[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fa...[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.展开更多
Objective:To observe the effects of moxibustion at different temperatures(38℃,46℃)on blood lipids,endothelial morphology of the thoracic aorta,serum endothelin-1(ET-1),calcitonin gene-related peptide(CGRP),nitric ox...Objective:To observe the effects of moxibustion at different temperatures(38℃,46℃)on blood lipids,endothelial morphology of the thoracic aorta,serum endothelin-1(ET-1),calcitonin gene-related peptide(CGRP),nitric oxide(NO),and endothelial NO synthase(eNOS)in hyperlipidemic rats.Methods:Using the random number table method,60 Sprague Dawley rats were randomly and evenly divided into blank,model,38℃-moxibustion,and 46℃-moxibustion groups.Rats in the 3 experimental groups were fed a high-fat feed to model hyperlipidemia in rats.Rats in the 38℃-moxibustion and 46℃-moxibustion groups were moxibustion on the Shenque and bilateral Zusanli acupoints for 10 minutes each,once every other day for 4 weeks,at temperatures of 38±1℃ and 46±1℃.After that,rat blood samples were collected to detect blood lipids and ET-1,CGRP,eNOS and NO.Take the endotheal tissue of the thoracic aorta to do HE staining.Results:(1)The serum total cholesterol,triglycerides,and low-density lipoprotein cholesterol of rats in the 46℃-moxibustion group were significantly lower than those in the model and 38℃-moxibustion groups.(2)Revealed by hematoxylin and eosin staining,showed necrosis in the local vascular endothelial cells and mild inflammatory cell infiltration in the tunica adventitia of the hyperlipidemic rats.These endothelial morphologies did not improve significantly after moxibustion at 38℃ but did improve at 46℃.(3)Compared with the blank group,serum ET-1 was significantly higher and serum CGRP,NO,eNOS were significantly lower in the model group.Compared with the model and the 38℃-moxibustion groups,serum ET-1 was significantly lower and serum CGRP,NO,eNOS were significantly higher in 46℃-moxibustion groups.Conclusion:Moxibustion at 46℃ effectively regulated blood lipids,improved the morphology of the vascular endothelium,and protected vascular endothelial function.展开更多
Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats...Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats were fed a normal diet,and bilateral acu-point Fenglong(equivalent to ST40 in humans)on the hind legs were covered with a placebo(general mucilage)for 2 hours each day.Model group rats were fed a high-lipid diet for 2 weeks.Therapy group rats were fed a high-lipid diet for 2 weeks and then administered crude-herb moxibustion at ST40 for 2 hours each day for the next 2 weeks.Prevention group rats were administered crude-herb moxibustion 2 hours a day for 2 weeks and then fed a high-lipid diet for the subsequent 2 weeks.Prevention/Therapy group rats were each administered crude-herb moxibustion at ST40 for 2 hours each day for 2 weeks,followed by a high-lipid diet for the next 2 weeks,and then crude-herb moxibustion again at ST40 for another 2 weeks.Simvastatin group rats were fed a high-lipid diet for 2 weeks and then treated with simvastatin for the next 2 weeks.Blood lipids,hepatosomatic indices(HSIs)and epididymal fat pad weights of all rats were examined.Results:Compared with the Model group,levels of total cholesterol(TC),glycerinate,lowdensity lipoprotein cholesterol(LDL-C)and very low-density lipoprotein cholesterol(VLDL-C)in plasma collected from the Therapy group,the Prevention/Therapy group,and the Simvastatin group were decreased.Moreover,compared with the Model group,HSIs in Therapy group rats were also decreased following administration of crude-herb moxibustion,but TC,TG,HDLC,LDL-C,and VLDL-C levels in the Prevention group were higher than those in the Model group.Conclusion:The results reveal that blood lipids and HSIs appear to be modulated by the effect of crude-herb moxibustion and suggest therapeutic strategies for the treatment of dyslipidemia.展开更多
Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular risk.Methods Eighty three subjects with high risk factors of cardiovascular diseases were...Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular risk.Methods Eighty three subjects with high risk factors of cardiovascular diseases were enrolled into the study and randomized to two groups,i.e.,the ZBT group(n =44,treated with ZBT 0.48 g twice per day) and the atorvastatin(ATO) group(n =39,treated with ATO 10 mg per day).The levels of fasting serum lipids including total cholesterol(TC),triglyceride(TG),high and low density lipoprotein cholesterol(HDL-C and LDL-C) and pulse wave velocity(PWV) were investigated before and eight weeks after treatment.Results The serum levels of TG,TC,LDL-C,femoral-ankle PWV(FAPWV) and carotid-radial PWV(CRPWV) were markedly decreased after the therapy with ZBT or ATO for 8 weeks(P <0.05).There was no significant alteration in HDL-C and carotid-femoral PWV(CFPWV) levels in both ZBT and ATO groups(P >0.05) after eight-week's treatment.Conclusion ZBT could reduce the levels of FAPWV and CRPWV,thus improve the elasticity of medium-sized peripheral muscular arteries in addition to its lipids lowering effect.The efficacy of ZBT is similar to that of ATO.展开更多
Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can sup...Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can suppress the development of atherosclerosis.The aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential mechanisms.Methods:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or rosuvastatin.After feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were measured.Serum metabolic profiles were detected by an automatic biochemical analyser.Serum inflammatory cytokines were quantified by enzyme-linked immunosorbent assay kits.Atherosclerotic plaque areas were analysed using Oil Red O staining.Results:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model group.YDHP inhibited the area of atherosclerotic lesions.In addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and tumor necrosis factorα(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group).Conclusion:Our study demonstrated that YDHP showed considerable activity in alleviating the formation of atherosclerotic plaques in ApoE^(-/-)mice by reducing blood lipids and exerting anti-inflammatory activity.展开更多
BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarct...BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine.OBJECTIVE:To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction,and compare the results with those of simple cinepazide maleate treatment.DESIGN:A non-randomized case-controlled observation.SETTINGS:Hebei North University;the Second Affiliated Hospitals of Hebei North University;the Third Affiliated Hospitals of Hebei North University.PARTICIPANTS:Eighty-six inpatients with cerebral infarction were selected from the infirmary,the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006.They were all diagnosed to have acute cerebral infarction by CT or MRI,and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995.Meanwhile,40 teachers and medical staff of voluntary physical examinees were selected as the control group.Informed contents were obtained from all the patients and their relatives.METHODS:The patients were divided into combined treatment group(n=43)and simple treatment group(n=43).In the combined treatment group,the patients were administrated with 160 mg cinepazide maleate injection(Beijing Four-ring Pharmaceutical,Co.,Ltd,No.H200220125;80 mg/2 mL)added in 5% glucose,and 40 mg tanshinone Ⅱ sodium sulfonate(Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd.,No.H31022558,10 mg/2 mL)added in 250 mL normal saline.In the simple treatment group,the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or 250 mL normal saline.They were treated for 1 or 2 courses,once a day,and 14 days as a course.The patients were detected before treatment and at 14 and 28 days after treatment respectively.① Determination of hemorrheologic indexes:Whole blood viscosity was determined with LBY-N6B automatic hemorrheologic meter;Plasma viscosity with LBY-F200B automatic plasma viscosity meter;Volume of fibrinogen was determined by the method of 12.5% sodium nitrate depositing biuret reaction.② Determination of blood lipids:The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were determined.③ Severity of neurological deficit:The total score of neurological deficit score(NDS)ranged from 0 to 45 points,0-15 points was taken as mild,16-30 points as moderate and 31-45 points as severe.④ Evaluation of curative effects:Generally cured:NDS decreased by 91%-100%,and disabled severity of grade 0;Significantly improved:NDS decreased by 46%-90%,and disabled severity of grades 1-3;Improved:NDS decreased by 18%-45%;No change:NDS decreased by less than 18%;Aggravated:NDS increased by more than 18%.Generally cured and significant improved were taken as significant effect.⑤ The adverse events and side effects after medication were observed.MAIN OUTCOME MEASURES:① Results of hemorrheologic indexes and blood lipids;② NDS results in the combined treatment group and simple treatment group;③ Therapeutic effects and adverse events.RESULTS:All the 86 patients with cerebral infarction and 40 healthy controls were involved in the analysis of results.① Results of hemorrheologic indexes and blood lipids:The hemorrheologic indexes and blood lipids before treatment were manifested as abnormalities to different extents in both the combined treatment group and simple treatment group;The hemorrheologic indexes after treatment were obviously improved in both groups.But the hemorrheologic indexes were improved more obviously in the combined treatment group as compared with those in the simple treatment group(P < 0.05);The levels of TC,TG and LDL-Cafter treatment in the combined treatment group were obviously lowered(P < 0.05),whereas those in the simple treatment group were not significantly changed(P > 0.05).② NDS results:The NDS scores at 14 and 28 days after treatment in the combined treatment group(6.23±2.34),(4.27±1.83)points were obviously lower than those in the simple treatment group(8.76±3.41),(6.65±2.49)points,P < 0.05.③ Therapeutic effects and side effects:The total significant effective rates in the combined treatment group and simple treatment group were 93% and 81% respectively.In the combined treatment group,1 case suffered from palpitation,dizziness and agrypnia.In the simple treatment group,1 case suffered from palpitation,dizziness and agrypnia,1 case had itch of skin.All the above symptoms disappeared gradually after the transfusing speed was adjusted to be slower.No drug withdrawal occurred in the patients due to the adverse events.CONCLUSION:Cinepazide maleate combined with tanshinon can obviously improve the abnormalities of hemorrheologic indexes and blood lipids and nerve function in patients with acute cerebral infarction,and its curative effect is faster than that of simple cinepazide maleate treatment.展开更多
Anamnestic data on general health and medical conditions were achieved from 136 men (20-49 yrs). Beck Depression Inventory II (BDI-II) questionnaire was used to assess depressive symptomatology. Body weight, height, w...Anamnestic data on general health and medical conditions were achieved from 136 men (20-49 yrs). Beck Depression Inventory II (BDI-II) questionnaire was used to assess depressive symptomatology. Body weight, height, waist and hip circumference, arterial blood pressure were mea- sured. Serum levels of total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglicerydes (TG), glucose, SHBG, total testosterone, DHEA-S and estradiol were determined. Calculated were body mass index (BMI), waist to hip ratio (WHR) and free testosterone index (FTI). In men aged 40-49 general health significantly got worse, BMI, WHR, blood pressure increased and mean serum levels of FTI, DHEA-S, estradiol decreased in comparison to younger men. Only in 40-49 age band BDI-II scoring was negatively related with FTI, however, in the whole group there were no significant correlations. Nevertheless, some symptoms of depression were negatively related with LDL-C or HDL-C and positively with TG. Similar relations were found among young men, but not in the middle-aged. Conclusions: Only blood lipids may have influence on emotional well-being in young healthy men. The decreased testosterone level becomes probably the main risk factor for the lower mood in middle-aged men. Atherosclerosis risk factors and general health worsen with the advancing age, but they have no significant effect on psychological situation.展开更多
Objective: To observe the effects of Xuezhikang (red yeast rice) on blood lipids, blood rheology, and expression of P65 and tissue factor, and to explore the anti-atherosclerosis effect and related mechanisms of Xuezh...Objective: To observe the effects of Xuezhikang (red yeast rice) on blood lipids, blood rheology, and expression of P65 and tissue factor, and to explore the anti-atherosclerosis effect and related mechanisms of Xuezhikang (red yeast rice). Methods: 32 Wistar rats were randomly divided into normal control group, Xuezhikang treatment group, lovastatin treatment group and atherosclerosis model group (8 in each group). Blood lipids, blood rheology, malondialdehyde (MDA), total antioxidant capacity (T-AOC), and expression of aortic tissue factor (TF) and P65 were measured in each group. Results:(1) Both Xuezhikang and lovastatin could reduce blood lipid levels, but there was no significant difference between the two groups;(2) Both Xuezhikang and lovastatin can improve the hemorheology of atherosclerotic rats, but the difference between the two groups is not significant;(3) Compared with lovastatin, Xuezhikang inhibited the expression of TF and P65 in aorta of rats with atherosclerosis;(4) Compared with lovastatin, the Xuezhikang group had lower MDA levels and higher T-AOC. Conclusion: Xuezhikang can improve blood lipid levels and hemorheology in rats with atherosclerosis. Compared with lovastatin, Xuezhikang has stronger effects on inhibiting oxidative stress and down-regulating the expression of tissue factor and P65.展开更多
During the years of 1982-1986,we treatedpatients of hypertension and hyperlipidemia with“Hou’s black powder”(侯氏黑散)as recordedin Synopsis of the Golden Chamber,andobtained effects of reducing the blood pressurea...During the years of 1982-1986,we treatedpatients of hypertension and hyperlipidemia with“Hou’s black powder”(侯氏黑散)as recordedin Synopsis of the Golden Chamber,andobtained effects of reducing the blood pressureand the blood lipids simultaneously.83展开更多
Objective To investigate the relationships between erythrocyte membrane n‐6:n‐3 PUFAs ratio and blood lipids and high sensitivity C‐reactive protein (hs‐CRP).Methods The observational study consisted of a populat...Objective To investigate the relationships between erythrocyte membrane n‐6:n‐3 PUFAs ratio and blood lipids and high sensitivity C‐reactive protein (hs‐CRP).Methods The observational study consisted of a population‐based cross‐sectional study of 456 Chinese and a subsequent 1‐year follow‐up study of 171 subjects with the fasting plasma total cholesterol of 5.13‐8.00 mmol/L.Results In the cross‐sectional analysis,plasma low‐density lipoprotein cholesterol (LDL‐c) had a significant and negative association with the erythrocyte membrane n‐6:n‐3 PUFAs ratio (P for trend=0.019) after adjusting for sex,age and total PUFA percentage.In the follow‐up study,171 subjects were categorized into quartiles by the changes of n‐6:n‐3 ratio in erythrocyte membrane (△=month 12‐month 0).In the top quartile whose ratios of n‐6:n‐3 increased by an average of 1.25 during the follow‐up,the LDL‐c‐lowering extent was 3.3 times of that in the lowest quartile whose ratios of n‐6:n‐3 decreased by an average of 1.13 (‐1.07 mmol/L v.s.‐0.32 mmol/L).The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile (P for difference=0.052).Conclusion Our results suggested that the balance between n‐6 and n‐3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.展开更多
Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 ...Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C.展开更多
Objective: Evaluate the effect of a physical activity program on the blood lipid profile in women between 40 and 55 years old. Methods: 7 female participants from the city of Chihuahua, Chihuahua, Mexico, on a program...Objective: Evaluate the effect of a physical activity program on the blood lipid profile in women between 40 and 55 years old. Methods: 7 female participants from the city of Chihuahua, Chihuahua, Mexico, on a program of moderateintensity physical activity lasting 4 months, evaluated before and after the implementation of the program in the variables of total cholesterol, triglycerides, LDL and HDL, as well as the atherogenic index and cardiovascular risk. Data were analyzed with Student t test for related samples with a significance level of 0.05. Results: Total cholesterol levels and LDL in samples collected after physical exercise program decreased significantly compared to those collected before the implementation of the exercise program, while statistically, HDL and triglycerides did not show significant changes. The atherogenic index and cardiovascular risk showed positive trends, thus favoring that moderate intensity aerobic exercise decreased cardiovascular risk in women reaching the perimenopause period.展开更多
In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis ...In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis (AS) in the rabbit. An experimental model of atherosclerosis was established in cholesterol-fed rabbits. In the 2nd, 4th, 8th and 12th week, the parametersmentioned above were determined and the pathological changes of the aorta examined. It was found that serum triglyceride (TG)was increased in the 4th week and total serum cholesterol (TCh) was significantly higher in the 4th, 8th and 12th week than thatin the control. Erythrocytic Na+ -K+ -ATPase activity decreased progressively and it was negatively correlated to TCh in the 4thand 12th week (r = - 0.67 and - 0.51, P < 0.01 and 0.05). G’ was significantly increased in the 4th week only when theshear rate was 0. 190 Hz whereas G and η’ increased progressively from the 8th to 12th week. It is believed that the determinationof blood lipids, Na+ -K+ -ATPase activity and viscoelastic parameters of the whole blood is useful for the prediction of the propession of the pathological changes in different stages of AS.展开更多
Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum li...Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum lipids with the risk and the prognosis of various types of cancers including ovarian cancer. The association between the risk of the incidence of ovarian cancer and the alterations in the levels of blood glucose and serum lipids is not well defined. Objective: In this study we aimed to compare the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in patients with different stages of ovarian cancer and healthy controls to determine how they relate to the risk and prognosis of ovarian cancer. Methodology: In a case-control cross sectional study, we enrolled ninety-nine Sudanese women, diagnosed with ovarian cancer but had not received any kind of treatment as the study group, and a control group of forty-one age-matched, apparently healthy women. The patients were classified according to the International Federation of Obstetricians and Gynecologists staging system into two groups: early stages (stage I & II) and late stages (stages III & IV). Blood glucose and serum lipids;triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were determined by enzymatic colorimetric methods using commercially available analytical kits. The IBM SPSS version 20 software was used for statistical analysis. A Mann-Whitney U test was used for comparison of the median concentrations of blood glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the study groups. Logistic regression model was used to estimate the relative risk of ovarian cancer in relation to levels of blood glucose and serum lipids. P value of 0.05 was considered significant. Results: Our data indicated significantly higher levels of blood glucose (p < 0.001), triacylglycerols (p = 0.002), and low-density lipoprotein cholesterol (p < 0.001), and lower levels of high-density lipoprotein cholesterol (p = 0.023), in ovarian cancer patients compared to the control subjects. No significant difference was found in the levels of blood glucose or any of the serum lipids between patients in the early stages (stage I & II) and those in late stages (stage III & IV) of ovarian cancer. The logistic regression analysis indicated significant association between the elevated levels of the blood glucose, triacylglycerols and low-density lipoprotein cholesterol and the risk of the ovarian cancer. Conclusion: We conclude that the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol differ significantly between ovarian cancer patients and the healthy control subjects. The risk of ovarian cancer was positively associated with the levels of blood glucose, triacylglycerols and low-density lipoprotein cholesterol, and negatively associated with levels of high-density lipoprotein cholesterol. Therefore, determination of blood glucose and serum lipids, particularly, triacylglycerols, low-density lipoprotein cholesterol may be helpful as diagnostic indicators of ovarian cancer (OC).展开更多
Summary What is already known about this topic?Dyslipidemia is attributed to cardiovascular disease(CVD).A recent report suggests dyslipidemia prevalence has increased among children and adolescents.What is added by t...Summary What is already known about this topic?Dyslipidemia is attributed to cardiovascular disease(CVD).A recent report suggests dyslipidemia prevalence has increased among children and adolescents.What is added by this report?Dyslipidemia prevalence was 19.43% among Chinese children and adolescents aged 6-17 years in 2016–2017.The abnormal blood lipid prevalence and the average blood lipid levels showed a diversified distribution across demographics.What are the implications for public health practice?Continued monitoring of abnormal blood lipids among Chinese children and adolescents,especially triglyceride(TG)and high-density lipoprotein cholesterol(HDL-C),may inform public health interventions to promote long-term cardiovascular health and prevent CVD in adulthood.展开更多
Many patients with neurodegenerative diseases,such as Alzheimer’s(AD)and Parkinson’s(PD)diseases suffer from disease progression without any satisfying clinical intervention,likely due to our lack of knowledge on ho...Many patients with neurodegenerative diseases,such as Alzheimer’s(AD)and Parkinson’s(PD)diseases suffer from disease progression without any satisfying clinical intervention,likely due to our lack of knowledge on how normal aging impacts the pathogenic mechanisms of these debilitating diseases.A growing body of literature has emerged in recent years that clearly demonstrates the involvement of glycolipids in the protein-oligomerization of neurodegenerative disorders.We hypothesize that changes in glycolipids composition are a common mechanism underlying the shift from healthy brain aging to the neuropathological processes of neurodegenerative diseases.展开更多
The blood-brain barrier(BBB)(discovered and defined by Max Lewandowsky and Lina Stern,and not,as it is universally,and yet erroneously believed,by Paul Ehrlich(Verkhratsky and Pivoriunas,2023))that separates the nervo...The blood-brain barrier(BBB)(discovered and defined by Max Lewandowsky and Lina Stern,and not,as it is universally,and yet erroneously believed,by Paul Ehrlich(Verkhratsky and Pivoriunas,2023))that separates the nervous system from the circulation is evolutionarily conserved from arthropods to man.The primeval BBB of the invertebrates and some early vertebrates was made solely by glial cells and secured(in invertebrates)by septate junctions.展开更多
Thyroid nodules are a common clinical problem caused by various factors,including environmental and nutritional factors and genetic background.The environment can modulate and influence not only the risk of thyroid no...Thyroid nodules are a common clinical problem caused by various factors,including environmental and nutritional factors and genetic background.The environment can modulate and influence not only the risk of thyroid nodules but also the severity of disease in humans[1].The environment is awash with elements,and all mineral elements,including heavy metals and trace elements,are considered potentially toxic.A significantly higher incidence of thyroid cancer has been reported in populations exposed to low doses of metallic elements in volcanic areas over a long period[2].As research on thyroid disorders continues,it is becoming clear that abnormalities in trace elements in the body can affect the development of thyroid-related disorders.展开更多
Background:Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain barrier(BBB),which interfaces between the brain parenchyma and the lumen of b...Background:Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain barrier(BBB),which interfaces between the brain parenchyma and the lumen of blood microvessels,and by the blood-cerebrospinal fluid barrier,which separates the cerebrospinal fluid from the blood vessels of the choroid plexus(Villabona-Rueda et al.,2019).Here,the focus will be on the BBB,the impairment of which is considered the earliest common denominator in neurovascular diseases.展开更多
In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, ...In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, no study has been done so far to study the influence of friction on the red blood cell indentation response using optical tweezers. In this study, we have developed a new approach to determine the coefficient of friction as well as the frictional forces of the red blood cell. This approach therefore allowed us to simultaneously carry out the indentation and traction test, which allowed us to extract the interfacial properties of the microbead red blood cell couple, among other things, the friction coefficient. This property would be extremely important to investigate the survival and mechanical features of cells, which will be of great physiological and pathological significance. But taking into account the hypothesis of friction as defined by the isotropic Coulomb law. The experiment performed for this purpose is the Brinell Hardness Test (DB).展开更多
基金Supported by the National Innovation Planning Project for University Students in 2022 in Guangxi(S202210599012).
文摘[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.
基金This work was supported by National Natural Science Foundation of China(NO.81603695).
文摘Objective:To observe the effects of moxibustion at different temperatures(38℃,46℃)on blood lipids,endothelial morphology of the thoracic aorta,serum endothelin-1(ET-1),calcitonin gene-related peptide(CGRP),nitric oxide(NO),and endothelial NO synthase(eNOS)in hyperlipidemic rats.Methods:Using the random number table method,60 Sprague Dawley rats were randomly and evenly divided into blank,model,38℃-moxibustion,and 46℃-moxibustion groups.Rats in the 3 experimental groups were fed a high-fat feed to model hyperlipidemia in rats.Rats in the 38℃-moxibustion and 46℃-moxibustion groups were moxibustion on the Shenque and bilateral Zusanli acupoints for 10 minutes each,once every other day for 4 weeks,at temperatures of 38±1℃ and 46±1℃.After that,rat blood samples were collected to detect blood lipids and ET-1,CGRP,eNOS and NO.Take the endotheal tissue of the thoracic aorta to do HE staining.Results:(1)The serum total cholesterol,triglycerides,and low-density lipoprotein cholesterol of rats in the 46℃-moxibustion group were significantly lower than those in the model and 38℃-moxibustion groups.(2)Revealed by hematoxylin and eosin staining,showed necrosis in the local vascular endothelial cells and mild inflammatory cell infiltration in the tunica adventitia of the hyperlipidemic rats.These endothelial morphologies did not improve significantly after moxibustion at 38℃ but did improve at 46℃.(3)Compared with the blank group,serum ET-1 was significantly higher and serum CGRP,NO,eNOS were significantly lower in the model group.Compared with the model and the 38℃-moxibustion groups,serum ET-1 was significantly lower and serum CGRP,NO,eNOS were significantly higher in 46℃-moxibustion groups.Conclusion:Moxibustion at 46℃ effectively regulated blood lipids,improved the morphology of the vascular endothelium,and protected vascular endothelial function.
基金the Ministry of Education of the People’s Republic of China(NO:201210026044)supervised by Beijing University of Chinese Medicine.
文摘Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats were fed a normal diet,and bilateral acu-point Fenglong(equivalent to ST40 in humans)on the hind legs were covered with a placebo(general mucilage)for 2 hours each day.Model group rats were fed a high-lipid diet for 2 weeks.Therapy group rats were fed a high-lipid diet for 2 weeks and then administered crude-herb moxibustion at ST40 for 2 hours each day for the next 2 weeks.Prevention group rats were administered crude-herb moxibustion 2 hours a day for 2 weeks and then fed a high-lipid diet for the subsequent 2 weeks.Prevention/Therapy group rats were each administered crude-herb moxibustion at ST40 for 2 hours each day for 2 weeks,followed by a high-lipid diet for the next 2 weeks,and then crude-herb moxibustion again at ST40 for another 2 weeks.Simvastatin group rats were fed a high-lipid diet for 2 weeks and then treated with simvastatin for the next 2 weeks.Blood lipids,hepatosomatic indices(HSIs)and epididymal fat pad weights of all rats were examined.Results:Compared with the Model group,levels of total cholesterol(TC),glycerinate,lowdensity lipoprotein cholesterol(LDL-C)and very low-density lipoprotein cholesterol(VLDL-C)in plasma collected from the Therapy group,the Prevention/Therapy group,and the Simvastatin group were decreased.Moreover,compared with the Model group,HSIs in Therapy group rats were also decreased following administration of crude-herb moxibustion,but TC,TG,HDLC,LDL-C,and VLDL-C levels in the Prevention group were higher than those in the Model group.Conclusion:The results reveal that blood lipids and HSIs appear to be modulated by the effect of crude-herb moxibustion and suggest therapeutic strategies for the treatment of dyslipidemia.
文摘Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular risk.Methods Eighty three subjects with high risk factors of cardiovascular diseases were enrolled into the study and randomized to two groups,i.e.,the ZBT group(n =44,treated with ZBT 0.48 g twice per day) and the atorvastatin(ATO) group(n =39,treated with ATO 10 mg per day).The levels of fasting serum lipids including total cholesterol(TC),triglyceride(TG),high and low density lipoprotein cholesterol(HDL-C and LDL-C) and pulse wave velocity(PWV) were investigated before and eight weeks after treatment.Results The serum levels of TG,TC,LDL-C,femoral-ankle PWV(FAPWV) and carotid-radial PWV(CRPWV) were markedly decreased after the therapy with ZBT or ATO for 8 weeks(P <0.05).There was no significant alteration in HDL-C and carotid-femoral PWV(CFPWV) levels in both ZBT and ATO groups(P >0.05) after eight-week's treatment.Conclusion ZBT could reduce the levels of FAPWV and CRPWV,thus improve the elasticity of medium-sized peripheral muscular arteries in addition to its lipids lowering effect.The efficacy of ZBT is similar to that of ATO.
基金the Wuhan Municipal Health Commission Foundation(No.wx21Q38).
文摘Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can suppress the development of atherosclerosis.The aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential mechanisms.Methods:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or rosuvastatin.After feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were measured.Serum metabolic profiles were detected by an automatic biochemical analyser.Serum inflammatory cytokines were quantified by enzyme-linked immunosorbent assay kits.Atherosclerotic plaque areas were analysed using Oil Red O staining.Results:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model group.YDHP inhibited the area of atherosclerotic lesions.In addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and tumor necrosis factorα(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group).Conclusion:Our study demonstrated that YDHP showed considerable activity in alleviating the formation of atherosclerotic plaques in ApoE^(-/-)mice by reducing blood lipids and exerting anti-inflammatory activity.
基金a grant from Zhangjiakou Bureau of Technology,No. 060132
文摘BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine.OBJECTIVE:To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction,and compare the results with those of simple cinepazide maleate treatment.DESIGN:A non-randomized case-controlled observation.SETTINGS:Hebei North University;the Second Affiliated Hospitals of Hebei North University;the Third Affiliated Hospitals of Hebei North University.PARTICIPANTS:Eighty-six inpatients with cerebral infarction were selected from the infirmary,the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006.They were all diagnosed to have acute cerebral infarction by CT or MRI,and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995.Meanwhile,40 teachers and medical staff of voluntary physical examinees were selected as the control group.Informed contents were obtained from all the patients and their relatives.METHODS:The patients were divided into combined treatment group(n=43)and simple treatment group(n=43).In the combined treatment group,the patients were administrated with 160 mg cinepazide maleate injection(Beijing Four-ring Pharmaceutical,Co.,Ltd,No.H200220125;80 mg/2 mL)added in 5% glucose,and 40 mg tanshinone Ⅱ sodium sulfonate(Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd.,No.H31022558,10 mg/2 mL)added in 250 mL normal saline.In the simple treatment group,the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or 250 mL normal saline.They were treated for 1 or 2 courses,once a day,and 14 days as a course.The patients were detected before treatment and at 14 and 28 days after treatment respectively.① Determination of hemorrheologic indexes:Whole blood viscosity was determined with LBY-N6B automatic hemorrheologic meter;Plasma viscosity with LBY-F200B automatic plasma viscosity meter;Volume of fibrinogen was determined by the method of 12.5% sodium nitrate depositing biuret reaction.② Determination of blood lipids:The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were determined.③ Severity of neurological deficit:The total score of neurological deficit score(NDS)ranged from 0 to 45 points,0-15 points was taken as mild,16-30 points as moderate and 31-45 points as severe.④ Evaluation of curative effects:Generally cured:NDS decreased by 91%-100%,and disabled severity of grade 0;Significantly improved:NDS decreased by 46%-90%,and disabled severity of grades 1-3;Improved:NDS decreased by 18%-45%;No change:NDS decreased by less than 18%;Aggravated:NDS increased by more than 18%.Generally cured and significant improved were taken as significant effect.⑤ The adverse events and side effects after medication were observed.MAIN OUTCOME MEASURES:① Results of hemorrheologic indexes and blood lipids;② NDS results in the combined treatment group and simple treatment group;③ Therapeutic effects and adverse events.RESULTS:All the 86 patients with cerebral infarction and 40 healthy controls were involved in the analysis of results.① Results of hemorrheologic indexes and blood lipids:The hemorrheologic indexes and blood lipids before treatment were manifested as abnormalities to different extents in both the combined treatment group and simple treatment group;The hemorrheologic indexes after treatment were obviously improved in both groups.But the hemorrheologic indexes were improved more obviously in the combined treatment group as compared with those in the simple treatment group(P < 0.05);The levels of TC,TG and LDL-Cafter treatment in the combined treatment group were obviously lowered(P < 0.05),whereas those in the simple treatment group were not significantly changed(P > 0.05).② NDS results:The NDS scores at 14 and 28 days after treatment in the combined treatment group(6.23±2.34),(4.27±1.83)points were obviously lower than those in the simple treatment group(8.76±3.41),(6.65±2.49)points,P < 0.05.③ Therapeutic effects and side effects:The total significant effective rates in the combined treatment group and simple treatment group were 93% and 81% respectively.In the combined treatment group,1 case suffered from palpitation,dizziness and agrypnia.In the simple treatment group,1 case suffered from palpitation,dizziness and agrypnia,1 case had itch of skin.All the above symptoms disappeared gradually after the transfusing speed was adjusted to be slower.No drug withdrawal occurred in the patients due to the adverse events.CONCLUSION:Cinepazide maleate combined with tanshinon can obviously improve the abnormalities of hemorrheologic indexes and blood lipids and nerve function in patients with acute cerebral infarction,and its curative effect is faster than that of simple cinepazide maleate treatment.
文摘Anamnestic data on general health and medical conditions were achieved from 136 men (20-49 yrs). Beck Depression Inventory II (BDI-II) questionnaire was used to assess depressive symptomatology. Body weight, height, waist and hip circumference, arterial blood pressure were mea- sured. Serum levels of total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglicerydes (TG), glucose, SHBG, total testosterone, DHEA-S and estradiol were determined. Calculated were body mass index (BMI), waist to hip ratio (WHR) and free testosterone index (FTI). In men aged 40-49 general health significantly got worse, BMI, WHR, blood pressure increased and mean serum levels of FTI, DHEA-S, estradiol decreased in comparison to younger men. Only in 40-49 age band BDI-II scoring was negatively related with FTI, however, in the whole group there were no significant correlations. Nevertheless, some symptoms of depression were negatively related with LDL-C or HDL-C and positively with TG. Similar relations were found among young men, but not in the middle-aged. Conclusions: Only blood lipids may have influence on emotional well-being in young healthy men. The decreased testosterone level becomes probably the main risk factor for the lower mood in middle-aged men. Atherosclerosis risk factors and general health worsen with the advancing age, but they have no significant effect on psychological situation.
文摘Objective: To observe the effects of Xuezhikang (red yeast rice) on blood lipids, blood rheology, and expression of P65 and tissue factor, and to explore the anti-atherosclerosis effect and related mechanisms of Xuezhikang (red yeast rice). Methods: 32 Wistar rats were randomly divided into normal control group, Xuezhikang treatment group, lovastatin treatment group and atherosclerosis model group (8 in each group). Blood lipids, blood rheology, malondialdehyde (MDA), total antioxidant capacity (T-AOC), and expression of aortic tissue factor (TF) and P65 were measured in each group. Results:(1) Both Xuezhikang and lovastatin could reduce blood lipid levels, but there was no significant difference between the two groups;(2) Both Xuezhikang and lovastatin can improve the hemorheology of atherosclerotic rats, but the difference between the two groups is not significant;(3) Compared with lovastatin, Xuezhikang inhibited the expression of TF and P65 in aorta of rats with atherosclerosis;(4) Compared with lovastatin, the Xuezhikang group had lower MDA levels and higher T-AOC. Conclusion: Xuezhikang can improve blood lipid levels and hemorheology in rats with atherosclerosis. Compared with lovastatin, Xuezhikang has stronger effects on inhibiting oxidative stress and down-regulating the expression of tissue factor and P65.
文摘During the years of 1982-1986,we treatedpatients of hypertension and hyperlipidemia with“Hou’s black powder”(侯氏黑散)as recordedin Synopsis of the Golden Chamber,andobtained effects of reducing the blood pressureand the blood lipids simultaneously.83
基金supported by research grants from the National Natural Science Foundation of China (30872102)the Diet Nutrition Research & Communication Grant of Danone Institute China (DIC2008‐12)
文摘Objective To investigate the relationships between erythrocyte membrane n‐6:n‐3 PUFAs ratio and blood lipids and high sensitivity C‐reactive protein (hs‐CRP).Methods The observational study consisted of a population‐based cross‐sectional study of 456 Chinese and a subsequent 1‐year follow‐up study of 171 subjects with the fasting plasma total cholesterol of 5.13‐8.00 mmol/L.Results In the cross‐sectional analysis,plasma low‐density lipoprotein cholesterol (LDL‐c) had a significant and negative association with the erythrocyte membrane n‐6:n‐3 PUFAs ratio (P for trend=0.019) after adjusting for sex,age and total PUFA percentage.In the follow‐up study,171 subjects were categorized into quartiles by the changes of n‐6:n‐3 ratio in erythrocyte membrane (△=month 12‐month 0).In the top quartile whose ratios of n‐6:n‐3 increased by an average of 1.25 during the follow‐up,the LDL‐c‐lowering extent was 3.3 times of that in the lowest quartile whose ratios of n‐6:n‐3 decreased by an average of 1.13 (‐1.07 mmol/L v.s.‐0.32 mmol/L).The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile (P for difference=0.052).Conclusion Our results suggested that the balance between n‐6 and n‐3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.
文摘Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C.
基金Faculty of Physical Education and Sport Sciences at the Autonomous University of Chihuahua, Mexico
文摘Objective: Evaluate the effect of a physical activity program on the blood lipid profile in women between 40 and 55 years old. Methods: 7 female participants from the city of Chihuahua, Chihuahua, Mexico, on a program of moderateintensity physical activity lasting 4 months, evaluated before and after the implementation of the program in the variables of total cholesterol, triglycerides, LDL and HDL, as well as the atherogenic index and cardiovascular risk. Data were analyzed with Student t test for related samples with a significance level of 0.05. Results: Total cholesterol levels and LDL in samples collected after physical exercise program decreased significantly compared to those collected before the implementation of the exercise program, while statistically, HDL and triglycerides did not show significant changes. The atherogenic index and cardiovascular risk showed positive trends, thus favoring that moderate intensity aerobic exercise decreased cardiovascular risk in women reaching the perimenopause period.
文摘In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis (AS) in the rabbit. An experimental model of atherosclerosis was established in cholesterol-fed rabbits. In the 2nd, 4th, 8th and 12th week, the parametersmentioned above were determined and the pathological changes of the aorta examined. It was found that serum triglyceride (TG)was increased in the 4th week and total serum cholesterol (TCh) was significantly higher in the 4th, 8th and 12th week than thatin the control. Erythrocytic Na+ -K+ -ATPase activity decreased progressively and it was negatively correlated to TCh in the 4thand 12th week (r = - 0.67 and - 0.51, P < 0.01 and 0.05). G’ was significantly increased in the 4th week only when theshear rate was 0. 190 Hz whereas G and η’ increased progressively from the 8th to 12th week. It is believed that the determinationof blood lipids, Na+ -K+ -ATPase activity and viscoelastic parameters of the whole blood is useful for the prediction of the propession of the pathological changes in different stages of AS.
文摘Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum lipids with the risk and the prognosis of various types of cancers including ovarian cancer. The association between the risk of the incidence of ovarian cancer and the alterations in the levels of blood glucose and serum lipids is not well defined. Objective: In this study we aimed to compare the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in patients with different stages of ovarian cancer and healthy controls to determine how they relate to the risk and prognosis of ovarian cancer. Methodology: In a case-control cross sectional study, we enrolled ninety-nine Sudanese women, diagnosed with ovarian cancer but had not received any kind of treatment as the study group, and a control group of forty-one age-matched, apparently healthy women. The patients were classified according to the International Federation of Obstetricians and Gynecologists staging system into two groups: early stages (stage I & II) and late stages (stages III & IV). Blood glucose and serum lipids;triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were determined by enzymatic colorimetric methods using commercially available analytical kits. The IBM SPSS version 20 software was used for statistical analysis. A Mann-Whitney U test was used for comparison of the median concentrations of blood glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the study groups. Logistic regression model was used to estimate the relative risk of ovarian cancer in relation to levels of blood glucose and serum lipids. P value of 0.05 was considered significant. Results: Our data indicated significantly higher levels of blood glucose (p < 0.001), triacylglycerols (p = 0.002), and low-density lipoprotein cholesterol (p < 0.001), and lower levels of high-density lipoprotein cholesterol (p = 0.023), in ovarian cancer patients compared to the control subjects. No significant difference was found in the levels of blood glucose or any of the serum lipids between patients in the early stages (stage I & II) and those in late stages (stage III & IV) of ovarian cancer. The logistic regression analysis indicated significant association between the elevated levels of the blood glucose, triacylglycerols and low-density lipoprotein cholesterol and the risk of the ovarian cancer. Conclusion: We conclude that the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol differ significantly between ovarian cancer patients and the healthy control subjects. The risk of ovarian cancer was positively associated with the levels of blood glucose, triacylglycerols and low-density lipoprotein cholesterol, and negatively associated with levels of high-density lipoprotein cholesterol. Therefore, determination of blood glucose and serum lipids, particularly, triacylglycerols, low-density lipoprotein cholesterol may be helpful as diagnostic indicators of ovarian cancer (OC).
基金The National Health Commission of the People’s Republic of China Medical Reform Major Program:China Nutrition and Health Surveillance of Children and Lactating Mothers(2016-2017).
文摘Summary What is already known about this topic?Dyslipidemia is attributed to cardiovascular disease(CVD).A recent report suggests dyslipidemia prevalence has increased among children and adolescents.What is added by this report?Dyslipidemia prevalence was 19.43% among Chinese children and adolescents aged 6-17 years in 2016–2017.The abnormal blood lipid prevalence and the average blood lipid levels showed a diversified distribution across demographics.What are the implications for public health practice?Continued monitoring of abnormal blood lipids among Chinese children and adolescents,especially triglyceride(TG)and high-density lipoprotein cholesterol(HDL-C),may inform public health interventions to promote long-term cardiovascular health and prevent CVD in adulthood.
基金supported by a National Institute of Neurological Disorders and Stroke grant(R01 NS100839)a Sheffield Memorial Grant of the CSRA Parkinson’s Disease Support Group,and the excellent infrastructural support of the Department of Neuroscience and Regenerative Medicine,Medical College of Georgia at Augusta University(all to YI).
文摘Many patients with neurodegenerative diseases,such as Alzheimer’s(AD)and Parkinson’s(PD)diseases suffer from disease progression without any satisfying clinical intervention,likely due to our lack of knowledge on how normal aging impacts the pathogenic mechanisms of these debilitating diseases.A growing body of literature has emerged in recent years that clearly demonstrates the involvement of glycolipids in the protein-oligomerization of neurodegenerative disorders.We hypothesize that changes in glycolipids composition are a common mechanism underlying the shift from healthy brain aging to the neuropathological processes of neurodegenerative diseases.
基金funding from European Regional Development Fund(project No 13.1.1-LMT-K-718-05-0005)under grant agreement with the Research Council of Lithuania(LMTLT)。
文摘The blood-brain barrier(BBB)(discovered and defined by Max Lewandowsky and Lina Stern,and not,as it is universally,and yet erroneously believed,by Paul Ehrlich(Verkhratsky and Pivoriunas,2023))that separates the nervous system from the circulation is evolutionarily conserved from arthropods to man.The primeval BBB of the invertebrates and some early vertebrates was made solely by glial cells and secured(in invertebrates)by septate junctions.
基金The College Students’ Innovative Entrepreneurial Training Plan Program [202110594024]Science and Technology Plan Projects of Liuzhou [2022CAC0299]
文摘Thyroid nodules are a common clinical problem caused by various factors,including environmental and nutritional factors and genetic background.The environment can modulate and influence not only the risk of thyroid nodules but also the severity of disease in humans[1].The environment is awash with elements,and all mineral elements,including heavy metals and trace elements,are considered potentially toxic.A significantly higher incidence of thyroid cancer has been reported in populations exposed to low doses of metallic elements in volcanic areas over a long period[2].As research on thyroid disorders continues,it is becoming clear that abnormalities in trace elements in the body can affect the development of thyroid-related disorders.
基金supported by Fondo per la Ricerco di Ateneo (FAR) 2022,University of Ferrara,Ferrara,Italy (to BP)
文摘Background:Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain barrier(BBB),which interfaces between the brain parenchyma and the lumen of blood microvessels,and by the blood-cerebrospinal fluid barrier,which separates the cerebrospinal fluid from the blood vessels of the choroid plexus(Villabona-Rueda et al.,2019).Here,the focus will be on the BBB,the impairment of which is considered the earliest common denominator in neurovascular diseases.
文摘In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, no study has been done so far to study the influence of friction on the red blood cell indentation response using optical tweezers. In this study, we have developed a new approach to determine the coefficient of friction as well as the frictional forces of the red blood cell. This approach therefore allowed us to simultaneously carry out the indentation and traction test, which allowed us to extract the interfacial properties of the microbead red blood cell couple, among other things, the friction coefficient. This property would be extremely important to investigate the survival and mechanical features of cells, which will be of great physiological and pathological significance. But taking into account the hypothesis of friction as defined by the isotropic Coulomb law. The experiment performed for this purpose is the Brinell Hardness Test (DB).
