Three salts of labdanic acids, named as magnesium andrographate, disodium andrographate and dipotassium andrographate 19-O-beta -D-glucoside were isolated from the hydrophilic extract of Andrographis paniculata Nees. ...Three salts of labdanic acids, named as magnesium andrographate, disodium andrographate and dipotassium andrographate 19-O-beta -D-glucoside were isolated from the hydrophilic extract of Andrographis paniculata Nees. (Acanthaceae), together with guanosine, uridine, 6-epihardpagide, procumbide, violanthin and apigenin 7-O-beta -D-glucoside. Their structures were determined by spectroscopic analysis and chemical transformation.展开更多
A new genus,Wuacanthus Y.F.Deng,N.H.Xia&H.Peng(Acanthaceae),is described from the Hengduan Mountains,China.Wuacanthus is based on Wuacanthus microdontus(W.W.Sm.)Y.F.Deng,N.H.Xia&H.Peng,originally published in ...A new genus,Wuacanthus Y.F.Deng,N.H.Xia&H.Peng(Acanthaceae),is described from the Hengduan Mountains,China.Wuacanthus is based on Wuacanthus microdontus(W.W.Sm.)Y.F.Deng,N.H.Xia&H.Peng,originally published in Justicia and then moved to Mananthes.The new genus is characterized by its shrub habit,strongly 2-lipped corolla,the 2-lobed upper lip,3-lobed lower lip,2 stamens,bithecous anthers,parallel thecae with two spurs at the base,2 ovules in each locule,and the 4-seeded capsule.Phylogenetic analyses show that the new genus belongs to the Pseuderanthemum lineage in tribe Justicieae.Wuacanthus is closely related to Pseuderanthemum but differs from the latter by its shorter corolla tube and two minute spurs at the base of each anther-theca.W.microdontus is assessed with the status EN B2ab(iii)based on the IUCN Red List Categories and Criteria.展开更多
Acanthaceae has received considerable taxonomic attention at the familial, subfamilial, tribal and subtribal levels. Several different infra-familial classifications have been proposed for the Acanthaceae, but no taxo...Acanthaceae has received considerable taxonomic attention at the familial, subfamilial, tribal and subtribal levels. Several different infra-familial classifications have been proposed for the Acanthaceae, but no taxonomic consensus has yet been reached. The main objective of the present study is to throw light on the phenetic relationships and to explore the contribution of morphological and molecular characters in systematics of Acanthaceae. The morphological data viz. macromorphology, stomatography, lamina architecture and ISSR profiles of 30 Egyptian acanthaceous taxa were investigated. The phenetic analysis using NTSYS-PC version 2.02 software based on 55 potentially informative morphological and molecular characters indicated that the used morphological and ISSR criteria is likely to be useful and valuable taxonomic traits. The morphological characters and ISSR aspects of all the studied species produced a phenogram that showed two series;one of them had two subseries, the first one comprised only three taxa while the second divided into two clusters, each contained two groups. The delimitation and the membership of the studied taxa clearly merit additional study using more criteria. The phenetic analysis of both morphological and molecular attributes clarified the segregation of genus Avicennia as a distinct identity away from Acanthaceae. Acanthus mollis & A. montanus are isolated in its own series that comparable to tribe Acantheae of the current taxonomic systems. The studied species of Thunbergia are gathered its own subseries that comparable to tribe Thunbergiae and Ruellia in its own group that comparable to tribe Ruellieae.展开更多
The practice of plants for the deterrence and management of innumerable physiological states and diseases dates back to the history of humankind. Although many of today’s medicinal yields are achieved synthetically, ...The practice of plants for the deterrence and management of innumerable physiological states and diseases dates back to the history of humankind. Although many of today’s medicinal yields are achieved synthetically, they are often modelled on the chemical composition of medicinal plants. In this accordance, Acanthus genus (Family Acanthaceae) has acknowledged considerable attention due to its wide range of secondary metabolites and its customary usage in Indian and Chinese system of medicine. It is worth to mention that A. ilicifolius is enormously medicinal among all the species of Acanthus genus. This plant is considered to be rich sources of steroids, triterpenoids, saponins, flavonoids, alkaloids, and tannins. Traditionally, the plant has been used for asthma, diabetes, dyspepsia, hepatitis, leprosy, neuralgia, paralysis, ringworm, skin disease, snake bite, leukemia. Toxicological investigation in mice model has showed that, the ethanolic extract of the leaves of this plant have no toxic effect up to dose of 1000 mg/kg BW, 2000 mg/kg BW dose have mild toxicity and 5000 mg/kg BW dose have caused toxic effect in some organ system like liver, heart, pancreas, lung and kidney. Different extract of this plant also exhibited Anti-inflammatory, anti-leishmanial, osteoblastic, hepatoprotective, antioxidant and anticancer activities. This review article is an endeavor to cover current expansion in phytochemical and pharmacological potential of this plant species which will be a good reference tool for investigators who wish to work on natural products.展开更多
Objective:To investigate the phytochemical,antibacterial,antifungal and anticandidal activity of successive extracts of Crossandra infundibuliformis(Acanthaceae) leaves.Methods:Preliminary screening on the presence of...Objective:To investigate the phytochemical,antibacterial,antifungal and anticandidal activity of successive extracts of Crossandra infundibuliformis(Acanthaceae) leaves.Methods:Preliminary screening on the presence of alkaloids,saponins,phytosterols,phenolic compounds,flavanoids, tannins,carbohydrates,terpenoids,oils and fats were carried out by phytochemical analysis.The antibacterial,antifungal and anticandidal activities were done by agar well diffusion technique. Results:The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0μg/mL.In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250μg/mL.Conclusions:These findings demonstrate that the leaf extracts of C.infimdibuliformis presents excellent antimicrobial activities and thus have great potential as a source for natural health care products.展开更多
Andrographolide (AG) is the characteristic constituent of Andrographis paniculata, of the Acanthaceae family. This plant is a well-known Asian medicinal plant that is widely used in India, China, and Thailand. A monog...Andrographolide (AG) is the characteristic constituent of Andrographis paniculata, of the Acanthaceae family. This plant is a well-known Asian medicinal plant that is widely used in India, China, and Thailand. A monograph of Herba Andrographidis (Chuanxinlian) is included in the Chinese Pharmacopoeia, which reports that this decoction can “remove heat, counteract toxicity, and reduce swellings.” The numerous potential activities of AG range from anti-inflammatory to anti-diabetic action, from neuroprotection to antitumor activity, and from hepatoprotective to anti-obesity properties. However, AG has low bioavailability and poor water solubility, which can limit its distribution and accumulation in the body after administration. In addition, AG is not stable in gastrointestinal alkaline and acidic environments, and has been reported to have a very short half-life. Among the diverse strategies that have been adopted to increase AG water solubility and permeability, the technological approach is the most useful way to develop appropriate delivery systems. This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with AG. MPs based on polylactic-glycolic acid (PLGA), alginic acid, and glucan derivatives have been developed for parenteral oral and pulmonary administration, respectively. NPs include vesicles (both liposomes and niosomes);polymeric NPs (based on polyvinyl alcohol, polymerized phenylboronic acid, PLGA, human serum albumin, poly ethylcyanoacrylate, and polymeric micelles);solid lipid NPs;microemulsions and nanoemulsions;gold NPs;nanocrystals;and nanosuspensions. Improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported.展开更多
A new ent-labdane diterpenoid lactone with a new natural product was isolated from Andrographis paniculata. Their structures were elucidated on the basis of spectral evidences including 2D NMR.
A new ent-labdane diterpenoid,19-O-β-D-glucopyranosyl-ent-labda-8（17）,13-dien-15,16,19-triol,together with six known ent-labdane diterpenoids,was isolated from the aerial parts of Andrographis paniculaia.The struct...A new ent-labdane diterpenoid,19-O-β-D-glucopyranosyl-ent-labda-8（17）,13-dien-15,16,19-triol,together with six known ent-labdane diterpenoids,was isolated from the aerial parts of Andrographis paniculaia.The structure of the new compound was elucidated by extensive spectral analysis.展开更多
The genus Strobilanthes belonging to the family Acanthaceae,is mainly distributed in Kashmir,Bhutan,Bangladesh and the Khasi mountains of northeast India and southwest of China.The main purpose of this review is to pr...The genus Strobilanthes belonging to the family Acanthaceae,is mainly distributed in Kashmir,Bhutan,Bangladesh and the Khasi mountains of northeast India and southwest of China.The main purpose of this review is to provide the available information on the phytochemistry,pharmacology and the traditional applications aspects of the genus Strobilanthes,and provides trends and perspectives for the further studies on its chemical constituents.The present review collected the literatures published prior to 2022 on the phytochemistry,and pharmacology of the genus Strobilanthes.The available literatures were excerpted from scientific databases,such as Sci-finder,PubMed,Web of Science,Google Scholar,and CNKI,Baidu Scholar,books,and others.The plants from the genus Strobilanthes have been usually used in some traditional herbal prescriptions,and pharmacological researches in vitro and in vivo revealed that the extracts possessed significant anticancer,antioxidant,anti-inflammatory,anti-allergic activities,etc.To date,the majority of articles mainly focused on the research of crude extracts.However,the data in previous literatures indicated the research potential of this genus in phytochemical and pharmacological aspects.In addition,the further in-depth investigations on the safety,efficacy,as well as the specific chemical composition,stereo-chemistry and structure-activity relationships of pure compounds from this genus are essential in the future investigation.展开更多
In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside(1) and 14-deoxy-15-methoxy-andrographolide(2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidat...In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside(1) and 14-deoxy-15-methoxy-andrographolide(2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of NMR, MS, and chemical methods. The configurations of 1 and 2 were established based on the analysis of ROESY data and single crystal X-ray diffraction experiment.展开更多
文摘Three salts of labdanic acids, named as magnesium andrographate, disodium andrographate and dipotassium andrographate 19-O-beta -D-glucoside were isolated from the hydrophilic extract of Andrographis paniculata Nees. (Acanthaceae), together with guanosine, uridine, 6-epihardpagide, procumbide, violanthin and apigenin 7-O-beta -D-glucoside. Their structures were determined by spectroscopic analysis and chemical transformation.
基金supported by the National Natural Science Foundation of China (grant nos. 30670124,31270247,31470302,31400184,31670191,31110103911)Science and Technology Basic Work (grant no. 2013FY112100)
文摘A new genus,Wuacanthus Y.F.Deng,N.H.Xia&H.Peng(Acanthaceae),is described from the Hengduan Mountains,China.Wuacanthus is based on Wuacanthus microdontus(W.W.Sm.)Y.F.Deng,N.H.Xia&H.Peng,originally published in Justicia and then moved to Mananthes.The new genus is characterized by its shrub habit,strongly 2-lipped corolla,the 2-lobed upper lip,3-lobed lower lip,2 stamens,bithecous anthers,parallel thecae with two spurs at the base,2 ovules in each locule,and the 4-seeded capsule.Phylogenetic analyses show that the new genus belongs to the Pseuderanthemum lineage in tribe Justicieae.Wuacanthus is closely related to Pseuderanthemum but differs from the latter by its shorter corolla tube and two minute spurs at the base of each anther-theca.W.microdontus is assessed with the status EN B2ab(iii)based on the IUCN Red List Categories and Criteria.
文摘Acanthaceae has received considerable taxonomic attention at the familial, subfamilial, tribal and subtribal levels. Several different infra-familial classifications have been proposed for the Acanthaceae, but no taxonomic consensus has yet been reached. The main objective of the present study is to throw light on the phenetic relationships and to explore the contribution of morphological and molecular characters in systematics of Acanthaceae. The morphological data viz. macromorphology, stomatography, lamina architecture and ISSR profiles of 30 Egyptian acanthaceous taxa were investigated. The phenetic analysis using NTSYS-PC version 2.02 software based on 55 potentially informative morphological and molecular characters indicated that the used morphological and ISSR criteria is likely to be useful and valuable taxonomic traits. The morphological characters and ISSR aspects of all the studied species produced a phenogram that showed two series;one of them had two subseries, the first one comprised only three taxa while the second divided into two clusters, each contained two groups. The delimitation and the membership of the studied taxa clearly merit additional study using more criteria. The phenetic analysis of both morphological and molecular attributes clarified the segregation of genus Avicennia as a distinct identity away from Acanthaceae. Acanthus mollis & A. montanus are isolated in its own series that comparable to tribe Acantheae of the current taxonomic systems. The studied species of Thunbergia are gathered its own subseries that comparable to tribe Thunbergiae and Ruellia in its own group that comparable to tribe Ruellieae.
文摘The practice of plants for the deterrence and management of innumerable physiological states and diseases dates back to the history of humankind. Although many of today’s medicinal yields are achieved synthetically, they are often modelled on the chemical composition of medicinal plants. In this accordance, Acanthus genus (Family Acanthaceae) has acknowledged considerable attention due to its wide range of secondary metabolites and its customary usage in Indian and Chinese system of medicine. It is worth to mention that A. ilicifolius is enormously medicinal among all the species of Acanthus genus. This plant is considered to be rich sources of steroids, triterpenoids, saponins, flavonoids, alkaloids, and tannins. Traditionally, the plant has been used for asthma, diabetes, dyspepsia, hepatitis, leprosy, neuralgia, paralysis, ringworm, skin disease, snake bite, leukemia. Toxicological investigation in mice model has showed that, the ethanolic extract of the leaves of this plant have no toxic effect up to dose of 1000 mg/kg BW, 2000 mg/kg BW dose have mild toxicity and 5000 mg/kg BW dose have caused toxic effect in some organ system like liver, heart, pancreas, lung and kidney. Different extract of this plant also exhibited Anti-inflammatory, anti-leishmanial, osteoblastic, hepatoprotective, antioxidant and anticancer activities. This review article is an endeavor to cover current expansion in phytochemical and pharmacological potential of this plant species which will be a good reference tool for investigators who wish to work on natural products.
文摘Objective:To investigate the phytochemical,antibacterial,antifungal and anticandidal activity of successive extracts of Crossandra infundibuliformis(Acanthaceae) leaves.Methods:Preliminary screening on the presence of alkaloids,saponins,phytosterols,phenolic compounds,flavanoids, tannins,carbohydrates,terpenoids,oils and fats were carried out by phytochemical analysis.The antibacterial,antifungal and anticandidal activities were done by agar well diffusion technique. Results:The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0μg/mL.In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250μg/mL.Conclusions:These findings demonstrate that the leaf extracts of C.infimdibuliformis presents excellent antimicrobial activities and thus have great potential as a source for natural health care products.
基金the Fondazione Cassa Risparmio di Firenze for kindly supporting this review study
文摘Andrographolide (AG) is the characteristic constituent of Andrographis paniculata, of the Acanthaceae family. This plant is a well-known Asian medicinal plant that is widely used in India, China, and Thailand. A monograph of Herba Andrographidis (Chuanxinlian) is included in the Chinese Pharmacopoeia, which reports that this decoction can “remove heat, counteract toxicity, and reduce swellings.” The numerous potential activities of AG range from anti-inflammatory to anti-diabetic action, from neuroprotection to antitumor activity, and from hepatoprotective to anti-obesity properties. However, AG has low bioavailability and poor water solubility, which can limit its distribution and accumulation in the body after administration. In addition, AG is not stable in gastrointestinal alkaline and acidic environments, and has been reported to have a very short half-life. Among the diverse strategies that have been adopted to increase AG water solubility and permeability, the technological approach is the most useful way to develop appropriate delivery systems. This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with AG. MPs based on polylactic-glycolic acid (PLGA), alginic acid, and glucan derivatives have been developed for parenteral oral and pulmonary administration, respectively. NPs include vesicles (both liposomes and niosomes);polymeric NPs (based on polyvinyl alcohol, polymerized phenylboronic acid, PLGA, human serum albumin, poly ethylcyanoacrylate, and polymeric micelles);solid lipid NPs;microemulsions and nanoemulsions;gold NPs;nanocrystals;and nanosuspensions. Improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported.
基金supported by Bureau of Science & Technology of Dalian City(No.2008J23JH042).
文摘A new ent-labdane diterpenoid lactone with a new natural product was isolated from Andrographis paniculata. Their structures were elucidated on the basis of spectral evidences including 2D NMR.
基金supported by the National Basic Research Program(973 Program,No.2007CB512604)
文摘A new ent-labdane diterpenoid,19-O-β-D-glucopyranosyl-ent-labda-8（17）,13-dien-15,16,19-triol,together with six known ent-labdane diterpenoids,was isolated from the aerial parts of Andrographis paniculaia.The structure of the new compound was elucidated by extensive spectral analysis.
基金The authors thank the National Natural Science Foundation of China(NSFC)(No.82141216)Chunhui Program-Cooperative Research Project of the Ministry of Education,Liaoning Province Natural Science Foundation(No.2020-MZLH-31)+2 种基金China Postdoctoral Science Foundation(No.2021M693957)Shenyang Young and Middle-aged Innovative Talents Support Program(RC210446)Project of the Educational Department of Liaoning Province(No.LJKZ0919)for financial supports.
文摘The genus Strobilanthes belonging to the family Acanthaceae,is mainly distributed in Kashmir,Bhutan,Bangladesh and the Khasi mountains of northeast India and southwest of China.The main purpose of this review is to provide the available information on the phytochemistry,pharmacology and the traditional applications aspects of the genus Strobilanthes,and provides trends and perspectives for the further studies on its chemical constituents.The present review collected the literatures published prior to 2022 on the phytochemistry,and pharmacology of the genus Strobilanthes.The available literatures were excerpted from scientific databases,such as Sci-finder,PubMed,Web of Science,Google Scholar,and CNKI,Baidu Scholar,books,and others.The plants from the genus Strobilanthes have been usually used in some traditional herbal prescriptions,and pharmacological researches in vitro and in vivo revealed that the extracts possessed significant anticancer,antioxidant,anti-inflammatory,anti-allergic activities,etc.To date,the majority of articles mainly focused on the research of crude extracts.However,the data in previous literatures indicated the research potential of this genus in phytochemical and pharmacological aspects.In addition,the further in-depth investigations on the safety,efficacy,as well as the specific chemical composition,stereo-chemistry and structure-activity relationships of pure compounds from this genus are essential in the future investigation.
基金supported by National Natural Science Foundation of China(Nos.81473117 and 81502939)the Joint Fund of NSFC-Guangdong Province(No.U1401225)
文摘In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside(1) and 14-deoxy-15-methoxy-andrographolide(2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of NMR, MS, and chemical methods. The configurations of 1 and 2 were established based on the analysis of ROESY data and single crystal X-ray diffraction experiment.
