receiving GP.However,more well-designedand multicenter RCTs should be performed to verify this result because of the quality of enrolled RCTs.
文摘Objective:To evaluate the clinical efficacy and safety of Urinary Kallidinogenase for Injection in the treatment of acute cerebral infarction.Methods:PubMed,The Cochrane Library,Embase,CNKI,VIP,Wan Fang and bibliographic database of Chinese medicine were searched by computer to collect randomized controlled trials of Urinary Kallidinogenase's treatment of acute cerebral infarction.The time limit was set up until September 2019.At the same time,the references and grey literature in the literature were manually screened.Two independent researchers were screened,evaluated and extracted according to inclusion and exclusion criteria.Meta-analysis was carried out by RevMan 5.3 software.Results:A total of 17 randomized controlled trials involving 2,066 patients,including 1,033 in the experimental group,and 1,033 in the control group.meta-analysis results showed that compared with the conventional treatment,Urinary Kallidinogenase had better effect in the treatment of acute cerebral infarction[OR=3.26,95%CI(2.56,4.16),P<0.00001];the national institule of Health Stroke Scale of the Urinary Kallidinogenase group was significantly better than that of the control group.Urinary Kallidinogenase group activity of daily living scale was better than the control group[OR=21.33,95%CI(6.64,36.01),P=0.004];a total of 7 articles reported adverse reactions,including 19 cases in the trial group and 21 cases in the control group,the main adverse reactions were blood pressure drop,other symptoms were chest tightness,facial redness,dizziness fever,nausea and vomiting,arrhythmia,and no other serious adverse reactions.It can recover itself.Conclusion:the available evidence shows that Urinary Kallidinogenase can effectively improve the symptoms of neurological deficits and improve the ability of daily living in patients with acute cerebral infarction,and is safe.However,the quality of the study is limited.
文摘Objective:To explore the relationship between mental nurses'discrimination against mental patients and the cognitive level of ethical atmosphere.Methods:Convenience sampling was adopted,147 psychiatric nurses from two psychiatric hospitals in guangdong province were selected as research subjects from march to May 2019.A discrimination against mental patients scale(DAMPS)and a ethical Climate Questionnaire(ECQ)were investigated.Results:The total score of ECQ was(87.33±10.99);the score of DAMPS was(1.94±0.60).The cognitive level of ethical atmosphere of psychiatric nurses was negatively correlated with the attitude of discriminating against psychopaths;Gender,marital status,department category,whether they are psychiatric nurses,whether they accept ethical knowledge,and the cognitive level of ethical atmosphere are the influencing factors of the attitude of psychiatric nurses to discriminate against psychiatric patients(R2=0.476,P<0.05).Conclusion:There was a negative correlation between the ethical cognition level of psychiatric nurses and the attitude of discriminating against psychopaths.Hospitals should pay attention to the improvement of the ethical atmosphere of psychiatric nurses and strengthen their ethical education.
文摘Objective:To investigate the efficacy of the Shengxuebao Mixture in treating anemia after concurrent chemoradiotherapy for cervical cancer.Methods:The patients who met the criteria were randomly divided into the study group(n=30)and the control group(n=30).The study group was treated with Shengxuebao Mixture(15 ml once,three times a day)for 30 days,and the control group was treated with ferrous succinate tablets(0.1 g,twice a day),folic acid tablets(5 mg,three times a day),and vitamin B12 tablets(25μg,once a day)for 30 days.Observed the hemoglobin level,erythropoietin level,TCM syndrome score,karnofsky performance status score before and after treatment in the two groups,compared the relevant data and clinical efficacy between the two groups and observed the adverse drug reactions at the same time.Results:The age,pathological type,stage,baseline hemoglobin level,erythropoietin level,TCM syndrome score,and karnofsky performance status score were comparable between the two groups(P>0.05).The hemoglobin level of the two groups after treatment was higher than before treatment(P<0.05).After treatment,the hemoglobin level in the study group was significantly higher than that in the control group(P<0.05),and the number of effective cases in the study group was more than that in the control group,and the effective rate in the study group was higher than that in the control group(P<0.05).The erythropoietin level of the two groups after treatment was lower than before treatment(P<0.05).After treatment,the erythropoietin level in the study group was significantly lower than that in the control group(P<0.05).The TCM syndrome score of the study group decreased significantly after treatment(P<0.05),but there was no significant change in the control group(P>0.05).After treatment,the TCM syndrome score of the study group was significantly lower than that of the control group(P<0.05),and the number of effective cases in the study group was more than that in the control group,and the effective rate in the study group was higher than that in the control group(P<0.05).There was no significant change in the karnofsky performance status score of the study group after treatment(P>0.05),but the karnofsky performance status score of the control group decreased significantly(P<0.05).After treatment,the karnofsky performance status score of the study group was higher than that of the control group(P<0.05),and the number of effective cases in the study group was more than that of the control group,and the effective rate was higher than that of the control group(P<0.05).And there were no obvious adverse reactions in this study.Conclusion:To some extent,this study showed that the Shengxuebao Mixture has a definite effect in treating anemia after concurrent chemoradiotherapy for cervical cancer,can promote the use of erythropoietin,improve TCM syndromes and stabilize the quality of life of patients.
基金The project was supported by the Scientific Research Project of Shanxi Administration of Traditional Chinese Medicine(NO.2016ZYYC07)。
文摘Objective:Observe the advantages and characteristics of Acupuncture therapy and Point Thread Embedding therapy in the treatment of simple obesity and to select the superior treatment schemes.Methods:on the basis of syndrome differentiation,acupuncture and Point Thread Embedding therapy were adopted respectively for 3 courses of treatment.Observe the changes of body weight and abdomen/waist/hip circumference in different stages of treatment and evaluate the curative effect.Results:Both acupuncture and Point Thread Embedding could lessen the weight and the abdomen/waist/hip circumference of simple obesity.Acupuncture and Point Thread Embedding can not only reduce body weight,but also improve clinical symptoms of simple obesity.The effect rate of clinical symptoms is better than that of weight(P<0.05);The efficiency of Point Thread Embedding group is better than that of Acupuncture group(P<0.05).There was no significant weight loss from the second course of treatment especially in acupuncture group(P>0.05).Conclusion:Acupuncture and Point Thread Embedding in the treatment of simple obesity focus more on the adjustment of body shape and constitution of obese patients;Compare with acupuncture treatment,point thread embedding group had a slower onset time and a longer duration of curative effect while acupuncture group had a faster onset time but a shorter duration.When the body weight is reduced to 5kg,the plateau stage occurs.Point Thread Embedding therapy is easier to be popularized and applied in clinic Because of its convenient and stable therapeutic effect.
文摘Peripheral vascular disease with increasing prevalence rate is one among many conditions where a dependable cure is still elusive.Peripheral arterial disease(PAD),of which is a common form that results from atherosclerosis of arteries leading to reduced blood flow to the extremities.Commonly affecting the lower extremity,PAD presents with pain during ambulation,which is known as“intermittent claudication”which later manifests into“rest pain”.Due to the cry of the dying nerves,the pain is so severe that even common analgesics fail to relieve it.It is observed that the pathogenesis and clinical manifestation of PAD has striking similarities with“gambhira vatarakta”which is characterised by burning sensation,severe pain,excessive sweating,thirst,suppuration and tenderness.Keeping this view in mind the patients diagnosed with vatarakta were selected for jalauka avacharana(Leech therapy)followed by manjishtadi kshara basti(Decoction enema prepared by adding several drugs).This protocol showed remarkable results in relieving pain and ultimately vyadhi upashaya.
文摘Objective:To investigate the clinical efficacy and safety of Banxia Xiexin decoction and omeprazole in the treatment of gastroesophageal reflux disease(GERD).Methods:EMbase,Cochrane,PubMed,CNKI,Wan Fang and VIP database were searched from inception to November 2018 according to the search strategy.Eligible randomized controlled clinical trials related to the efficacy of omeprazole compared with Banxia Xiexin decoction in the treatment of GERD were included according to the inclusion and exclusion criteria.Total effective rate,pathological improvement rate,total symptom score,acid reflux symptoms,heartburn symptoms,improvement of post-sternal pain symptoms,and incidence of adverse reactions were evaluated.Data analysis was performed with RevMan5.3 software provided by Cochrane Collaboration.Results:A total of 15 studies were enrolled,including 1,532 patients.Meta-analysis results showed that the total effective rate of Banxia Xiexinfang was higher than that of omeprazole in the treatment of GERD(odds ratio(OR)=3.99,95%confidence intervals(CI)(2.58,6.15),P<0.00001).Pathological improvement under endoscopy was not obvious(OR=1.98,95%CI(0.94,4.19),P=0.07)between the two groups.The total symptom score improved significantly,indicating that Banxia Xiexin decoction has an objective advantage over omeprazole in the treatment of GERD(standardised mean difference(SMD)=?2.56,95%CI(?3.86,?1.26),P=0.0001),The incidence of adverse reactions in patients treated with Banxia Xiexin decoction is lower than omeprazole group(OR=0.09,95%CI(0.02,0.39),P=0.001].In addition,total effective rate of Banxia Xiexin decoction combined with omeprazole was higher than omeprazole alone(OR=6.31,95%CI(2.86,13.92),P<0.00001).Conclusion:Banxia Xiexin decoction is superior to omeprazole in total effective rate,total symptom score and adverse reaction rate in the treatment of GERD.The clinical efficacy of Banxia Xiexin decoction combined with omeprazole is better than that of omeprazole alone.However,due to the low quality of the included literatures,large-scale and high-quality RCTs are still needed for further confirmation.
文摘Objective:To explore the clinical drug use of Professor Liu Shangyi,a master of Chinese medicine,in the treatment of thyroid cancer based on the ancient and modern medical record cloud platform v1.5.7 software.Methods:From January 01,2018 to April 01,2019,the information input system of Professor Liu Shangyi,traditional Chinese Medicine Hospital of Guizhou Province,was screened.The data mining and analysis module was used to explore the clinical drug use of Professor Liu Shangyi in the treatment of thyroid cancer.Results:A total of 207 medical cases were recorded in this study,with 207 prescriptions,involving 129 kinds of herbs.The five most frequently used herbs are Ezhu(Curcumae Rhizoma),Biejia(Trionycis Carapax),Maozhuacao(Ranunculi Ternati Radix),Donglingcao(Rabdosia rubescens)and Chaojiezi(Sinapis Semen).Most of the drugs are warm and cold;most of the five flavors are sweet and bitter;most of the Meridian tropism are lung and liver;and the main efficacy are clearing away heat and toxic materials,eliminating phlegm and resolving hard mass.The most frequent correlation analysis of traditional Chinese medicines(TCM)are Bie Jia(Trionycis Carapax)-Ezhu(Curcumae Rhizoma),Donglingcao(Rabdosia rubescens)-Ezhu(Curcumae Rhizoma).Conclusion:Professor Liu Shangyi often use clearing away heat and toxic materials,resolving phlegm and disperse knot combined with tonifying liver and kidney in order to help fostering vital Qi and dispeling evil in clinical treatment of thyroid cancer.
文摘Oral lichen planus(OLPS),a common oral mucosa disease,not only affects the patients’daily life,but also has a certain risk of cancerization.In traditional Chinese medicine,“phlegm”and“heat”can cause many various illnesses.Professor Bo Zhang holds the point that the pathogenesis of OLPS is related to phlegm-heat amassment.He treated the patient in the case report with traditional Chinese medicine which was based on the principle of clearing phlegm and heat,and got a good curative effect.He treats OLPS with his own unique experience,which is taking clearing phlegm-heat and coordinating spleen-stomach as the main method,taking strengthening vital Qi to eliminate pathogenic factor as the supplement,and applying Wendan Decoction flexiblly.In order to provide a reference and guidance for clinicians,we report the typical case of OLPS.
文摘Objective:To systematically evaluate the cllinical efficacy of Duhuo Jisheng decoction(DHJSD)combined with non-surgical therapy on lumbar disc herniation(LDH).Methods:China Science and Technology Journal Database(VIP),Chinese National Knowledge Infrastructure(CNKI),WanFang Data,PubMed were searched and eligible randomized controlled clinical trials(RCTs)were included.Two reviewers evaluated the quality of the included RCTs and extracted data independently.Then,data analysis was performed with RevMetn 4.2 software.Results:A total of 18 RCTs were enrolled,including 1682 patients.Meta-analysis results showed that the overall response rate of DHJSD combined with non-operative therapy group(treatment group)in the treatment of LDH was better than that of the non-operative therapy group(control group)[OR=4.29,95%CI(3.19,5.76),P<0.001].JOA score of the treatment group was significantly higher than that of control group[OR=3.96,95%CI(3.4,4.52),P<0.001].VAS score was dramatically lower in the treatment group than the control group[OR=-1.58,95%CI(-1.97,-1.18),P<0.001].Conclusion:The clinical efficacy of DHJSD combined with non-surgical therapy is better than that of non-surgical therapy alone.However,due to the low quality of the included literatures,large-scale and high-quality RCTs are still needed for further confirmation.
文摘Etiology and pathogenesis of vitiligo has not been interpreted perfectly.Epidemiologic evidence about falling level of copper and zinc in blood serum increasing the risk of vitiligo remains contradictory.We investigated the association between blood serum copper and zinc with vitiligo via performing a meta-analysis.Results indicates there was a significant lower level of copper and zinc in patients with vitiligo compared with healthy population((Z=3.55,P=0.000;SMDCu=?0.84,95%CI,?1.30 to?0.38)and(Z=5.40,P=0.000;SMDZn=?1.01,95%CI,?1.38 to?0.64),respectively).Meanwhile,no statistical evidence for publication bias in the end outcome.Conclusion from our finding offers a meaningful insight into lower level of copper and zinc in serum confer risk to vitiligo.
文摘This paper reviews the published literature according to the Arksey and O’Malley’framework in order to determine the factors that influencing factors of nursing interns'belongingness in clinical nursing.Five influencing factors were extracted from 11 included studies:nursing students themselves,clinical teacher,clinical placement environment,relationships with patients and their families.
基金National Natural Science Foundation of China(Nos.81803979,81741130,81673979 and 81473688)Natural Science Foundation of Guangdong Province(Nos.2018A030313393,2016A030313114)+3 种基金Science and Technology Program of Guangzhou(Nos.201803010051,201707010245,201704020117)Science and Technology Program of Guangdong(No.2014A020212672)the Fourth Batch of TCM Clinical Outstanding Talent Program of China(No.444258)Scientific Research and Innovation Fund of Jinan University/the Fundamental Research Funds for the Central Universities,China(Nos.21617467,21615412).
文摘Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.
文摘Objective:To guide the pregnancy and delivery of patients with abnormal uterus through analyzing the delivery outcomes of them.Methods:A total of 32 pregnant cases with abnormal uterus were collected in the North China University of Science and Technology Affiliated Hospital from 2011 to 2018.7615 cases with normal uterus who visited the hospital and delivered during the same period were also collected.The rate of abnormal fetal position,premature rupture of membranes,premature delivery,postpartum complications,and caesarean section,were compared between the two groups by the χ^2 test through SPSS.P values less than 0.05 were considered statistically significant.Results:There were significant differences in abnormal fetal position,premature rupture of membranes,premature delivery and spontaneous birth rate between the two groups(P<0.05),but there was no significant difference in the incidence of postpartum hemorrhage between the two groups(P>0.05).In the cause of cesarean section,there was significant difference in abnormal fetal position and scarred uterus(P<0.05),but no significant difference in placenta previa and other causes(P>0.05).Conclusion:Abnormal fetal position,premature rupture of membranes and premature delivery are more likely to occur in pregnant women with abnormal uterus than in normal ones.The rate of cesarean section in patients with abnormal uterus is significantly higher than that of normal uterus,due to the main reason of abnormal fetal position.Abnormal uterus is a high-risk factor for pregnant women,and patients with abnormal uterus should be strengthened the management of pregnancy and relaxed the indications of cesarean section.
基金"No.333 Talent Project"Program of Hebei Province:2016-3-0713Heritage program of the sixth national batch of old traditional Chinese medicine expertsScientific Research Plan Program of Hebei Administration of Traditional Chinese Medicine:Dou Hanqing's Life Story and Research on His Academic Thoughts(No.2021096).
文摘Professor Jia Chunsheng is one of the sixth of old traditional Chinese medicine experts,and often instructs students in ordinary clinics to attach importance to learning and clinical practices of classic works.Now Professor Jia Chunsheng selects a poet-Song to Elucidate Mysteries in the Guidelines of Acupuncture Classic by Dou Hanqing in the Jin and Yuan Dynasties,and requires the students to read carefully,investigate deeply,and apply at times;Moreover,Professor Jia Chunsheng discusses the"important factors to achieve good clinical therapeutic effects by acupuncture"contained in the Song to Elucidate Mysteries,in many aspects of understanding acupoint characteristics,defining clearly acupoint compatibility,selecting appropriate needling manipulation,how to determine needling depth,how to determine needling direction,how to determine needle retention time,and how to select acupuncture&moxibustion method,etc.Now they are discussed as follows,to discover and spread Dou's acupuncture technique and to increase clinical therapeutic effects.
文摘Currently,the influence of change in the intestinal flora on the human body has become a popular topic for clinical research.Several studies show that the nutritional balance,physiological metabolism,immune protection,and even the occurrence and development of various chronic diseases are related to the change in intestinal flora.This chapter focuses on the changes in the intestinal microflora in pregnant women and the impact on the health of their offspring in order to provide some theoretical basis for clinical guidance.
文摘Background:Robotic surgery is a complex innovation intervention.Recently,the number of robotic surgery case reports is increasing,but there is unclear on its reporting and methodological quality.Methods:The PubMed database will be searched with high-specificity search strategy from Jan 1,2012 to Aug 1,2018 to identify relevant records.Microsoft Excel 2016 will be used to generate random number and to select 100 robotic surgery case reports according our eligibility criteria.A data extraction form will be used to extract relevant information including first author,year of publication,journal,etc.The CARE guideline and JBI checklist will be used to separately assess the reporting and methodological quality of included studies.The data extraction and assessment of quality will be completed by independent two authors and any disagreement will be resolved through discussion or consulting the third author.Stratified analyses will be conducted based on extracted information.Review Manager 5.3 software will be used to present the results of stratified analyses with Inverse-Variance random-effect model.Results:The study is ongoing and will be submitted to a peerreviewed journal.Conclusion:The present study will summarize evidence on the reporting and methodological quality of robotic surgery case reports,and provide reference for future case reports but not limited to robotic surgery.Ethics and dissemination:Ethical approval is not required because this study will not include any confidential personal data and interventions on the patients.The results of this study will be published in a peerreviewed publication.
文摘Background:To explore diagnostic value and clinical significance of preoperative neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)combined with serum carbohydrate antigen(CA),including CA125,CA153 and CA199,in endometrial cancer(EC).Methods:The clinical data of 135 patients who underwent endometrial pathology examination in our hospital from January 2014 to June 2019 were retrospectively analyzed,including 65 cases of EC,40 cases of proliferative endometrial lesions and 50 cases of normal endometrium.Blood routine analyzer and electrochemical luminescence method were used to detect 5 parameters of NLR,PLR,CA125,CA153 and CA199 in these patients.The study explored the relationship between the five indicators and different levels of endometrial lesions,and analyzed their relationship with clinical pathological characteristics of EC patients.The diagnostic efficacy of NLR,PLR,CA,NLR combined CA,PLR combined CA was evaluated by receiver operating curve(ROC)combined with logistic regression equation.Results:The expression of the five parameters was different in different levels of endometrial lesions,and the expression level increased with the increase of endometrial lesion level.The difference among the three groups was statistically significant(P<0.05).CA125 level was related to International Federation of Gynecology and Obstetrics(FIGO)stage,lymph node metastasis and ki-67 index.CA153 level was related to ki-67 index.CA199 was related to FIGO stage,tissue differentiation and lymph node metastasis.NLR was related to FIGO stage,pathological type,tissue differentiation,myometrial invasion and lymph node metastasis.PLR was correlated with tissue differentiation,and the differences were statistically significant(P<0.05).The diagnosis of NLR combined with CA was the largest area under ROC curve(0.940),and its accuracy,sensitivity and specificity were higher than those of individual parameters and NLR combined with CA.Conclusion:NLR,PLR,CA125,CA153 and CA199 were highly expressed in EC and were correlated with clinical pathological data of EC patients respectively.NLR and PLR combined with CA could significantly improve the diagnostic efficiency of EC,providing clinical reference value for EC screening,therapeutic effect evaluation and disease progression evaluation.
