To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capab...To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capable of matching 3D models efficiently and effectively. In this paper, an enhanced shape distributions-based technique of using geometrical and topological information to search 3D engineering models represented by polygonal meshes was presented. A simplification method of polygonal meshes was used to simplify engineering model as the pretreatment for generation of sample points. The method of sampling points was improved and a pair of functions that was more sensitive to shape was employed to construct a 2D shape distribution. Experiments were conducted to evaluate the proposed algorithm utilizing the Engineering Shape Benchmark (ESB) database. The experiential results suggest that the search effectiveness is significantly improved by enforcing the simplification and enhanced shape distributions to engineering model retrieval.展开更多
As the progress of 3D rendering technology and the changes of market demand, the 3D application has been widely used and reached as far as education, entertainment, medical treatment, city planning, military training ...As the progress of 3D rendering technology and the changes of market demand, the 3D application has been widely used and reached as far as education, entertainment, medical treatment, city planning, military training and so on. Its trend is gradually changed from client to web, and so many people start to research the 3D graphics engine technology on the web. WebGL and HTML5 rise in recent years and WebGL solves two problems of interactive 3D application on the web perfectly. Firstly, it implements the interactive 3D web application by JavaScript without any browser plug-in components. Secondly, it makes graphics rendering using the underlying graphics hardware, which is united, standard and cross-platform OpenGL interface. However, it is very difficult for 3D application web programmer to understand multifarious details. Therefore, a 3D engine based on WebGL comes into being. The paper consults the existing 3D engine design idea, architecture and implementation experience, and designs a 3D graphics engine based on WebGL and Typescript.展开更多
Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage.Depending on the infection route and virus type,infectious diseases are classified as respirato...Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage.Depending on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin infections.Since these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent necessity.Although infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is required.Recently,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were developed.Furthermore,recent studies have shown that these models can recapitulate infection-associated pathologies.In this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral infections.First,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection pathology.Next,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection pathologies.Finally,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.展开更多
Diffraction intensities of the 3D ptychographic iterative engine(3PIE)were written as a set of linear equations of the selfcorrelations of Fourier components of all sample slices,and an effective computing method was ...Diffraction intensities of the 3D ptychographic iterative engine(3PIE)were written as a set of linear equations of the selfcorrelations of Fourier components of all sample slices,and an effective computing method was developed to solve these linear equations for the transmission functions of all sample slices analytically.With both theoretical analysis and numerical simulations,this study revealed the underlying physics and mathematics of 3PIE and demonstrated for the first time,to our knowledge,that 3PIE can generate mathematically unique reconstruction even with noisy data.展开更多
Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s,the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical re...Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s,the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development.In particular,the recent development of the CRISPR/Cas9 system has greatly expedited genetic dissection of 3D genomes.CRISPR gene-editing outcomes result from targeted genome cleavage by ectopic bacterial Cas9 nuclease followed by presumed random ligations via the host double-strand break repair machineries.Recent studies revealed,however,that the CRISPR genomeediting system is precise and predictable because of cohesive Cas9 cleavage of targeting DNA.Here,we synthesize the current understanding of CRISPR DNA fragment-editing mechanisms and recent progress in predictable outcomes from precise genetic engineering of 3D genomes.Specifically,we first briefly describe historical genetic studies leading to CRISPR and 3D genome engineering.We then summarize different types of chromosomal rearrangements by DNA fragment editing.Finally,we review significant progress from precise ID gene editing toward predictable 3D genome engineering and synthetic biology.The exciting and rapid advances in this emerging field provide new opportunities and challenges to understand or digest 3D genomes.展开更多
Recently, virtual reality and interactive somatosensory technology has become one of the hot issues in the research of computer applications. Leap Motion is a new type of interactive somatosensory devices which bring ...Recently, virtual reality and interactive somatosensory technology has become one of the hot issues in the research of computer applications. Leap Motion is a new type of interactive somatosensory devices which bring users senses of immersion efficiently. This paper studies a interactive somatosensory game model based on Leap Motion and implemented with Unity. Based on the two core technology philosophy of Leap Motion, i.e., virtual reality technology and body sense of interactive technology, the design implementation of each sub module of the system and Leap Motion game algorithm are thoroughly addressed. This paper has certain significance for future application of Leap Motion in film, television, and interactive games.展开更多
Based on radon gas properties and its existing projects applications, we firstly attempted to apply geo- physical and chemical properties of radon gas in the field of mining engineering, and imported radioac- tive mea...Based on radon gas properties and its existing projects applications, we firstly attempted to apply geo- physical and chemical properties of radon gas in the field of mining engineering, and imported radioac- tive measurement method to detect the development process of the overlying strata mining-induced fractures and their contained water quality in underground coal mining, which not only innovates a more simple-fast-reliable detection method, but also further expands the applications of radon gas detection technology in mining field. A 3D simulation design of comprehensive testing system for detecting strata mining-induced fractures on surface with radon gas (CTSR) was carried out by using a large-scale 3D solid model design software Pro/Engineer (Pro/E), which overcame three main disadvantages of ''static design thought, 2D planar design and heavy workload for remodification design'' on exiting design for mining engineering test systems. Meanwhile, based on the simulation design results of Pro/E software, the sta- bility of the jack-screw pressure bar for the key component in CTSR was checked with a material mechan- ics theory, which provided a reliable basis for materials selection during the latter machining process.展开更多
基金The Basic Research of COSTIND,China (No.D0420060521)
文摘To reuse and share the valuable knowledge embedded in repositories of engineering models for accelerating the design process, improving product quality, and reducing costs, it is crucial to devise search engines capable of matching 3D models efficiently and effectively. In this paper, an enhanced shape distributions-based technique of using geometrical and topological information to search 3D engineering models represented by polygonal meshes was presented. A simplification method of polygonal meshes was used to simplify engineering model as the pretreatment for generation of sample points. The method of sampling points was improved and a pair of functions that was more sensitive to shape was employed to construct a 2D shape distribution. Experiments were conducted to evaluate the proposed algorithm utilizing the Engineering Shape Benchmark (ESB) database. The experiential results suggest that the search effectiveness is significantly improved by enforcing the simplification and enhanced shape distributions to engineering model retrieval.
文摘As the progress of 3D rendering technology and the changes of market demand, the 3D application has been widely used and reached as far as education, entertainment, medical treatment, city planning, military training and so on. Its trend is gradually changed from client to web, and so many people start to research the 3D graphics engine technology on the web. WebGL and HTML5 rise in recent years and WebGL solves two problems of interactive 3D application on the web perfectly. Firstly, it implements the interactive 3D web application by JavaScript without any browser plug-in components. Secondly, it makes graphics rendering using the underlying graphics hardware, which is united, standard and cross-platform OpenGL interface. However, it is very difficult for 3D application web programmer to understand multifarious details. Therefore, a 3D engine based on WebGL comes into being. The paper consults the existing 3D engine design idea, architecture and implementation experience, and designs a 3D graphics engine based on WebGL and Typescript.
基金National Research Foundation of Korea(NRF)grant(Nos.2021R1A2B5B02086828 and 2022M3A9B6082678)(H.N.K)funded by the Korean Government(MSIT)Korea Environment Industry&Technology Institute(KEITI)through Technology Development Project for Biological Hazards Management in Indoor Air Program(or Project),funded by Korea Ministry of Environment(MOE)(No.2021003370005).
文摘Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage.Depending on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin infections.Since these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent necessity.Although infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is required.Recently,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were developed.Furthermore,recent studies have shown that these models can recapitulate infection-associated pathologies.In this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral infections.First,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection pathology.Next,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection pathologies.Finally,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.
基金This work was supported by the National Natural Science Foundation of China(No.61827816).
文摘Diffraction intensities of the 3D ptychographic iterative engine(3PIE)were written as a set of linear equations of the selfcorrelations of Fourier components of all sample slices,and an effective computing method was developed to solve these linear equations for the transmission functions of all sample slices analytically.With both theoretical analysis and numerical simulations,this study revealed the underlying physics and mathematics of 3PIE and demonstrated for the first time,to our knowledge,that 3PIE can generate mathematically unique reconstruction even with noisy data.
基金This work was supported by grants from the National Natural Science Foundation of China(31630039 and 32000425)the Ministry of Science and Technology of China(2017YFA0504203 and 2018YFC1004504)the Science and Technology Commission of Shanghai Municipality(19JC1412500).
文摘Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s,the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development.In particular,the recent development of the CRISPR/Cas9 system has greatly expedited genetic dissection of 3D genomes.CRISPR gene-editing outcomes result from targeted genome cleavage by ectopic bacterial Cas9 nuclease followed by presumed random ligations via the host double-strand break repair machineries.Recent studies revealed,however,that the CRISPR genomeediting system is precise and predictable because of cohesive Cas9 cleavage of targeting DNA.Here,we synthesize the current understanding of CRISPR DNA fragment-editing mechanisms and recent progress in predictable outcomes from precise genetic engineering of 3D genomes.Specifically,we first briefly describe historical genetic studies leading to CRISPR and 3D genome engineering.We then summarize different types of chromosomal rearrangements by DNA fragment editing.Finally,we review significant progress from precise ID gene editing toward predictable 3D genome engineering and synthetic biology.The exciting and rapid advances in this emerging field provide new opportunities and challenges to understand or digest 3D genomes.
基金Supported by Gansu Science and Technology Major Project(1302FKDA036)
文摘Recently, virtual reality and interactive somatosensory technology has become one of the hot issues in the research of computer applications. Leap Motion is a new type of interactive somatosensory devices which bring users senses of immersion efficiently. This paper studies a interactive somatosensory game model based on Leap Motion and implemented with Unity. Based on the two core technology philosophy of Leap Motion, i.e., virtual reality technology and body sense of interactive technology, the design implementation of each sub module of the system and Leap Motion game algorithm are thoroughly addressed. This paper has certain significance for future application of Leap Motion in film, television, and interactive games.
基金support for this work provided by the Fundamental Research Funds for the Central Universities(China University of Mining & Technology) (No. 2010ZDP02B02)the State Key Laboratory of Coal Resources and Safe Mining(No. SKLCRSM08X02)
文摘Based on radon gas properties and its existing projects applications, we firstly attempted to apply geo- physical and chemical properties of radon gas in the field of mining engineering, and imported radioac- tive measurement method to detect the development process of the overlying strata mining-induced fractures and their contained water quality in underground coal mining, which not only innovates a more simple-fast-reliable detection method, but also further expands the applications of radon gas detection technology in mining field. A 3D simulation design of comprehensive testing system for detecting strata mining-induced fractures on surface with radon gas (CTSR) was carried out by using a large-scale 3D solid model design software Pro/Engineer (Pro/E), which overcame three main disadvantages of ''static design thought, 2D planar design and heavy workload for remodification design'' on exiting design for mining engineering test systems. Meanwhile, based on the simulation design results of Pro/E software, the sta- bility of the jack-screw pressure bar for the key component in CTSR was checked with a material mechan- ics theory, which provided a reliable basis for materials selection during the latter machining process.
