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Biobanks and biomarkers:Their current and future role in biomedical research
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作者 Michael Colwill Samantha Baillie +1 位作者 Richard Pollok Andrew Poullis 《World Journal of Methodology》 2024年第4期77-83,共7页
The importance and utility of biobanks has increased exponentially since their inception and creation.Initially used as part of translational research,they now contribute over 40%of data for all cancer research papers... The importance and utility of biobanks has increased exponentially since their inception and creation.Initially used as part of translational research,they now contribute over 40%of data for all cancer research papers in the United States of America and play a crucial role in all aspects of healthcare.Multiple classification systems exist but a simplified approach is to either classify as population-based or disease-oriented entities.Whilst historically publicly funded institutions,there has been a significant increase in industry funded entities across the world which has changed the dynamic of biobanks offering new possibilities but also new challenges.Biobanks face legal questions over data sharing and intellectual property as well as ethical and sustainability questions particularly as the world attempts to move to a low-carbon economy.International collaboration is required to address some of these challenges but this in itself is fraught with complexity and difficulty.This review will examine the current utility of biobanks in the modern healthcare setting as well as the current and future challenges these vital institutions face. 展开更多
关键词 BIOBANKS Biomarkers biomedical research research methodology research ethics
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Co-occurrence of Cell Lines, Basal Media and Supplementation in the Biomedical Research Literature 被引量:3
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作者 Jessica Cox Darin McBeath +1 位作者 Corey Harper Ron Daniel 《Journal of Data and Information Science》 CSCD 2020年第3期161-177,共17页
Purpose: The use of in vitro cell culture and experimentation is a cornerstone of biomedical research, however, more attention has recently been given to the potential consequences of using such artificial basal media... Purpose: The use of in vitro cell culture and experimentation is a cornerstone of biomedical research, however, more attention has recently been given to the potential consequences of using such artificial basal medias and undefined supplements. As a first step towards better understanding and measuring the impact these systems have on experimental results, we use text mining to capture typical research practices and trends around cell culture.Design/methodology/approach: To measure the scale of in vitro cell culture use, we have analyzed a corpus of 94,695 research articles that appear in biomedical research journals published in ScienceDirect from 2000–2018. Central to our investigation is the observation that studies using cell culture describe conditions using the typical sentence structure of cell line, basal media, and supplemented compounds. Here we tag our corpus with a curated list of basal medias and the Cellosaurus ontology using the Aho-Corasick algorithm. We also processed the corpus with Stanford CoreNLP to find nouns that follow the basal media, in an attempt to identify supplements used. Findings: Interestingly, we find that researchers frequently use DMEM even if a cell line's vendor recommends less concentrated media. We see long-tailed distributions for the usage of media and cell lines, with DMEM and RPMI dominating the media, and HEK293, HEK293 T, and HeLa dominating cell lines used. Research limitations: Our analysis was restricted to documents in ScienceDirect, and our text mining method achieved high recall but low precision and mandated manual inspection of many tokens.Practical implications: Our findings document current cell culture practices in the biomedical research community, which can be used as a resource for future experimental design.Originality/value: No other work has taken a text mining approach to surveying cell culture practices in biomedical research. 展开更多
关键词 Cell culture biomedical research Text mining
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Subject index of Journal of Biomedical Research 2010 Volume 24
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《The Journal of Biomedical Research》 CAS 2010年第6期483-485,共3页
关键词 2010 Subject index of Journal of biomedical research 2010 Volume 24 308
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Exploring Bioinspired AI for Advanced Cell Labeling:Advancements and Applications in Biomedical Research
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作者 Mirza Abdul Aleem Baig 《IJLAI Transactions on Science and Engineering》 2024年第3期66-71,共6页
Context:Bioinspired Artificial Intelligence(Bio-AI)has emerged as a transformative tool in biomedical research,addressing challenges in cell labeling essential for understanding cellular behavior and interactions.Trad... Context:Bioinspired Artificial Intelligence(Bio-AI)has emerged as a transformative tool in biomedical research,addressing challenges in cell labeling essential for understanding cellular behavior and interactions.Traditional cell labeling methods often struggle with accuracy,scalability,and adaptability in complex datasets.Objective:This paper theoretically explores the integration of Bio-AI models into cell labeling process.It aims to assess how these models C encompassing neural networks,swarm intelligence,evolutionary algorithms,and self-organizing maps C can enhance cell identification and classification.Method:The paper examines various Bio-AI models that mimic biological processes such as neural functioning,swarm behavior,and evolutionary dynamics.It also evaluates the application of multimodal AI systems that combine imaging data with molecular and genetic information.In addition,the potential of dynamic cell labeling,inspired by neural plasticity,is discussed.Result:The integration of Bio-AI models has demonstrated significant improvements in accuracy,adaptability,and scalability for cell labeling.Automated labeling systems minimize human error and enhance reproducibility.Recent advancements in multimodal AI systems have shown promise in combining imaging with genetic and molecular data,providing more comprehensive insights into cellular behavior.Dynamic labeling models inspired by neural plasticity offer enhanced tracking of cellular transitions over time.Conclusion:Bio-AI holds transformative potential in biomedical research via enabling real-time,dynamic labeling,essential for tracking cellular changes over time in processes like cancer progression,stem cell differentiation,and immune response.The continued evolution of these AI-driven approaches is expected to accelerate breakthroughs in understanding diseases,tissue engineering,and regenerative medicine. 展开更多
关键词 Bioinspired Artificial Intelligence biomedical research Cell Labeling Bio-AI Models
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Applications and advancements in animal models for antiviral research on mosquito-borne arboviruses
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作者 Megan Caifeng Tang Ka Heng Wong +1 位作者 Adzzie Shazleen Azman Rafidah Lani 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第5期673-684,共12页
Vector-borne diseases caused by arthropod-borne viruses(arboviruses) are a considerable challenge to public health globally. Mosquito-borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of ... Vector-borne diseases caused by arthropod-borne viruses(arboviruses) are a considerable challenge to public health globally. Mosquito-borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito-borne arboviruses, playing a role in understanding disease mechanisms,vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal-to-human translational success. Genetically engineered mouse models, hamster models and non-human primate(NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long-tailed macaques as potential NHP models for arbovirus research is possible;however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld. 展开更多
关键词 animal models ARBOVIRUS biomedical research ETHICS i nfectious diseases
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Auricular Acupuncture and Biomedical Research——A Promising Sino-Austrian Research Cooperation 被引量:6
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作者 荣培晶 赵敬军 +7 位作者 李宇清 Daniela Litscher 李少源 Ingrid Gaischek 翟煦 WANG Lu 罗曼 Gerhard Litscher 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第12期887-894,共8页
Treatment by auricular acupuncture has a long history. Ear-acupoint research has been advancing step by step in China and also in Europe. Auricles are rich in nerves, therefore a close relationship with different func... Treatment by auricular acupuncture has a long history. Ear-acupoint research has been advancing step by step in China and also in Europe. Auricles are rich in nerves, therefore a close relationship with different functions of the human body has been proved by the research teams of the two main authors of this article from China and Austria. In recent years, great progress has been made in the research of regulating human body functions through electroacupuncture at the auricular branch of the vagus nerve, which is part of auricular acupuncture therapy. It is well known that the auricular branch of the vagus nerve is the only peripheral pathway to the cerebral cortex. Studies of the Chinese team on hypertension, diabetes, epilepsy and depression have shown that the mechanism of auricular vagus nerve stimulation (VNS) may be comparable with cervical VNS in terms of pathways. Auricular VNS has a broad clinical application prospect. 展开更多
关键词 auricular acupuncture biomedical research vagus nerve
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The Content of Statistical Requirements for Authors in Biomedical Research Journals 被引量:5
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作者 Tian-Yi Liu Si-Yu Cai +3 位作者 Xiao-Lu Hie Ya-Qi Lyu Xiao-Xia Peng Guo-Shuang Feng 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第20期2491-2496,共6页
Background:Robust statistical designing,sound statistical analysis,and standardized presentation are important to enhance the quality and transparency of biomedical research.This systematic review was conducted to su... Background:Robust statistical designing,sound statistical analysis,and standardized presentation are important to enhance the quality and transparency of biomedical research.This systematic review was conducted to summarize the statistical reporting requirements introduced by biomedical research journals with an impact factor of 10 or above so that researchers are able to give statistical issues' serious considerations not only at the stage of data analysis but also at the stage of methodological design.Methods:Detailed statistical instructions for authors were downloaded from the homepage of each of the included journals or obtained from the editors directly via email.Then,we described the types and numbers of statistical guidelines introduced by different press groups.Items of statistical reporting guideline as well as particular requirements were summarized in frequency,which were grouped into design,method of analysis,and presentation,respectively.Finally,updated statistical guidelines and particular requirements for improvement were summed up.Results:Totally,21 of 23 press groups introduced at least one statistical guideline.More than half of press groups can update their statistical instruction for authors gradually relative to issues of new statistical reporting guidelines.In addition,16 press groups,covering 44 journals,address particular statistical requirements.The most of the particular requirements focused on the performance of statistical analysis and transparency in statistical reporting,including "address issues relevant to research design,including participant flow diagram,eligibility criteria,and sample size estimation," and "statistical methods and the reasons." Conclusions:Statistical requirements for authors are becoming increasingly perfected.Statistical requirements for authors remind researchers that they should make sufficient consideration not only in regards to statistical methods during the research design,but also standardized statistical reporting,which would be beneficial in providing stronger evidence and making a greater critical appraisal of evidence more accessible. 展开更多
关键词 biomedical research Journal Statistical Reporting Requirement Systematic Review
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Molecular epigenetics: dawn of a new era of biomedical research 被引量:5
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作者 XU Rui-Ming Institute of Biophysics, Chinese Academy of Sciences 15 Datun Road, Chaoyang District, Beijing 100101, China 《Science China(Life Sciences)》 SCIE CAS 2009年第4期309-310,共2页
At about the same time in 1940s when Erwin Schrdinger published his famous little book What Is Life, which sparked the birth of molecular biology, the term epigenetics was coined by the English biologist Conrad Wadd... At about the same time in 1940s when Erwin Schrdinger published his famous little book What Is Life, which sparked the birth of molecular biology, the term epigenetics was coined by the English biologist Conrad Waddington. The concept of epi-inheritance can be traced back to French naturalist Jean-Baptiste Lamarck’s idea of "inheritance 展开更多
关键词 Molecular epigenetics dawn of a new era of biomedical research CPG
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Funding of FY 2012 NSFC-NIH Joint Program on Biomedical Research
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《Science Foundation in China》 CAS 2012年第1期39-41,共3页
关键词 Funding of FY 2012 NSFC-NIH Joint Program on biomedical research NSFC NIH
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Data analysis guidelines for single‑cell RNA‑seq in biomedical studies and clinical applications
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作者 Min Su Tao Pan +14 位作者 Qiu‑Zhen Chen Wei‑Wei Zhou Yi Gong Gang Xu Huan‑Yu Yan Si Li Qiao‑Zhen Shi Ya Zhang Xiao He Chun‑Jie Jiang Shi‑Cai Fan Xia Li Murray J.Cairns Xi Wang Yong‑Sheng Li 《Military Medical Research》 SCIE CAS CSCD 2023年第4期529-553,共25页
The application of single-cell RNA sequencing(scRNA-seq)in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic strategie... The application of single-cell RNA sequencing(scRNA-seq)in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic strategies.With the expansion of capacity for high-throughput scRNA-seq,including clinical samples,the analysis of these huge volumes of data has become a daunting prospect for researchers entering this field.Here,we review the workflow for typical scRNA-seq data analysis,covering raw data processing and quality control,basic data analysis applicable for almost all scRNA-seq data sets,and advanced data analysis that should be tailored to specific scientific questions.While summarizing the current methods for each analysis step,we also provide an online repository of software and wrapped-up scripts to support the implementation.Recommendations and caveats are pointed out for some specific analysis tasks and approaches.We hope this resource will be helpful to researchers engaging with scRNA-seq,in particular for emerging clinical applications. 展开更多
关键词 Single-cell RNA-sequencing(scRNA-seq) Data analysis biomedical research Clinical applications
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Artificial Intelligence in Healthcare:Review and Prediction Case Studies 被引量:11
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作者 Guoguang Rong Arnaldo Mendez +2 位作者 Elie Bou Assi Bo Zhao Mohamad Sawan 《Engineering》 SCIE EI 2020年第3期291-301,共11页
Artificial intelligence(AI)has been developing rapidly in recent years in terms of software algorithms,hardware implementation,and applications in a vast number of areas.In this review,we summarize the latest developm... Artificial intelligence(AI)has been developing rapidly in recent years in terms of software algorithms,hardware implementation,and applications in a vast number of areas.In this review,we summarize the latest developments of applications of AI in biomedicine,including disease diagnostics,living assistance,biomedical information processing,and biomedical research.The aim of this review is to keep track of new scientific accomplishments,to understand the availability of technologies,to appreciate the tremendous potential of AI in biomedicine,and to provide researchers in related fields with inspiration.It can be asserted that,just like AI itself,the application of AI in biomedicine is still in its early stage.New progress and breakthroughs will continue to push the frontier and widen the scope of AI application,and fast developments are envisioned in the near future.Two case studies are provided to illustrate the prediction of epileptic seizure occurrences and the filling of a dysfunctional urinary bladder. 展开更多
关键词 Artificial intelligence Machine learning Deep learning Neural network biomedical research Healthcare applications Epileptic seizure Urinary bladder filling
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Statistical testing and distribution for lead chloride toxicity
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作者 John H.Lange 《Asian Journal of Andrology》 SCIE CAS CSCD 2005年第1期107-108, ,共2页
Dear Sir, Graca et al.[1]provided an interesting investigationon the toxicity of lead chloride and sperm developmentin mice.However, I would like to make a comment onthe statistical analysis presented.Table 1 and its ... Dear Sir, Graca et al.[1]provided an interesting investigationon the toxicity of lead chloride and sperm developmentin mice.However, I would like to make a comment onthe statistical analysis presented.Table 1 and its resultsSuggest that a comparison of treated(experlment) andcontrol mice were undertaken using the t-test.The au- 展开更多
关键词 ANIMALS biomedical research Comparative Study LEAD MALE Mice SPERMATOGENESIS
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Medline-based bibliometric analysis of gastroenterology journals between 2001 and 2007
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作者 Li-Fang Chou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第23期2933-2939,共7页
AIM: To analyze the MEDLINE-indexed publications in gastroenterology specialty journals from 2001 to 2007. Special attention was paid to specific types of articles, the number of publications for individual authors an... AIM: To analyze the MEDLINE-indexed publications in gastroenterology specialty journals from 2001 to 2007. Special attention was paid to specific types of articles, the number of publications for individual authors and the author count in each journal. METHODS: The bibliographic entries of papers belonging to journals listed under the subject heading of "gastroenterology" were downloaded from MEDLINE on the PubMed web site. The analysis was limited to journal articles published between January 1, 2001 and December 31, 2007. The analytical dimensions of an article included journal, publication year, publication type, and author name (the last name and initials). RESULTS: According to MEDLINE, 81 561 articles were published in 91 gastroenterology journals from 2001 to 2007. The number of articles increased from 9447 in 2001 to 13 340 in 2007. Only 12 journals had more than 2000 articles indexed in MEDLINE. The "World Journal of Gastroenterology" had the largest number of publications (5684 articles), followed by "Hepato-Gastroenterology" (3036) and "Gastrointestinal Endoscopy" (3005). Of all the articles published, reviews accounted for 17.2% and case reports for 15.4%. Only 3739 randomized controlled trials (4.6% of all articles) were published and their annual number increased from 442 in 2001 to 572 in 2007. Among 141 741 author names appearing in the articles of gastroenterology journals, 92 429 had published only in one journal, 22 585 in two journals, 9996 in three journals, and 16 731 in more than three journals. The "World Journal of Gastroenterology " had the greatest number of authors (17 838),followed by "Gastroenterology " (12 770), "Digestive Diseases and Sciences" (11 395), "American Journal of Gastroenterology" (10 889), and "Hepatology" (10 588). CONCLUSION: Global gastroenterology publications displayed a continuous growth in the new millennium. The change was most striking in certain journals. Regular bibliometric analyses on the trends and specific topics would help researchers publish more efficiently and allow editors to adjust the policy more accurately. 展开更多
关键词 Bibliographic databases BIBLIOMETRICS biomedical research GASTROENTEROLOGY MEDLINE
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Dissecting Cohen
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作者 Keith Burgess-Jackson 《Journal of Philosophy Study》 2021年第1期11-36,共26页
Readers of The New England Journal of Medicine may be excused for thinking that there is a good case for, and nogood case against, the use of animals in biomedical research. In October 1986, philosopher Carl Cohen, wh... Readers of The New England Journal of Medicine may be excused for thinking that there is a good case for, and nogood case against, the use of animals in biomedical research. In October 1986, philosopher Carl Cohen, who is knownfor his principled positions on affirmative action and other issues, published an article in that journal in which heclaimed that there are (only) two kinds of argument against the use of animals in biomedical research. After examiningboth arguments, Cohen concluded that they “deserve definitive dismissal.” In this article, I show that both of Cohen’sattempted refutations fail. Not only has he not laid a glove on the arguments in question;his discussion betrays afundamental misunderstanding of the arguments that he so cavalierly dismisses. Readers of Cohen’s article owe it tothemselves—and, more importantly, to the animals whose use as research subjects Cohen defends—to take anotherlook at the issue. 展开更多
关键词 Carl Cohen(1931-) animals animal rights animal liberation medicine science biology biomedical research EXPERIMENTATION vivisection SENTIENCE RIGHTS INTERESTS
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Acknowledgments
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《The Journal of Biomedical Research》 CAS CSCD 2018年第1期I0007-I0007,共1页
Epilepsy is the most common neurological disorder of the brain that affects people worldwide at any age from newborn to adult. It is characterized by recurrent seizures, which are brief episodes of signs or symptoms d... Epilepsy is the most common neurological disorder of the brain that affects people worldwide at any age from newborn to adult. It is characterized by recurrent seizures, which are brief episodes of signs or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. The electroencephalogram, or EEG, is a physiological method to measure and record the electrical 展开更多
关键词 EEG The Journal of biomedical research plans to publish a special issue on Advances in EEG Signal Processing and Machine Learning for Epileptic Seizure Detection and Prediction
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PETG:Applications in Modern Medicine
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作者 Catherine Yan Corinne Kleiner +4 位作者 Aaron Tabigue Veer Shah Gregory Sacks Darshi Shah Vincent DeStefano 《Engineered Regeneration》 EI 2024年第1期45-55,共11页
Polyethylene terephthalate glycol,PETG,is a miscible,transparent thermoplastic known to have strong tensile properties,high ductility,as well as resistance to heat and chemical insults.PETG may be manufactured in seve... Polyethylene terephthalate glycol,PETG,is a miscible,transparent thermoplastic known to have strong tensile properties,high ductility,as well as resistance to heat and chemical insults.PETG may be manufactured in several ways,most notably 3D printing modalities.As such,PETG has emerged as a viable biomaterial for a variety of medical applications such as tissue engineering,dentistry,optometry,vascular health,cardiology,orthopedics,neurology,gynecology,and surgery.PETG also serves a valuable role in biomedical research and engineering by offering improvements in cell studies,drug carriers,and anti-bacterial measures.Further medical research and innovation utilizing PETG will better characterize its value as an inexpensive and versatile biomaterial. 展开更多
关键词 Polyethylene terephthalate glycol Tissue Engineering 3D Printing Clinical Applications biomedical research
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Bridging the Gap:Integration of Artificial Intelligence with Organ-on-Chip(AI-OoC)
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作者 Mirza Abdul Aleem Baig 《IJLAI Transactions on Science and Engineering》 2024年第1期17-23,共7页
.Organ-on-Chip(OoC)has emerged as a revolutionary approach to emulate human organ function-ality in vitro,offering unparalleled insights into physiological processes and disease modeling.The integration of artificial i... .Organ-on-Chip(OoC)has emerged as a revolutionary approach to emulate human organ function-ality in vitro,offering unparalleled insights into physiological processes and disease modeling.The integration of artificial intelligence(AI)with OoC platforms presents a transformative synergy,combining the precision of microscale organ replication with the analytical prowess of intelligent algorithms,is emerging as a transforma-tive force in harnessing the full potential of OoC.This perspective investigates the multifaceted implications of integrating AI with OoC,examining its impact on biomedical research,acknowledging the synergistic po-tential that arises from combining the precision of microscale organ replication with the analytical capabilities of intelligent algorithms,and fostering a future where the intricate workings of the technology and biology. 展开更多
关键词 Organ-on-Chip(OoC) Artificial Intelligence(AI) biomedical research Technology&Biology.
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Mixed methods research in complementary and alternative medicine:a scoping review 被引量:1
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作者 DU Wanqing WANG Liuding +4 位作者 JIA Min LIANG Xiao LI Bo ZHANG Yunling LIAO Xing 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2022年第4期652-666,共15页
OBJECTIVE:To update the current characteristics about the scope and quality of mixed methods research(MMR)in complementary and alternative medicine(CAM)after nearly 10 years.METHODS:A 5-stage approach for conducting a... OBJECTIVE:To update the current characteristics about the scope and quality of mixed methods research(MMR)in complementary and alternative medicine(CAM)after nearly 10 years.METHODS:A 5-stage approach for conducting a scoping review was adopted.Articles published on the top 10 journals in CAM with the highest impact factor in 2020 were screened for MMR.Information of included articles were extracted,and then synthesized to illustrate the current state.Methodological quality was evaluated according to the Mixed Method Appraisal Tool(MMAT)2018 version.RESULTS:A total of 55(55/2991,2%)articles using mixed methods were retrieved,including 17 medical studies and 38 ethnobotanical studies.We performed an in-depth analysis on the 17 medical studies,which studied cancer,stress,pain,fatigue,exercises,mindfulness intervention,herbal medicine use,art and acupuncture.Thirteen pilot studies applied MMR to evaluate the feasibility of interventions or programs(13/17,76%);phenomenology was inferred as the most common philosophical assumptions(13/17,76%);the most applied type of MMR was convergent design(16/17,94%);integration often took place at integration(12/17,71%).Among the 16 eligible studies for quality appraisal,majority were rated as good(14/16,88%),whereas two studies were rated as poorly described.Primarily,a poor rating was due to incomplete reporting of data analysis and citations in qualitative components;lack of confounder controlling and the sampling strategy in quantitative components;poor description of integration and justification for mixed methods.Comparing with the previous review,fewer MMR were published in 2020 in CAM,but the proportion of studies that clearly reported MMR has increased by 4 times(4%→15%).CONCLUSION:CAM researchers need to realize the benefits that MMR can have on conducting further health care research.Our findings highlight that applying MMR will be helpful to understand the complex dynamics and interdisciplinary nature of complex intervention.In addition,addressing a standardized reporting criteria for MMR is recommended. 展开更多
关键词 complementary therapies REVIEW biomedical research pilot projects mixed methods
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The clinical characteristics and therapy of syndrome of craniocerebral- cervical vertebral injury 被引量:3
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作者 刘胜 刘远新 王诚 《Chinese Journal of Traumatology》 CAS 2005年第3期183-185,共3页
Objective: To explore the clinical characteristics and new treatment for syndrome of craniocerebral-cervical vertebral injury. Methods: The clinical data of 52 patients with head injury accompanied by neck injury were... Objective: To explore the clinical characteristics and new treatment for syndrome of craniocerebral-cervical vertebral injury. Methods: The clinical data of 52 patients with head injury accompanied by neck injury were analyzed retrospectively. Results: Craniocerebral injury could result in damage to cervical vertebrae, muscles, vessels and nerves, and even cause vertebral artery injury, which may lead to insufficient blood-supply of vertebral-basal artery. All patients were treated with cervical vertebral traction and the results were good. Conclusions: Acute craniocerebral injury with symptom of insufficient blood-supply of vertebral-basal artery, evident neurosis and atlas-axis half-dislocation in X-ray should be treated by cervical vertebral traction, which will yield better outcome. 展开更多
关键词 Trauma nervous system Cervical vertebrae biomedical research
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Kidney organoids as a promising tool in nephrology 被引量:1
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作者 Mengyuan Wu Tingting Hu +5 位作者 Ping Zhu Moussa Ide Nasser Jie Shen Fang Sun Qingnan He Mingyi Zhao 《Genes & Diseases》 SCIE 2022年第3期585-597,共13页
Kidney disease has become a global public health problem affecting over 750 million people worldwide and imposing a heavy economic burden on patients.The complex architecture of the human kidney makes it very difficul... Kidney disease has become a global public health problem affecting over 750 million people worldwide and imposing a heavy economic burden on patients.The complex architecture of the human kidney makes it very difficult to study the pathophysiology of renal diseases in vitro and to develop effective therapeutic options for patients.Even though cell lines and animal models have enriched our understanding,they fail to recapitulate key aspects of human kidney development and renal disease at cellular and functional levels.Organoids can be derived from either pluripotent stem cells or adult stem cells by strictly regulating key signalling pathways.Today,these self-differentiated organoids represent a promising technology to further understand the human kidney,one of the most complex organs,in an unprecedented way.The newly established protocols improved by organ-on-chip and coculture with immune cells will push kidney organoids towards the next generation.Herein,we focus on recent achievements in the application of kidney organoids in disease modelling,nephrotoxic testing,precision medicine,biobanking,and regenerative therapy,followed by discussions of novel strategies to improve their utility for biomedical research.The applications we discuss may help to provide new ideas in clinical fields. 展开更多
关键词 biomedical research Disease modelling Kidney organoids Precision medicine Stem cells
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