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Analysis of differentially expressed genes in Verruca vulgaris vs.adjacent normal skin by RNA-sequencing
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作者 QINGQING GUO JIAYUE QI +4 位作者 XIAOQIANG LIANG ZIGANG ZHAO JIA BAI FANG XIE CHENGXIN LI 《BIOCELL》 SCIE 2023年第11期2435-2443,共9页
Introduction:Verruca vulgaris is one of the most common low-risk HPV infections and is characterized by excessive proliferation of keratinocytes.Currently,very little genetic information is available regarding verruca... Introduction:Verruca vulgaris is one of the most common low-risk HPV infections and is characterized by excessive proliferation of keratinocytes.Currently,very little genetic information is available regarding verruca vulgaris in the Chinese population.This study aimed to obtain comprehensive transcript information of verruca vulgaris by RNA sequencing.Methods:High-throughput sequencing was performed on three fresh verruca vulgaris samples and adjacent normal skin on the Illumina sequencing platform.The transcriptomes were analyzed using bioinformatics and the differentially expressed genes(DEGs)were verified by immunohistochemistry.Verruca vulgaris exhibited a unique molecular signature.Results:In total,1,643 DEGs were identified in verruca vulgaris compared to normal skin.The functions of the DEGs were studies by Gene Ontology(GO)enrichment,Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis,DEGs Reactome analysis,disease annotation function,and STRING protein-protein interaction(PPI)network analysis.The results revealed 595 GO terms associated with the cell cycle,signal transduction,immune system,signaling molecules,and interaction.The Reactome analysis revealed enrichment in reversible hydration of carbon dioxide and BMP signaling,while the disease annotation function revealed that the enriched DEGs are involved in keratosis disorders.The STRING PPI network showed that the edges with the highest density mainly included the 2′-5′oligoadenylate synthase(OAS)family-related proteins.Furthermore,the M-code analysis found ISG15,IRF7,and OASL were scored as significant modules and their high expression compared to the control was verified by immunohistochemistry.Conclusion:These findings contribute to the genetic information of verruca vulgaris in the Chinese population,revealing that interferon-stimulated genes may play essential roles in verruca vulgaris. 展开更多
关键词 Differentially expressed genes RNA-SEQ TRANSCRIPTOME verruca vulgaris Interferon-stimulated genes
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声带寻常疣1例
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作者 杨龙 张佐娣 《中国耳鼻咽喉头颈外科》 CSCD 2023年第9期609-609,共1页
1临床资料患者,男,52岁,因“声音嘶哑、呼吸困难2个月余”于2019年7月就诊于云南省保山市第二人民医院。患者2个月前无明显诱因出现声音嘶哑及呼吸困难,偶有咳嗽且咳少量黄色脓痰,无咽喉疼痛、头痛及吞咽困难。患者既往体健,否认烟酒史... 1临床资料患者,男,52岁,因“声音嘶哑、呼吸困难2个月余”于2019年7月就诊于云南省保山市第二人民医院。患者2个月前无明显诱因出现声音嘶哑及呼吸困难,偶有咳嗽且咳少量黄色脓痰,无咽喉疼痛、头痛及吞咽困难。患者既往体健,否认烟酒史,否认有免疫系统疾病及慢性疾病病史。体格检查:一般情况可,气管居中,颈部未触及明显肿物。 展开更多
关键词 声带(Vocal Cords) 皮肤疾病 病毒性(SkinDiseases Viral) 寻常疣(verruca vulgaris)
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