目的:比较罗哌卡因与布比卡因腰硬联合麻醉在剖宫产产妇中的应用效果。方法:选取2020年1月至2022年12月该院收治的80例剖宫产产妇进行前瞻性研究,按照随机数字表法将其分为观察组与对照组各40例。对照组行布比卡因腰硬联合麻醉,观察组...目的:比较罗哌卡因与布比卡因腰硬联合麻醉在剖宫产产妇中的应用效果。方法:选取2020年1月至2022年12月该院收治的80例剖宫产产妇进行前瞻性研究,按照随机数字表法将其分为观察组与对照组各40例。对照组行布比卡因腰硬联合麻醉,观察组行罗哌卡因腰硬联合麻醉,比较两组感觉阻滞起效时间、运动阻滞起效时间、新生儿出生1 min Apgar评分、平均动脉压、心率和不良反应发生率。结果:观察组产妇感觉阻滞、运动阻滞起效时间均长于对照组,差异有统计学意义(P<0.05);切皮即刻、胎儿娩出时,观察组平均动脉压、心率高于对照组,差异均有统计学意义(P<0.05);观察组不良反应发生率为7.50%,明显低于对照组的25.00%,差异有统计学意义(P<0.05);两组新生儿出生1 min Apgar评分比较,差异无统计学意义(P>0.05)。结论:罗哌卡因腰硬联合麻醉用于剖宫产产妇中可提高产妇术中平均动脉压、心率,降低不良反应发生率,效果优于布比卡因腰硬联合麻醉,但会延长感觉阻滞、运动阻滞起效时间。展开更多
目的分析不同剂量右美托咪定(Dex)复合腰硬联合麻醉对产科手术中麻醉效果、血压及视觉模拟评分法(VAS)评分的影响。方法200例产妇作为观察对象,根据Dex剂量不同分为对照组(C组)、低剂量组(D1组)、中剂量组(D2组)、中-高剂量组(D3组)和...目的分析不同剂量右美托咪定(Dex)复合腰硬联合麻醉对产科手术中麻醉效果、血压及视觉模拟评分法(VAS)评分的影响。方法200例产妇作为观察对象,根据Dex剂量不同分为对照组(C组)、低剂量组(D1组)、中剂量组(D2组)、中-高剂量组(D3组)和高剂量组(D4组),每组40例。对比五组不同时段Ramsay评分、视觉模拟评分法(VAS)评分、血压水平、不良反应发生率、新生儿1 min及5 min Apgar评分。结果入室麻醉后平卧位即刻(T0),五组产妇Ramsay、VAS评分对比差异无统计学意义(P>0.05);胎儿娩出时(T1),D2组、D3组及D4组产妇Ramsay评分分别为(4.92±0.11)、(4.95±0.13)、(4.88±0.11)分,明显高于C组的(2.84±0.24)分与D1组的(3.12±0.14)分,VAS评分分别为(2.06±0.22)、(2.03±0.19)、(2.02±0.19)分,明显低于C组的(4.13±0.24)分与D1组的(3.13±0.27)分,且D1组产妇Ramsay评分明显高于C组,VAS评分明显低于C组(P<0.05);术后12 h(T2),D2组、D3组及D4组产妇VAS评分分别为(2.46±0.37)、(2.49±0.36)、(2.42±0.34)分,明显低于C组的(5.13±0.24)分与D1组的(4.05±0.71)分,且D1组产妇VAS评分明显低于C组(P<0.05);D2组、D3组及D4组产妇T1时的Ramsay、VAS评分及T2时的VAS评分对比差异无统计学意义(P>0.05)。五组新生儿1 min及5 min Apgar评分对比差异无统计学意义(P>0.05)。T0时,五组产妇收缩压及舒张压水平对比差异无统计学意义(P>0.05);T1、T2时,D2组、D3组及D4组产妇收缩压及舒张压水平明显低于C组与D1组,且D1组产妇收缩压及舒张压水平明显低于C组(P<0.05);D2组、D3组及D4组产妇T1、T2时的收缩压及舒张压水平对比差异无统计学意义(P>0.05)。D2组产妇不良反应发生率2.5%(1/40)低于C组的15.0%(6/40)、D1组的15.0%(6/40)、D3组的15.0%(6/40)、D4组的17.5%(7/40)(P<0.05)。结论0.5μg/kg Dex有助于稳定血压水平,提高麻醉效果,减轻术中疼痛,降低麻醉后不良反应发生率,且不会对新生儿出生造成不利影响,可作为最佳调控剂量。展开更多
Background: Anesthetic agents are commonly utilized in the handling of non‐human primates for prevent the stress caused in physical exploration or physical restrain. For this reason, the objective of this work was to...Background: Anesthetic agents are commonly utilized in the handling of non‐human primates for prevent the stress caused in physical exploration or physical restrain. For this reason, the objective of this work was to describe the effect of age and dissociative anesthetics (ketamine and tiletamine), and their combinations with acepromazine, xylazine and zolazepam, on the physiological and blood biochemical parameters in Macaca mulatta. Methods: Eighty male Macaca mulatta were divided into four experimental groups depending on the anesthetic mixture applied. Each group of 20 males was divided into five sub‐groups according to age. Physiological parameters were recorded every five minutes during a 30‐minute period. A blood sample was drawn to analyze blood biochemistry. Results: Statistical analyses revealed significant differences in the physiological parameters between the ketamine‐acepromazine and ketamine‐xylazine groups compared to the control group. The analysis of blood biochemistry found significant differences by age and by anesthetic mixture among all groups. Conclusion: These findings contribute to standardizing this animal model in biological research.展开更多
文摘目的:比较罗哌卡因与布比卡因腰硬联合麻醉在剖宫产产妇中的应用效果。方法:选取2020年1月至2022年12月该院收治的80例剖宫产产妇进行前瞻性研究,按照随机数字表法将其分为观察组与对照组各40例。对照组行布比卡因腰硬联合麻醉,观察组行罗哌卡因腰硬联合麻醉,比较两组感觉阻滞起效时间、运动阻滞起效时间、新生儿出生1 min Apgar评分、平均动脉压、心率和不良反应发生率。结果:观察组产妇感觉阻滞、运动阻滞起效时间均长于对照组,差异有统计学意义(P<0.05);切皮即刻、胎儿娩出时,观察组平均动脉压、心率高于对照组,差异均有统计学意义(P<0.05);观察组不良反应发生率为7.50%,明显低于对照组的25.00%,差异有统计学意义(P<0.05);两组新生儿出生1 min Apgar评分比较,差异无统计学意义(P>0.05)。结论:罗哌卡因腰硬联合麻醉用于剖宫产产妇中可提高产妇术中平均动脉压、心率,降低不良反应发生率,效果优于布比卡因腰硬联合麻醉,但会延长感觉阻滞、运动阻滞起效时间。
文摘目的分析不同剂量右美托咪定(Dex)复合腰硬联合麻醉对产科手术中麻醉效果、血压及视觉模拟评分法(VAS)评分的影响。方法200例产妇作为观察对象,根据Dex剂量不同分为对照组(C组)、低剂量组(D1组)、中剂量组(D2组)、中-高剂量组(D3组)和高剂量组(D4组),每组40例。对比五组不同时段Ramsay评分、视觉模拟评分法(VAS)评分、血压水平、不良反应发生率、新生儿1 min及5 min Apgar评分。结果入室麻醉后平卧位即刻(T0),五组产妇Ramsay、VAS评分对比差异无统计学意义(P>0.05);胎儿娩出时(T1),D2组、D3组及D4组产妇Ramsay评分分别为(4.92±0.11)、(4.95±0.13)、(4.88±0.11)分,明显高于C组的(2.84±0.24)分与D1组的(3.12±0.14)分,VAS评分分别为(2.06±0.22)、(2.03±0.19)、(2.02±0.19)分,明显低于C组的(4.13±0.24)分与D1组的(3.13±0.27)分,且D1组产妇Ramsay评分明显高于C组,VAS评分明显低于C组(P<0.05);术后12 h(T2),D2组、D3组及D4组产妇VAS评分分别为(2.46±0.37)、(2.49±0.36)、(2.42±0.34)分,明显低于C组的(5.13±0.24)分与D1组的(4.05±0.71)分,且D1组产妇VAS评分明显低于C组(P<0.05);D2组、D3组及D4组产妇T1时的Ramsay、VAS评分及T2时的VAS评分对比差异无统计学意义(P>0.05)。五组新生儿1 min及5 min Apgar评分对比差异无统计学意义(P>0.05)。T0时,五组产妇收缩压及舒张压水平对比差异无统计学意义(P>0.05);T1、T2时,D2组、D3组及D4组产妇收缩压及舒张压水平明显低于C组与D1组,且D1组产妇收缩压及舒张压水平明显低于C组(P<0.05);D2组、D3组及D4组产妇T1、T2时的收缩压及舒张压水平对比差异无统计学意义(P>0.05)。D2组产妇不良反应发生率2.5%(1/40)低于C组的15.0%(6/40)、D1组的15.0%(6/40)、D3组的15.0%(6/40)、D4组的17.5%(7/40)(P<0.05)。结论0.5μg/kg Dex有助于稳定血压水平,提高麻醉效果,减轻术中疼痛,降低麻醉后不良反应发生率,且不会对新生儿出生造成不利影响,可作为最佳调控剂量。
文摘Background: Anesthetic agents are commonly utilized in the handling of non‐human primates for prevent the stress caused in physical exploration or physical restrain. For this reason, the objective of this work was to describe the effect of age and dissociative anesthetics (ketamine and tiletamine), and their combinations with acepromazine, xylazine and zolazepam, on the physiological and blood biochemical parameters in Macaca mulatta. Methods: Eighty male Macaca mulatta were divided into four experimental groups depending on the anesthetic mixture applied. Each group of 20 males was divided into five sub‐groups according to age. Physiological parameters were recorded every five minutes during a 30‐minute period. A blood sample was drawn to analyze blood biochemistry. Results: Statistical analyses revealed significant differences in the physiological parameters between the ketamine‐acepromazine and ketamine‐xylazine groups compared to the control group. The analysis of blood biochemistry found significant differences by age and by anesthetic mixture among all groups. Conclusion: These findings contribute to standardizing this animal model in biological research.
