【目的】分析28~36周早产儿生后3~21 d FT3、FT4、TSH变化的特征。【方法】回顾性分析2018年7月至2019年6月中山大学附属第三医院新生儿科住院的236例28~36周早产儿的临床资料,包括甲状腺功能检查(FT3、FT4和TSH)、胎龄、性别、出生体...【目的】分析28~36周早产儿生后3~21 d FT3、FT4、TSH变化的特征。【方法】回顾性分析2018年7月至2019年6月中山大学附属第三医院新生儿科住院的236例28~36周早产儿的临床资料,包括甲状腺功能检查(FT3、FT4和TSH)、胎龄、性别、出生体质量、出生身长、检查日龄、辅助生殖方式、单胎或多胎、母亲甲状腺疾病和母亲妊娠期糖尿病,比较早产儿3~7 d与8~21 d FT3、FT4和TSH水平的差异;分析影响早产儿FT3、FT4和TSH水平的独立因素;比较不同胎龄早产儿FT3、FT4和TSH水平差异。【结果】早产儿3~7 d FT3水平(3.23±0.54)pmol/L,低于8~21 d的(3.41±0.76)pmol/L,差异有统计学意义(P=0.040);早产儿3~7 d的FT4水平(15.36±3.40)pmol/L,高于8~21 d的(13.20±2.63)pmol/L,差异有统计学意义(P<0.001);3~7 d与8~21 d的TSH分布的差异没有统计学意义(P=0.846);早产儿3~7 d FT3水平受到胎龄的影响(P<0.001),3~7天FT4水平受到胎龄和检查日龄的影响(P<0.001),8~21 d的FT3、FT4水平均受到胎龄和性别的影响(P<0.001、P<0.001);3~7 d、8~21 d的FT3、FT4水平与胎龄为正相关(P<0.001,P<0.001;P<0.001,P=0.001)。【结论】胎龄影响生后3~21 d早产儿的甲状腺功能,胎龄越小,FT3、FT4越低,需要建立一个胎龄相关的的FT4或T4参考范围,结合TSH联合评估甲状腺功能。展开更多
Background: Cardiovascular diseases, such as hypertension and coronary heart disease, are often accompanied by thyroid and mental diseases, the harm of which poses great threats to patients’ health. Objective: To exp...Background: Cardiovascular diseases, such as hypertension and coronary heart disease, are often accompanied by thyroid and mental diseases, the harm of which poses great threats to patients’ health. Objective: To explore the correlation between free triiodothyronine (FT3), free thyroxine (FT4) and hypertension in depression patients with hypothyroidism and its clinical guiding value. Methods: A total of 548 patients diagnosed with hypothyroidism in Wuxue First People’s Hospital of Hubei Province from January 2018 to September 2022 were enrolled. According to whether complicated with depression, they were divided into hypothyroidism without depression group (group A) and hypothyroidism with depression group (group B). The gender, age, comorbidities (such as depression, hypertension, diabetes, dyslipidemia, acute myocardial infarction), FT3, FT4, and thyroid stimulating hormone (TSH) levels were recorded. Spearman rank correlation was used to analyze hypertensive patients with hypothyroidism. Multivariate binary Logistic regression was used to analyze the influencing factors of hypertension in patients with hypothyroidism. Results: The TSH level, the number of hypertension, coronary heart disease and hyperlipidemia in group B were statistically significantly higher than those in group A (P 3 level in group B was statistically significantly lower than that in group A (P s = 0.092), coronary heart disease (rs = 0.000), hyperlipidemia (rs = 0.000), diabetes (rs = 0.000), and age (rs = 0.000), and negatively correlated with FT3 (rs = 0.000) (P 3 and FT4 were the influencing factors of hypertension. The risk of hypertension in patients with coronary heart disease and hyperlipidemia significantly increased by 3.425 and 1.761 times (P 3, the risk of hypertension increased (P 4, the risk of hypertension significantly increased (P 3 and FT4 are the influencing factors of hypertension. The lower the FT3 level, the higher the FT4 level, the higher the risk of hypertension. FT3 and FT4 may be potential biomarkers of depression in hypertensive patients. Thyroid function assessment is recommended in patients with hypertension.展开更多
文摘【目的】分析28~36周早产儿生后3~21 d FT3、FT4、TSH变化的特征。【方法】回顾性分析2018年7月至2019年6月中山大学附属第三医院新生儿科住院的236例28~36周早产儿的临床资料,包括甲状腺功能检查(FT3、FT4和TSH)、胎龄、性别、出生体质量、出生身长、检查日龄、辅助生殖方式、单胎或多胎、母亲甲状腺疾病和母亲妊娠期糖尿病,比较早产儿3~7 d与8~21 d FT3、FT4和TSH水平的差异;分析影响早产儿FT3、FT4和TSH水平的独立因素;比较不同胎龄早产儿FT3、FT4和TSH水平差异。【结果】早产儿3~7 d FT3水平(3.23±0.54)pmol/L,低于8~21 d的(3.41±0.76)pmol/L,差异有统计学意义(P=0.040);早产儿3~7 d的FT4水平(15.36±3.40)pmol/L,高于8~21 d的(13.20±2.63)pmol/L,差异有统计学意义(P<0.001);3~7 d与8~21 d的TSH分布的差异没有统计学意义(P=0.846);早产儿3~7 d FT3水平受到胎龄的影响(P<0.001),3~7天FT4水平受到胎龄和检查日龄的影响(P<0.001),8~21 d的FT3、FT4水平均受到胎龄和性别的影响(P<0.001、P<0.001);3~7 d、8~21 d的FT3、FT4水平与胎龄为正相关(P<0.001,P<0.001;P<0.001,P=0.001)。【结论】胎龄影响生后3~21 d早产儿的甲状腺功能,胎龄越小,FT3、FT4越低,需要建立一个胎龄相关的的FT4或T4参考范围,结合TSH联合评估甲状腺功能。
文摘Background: Cardiovascular diseases, such as hypertension and coronary heart disease, are often accompanied by thyroid and mental diseases, the harm of which poses great threats to patients’ health. Objective: To explore the correlation between free triiodothyronine (FT3), free thyroxine (FT4) and hypertension in depression patients with hypothyroidism and its clinical guiding value. Methods: A total of 548 patients diagnosed with hypothyroidism in Wuxue First People’s Hospital of Hubei Province from January 2018 to September 2022 were enrolled. According to whether complicated with depression, they were divided into hypothyroidism without depression group (group A) and hypothyroidism with depression group (group B). The gender, age, comorbidities (such as depression, hypertension, diabetes, dyslipidemia, acute myocardial infarction), FT3, FT4, and thyroid stimulating hormone (TSH) levels were recorded. Spearman rank correlation was used to analyze hypertensive patients with hypothyroidism. Multivariate binary Logistic regression was used to analyze the influencing factors of hypertension in patients with hypothyroidism. Results: The TSH level, the number of hypertension, coronary heart disease and hyperlipidemia in group B were statistically significantly higher than those in group A (P 3 level in group B was statistically significantly lower than that in group A (P s = 0.092), coronary heart disease (rs = 0.000), hyperlipidemia (rs = 0.000), diabetes (rs = 0.000), and age (rs = 0.000), and negatively correlated with FT3 (rs = 0.000) (P 3 and FT4 were the influencing factors of hypertension. The risk of hypertension in patients with coronary heart disease and hyperlipidemia significantly increased by 3.425 and 1.761 times (P 3, the risk of hypertension increased (P 4, the risk of hypertension significantly increased (P 3 and FT4 are the influencing factors of hypertension. The lower the FT3 level, the higher the FT4 level, the higher the risk of hypertension. FT3 and FT4 may be potential biomarkers of depression in hypertensive patients. Thyroid function assessment is recommended in patients with hypertension.
