BACKGROUND Although the etiology of nonalcoholic fatty liver disease(NAFLD)has not been thoroughly understood,the emerging roles of anthropometric indicators in assessing and predicting the risk of NAFLD have been hig...BACKGROUND Although the etiology of nonalcoholic fatty liver disease(NAFLD)has not been thoroughly understood,the emerging roles of anthropometric indicators in assessing and predicting the risk of NAFLD have been highlighted by accumulating evidence.AIM To evaluate the causal relationships between five anthropometric indicators and NAFLD employing Mendelian randomization(MR)design.METHODS The Anthropometric Consortium provided genetic exposure data for five anthropometric indicators,including hip circumference(HC),waist circumference(WC),waist-to-hip ratio(WHR),body mass index(BMI),and body fat percentage(BF).Genetic outcome data for NAFLD were obtained from the United Kingdom Biobank and FinnGen Consortium.Genome-wide significant single nucleotide polymorphisms were chosen as instrumental variables.Univariable MR(UVMR)and multivariable MR(MVMR)designs with analytical approaches,including inverse variance weighted(IVW),MR-Egger,weighted median(WM),and weighted mode methods,were used to assess the causal relationships between anthropometric indicators and NAFLD.RESULTS Causal relationships were revealed by UVMR,indicating that a higher risk of NAFLD was associated with a perunit increase in WC[IVW:odds ratio(OR)=2.67,95%CI:1.42-5.02,P=2.25×10^(−3)],and BF was causally associated with an increased risk of NAFLD(WM:OR=2.23,95%CI:1.07-4.66,P=0.033).The presence of causal effects of WC on the decreased risk of NAFLD was supported by MVMR after adjusting for BMI and smoking.However,no causal association between BF and NAFLD was observed.In addition,other causal relationships of HC,WHR(BMI adjusted),and BMI with the risk of NAFLD were not retained after FDR correction.CONCLUSION This study establishes a causal relationship,indicating that an increase in WC is associated with a higher risk of NAFLD.This demonstrates that a suitable decrease in WC is advantageous for preventing NAFLD.展开更多
提出一种基于SABO-GRU-Attention(subtraction average based optimizer-gate recurrent unitattention)的锂电池SOC(state of charge)估计方法。采用基于平均减法优化算法自适应更新GRU神经网络的超参数,融合SE(squeeze and excitation...提出一种基于SABO-GRU-Attention(subtraction average based optimizer-gate recurrent unitattention)的锂电池SOC(state of charge)估计方法。采用基于平均减法优化算法自适应更新GRU神经网络的超参数,融合SE(squeeze and excitation)注意力机制自适应分配各通道权重,提高学习效率。对马里兰大学电池数据集进行预处理,输入电压、电流参数,进行锂电池充放电仿真实验,并搭建锂电池荷电状态实验平台进行储能锂电池充放电实验。结果表明,提出的SOC神经网络估计模型明显优于LSTM、GRU以及PSO-GRU等模型,具有较高的估计精度与应用价值。展开更多
针对光伏发电应用领域太阳能路灯系统的过充电或过放电现象对蓄电池本身特性产生影响、降低使用寿命的问题,采用单片机和LabVIEW进行太阳能路灯蓄电池电压检测,采用BP神经网络进行太阳能路灯蓄电池荷电率(SOC)预测。BP神经网络将测得数...针对光伏发电应用领域太阳能路灯系统的过充电或过放电现象对蓄电池本身特性产生影响、降低使用寿命的问题,采用单片机和LabVIEW进行太阳能路灯蓄电池电压检测,采用BP神经网络进行太阳能路灯蓄电池荷电率(SOC)预测。BP神经网络将测得数据建立SOC(State of Charge)预测模型,LabVIEW可视化面板实时显示测量数据、波形及预测结果,实现太阳能路灯智能化控制。测试结果表明,系统能够实时检测蓄电池充电电压,并预测电池工作状态,BP神经网络蓄电池SOC预测值与蓄电池电量实测误差为0.1%~0.4%,满足网络误差要求。展开更多
基金Supported by Science and Technology Research Project of Sichuan Administration of Traditional Chinese Medicine,No.2023MS419.
文摘BACKGROUND Although the etiology of nonalcoholic fatty liver disease(NAFLD)has not been thoroughly understood,the emerging roles of anthropometric indicators in assessing and predicting the risk of NAFLD have been highlighted by accumulating evidence.AIM To evaluate the causal relationships between five anthropometric indicators and NAFLD employing Mendelian randomization(MR)design.METHODS The Anthropometric Consortium provided genetic exposure data for five anthropometric indicators,including hip circumference(HC),waist circumference(WC),waist-to-hip ratio(WHR),body mass index(BMI),and body fat percentage(BF).Genetic outcome data for NAFLD were obtained from the United Kingdom Biobank and FinnGen Consortium.Genome-wide significant single nucleotide polymorphisms were chosen as instrumental variables.Univariable MR(UVMR)and multivariable MR(MVMR)designs with analytical approaches,including inverse variance weighted(IVW),MR-Egger,weighted median(WM),and weighted mode methods,were used to assess the causal relationships between anthropometric indicators and NAFLD.RESULTS Causal relationships were revealed by UVMR,indicating that a higher risk of NAFLD was associated with a perunit increase in WC[IVW:odds ratio(OR)=2.67,95%CI:1.42-5.02,P=2.25×10^(−3)],and BF was causally associated with an increased risk of NAFLD(WM:OR=2.23,95%CI:1.07-4.66,P=0.033).The presence of causal effects of WC on the decreased risk of NAFLD was supported by MVMR after adjusting for BMI and smoking.However,no causal association between BF and NAFLD was observed.In addition,other causal relationships of HC,WHR(BMI adjusted),and BMI with the risk of NAFLD were not retained after FDR correction.CONCLUSION This study establishes a causal relationship,indicating that an increase in WC is associated with a higher risk of NAFLD.This demonstrates that a suitable decrease in WC is advantageous for preventing NAFLD.
文摘提出一种基于SABO-GRU-Attention(subtraction average based optimizer-gate recurrent unitattention)的锂电池SOC(state of charge)估计方法。采用基于平均减法优化算法自适应更新GRU神经网络的超参数,融合SE(squeeze and excitation)注意力机制自适应分配各通道权重,提高学习效率。对马里兰大学电池数据集进行预处理,输入电压、电流参数,进行锂电池充放电仿真实验,并搭建锂电池荷电状态实验平台进行储能锂电池充放电实验。结果表明,提出的SOC神经网络估计模型明显优于LSTM、GRU以及PSO-GRU等模型,具有较高的估计精度与应用价值。
文摘针对光伏发电应用领域太阳能路灯系统的过充电或过放电现象对蓄电池本身特性产生影响、降低使用寿命的问题,采用单片机和LabVIEW进行太阳能路灯蓄电池电压检测,采用BP神经网络进行太阳能路灯蓄电池荷电率(SOC)预测。BP神经网络将测得数据建立SOC(State of Charge)预测模型,LabVIEW可视化面板实时显示测量数据、波形及预测结果,实现太阳能路灯智能化控制。测试结果表明,系统能够实时检测蓄电池充电电压,并预测电池工作状态,BP神经网络蓄电池SOC预测值与蓄电池电量实测误差为0.1%~0.4%,满足网络误差要求。
