BACKGROUND As a well-known fact to the public,gestational diabetes mellitus(GDM)could bring serious risks for both pregnant women and infants.During this important investigation into the linkage between GDM patients a...BACKGROUND As a well-known fact to the public,gestational diabetes mellitus(GDM)could bring serious risks for both pregnant women and infants.During this important investigation into the linkage between GDM patients and their altered expression in the serum,proteomics techniques were deployed to detect the differentially expressed proteins(DEPs)of in the serum of GDM patients to further explore its pathogenesis,and find out possible biomarkers to forecast GDM occurrence.METHODS Subjects were divided into GDM and normal control groups according to the IADPSG diagnostic criteria.Serum samples were randomly selected from four cases in each group at 24-28 wk of gestation,and the blood samples were identified by applying iTRAQ technology combined with liquid chromatography-tandem mass spectrometry.Key proteins and signaling pathways associated with GDM were identified by bioinformatics analysis,and the expression of key proteins in serum from 12 wk to 16 wk of gestation was further verified using enzyme-linked immunosorbent assay (ELISA).RESULTS Forty-seven proteins were significantly differentially expressed by analyzing the serum samples between the GDMgravidas as well as the healthy ones. Among them, 31 proteins were found to be upregulated notably and the rest16 proteins were downregulated remarkably. Bioinformatic data report revealed abnormal expression of proteinsassociated with lipid metabolism, coagulation cascade activation, complement system and inflammatory responsein the GDM group. ELISA results showed that the contents of RBP4, as well as ANGPTL8, increased in the serumof GDM gravidas compared with the healthy ones, and this change was found to initiate from 12 wk to 16 wk ofgestation.CONCLUSION GDM symptoms may involve abnormalities in lipid metabolism, coagulation cascade activation, complementsystem and inflammatory response. RBP4 and ANGPTL8 are expected to be early predictors of GDM.展开更多
Three A10 absolute gravimeters(AGs) were first acquired in China by the Hubei Earthquake Agency under the Belt and Road Seismic Monitoring Network Project. Although AG measuring and testing technique is not new, the p...Three A10 absolute gravimeters(AGs) were first acquired in China by the Hubei Earthquake Agency under the Belt and Road Seismic Monitoring Network Project. Although AG measuring and testing technique is not new, the purchase and simultaneous testing of 3 A10 absolute gravimeters is unprecedented in China. This study conducted the first acceptance testing of the AGs at 3 locations(the Jiufengshan Gravity Observation Station, the Global Navigation Satellite System Observation Station in Wuhan, and the Jiugongshan Observation Station in Xianning). The results were compared using a method based on expert validation, and the acceptance testing scheme was formulated by referring to the Technical Regulations for Tectonic Environment Monitoring Networks in China and Specifications for Gravimetry Control. Based on the repeatability, precision, and consistency of the measured g values, the results from each instrument were evaluated using the air pressure precision test. Comparing the instrument reference values, the final test results can identify the indicator parameters for 3 A10 AGs, the effects of the surrounding environment, and the related parameters on measurement precision. The precision of A10-059, A10-058, and A10-057 exceeded 0.78 μGal, 0.79 μGal, and 0.42 μGal, respectively.This testing scheme can be used as a reference for conducting acceptance testing of AGs in the future and obtaining absolute gravimetric measurements.展开更多
An absolute gravimeter is a precision instrument for measuring gravitational acceleration, which plays an important role in earthquake monitoring, crustal deformation, national defense construction, etc. The frequency...An absolute gravimeter is a precision instrument for measuring gravitational acceleration, which plays an important role in earthquake monitoring, crustal deformation, national defense construction, etc. The frequency of laser interference fringes of an absolute gravimeter gradually increases with the fall time. Data are sparse in the early stage and dense in the late stage. The fitting accuracy of gravitational acceleration will be affected by least-squares fitting according to the fixed number of zero-crossing groups. In response to this problem, a method based on Fourier series fitting is proposed in this paper to calculate the zero-crossing point. The whole falling process is divided into five frequency bands using the Hilbert transformation. The multiplicative auto-regressive moving average model is then trained according to the number of optimal zero-crossing groups obtained by the honey badger algorithm. Through this model, the number of optimal zero-crossing groups determined in each segment is predicted by the least-squares fitting. The mean value of gravitational acceleration in each segment is then obtained. The method can improve the accuracy of gravitational measurement by more than 25% compared to the fixed zero-crossing groups method. It provides a new way to improve the measuring accuracy of an absolute gravimeter.展开更多
A recent article in the Opto-Electronic Advances(OEA)journal from Prof.Qian Chen and Prof.Chao Zuo’s group introduced a new and efficient 3D imaging system that captures high-speed images using deep learning-enabled ...A recent article in the Opto-Electronic Advances(OEA)journal from Prof.Qian Chen and Prof.Chao Zuo’s group introduced a new and efficient 3D imaging system that captures high-speed images using deep learning-enabled fringe projection profilometry(FPP).In this News&Views article,we explore potential avenues for future advancements,including expanding the measurement range through an extended number-theoretical approach,enhancing quality through the incorporation of horizontal fringes,and integrating data from other modalities to broaden the system's applications.展开更多
The possible absolute instability in superlattice miniband transport using the hydrodynamic balance equations for arbitrary energy dispersion is investigated.In contrast to the prediction of the drift-diffusion model ...The possible absolute instability in superlattice miniband transport using the hydrodynamic balance equations for arbitrary energy dispersion is investigated.In contrast to the prediction of the drift-diffusion model that in doped semiconductor superlattices absolute instability occurs closely following the onset of negative differential mobility(NDM),the present analysis shows that a wide-miniband planar superlattice may become absolutely unstable only when it is biased deep in the NDM regime.This result is in agreement with recent experimental findings.展开更多
It is generally accepted that stellar annual or secular aberration is attributed to the changes in velocity of the detector. We can say it in a slightly different way. By means of the all known experiments, stellar ab...It is generally accepted that stellar annual or secular aberration is attributed to the changes in velocity of the detector. We can say it in a slightly different way. By means of the all known experiments, stellar aberration is directly or indirectly detectable and measurable, only if a detector changes its velocity. Our presumption is that stellar aberration is not caused by the changes in the velocity of the detector. It exists due to the movement of the detector regarding to an absolute inertial frame. Therefore it is just the question of how to choose such a frame. In this paper it is proposed a method to detect and measure instantaneous stellar aberration due to absolute velocity. We can call it an “absolute” stellar aberration. Combining an “annual” and an “absolute” we can define a “total” stellar aberration.展开更多
Passively mode-locked fiber lasers emit femtosecond pulse trains with excellent short-term stability. The quantum-limited timing jitter of a free running femtosecond erbium-doped fiber laser working at room temperatur...Passively mode-locked fiber lasers emit femtosecond pulse trains with excellent short-term stability. The quantum-limited timing jitter of a free running femtosecond erbium-doped fiber laser working at room temperature is considerably below one femtosecond at high Fourier frequency. The ultrashort pulse train with ultralow timing jitter enables absolute time-of-flight measurements based on a dual-comb implementation, which is typically composed of a pair of optical frequency combs generated by femtosecond lasers. Dead-zone-free absolute distance measurement with sub-micrometer precision and kHz update rate has been routinely achieved with a dual-comb configuration, which is promising for a number of precision manufacturing applications, from large step-structure measurements prevalent in microelectronic profilometry to three coordinate measurements in large-scale aerospace manufacturing and shipbuilding. In this paper, we first review the sub-femtosecond precision timing jitter characterization methods and approaches for ultralow timing jitter mode-locked fiber laser design. Then, we provide an overview of the state-of-the-art dual-comb absolute ranging technology in terms of working principles, experimental implementations, and measurement precisions. Finally, we discuss the impact of quantum-limited timing jitter on the dual-comb ranging precision at a high update rate. The route to highprecision dual-comb range finder design based on ultralow jitter femtosecond fiber lasers is proposed.展开更多
AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute m...AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers.展开更多
Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studi...Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studies have identified the key proteins implicated in response to Kai-Xin-San treatment. In this study, rat models of chronic mild stress were established using different stress methods over 28 days. After 14 days of stress stimulation, rats received daily intragastric administrations of 600 mg/kg Kai-Xin-San. The sucrose preference test was used to determine depression-like behavior in rats, while isobaric tags were used for relative and absolute quantitation-based proteomics to identify altered proteins following Kai-Xin-San treatment. Kai-Xin-San treatment for 2 weeks noticeably improved depression-like behaviors in rats with chronic mild stress. We identified 33 differentially expressed proteins: 7 were upregulated and 26 were downregulated. Functional analysis showed that these differentially expressed proteins participate in synaptic plasticity, neurodevelopment, and neurogenesis. Our results indicate that Kai-Xin-San has an important role in regulating the key node proteins in the synaptic signaling network, and are helpful to better understand the mechanism of the antidepressive effects of Kai-Xin-San and to provide objective theoretical support for its clinical application. The study was approved by the Ethics Committee for Animal Research from the Chinese PLA General Hospital(approval No. X5-2016-07) on March 5, 2016.展开更多
An axially variable-length solid element with eight nodes is proposed by integrating the arbitrary Lagrangian-Eulerian (ALE) formulation and the absolute nodal coordinate formulation (ANCF). In addition to the nodal p...An axially variable-length solid element with eight nodes is proposed by integrating the arbitrary Lagrangian-Eulerian (ALE) formulation and the absolute nodal coordinate formulation (ANCF). In addition to the nodal positions and slopes of eight nodes, two material coordinates in the axial direction are used as the generalized coordinates. As a consequence, the nodes in the ALE-ANCF are not associated with any specific material points and the axial length of the solid element can be varied over time. These two material coordinates give rise to a variable mass matrix and an additional inertial force vector. Computationally efficient formulae of the additional inertial forces and elastic forces, as well as their Jacobians, are also derived. The dynamic equation of a flexible multibody system (FMBS) with variable-length bodies is presented. The maximum and minimum lengths of the boundary elements of an FMBS have to be appropriately defined to ensure accuracy and non-singularity when solving the dynamic equation. Three numerical examples of static and dynamic problems are given to validate the variable-length solid elements of ALE-ANCF and show their capability.展开更多
Compact atomic gravimeters are the potential next generation precision instruments for gravity survey from fundamental research to broad field applications.We report the calibration results of our home build compact a...Compact atomic gravimeters are the potential next generation precision instruments for gravity survey from fundamental research to broad field applications.We report the calibration results of our home build compact absolute atomic gravimeter USTC-AG02 at Changping Campus,the National Institute of Metrology(NIM),China in January 2019.The sensitivity of the atomic gravimeter reaches 35.5μGal/√Hz(1μGal=1×10-8 m/s2)and its long-term stability reaches 0.8μGal for averaging over 4000 seconds.Considering the statistical uncertainty,the dominant instrumental systematic errors and environmental effects are evaluated and corrected within a total uncertainty(2σ)of 15.3μGal.After compared with the reference g value given by the corner cube gravimeter NIM-3A,the atomic gravimeter USTC-AG02 reaches the degree of equivalence of 3.7μGal.展开更多
Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a label...Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags for relative and absolute quantitation to investigate the protein profiles of spinal nerve tissues from Sprague-Dawley rats. In response to Wallerian degeneration, a total of 626 proteins were screened in sensory nerves, of which 368 were upregulated and 258 were downregulated. In addition, 637 proteins were screened in motor nerves, of which 372 were upregulated and 265 were downregulated. All identified proteins were analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of bioinformatics, and the presence of several key proteins closely related to Wallerian degeneration were tested and verified using quantitative real-time polymerase chain reaction analyses. The differentially expressed proteins only identified in the sensory nerves were mainly relevant to various biological processes that included cell-cell adhesion, carbohydrate metabolic processes and cell adhesion, whereas differentially expressed proteins only identified in the motor nerves were mainly relevant to biological processes associated with the glycolytic process, cell redox homeostasis, and protein folding. In the aspect of the cellular component, the differentially expressed proteins in the sensory and motor nerves were commonly related to extracellular exosomes, the myelin sheath, and focal adhesion. According to the Kyoto Encyclopedia of Genes and Genomes, the differentially expressed proteins identified are primarily related to various types of metabolic pathways. In conclusion, the present study screened differentially expressed proteins to reveal more about the differences and similarities between sensory and motor nerves during Wallerian degeneration. The present findings could provide a reference point for a future investigation into the differences between sensory and motor nerves in Wallerian degeneration and the characteristics of peripheral nerve regeneration. The study was approved by the Ethics Committee of the Chinese PLA General Hospital, China(approval No. 2016-x9-07) in September 2016.展开更多
Correlation between the absolute configuration and the CDspectra of organic peroxides was studied by ab initio method with a mo-d el moleeule CH<sub>3</sub>-O-O-CH<sub>3</sub>.For P form when 0...Correlation between the absolute configuration and the CDspectra of organic peroxides was studied by ab initio method with a mo-d el moleeule CH<sub>3</sub>-O-O-CH<sub>3</sub>.For P form when 0°≤θ（twist angle of C-O-O-C）【90°, there is positive Cotton effect;when 90°【θ≤180°, there is nega-tive Cotton effect;the curve is bisignate at θ=90°.展开更多
In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,gener...In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,generalized elastic force,external load and mass matrices of the element are deduced to perform the element assembling by using the finite element method.Then the motion equation of the tendon/riser is established.In this study,the TLP in the International Ship Structures Committee(ISSC)model under the first and second wave forces is considered as the case study.The simulation is performed in the MATLAB environment.Moreover,the accuracy and reliability of the programs are verified for cases of beam model with theoretical solutions.It is found that the motion response of tendons is affected by the TLP movement and environmental load,simultaneously.Then,the motion response is calculated using the SESAM software and exported as the boundary of ANCF tendons.Finally,the static and dynamic characteristics of the four tendons of ISSC TLP are analyzed systematically by the ANCF method.Performed analysis proves the effectiveness and feasibility of the ANCF method.It is concluded that the proposed method is a powerful scheme for calculating the dynamics of tendon/riser in the field of ocean engineering.展开更多
Carbon Nano-Tube Field Effect Transistors(CNTFETs) are being widely studied as possible successors to silicon MOSFETs.Using current mode has many advantages such as performing sum operation by means of a simple wired ...Carbon Nano-Tube Field Effect Transistors(CNTFETs) are being widely studied as possible successors to silicon MOSFETs.Using current mode has many advantages such as performing sum operation by means of a simple wired connection.Also,direction of the current can be used to exhibit the sign of digits.It is expected that the advantages of current mode approaches will become even more important with increased speed requirements and decreased supply voltage.In this paper,we present five new circuit designs for differential absolute value in current mode logic which have been simulated by CNTFET model.The considered base current for this model is 2 μA and supply voltage is 0.9 V.In all of our designs we used N-type CNTFET current mirrors which operate as truncated difference circuits.The operation of Differential Absolute Value circuit calculates the difference between two input currents and our circuit designs are operate in 8 logic levels.展开更多
In this paper the authors study two classes of time-varring nonlinear controlsystems. A few sufficient conditions of absolute stability of these systems were obtainedby means of classical analysis and the analogue of ...In this paper the authors study two classes of time-varring nonlinear controlsystems. A few sufficient conditions of absolute stability of these systems were obtainedby means of classical analysis and the analogue of the edtion of constants formula ofnonlinear systems. Moreover, they gave some sufficient conditions of absolute stability inHurwitz angle for these systems.展开更多
In this paper, we investigate the absolute stability of the general Lurie control systems. The necessary and sufficient conditions for absolute stability are obtained. These conditions can be readily checked and are c...In this paper, we investigate the absolute stability of the general Lurie control systems. The necessary and sufficient conditions for absolute stability are obtained. These conditions can be readily checked and are convenient in application.展开更多
基金This study was reviewed and approved by the Maternal and child health hospital of Hubei Province(Approval No.20201025).
文摘BACKGROUND As a well-known fact to the public,gestational diabetes mellitus(GDM)could bring serious risks for both pregnant women and infants.During this important investigation into the linkage between GDM patients and their altered expression in the serum,proteomics techniques were deployed to detect the differentially expressed proteins(DEPs)of in the serum of GDM patients to further explore its pathogenesis,and find out possible biomarkers to forecast GDM occurrence.METHODS Subjects were divided into GDM and normal control groups according to the IADPSG diagnostic criteria.Serum samples were randomly selected from four cases in each group at 24-28 wk of gestation,and the blood samples were identified by applying iTRAQ technology combined with liquid chromatography-tandem mass spectrometry.Key proteins and signaling pathways associated with GDM were identified by bioinformatics analysis,and the expression of key proteins in serum from 12 wk to 16 wk of gestation was further verified using enzyme-linked immunosorbent assay (ELISA).RESULTS Forty-seven proteins were significantly differentially expressed by analyzing the serum samples between the GDMgravidas as well as the healthy ones. Among them, 31 proteins were found to be upregulated notably and the rest16 proteins were downregulated remarkably. Bioinformatic data report revealed abnormal expression of proteinsassociated with lipid metabolism, coagulation cascade activation, complement system and inflammatory responsein the GDM group. ELISA results showed that the contents of RBP4, as well as ANGPTL8, increased in the serumof GDM gravidas compared with the healthy ones, and this change was found to initiate from 12 wk to 16 wk ofgestation.CONCLUSION GDM symptoms may involve abnormalities in lipid metabolism, coagulation cascade activation, complementsystem and inflammatory response. RBP4 and ANGPTL8 are expected to be early predictors of GDM.
基金supported by the Open Fund of Wuhan,Gravitation and Solid Earth Tides,National Observation and Research Station (No. WHYWZ202214)the Scientific Research Fund of Institute of Seismology and Institute of Crustal Dynamics,China Earthquake Administration (Grant No.IS202236336, No. IS202226326)+1 种基金the Researchof Hubei Earthquake Agency (No. 2022HBJJ039)the National Natural Science Foundation of China (No. 41774093)
文摘Three A10 absolute gravimeters(AGs) were first acquired in China by the Hubei Earthquake Agency under the Belt and Road Seismic Monitoring Network Project. Although AG measuring and testing technique is not new, the purchase and simultaneous testing of 3 A10 absolute gravimeters is unprecedented in China. This study conducted the first acceptance testing of the AGs at 3 locations(the Jiufengshan Gravity Observation Station, the Global Navigation Satellite System Observation Station in Wuhan, and the Jiugongshan Observation Station in Xianning). The results were compared using a method based on expert validation, and the acceptance testing scheme was formulated by referring to the Technical Regulations for Tectonic Environment Monitoring Networks in China and Specifications for Gravimetry Control. Based on the repeatability, precision, and consistency of the measured g values, the results from each instrument were evaluated using the air pressure precision test. Comparing the instrument reference values, the final test results can identify the indicator parameters for 3 A10 AGs, the effects of the surrounding environment, and the related parameters on measurement precision. The precision of A10-059, A10-058, and A10-057 exceeded 0.78 μGal, 0.79 μGal, and 0.42 μGal, respectively.This testing scheme can be used as a reference for conducting acceptance testing of AGs in the future and obtaining absolute gravimetric measurements.
基金Project supported by the National Key R&D Program of China (Grant No. 2022YFF0607504)。
文摘An absolute gravimeter is a precision instrument for measuring gravitational acceleration, which plays an important role in earthquake monitoring, crustal deformation, national defense construction, etc. The frequency of laser interference fringes of an absolute gravimeter gradually increases with the fall time. Data are sparse in the early stage and dense in the late stage. The fitting accuracy of gravitational acceleration will be affected by least-squares fitting according to the fixed number of zero-crossing groups. In response to this problem, a method based on Fourier series fitting is proposed in this paper to calculate the zero-crossing point. The whole falling process is divided into five frequency bands using the Hilbert transformation. The multiplicative auto-regressive moving average model is then trained according to the number of optimal zero-crossing groups obtained by the honey badger algorithm. Through this model, the number of optimal zero-crossing groups determined in each segment is predicted by the least-squares fitting. The mean value of gravitational acceleration in each segment is then obtained. The method can improve the accuracy of gravitational measurement by more than 25% compared to the fixed zero-crossing groups method. It provides a new way to improve the measuring accuracy of an absolute gravimeter.
文摘A recent article in the Opto-Electronic Advances(OEA)journal from Prof.Qian Chen and Prof.Chao Zuo’s group introduced a new and efficient 3D imaging system that captures high-speed images using deep learning-enabled fringe projection profilometry(FPP).In this News&Views article,we explore potential avenues for future advancements,including expanding the measurement range through an extended number-theoretical approach,enhancing quality through the incorporation of horizontal fringes,and integrating data from other modalities to broaden the system's applications.
基金Supported by the National Natural Science Foundation of Chinathe National Commission of Science and Technology of China+1 种基金the Shanghai Municipal Commission of Science and Technologythe the Shanghai Foundation for Research and Development of Applied Materials.
文摘The possible absolute instability in superlattice miniband transport using the hydrodynamic balance equations for arbitrary energy dispersion is investigated.In contrast to the prediction of the drift-diffusion model that in doped semiconductor superlattices absolute instability occurs closely following the onset of negative differential mobility(NDM),the present analysis shows that a wide-miniband planar superlattice may become absolutely unstable only when it is biased deep in the NDM regime.This result is in agreement with recent experimental findings.
文摘It is generally accepted that stellar annual or secular aberration is attributed to the changes in velocity of the detector. We can say it in a slightly different way. By means of the all known experiments, stellar aberration is directly or indirectly detectable and measurable, only if a detector changes its velocity. Our presumption is that stellar aberration is not caused by the changes in the velocity of the detector. It exists due to the movement of the detector regarding to an absolute inertial frame. Therefore it is just the question of how to choose such a frame. In this paper it is proposed a method to detect and measure instantaneous stellar aberration due to absolute velocity. We can call it an “absolute” stellar aberration. Combining an “annual” and an “absolute” we can define a “total” stellar aberration.
基金supported by National Natural Science Foundation of China (Grant Nos.61475162,61675150,and 61535009)Tianjin Natural Science Foundation (Grant No.18JCYBJC16900)Tianjin Research Program of Application Foundation and Advanced Technology (Grant No.17JCJQJC43500)
文摘Passively mode-locked fiber lasers emit femtosecond pulse trains with excellent short-term stability. The quantum-limited timing jitter of a free running femtosecond erbium-doped fiber laser working at room temperature is considerably below one femtosecond at high Fourier frequency. The ultrashort pulse train with ultralow timing jitter enables absolute time-of-flight measurements based on a dual-comb implementation, which is typically composed of a pair of optical frequency combs generated by femtosecond lasers. Dead-zone-free absolute distance measurement with sub-micrometer precision and kHz update rate has been routinely achieved with a dual-comb configuration, which is promising for a number of precision manufacturing applications, from large step-structure measurements prevalent in microelectronic profilometry to three coordinate measurements in large-scale aerospace manufacturing and shipbuilding. In this paper, we first review the sub-femtosecond precision timing jitter characterization methods and approaches for ultralow timing jitter mode-locked fiber laser design. Then, we provide an overview of the state-of-the-art dual-comb absolute ranging technology in terms of working principles, experimental implementations, and measurement precisions. Finally, we discuss the impact of quantum-limited timing jitter on the dual-comb ranging precision at a high update rate. The route to highprecision dual-comb range finder design based on ultralow jitter femtosecond fiber lasers is proposed.
基金Supported by Kyung Hee University in 2006,No.KHU-20061216
文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers.
基金supported by the National Natural Science Foundation of China,No.81573876(to YH)
文摘Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studies have identified the key proteins implicated in response to Kai-Xin-San treatment. In this study, rat models of chronic mild stress were established using different stress methods over 28 days. After 14 days of stress stimulation, rats received daily intragastric administrations of 600 mg/kg Kai-Xin-San. The sucrose preference test was used to determine depression-like behavior in rats, while isobaric tags were used for relative and absolute quantitation-based proteomics to identify altered proteins following Kai-Xin-San treatment. Kai-Xin-San treatment for 2 weeks noticeably improved depression-like behaviors in rats with chronic mild stress. We identified 33 differentially expressed proteins: 7 were upregulated and 26 were downregulated. Functional analysis showed that these differentially expressed proteins participate in synaptic plasticity, neurodevelopment, and neurogenesis. Our results indicate that Kai-Xin-San has an important role in regulating the key node proteins in the synaptic signaling network, and are helpful to better understand the mechanism of the antidepressive effects of Kai-Xin-San and to provide objective theoretical support for its clinical application. The study was approved by the Ethics Committee for Animal Research from the Chinese PLA General Hospital(approval No. X5-2016-07) on March 5, 2016.
基金the National Natural Science Foundation of China (Grants 11521062, 11722216)the 111 China Project (Grant B16003)+1 种基金Postgraduate Research and Practice Innovation Program of Jiangsu Province (Grant KYCX17_0226)China Scholarship Council.
文摘An axially variable-length solid element with eight nodes is proposed by integrating the arbitrary Lagrangian-Eulerian (ALE) formulation and the absolute nodal coordinate formulation (ANCF). In addition to the nodal positions and slopes of eight nodes, two material coordinates in the axial direction are used as the generalized coordinates. As a consequence, the nodes in the ALE-ANCF are not associated with any specific material points and the axial length of the solid element can be varied over time. These two material coordinates give rise to a variable mass matrix and an additional inertial force vector. Computationally efficient formulae of the additional inertial forces and elastic forces, as well as their Jacobians, are also derived. The dynamic equation of a flexible multibody system (FMBS) with variable-length bodies is presented. The maximum and minimum lengths of the boundary elements of an FMBS have to be appropriately defined to ensure accuracy and non-singularity when solving the dynamic equation. Three numerical examples of static and dynamic problems are given to validate the variable-length solid elements of ALE-ANCF and show their capability.
基金Project supported by the National Key R&D Program of China(Grant No.2016YFA0301601)the National Natural Science Foundation of China(Grant No.11674301)+1 种基金Anhui Initiative in Quantum Information Technologies,China(Grant No.AHY120000)Shanghai Municipal Science and Technology Major Project,China(Grant No.2019SHZDZX01).
文摘Compact atomic gravimeters are the potential next generation precision instruments for gravity survey from fundamental research to broad field applications.We report the calibration results of our home build compact absolute atomic gravimeter USTC-AG02 at Changping Campus,the National Institute of Metrology(NIM),China in January 2019.The sensitivity of the atomic gravimeter reaches 35.5μGal/√Hz(1μGal=1×10-8 m/s2)and its long-term stability reaches 0.8μGal for averaging over 4000 seconds.Considering the statistical uncertainty,the dominant instrumental systematic errors and environmental effects are evaluated and corrected within a total uncertainty(2σ)of 15.3μGal.After compared with the reference g value given by the corner cube gravimeter NIM-3A,the atomic gravimeter USTC-AG02 reaches the degree of equivalence of 3.7μGal.
基金supported by National Key Research&Development Program of China,No.2016YFC11011601,2017YFA0104701the Youth Cultivation Project of Military Medical Science,China,No.15QNP091(to YW)People’s Liberation Army Youth Training Project for Medical Science of China,No.16QNP144(to YW)
文摘Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags for relative and absolute quantitation to investigate the protein profiles of spinal nerve tissues from Sprague-Dawley rats. In response to Wallerian degeneration, a total of 626 proteins were screened in sensory nerves, of which 368 were upregulated and 258 were downregulated. In addition, 637 proteins were screened in motor nerves, of which 372 were upregulated and 265 were downregulated. All identified proteins were analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of bioinformatics, and the presence of several key proteins closely related to Wallerian degeneration were tested and verified using quantitative real-time polymerase chain reaction analyses. The differentially expressed proteins only identified in the sensory nerves were mainly relevant to various biological processes that included cell-cell adhesion, carbohydrate metabolic processes and cell adhesion, whereas differentially expressed proteins only identified in the motor nerves were mainly relevant to biological processes associated with the glycolytic process, cell redox homeostasis, and protein folding. In the aspect of the cellular component, the differentially expressed proteins in the sensory and motor nerves were commonly related to extracellular exosomes, the myelin sheath, and focal adhesion. According to the Kyoto Encyclopedia of Genes and Genomes, the differentially expressed proteins identified are primarily related to various types of metabolic pathways. In conclusion, the present study screened differentially expressed proteins to reveal more about the differences and similarities between sensory and motor nerves during Wallerian degeneration. The present findings could provide a reference point for a future investigation into the differences between sensory and motor nerves in Wallerian degeneration and the characteristics of peripheral nerve regeneration. The study was approved by the Ethics Committee of the Chinese PLA General Hospital, China(approval No. 2016-x9-07) in September 2016.
文摘Correlation between the absolute configuration and the CDspectra of organic peroxides was studied by ab initio method with a mo-d el moleeule CH<sub>3</sub>-O-O-CH<sub>3</sub>.For P form when 0°≤θ（twist angle of C-O-O-C）【90°, there is positive Cotton effect;when 90°【θ≤180°, there is nega-tive Cotton effect;the curve is bisignate at θ=90°.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51879047 and 51890915)the Engineering Development Program of Deepwater Semi-submersible Production Storage and Unloading Platform of China(Grant No.SSBQ-2020-HN-03-03)the Natural Science Foundation of Heilongjiang Province of China(Grant No.E2017029)。
文摘In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,generalized elastic force,external load and mass matrices of the element are deduced to perform the element assembling by using the finite element method.Then the motion equation of the tendon/riser is established.In this study,the TLP in the International Ship Structures Committee(ISSC)model under the first and second wave forces is considered as the case study.The simulation is performed in the MATLAB environment.Moreover,the accuracy and reliability of the programs are verified for cases of beam model with theoretical solutions.It is found that the motion response of tendons is affected by the TLP movement and environmental load,simultaneously.Then,the motion response is calculated using the SESAM software and exported as the boundary of ANCF tendons.Finally,the static and dynamic characteristics of the four tendons of ISSC TLP are analyzed systematically by the ANCF method.Performed analysis proves the effectiveness and feasibility of the ANCF method.It is concluded that the proposed method is a powerful scheme for calculating the dynamics of tendon/riser in the field of ocean engineering.
文摘Carbon Nano-Tube Field Effect Transistors(CNTFETs) are being widely studied as possible successors to silicon MOSFETs.Using current mode has many advantages such as performing sum operation by means of a simple wired connection.Also,direction of the current can be used to exhibit the sign of digits.It is expected that the advantages of current mode approaches will become even more important with increased speed requirements and decreased supply voltage.In this paper,we present five new circuit designs for differential absolute value in current mode logic which have been simulated by CNTFET model.The considered base current for this model is 2 μA and supply voltage is 0.9 V.In all of our designs we used N-type CNTFET current mirrors which operate as truncated difference circuits.The operation of Differential Absolute Value circuit calculates the difference between two input currents and our circuit designs are operate in 8 logic levels.
文摘In this paper the authors study two classes of time-varring nonlinear controlsystems. A few sufficient conditions of absolute stability of these systems were obtainedby means of classical analysis and the analogue of the edtion of constants formula ofnonlinear systems. Moreover, they gave some sufficient conditions of absolute stability inHurwitz angle for these systems.
基金Project supported by the National Natural Science Foundation of China.
文摘In this paper, we investigate the absolute stability of the general Lurie control systems. The necessary and sufficient conditions for absolute stability are obtained. These conditions can be readily checked and are convenient in application.
