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Substrate concentration effect on gene expression in genetic circuits with additional positive feedback 被引量:3
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作者 WU LuLu WANG Pei Lü JinHu 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2018年第8期1175-1183,共9页
In gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation loops, auto-activat... In gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation loops, auto-activation loops are ubiquitous regulatory motifs. This paper aims to investigate a two-component dual-positive feedback genetic circuit, which consists of a double negative feedback circuit and an additional positive feedback loop(APFL). We study effect of substrate concentration on gene expression in the single and the networked systems with APFLs, respectively. We find that substrate concentration can tune stochastic switch behavior in the signal system and then we explore relationship of substrate concentration with positive feedback strength in aspect of stochastic switch behavior. Furthermore, we also discuss gene expression and stochastic switch behavior in the networked systems with APFLs. Based on analysis in the networked systems, we discover that genes express in some specific cells and do not express in the other cells when the expression achieves its steady state. These results can be used to well explain the character of regionalization in the expression of genes and the phenomenon of gene differentiation. 展开更多
关键词 substrate concentration additional positive feedback loop stochastic switch behavior gene expression gene differ-entiation
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Enhancing sensitivity of microbial fuel cell sensors for low concentration biodegradable organic matter detection:Regulation of substrate concentration,anode area and external resistance 被引量:2
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作者 Yangyang Gao Sha Wang +4 位作者 Fengjun Yin Pin Hu Xingzu Wang Yuan Liu Hong Liu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2021年第3期227-235,共9页
The relatively low sensitivity is an important reason for restricting the microbial fuel cell(MFC)sensors'application in low concentration biodegradable organic matter(BOM)detection.The startup parameters,includin... The relatively low sensitivity is an important reason for restricting the microbial fuel cell(MFC)sensors'application in low concentration biodegradable organic matter(BOM)detection.The startup parameters,including substrate concentration,anode area and external resistance,were regulated to enhance the sensitivity of MFC sensors.The results demonstrated that both the substrate concentration and anode area were positively correlated with the sensitivity of MFC sensors,and an external resistance of 210Ωwas found to be optimal in terms of sensitivity of MFC sensors.Optimized MFC sensors had lower detection limit(1 mg/L)and higher sensitivity(Slope value of the linear regression curve was 1.02),which effectively overcome the limitation of low concentration BOM detection.The essential reason is that optimized MFC sensors had higher coulombic efficiency,which was beneficial to improve the sensitivity of MFC sensors.The main impact of the substrate concentration and anode area was to regulate the proportion between electrogens and nonelectrogens,biomass and living cells of the anode biofilm.The external resistance mainly affected the morphology structure and the proportion of living cells of the anode.This study demonstrated an effective way to improve the sensitivity of MFC sensors for low concentration BOM detection. 展开更多
关键词 Microbial fuel cell sensor High sensitivity Biodegradable organic matter substrate concentration Anode area External resistance
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Effect of initial substrate and biomass concentrations on anaerobic fermentative hydrogen production in batch reactors
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作者 昌盛 李建政 +1 位作者 刘枫 王淑静 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2011年第6期11-15,共5页
The effects of initial substrate (5-60 g /L) and biomass concentration (0.5-3 g /L) on fermentative hydrogen production by mixed cultures were investigated in batch tests using glucose as substrate.The experimental re... The effects of initial substrate (5-60 g /L) and biomass concentration (0.5-3 g /L) on fermentative hydrogen production by mixed cultures were investigated in batch tests using glucose as substrate.The experimental results showed that the hydrogen production increases as the initial substrate concentration increases from 0 to 25 g /L.It indicated that the shift in the metabolic pathway or in the composition of the bacterial flora occurs.The maximum hydrogen yield of 1.78 mol /mol-glucose is obtained at the substrate concentration of 15 g /L.This study also shows that initial biomass concentration affects the hydrogen yield as the cumulative hydrogen production has been increased with the increase of initial cell concentration up to 1.5 g /L and reached the highest level.The maximum hydrogen yield is obtained at the cell concentration of 1.5 g /L.It indicated that the optimum biomass /substrate ratio,maximizing the hydrogen yield and the hydrogen production rate,is determined to be 0.1 g biomass /g glucose. 展开更多
关键词 fermentative hydrogen production hydrogen yield substrate concentration biomass concentration modified Gompertz model
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