This article represents the main positions of the theory of pleiotropic action of biologically active compounds (BACs) and medicines, which has been designed by the author based on her own experimental researches. The...This article represents the main positions of the theory of pleiotropic action of biologically active compounds (BACs) and medicines, which has been designed by the author based on her own experimental researches. The term “pleiotropy” means the ability of the BACs and medicines to implement more than one mechanism of action resulting in the specific biological (pharmacological) effect. The interaction of these mechanisms forms a distinct pattern of biological response (pleiotropic pattern), which reflects the change in his character with the increased dose (concentration)-dependent efficacy of BACs and medicines. The article consists of description of different pleiotropic patterns established in experiments on the model of reactive oxygen species (ROS) generation by macrophages dependent on activity of specialized enzyme called Nox2-NAD(P)H oxidase (Nox2, EC 1.6.3.1). Moreover, it consists of explanation of pharmacodynamic nature of pleiotropic patterns by means of application Chou-Talalay median effect equalization and combination index (CI) theory. The novel theory explains unsolved until now universal aspects of activity BACs and medicines, such as slope angles of “dose-effect” dependences in the conditions relevant in vivo, and it is of fundamental interest. However, it has applications in experimental pharmacology, as it allows defining the choice of the individual compounds and combinations, modulating the trust effect selectively and efficiently. This knowledge opens up new approaches to medicines discovery and evaluation, their rational dosing and combining.展开更多
Computer based automation and control systems are becoming increasingly important in smart sustainable buildings,often referred to as automated buildings(ABs),in order to automatically control,optimize and supervise a...Computer based automation and control systems are becoming increasingly important in smart sustainable buildings,often referred to as automated buildings(ABs),in order to automatically control,optimize and supervise a wide range of building performance applications over a network while minimizing energy consumption and associated green house gas emission.This technology generally refers to building automation and control systems(BACS)architecture.Instead of costly and time-consuming experiments,this paper focuses on development and design of a distributed dynamic simulation environment with the capability to represent BACS architecture in simulation by run-time coupling two or more different software tools over a network.This involves using distributed dynamic simulations as means to analyze the performance and enhance networked real-time control systems in ABs and improve the functions of real BACS technology.The application and capability of this new dynamic simulation environment are demonstrated by an experimental design,in this paper.展开更多
文摘This article represents the main positions of the theory of pleiotropic action of biologically active compounds (BACs) and medicines, which has been designed by the author based on her own experimental researches. The term “pleiotropy” means the ability of the BACs and medicines to implement more than one mechanism of action resulting in the specific biological (pharmacological) effect. The interaction of these mechanisms forms a distinct pattern of biological response (pleiotropic pattern), which reflects the change in his character with the increased dose (concentration)-dependent efficacy of BACs and medicines. The article consists of description of different pleiotropic patterns established in experiments on the model of reactive oxygen species (ROS) generation by macrophages dependent on activity of specialized enzyme called Nox2-NAD(P)H oxidase (Nox2, EC 1.6.3.1). Moreover, it consists of explanation of pharmacodynamic nature of pleiotropic patterns by means of application Chou-Talalay median effect equalization and combination index (CI) theory. The novel theory explains unsolved until now universal aspects of activity BACs and medicines, such as slope angles of “dose-effect” dependences in the conditions relevant in vivo, and it is of fundamental interest. However, it has applications in experimental pharmacology, as it allows defining the choice of the individual compounds and combinations, modulating the trust effect selectively and efficiently. This knowledge opens up new approaches to medicines discovery and evaluation, their rational dosing and combining.
文摘Computer based automation and control systems are becoming increasingly important in smart sustainable buildings,often referred to as automated buildings(ABs),in order to automatically control,optimize and supervise a wide range of building performance applications over a network while minimizing energy consumption and associated green house gas emission.This technology generally refers to building automation and control systems(BACS)architecture.Instead of costly and time-consuming experiments,this paper focuses on development and design of a distributed dynamic simulation environment with the capability to represent BACS architecture in simulation by run-time coupling two or more different software tools over a network.This involves using distributed dynamic simulations as means to analyze the performance and enhance networked real-time control systems in ABs and improve the functions of real BACS technology.The application and capability of this new dynamic simulation environment are demonstrated by an experimental design,in this paper.
