[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fa...[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.展开更多
Objectives:According to the findings of randomized controlled trials,blood lipid levels in patients with coronary heart disease(CHD)can be significantly decreased through a combination of pitavastatin and ezetimibe;ho...Objectives:According to the findings of randomized controlled trials,blood lipid levels in patients with coronary heart disease(CHD)can be significantly decreased through a combination of pitavastatin and ezetimibe;however,the effects and clinical applications of this treatment remain controversial.This meta-analysis was aimed at objectively assessing the efficacy and safety of pitavastatin and ezetimibe in lowering blood lipid levels.Design:Relevant studies were retrieved from electronic databases,including PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure,VIP,and WanFang Data,from database inception to June 8,2022.The lev-els of low-density lipoprotein cholesterol,total cholesterol,triglycerides,and high-density lipoprotein cholesterol in patients’serum after treatment were the primary endpoint.Results:Nine randomized controlled trials(2586 patients)met the inclusion criteria.The meta-analysis indi-cated that pitavastatin plus ezetimibe resulted in significantly lower levels of LDL-C[standardized mean difference(SMD)=−0.86,95%confidence interval(CI)(−1.15 to−0.58),P<0.01],TC[SMD=−0.84,95%CI(−1.10 to−0.59),P<0.01],and TG[SMD=−0.59,95%CI(−0.89 to−0.28),P<0.01]than pitavastatin alone.Conclusions:Pitavastatin plus ezetimibe significantly decreased serum LDL-C,TC,and TG levels in patients with CHD.展开更多
Objective:To observe the effects of moxibustion at different temperatures(38℃,46℃)on blood lipids,endothelial morphology of the thoracic aorta,serum endothelin-1(ET-1),calcitonin gene-related peptide(CGRP),nitric ox...Objective:To observe the effects of moxibustion at different temperatures(38℃,46℃)on blood lipids,endothelial morphology of the thoracic aorta,serum endothelin-1(ET-1),calcitonin gene-related peptide(CGRP),nitric oxide(NO),and endothelial NO synthase(eNOS)in hyperlipidemic rats.Methods:Using the random number table method,60 Sprague Dawley rats were randomly and evenly divided into blank,model,38℃-moxibustion,and 46℃-moxibustion groups.Rats in the 3 experimental groups were fed a high-fat feed to model hyperlipidemia in rats.Rats in the 38℃-moxibustion and 46℃-moxibustion groups were moxibustion on the Shenque and bilateral Zusanli acupoints for 10 minutes each,once every other day for 4 weeks,at temperatures of 38±1℃ and 46±1℃.After that,rat blood samples were collected to detect blood lipids and ET-1,CGRP,eNOS and NO.Take the endotheal tissue of the thoracic aorta to do HE staining.Results:(1)The serum total cholesterol,triglycerides,and low-density lipoprotein cholesterol of rats in the 46℃-moxibustion group were significantly lower than those in the model and 38℃-moxibustion groups.(2)Revealed by hematoxylin and eosin staining,showed necrosis in the local vascular endothelial cells and mild inflammatory cell infiltration in the tunica adventitia of the hyperlipidemic rats.These endothelial morphologies did not improve significantly after moxibustion at 38℃ but did improve at 46℃.(3)Compared with the blank group,serum ET-1 was significantly higher and serum CGRP,NO,eNOS were significantly lower in the model group.Compared with the model and the 38℃-moxibustion groups,serum ET-1 was significantly lower and serum CGRP,NO,eNOS were significantly higher in 46℃-moxibustion groups.Conclusion:Moxibustion at 46℃ effectively regulated blood lipids,improved the morphology of the vascular endothelium,and protected vascular endothelial function.展开更多
AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrho...AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrhosis were enrolled into the study. The values of triglyceride (TG), cholesterol (TC), high density lipoproteins (HDL) and low density lipoprotein (LDL) of each patient on the fi rst day of admission were retrieved from the medical records, and MELD was calculated. All the patients were followed up for 1 year. The relationship between the change of blood lipid level and the value of MELD score was studied by analysis of variance. The prognostic factors were screened by multivariate Cox proportional hazard model. Draw Kaplan-Meier survival curves were drawn. RESULTS: Forty-f ive patients died within 3 mo and 83 patients died within 1 year. The levels of TG, TC, HDL and LDL of the death group were all lower than those of the survivors. The serum TG, TC, HDL and LDL levels were lowered with the increase of the MELD score. Multivariate Cox proportional hazard model showed that MELD ≥18 and TC ≤2.8 mmol/L were independent risk factors for prognosis of decompensated cirrhosis. Survival analysis showed that MELD ≥18 combined with TC ≤ 2.8 mmol/L can clearly discriminate between the patients who would survive and die in 1 year. CONCLUSION: MELD ≥18 and TC ≤2.8 mmol/L are two important indexes to predict the prognosis of patients with decompensated cirrhosis. Their combination can effectively predict the long-term prognosis of patients with decompensated cirrhosis.展开更多
Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats...Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats were fed a normal diet,and bilateral acu-point Fenglong(equivalent to ST40 in humans)on the hind legs were covered with a placebo(general mucilage)for 2 hours each day.Model group rats were fed a high-lipid diet for 2 weeks.Therapy group rats were fed a high-lipid diet for 2 weeks and then administered crude-herb moxibustion at ST40 for 2 hours each day for the next 2 weeks.Prevention group rats were administered crude-herb moxibustion 2 hours a day for 2 weeks and then fed a high-lipid diet for the subsequent 2 weeks.Prevention/Therapy group rats were each administered crude-herb moxibustion at ST40 for 2 hours each day for 2 weeks,followed by a high-lipid diet for the next 2 weeks,and then crude-herb moxibustion again at ST40 for another 2 weeks.Simvastatin group rats were fed a high-lipid diet for 2 weeks and then treated with simvastatin for the next 2 weeks.Blood lipids,hepatosomatic indices(HSIs)and epididymal fat pad weights of all rats were examined.Results:Compared with the Model group,levels of total cholesterol(TC),glycerinate,lowdensity lipoprotein cholesterol(LDL-C)and very low-density lipoprotein cholesterol(VLDL-C)in plasma collected from the Therapy group,the Prevention/Therapy group,and the Simvastatin group were decreased.Moreover,compared with the Model group,HSIs in Therapy group rats were also decreased following administration of crude-herb moxibustion,but TC,TG,HDLC,LDL-C,and VLDL-C levels in the Prevention group were higher than those in the Model group.Conclusion:The results reveal that blood lipids and HSIs appear to be modulated by the effect of crude-herb moxibustion and suggest therapeutic strategies for the treatment of dyslipidemia.展开更多
Objective:The study aims to explore the interventional effect of Abrus cantonensis and Armeniaca mume Sieb and their compatibility on blood glucose and blood lipid in diabetic mice and to explore the optimal ratio of ...Objective:The study aims to explore the interventional effect of Abrus cantonensis and Armeniaca mume Sieb and their compatibility on blood glucose and blood lipid in diabetic mice and to explore the optimal ratio of efficacy of their compatibility.Methods:SPF Kunming male mice were fed with high sugar and high fat diet for 6 weeks and then intraperitoneally injected with STZ solution to establish a diabetes model.The successfully modeled mice were randomly divided into 6 groups according to their body weight:model group,Abrus Cantoniensis group,Armeniaca mume Sieb group,as well as Abrus Cantoniensis and Armeniaca mume Sieb group divided into 1:2,1:1 and 2:1 groups according to volume ratio with 10 mice in each group.Another 10 healthy mice were taken as blank group and intraperitoneally injected with sodium citrate buffer.The corresponding solution was given intragastric administration by body mass once a day for 20 days.After the last administration,fasting was performed for 12 hours.Serum was collected by the method of eyeball blood collection to determine the contents of fasting blood glucose,total cholesterol Triacylglycerol,triglyceride,low density lipoprotein and high-density lipoprotein.Results:Compared with Abrus Cantoniensis and Armeniaca mume Sieb groups,Glu,TG,TC and LDL-C of the three compatibility groups significantly decreased,with the most significant decrease in the compatibility group 1:2,while there was no significant difference in HDL-C among all groups.Conclusion:Abrus Cantoniensis and Armeniaca mume Sieb and their combination have synergistic effects on the improvement of blood glucose and lipid levels in mice with high glucose and high fat combined with STZ-induced diabetes mellitus model.Among all the experimental groups,the compatibility 1:2 group had the best effect.展开更多
Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular risk.Methods Eighty three subjects with high risk factors of cardiovascular diseases were...Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular risk.Methods Eighty three subjects with high risk factors of cardiovascular diseases were enrolled into the study and randomized to two groups,i.e.,the ZBT group(n =44,treated with ZBT 0.48 g twice per day) and the atorvastatin(ATO) group(n =39,treated with ATO 10 mg per day).The levels of fasting serum lipids including total cholesterol(TC),triglyceride(TG),high and low density lipoprotein cholesterol(HDL-C and LDL-C) and pulse wave velocity(PWV) were investigated before and eight weeks after treatment.Results The serum levels of TG,TC,LDL-C,femoral-ankle PWV(FAPWV) and carotid-radial PWV(CRPWV) were markedly decreased after the therapy with ZBT or ATO for 8 weeks(P <0.05).There was no significant alteration in HDL-C and carotid-femoral PWV(CFPWV) levels in both ZBT and ATO groups(P >0.05) after eight-week's treatment.Conclusion ZBT could reduce the levels of FAPWV and CRPWV,thus improve the elasticity of medium-sized peripheral muscular arteries in addition to its lipids lowering effect.The efficacy of ZBT is similar to that of ATO.展开更多
Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can sup...Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can suppress the development of atherosclerosis.The aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential mechanisms.Methods:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or rosuvastatin.After feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were measured.Serum metabolic profiles were detected by an automatic biochemical analyser.Serum inflammatory cytokines were quantified by enzyme-linked immunosorbent assay kits.Atherosclerotic plaque areas were analysed using Oil Red O staining.Results:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model group.YDHP inhibited the area of atherosclerotic lesions.In addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and tumor necrosis factorα(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group).Conclusion:Our study demonstrated that YDHP showed considerable activity in alleviating the formation of atherosclerotic plaques in ApoE^(-/-)mice by reducing blood lipids and exerting anti-inflammatory activity.展开更多
Objective:To explore the possible mechanism of Soufeng Qutan traditional Chinese medicine in the treatment of atherosclerosis.Methods:Mice of six weeks old which were knocked out gene ApoE and fed with a high-fat diet...Objective:To explore the possible mechanism of Soufeng Qutan traditional Chinese medicine in the treatment of atherosclerosis.Methods:Mice of six weeks old which were knocked out gene ApoE and fed with a high-fat diet for 13 weeks to establish a model of atherosclerotic unstable plaque,and they were randomly divided into the model group,the atorvastatin group and the low,medium,and high-dose Shoufeng Qutan groups.In addition,six weeks old C57BL/6J mice were set as the blank con?trol group. Both the blank control group and the model group were given 0.9% normal saline by gavage. The low,medium,and high-dose groups of Soufeng Qutangroup and the atorvastatin group were given different doses of Soufeng Qutan Chinese Medicine Decoction and atorvastatin. After 13 weeks,the mice were sacrificed,and the abdominal aortic blood vessels were observed by HE staining. Total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C). and high-density lipopro?tein cholesterol(HDL-C)content were detected by a biochemical automatic analyzer and IL-1β levels were detected by ELISA.Results:Compared with the blank control group,a large number of foam cells could be seen in the model group with obvious plaques;serum TC,TG,LDL-C,and IL-1β levels were significantly increased(P<0.05),and HDL-C level was markedly de?creased (P<0.05). Compared with the model group,the Soufeng Qutangroup at all doses and the atorvastatin group had a small amount of foam cells and reduced plaque area;serum TC,TG,LDL-C,and IL-1β levels were significantly decreased (P<0.05),and the level of HDL-C was significantly increased (P<0.05).Conclusion:Soufeng Qutan Chinesemedicine can inhibit the pro?gression of cellular inflammation,downregulate the expression of IL-1β,reduce plaques,and improve blood lipids. This may be one of the molecular mechanisms of Soufeng Qutan Chinese medicine in the early treatment of atherosclerosis.展开更多
Objectives To investigate prevalence of blood lipid level among 1401 residents aged≥60 years in rong-gui community.Methods 1401 ones(579 males,822 females, (68.12±6.64)years Of total 1503 residents aged≥60 year...Objectives To investigate prevalence of blood lipid level among 1401 residents aged≥60 years in rong-gui community.Methods 1401 ones(579 males,822 females, (68.12±6.64)years Of total 1503 residents aged≥60 years in the 2 villages which were randomly exampled in rong-gui community were investigated.867 ones aged among 60-69 years(61.9%),430 ones aged among 70-79 years (30.7%),104 ones aged≥60 years(7.4%).Investigative items included age,sex,total cholesterol(TC),triglyceride (TG),body height,body weight,waist circumference(WC), hip circumference(HC),fasting plasma glucose(FG),blood pressure,history of past illness,body mass index(BMI), waist hip ratio(WHR),waist height ratio(WHtR).Results (l)Of total 1401 residents,Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male(P【0.01), The difference among three age groups were not significant, the combined prevalence of hyperlipemia and borderline hyperlipemia was 80.1%.(2)The FG、BMI、SBP、DBP、WC、WHR、WHtR of residents with hyperlipemia were higher than ones with normal blood lipid level(P【0.01).(3)By Pearson correlation analysis,we found that hyperlipemia was obviously correlated with FG,BMI,WC,WHR,WHtR, SBP,DBP.Conclusions(1)Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male.(2) hyperlipemia were obviously correlated with higher FG、BMI、WC、WHR、WHtR、SBP、DBP.展开更多
<b><span style="font-family:Verdana;">Objective</span></b><span style="font-family:Verdana;">:</span><span><span style="font-family:Verdana;"&...<b><span style="font-family:Verdana;">Objective</span></b><span style="font-family:Verdana;">:</span><span><span style="font-family:Verdana;"> To explore the effects of Danqi Yishen Capsule (Danqi Capsule for Tonifying Kidney) on blood lipid levels and hemorheological indicators of hyperlipidemia patients. </span><span><span style="font-family:Verdana;"><b></b></span><b><b><span style="font-family:Verdana;">Methods</span></b></b></span></span><b><span style="font-family:Verdana;">:</span></b><b><span> </span></b><span style="font-family:Verdana;">A total of 96 patients </span><span style="font-family:Verdana;">with</span><span style="font-family:Verdana;"> hyperlipidemia were randomly divided into </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group and observation group of 48 cases respectively. The control group was given by simvastatin in oral administration of 10 mg half an hour after dinner, once a day, while the observation group based on the treatment of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group, was orally given Danshen Yishen Capsule of three capsules each time, three times a day. The treatment of both groups lasted for two months. Then the comparison focused on blood lipid levels, hemorheological indicators</span><span style="font-family:Verdana;">,</span><span><span style="font-family:Verdana;"> and adverse reactions between both groups before and after the treatment. </span><span><span style="font-family:Verdana;"><b></b></span><b><b><span style="font-family:Verdana;">Results</span></b></b></span></span><b><span style="font-family:Verdana;">:</span></b><span> </span><span style="font-family:Verdana;">There was no significant difference</span><span><span style="font-family:Verdana;"> in blood lipid levels and hemorheological indicators between both groups before the treatment (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i></span><i><span> </span></i><span><span style="font-family:Verdana;">> 0.05). The symptoms of both groups were significantly improved after the treatment, and the difference before and after the treatment was statistically significant (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i></span><span> </span><span><span style="font-family:Verdana;">< 0.05), and the difference between both groups was also statistically significant (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i></span><span style="font-family:Verdana;"> < 0.05). There was no significant difference in the incidence rate of adverse reactions between both groups (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i><span> </span><span><span style="font-family:Verdana;">> 0.05). </span><span><span style="font-family:Verdana;"><b></b></span><b><b><span style="font-family:Verdana;">Conclusion</span></b></b></span></span><b><span style="font-family:Verdana;">:</span></b><b><span> </span></b><span style="font-family:Verdana;">Danqi Yishen Capsule has a significant value in clinical applications, which can optimize clinical efficacy, improve blood lipid levels and hemorheological indicators of hyperlipidemia patients, as well as reduce the probability of adverse reactions in patients.</span>展开更多
Objective:To explore the effects of compound danshen dripping pills on the levels of serum inflammatory factors,brain natriuretic peptide(BNP)and blood lipid in CABG postoperative patients.Methods:156 cases of patient...Objective:To explore the effects of compound danshen dripping pills on the levels of serum inflammatory factors,brain natriuretic peptide(BNP)and blood lipid in CABG postoperative patients.Methods:156 cases of patients who were given CABG from January 2015 to January 2018 in Baogang Hospital were chosen and randomly divided into the observation group(n=78)and the control group(n=78).Both groups were given conventional drugs,simultaneously,the observation group was given compound danshen dripping pills.The treatment lasted 3 months.The clinical efficacy was compared between two groups of patients,and the levels of serum inflammatory factors,plasma BNP and blood lipid before and after treatment in two groups of patients were detected in order to make a comparison in the incidence of adverse cardiac events between two groups of patients.Results:After treatment,the total effective rate of treatment in the observation group was significantly higher than that in the control group;in the two groups,the levels of serum interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein and plasma BNP after treatment were obviously lower than those before treatment,and these indicators in the observation group were lower than those in the control group(p<.05);the levels of TG,TC and LDL-C in two groups were obviously lower(p<.05)with the level of HDL-C significantly higher(all p<.05),and the descending or ascending range of each indicator in the observation group was obviously larger than that in the control group(p<.05);in the follow-up visit,the incidence of adverse cardiac events in the observation group of patients was significantly lower than that in the control group of patients(p<.05).Conclusions:Compound danshen dripping pills can effectively reduce the levels of serum inflammatory factors and BNP,regulate blood lipid metabolism and reduce the incidence of adverse cardiac events in CABG postoperative patients.展开更多
Associations between "lipid-related" candidate genes,blood lipid concentrations and coronary artery disease(CHD) risk are not clear.We aimed to investigate the effect of three newly identified lipids loci fr...Associations between "lipid-related" candidate genes,blood lipid concentrations and coronary artery disease(CHD) risk are not clear.We aimed to investigate the effect of three newly identified lipids loci from genome-wide association studies on CHD and blood lipid levels in Chinese Han population.The genotypes of SNPs at three newly identified lipid loci and blood lipids concentrations were examined in 1360 CHD patients and 1360 age-and sex-frequency matched controls from an unrelated Chinese Han population.Allele T of rs16996148 occurred less frequently in CHD patients with the odds ratio(OR) being 0.64(95% CI 0.50 to 0.81),after adjusting for conventional risk factors and was associated with a 33% decreased CHD risk(P<0.01) comparing with the major allele G.Individuals with GT genotype had the lowest CHD risk.No associations were found between the polymorphisms of other two loci with CHD risk and all three SNPs had no effect on lipid profile in this population.SNP rs16996148 on chromosome 19p13 is significantly associated with lower risk for CHD in Chinese Han population.However,it remains unresolved why these lipid-related loci had significantly less effects than the correspondingly expected effects on blood lipids levels in this population.展开更多
BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarct...BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine.OBJECTIVE:To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction,and compare the results with those of simple cinepazide maleate treatment.DESIGN:A non-randomized case-controlled observation.SETTINGS:Hebei North University;the Second Affiliated Hospitals of Hebei North University;the Third Affiliated Hospitals of Hebei North University.PARTICIPANTS:Eighty-six inpatients with cerebral infarction were selected from the infirmary,the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006.They were all diagnosed to have acute cerebral infarction by CT or MRI,and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995.Meanwhile,40 teachers and medical staff of voluntary physical examinees were selected as the control group.Informed contents were obtained from all the patients and their relatives.METHODS:The patients were divided into combined treatment group(n=43)and simple treatment group(n=43).In the combined treatment group,the patients were administrated with 160 mg cinepazide maleate injection(Beijing Four-ring Pharmaceutical,Co.,Ltd,No.H200220125;80 mg/2 mL)added in 5% glucose,and 40 mg tanshinone Ⅱ sodium sulfonate(Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd.,No.H31022558,10 mg/2 mL)added in 250 mL normal saline.In the simple treatment group,the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or 250 mL normal saline.They were treated for 1 or 2 courses,once a day,and 14 days as a course.The patients were detected before treatment and at 14 and 28 days after treatment respectively.① Determination of hemorrheologic indexes:Whole blood viscosity was determined with LBY-N6B automatic hemorrheologic meter;Plasma viscosity with LBY-F200B automatic plasma viscosity meter;Volume of fibrinogen was determined by the method of 12.5% sodium nitrate depositing biuret reaction.② Determination of blood lipids:The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were determined.③ Severity of neurological deficit:The total score of neurological deficit score(NDS)ranged from 0 to 45 points,0-15 points was taken as mild,16-30 points as moderate and 31-45 points as severe.④ Evaluation of curative effects:Generally cured:NDS decreased by 91%-100%,and disabled severity of grade 0;Significantly improved:NDS decreased by 46%-90%,and disabled severity of grades 1-3;Improved:NDS decreased by 18%-45%;No change:NDS decreased by less than 18%;Aggravated:NDS increased by more than 18%.Generally cured and significant improved were taken as significant effect.⑤ The adverse events and side effects after medication were observed.MAIN OUTCOME MEASURES:① Results of hemorrheologic indexes and blood lipids;② NDS results in the combined treatment group and simple treatment group;③ Therapeutic effects and adverse events.RESULTS:All the 86 patients with cerebral infarction and 40 healthy controls were involved in the analysis of results.① Results of hemorrheologic indexes and blood lipids:The hemorrheologic indexes and blood lipids before treatment were manifested as abnormalities to different extents in both the combined treatment group and simple treatment group;The hemorrheologic indexes after treatment were obviously improved in both groups.But the hemorrheologic indexes were improved more obviously in the combined treatment group as compared with those in the simple treatment group(P < 0.05);The levels of TC,TG and LDL-Cafter treatment in the combined treatment group were obviously lowered(P < 0.05),whereas those in the simple treatment group were not significantly changed(P > 0.05).② NDS results:The NDS scores at 14 and 28 days after treatment in the combined treatment group(6.23±2.34),(4.27±1.83)points were obviously lower than those in the simple treatment group(8.76±3.41),(6.65±2.49)points,P < 0.05.③ Therapeutic effects and side effects:The total significant effective rates in the combined treatment group and simple treatment group were 93% and 81% respectively.In the combined treatment group,1 case suffered from palpitation,dizziness and agrypnia.In the simple treatment group,1 case suffered from palpitation,dizziness and agrypnia,1 case had itch of skin.All the above symptoms disappeared gradually after the transfusing speed was adjusted to be slower.No drug withdrawal occurred in the patients due to the adverse events.CONCLUSION:Cinepazide maleate combined with tanshinon can obviously improve the abnormalities of hemorrheologic indexes and blood lipids and nerve function in patients with acute cerebral infarction,and its curative effect is faster than that of simple cinepazide maleate treatment.展开更多
Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases,the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated...Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases,the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated.SpragueDawley rats were fed a diet containing the oils or trans-fat,and then body weights,blood lipids,and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion(MCAO) were analyzed.All the oils and trans-fat,except perilla oil,significantly increased body fats and body weight gain.Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides,respectively,while perilla oil decreased both cholesterols and triglycerides.Perilla oil not only attenuated cerebral infarction,but also restored locomotor activity and rota-rod performances of MCAO rats.It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke.展开更多
Objective To investigate the relationships between erythrocyte membrane n‐6:n‐3 PUFAs ratio and blood lipids and high sensitivity C‐reactive protein (hs‐CRP).Methods The observational study consisted of a populat...Objective To investigate the relationships between erythrocyte membrane n‐6:n‐3 PUFAs ratio and blood lipids and high sensitivity C‐reactive protein (hs‐CRP).Methods The observational study consisted of a population‐based cross‐sectional study of 456 Chinese and a subsequent 1‐year follow‐up study of 171 subjects with the fasting plasma total cholesterol of 5.13‐8.00 mmol/L.Results In the cross‐sectional analysis,plasma low‐density lipoprotein cholesterol (LDL‐c) had a significant and negative association with the erythrocyte membrane n‐6:n‐3 PUFAs ratio (P for trend=0.019) after adjusting for sex,age and total PUFA percentage.In the follow‐up study,171 subjects were categorized into quartiles by the changes of n‐6:n‐3 ratio in erythrocyte membrane (△=month 12‐month 0).In the top quartile whose ratios of n‐6:n‐3 increased by an average of 1.25 during the follow‐up,the LDL‐c‐lowering extent was 3.3 times of that in the lowest quartile whose ratios of n‐6:n‐3 decreased by an average of 1.13 (‐1.07 mmol/L v.s.‐0.32 mmol/L).The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile (P for difference=0.052).Conclusion Our results suggested that the balance between n‐6 and n‐3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.展开更多
Objectives To observe the relationship between Thyroid Hormone (TH) level and blood lipid level in the healthy elderly with therapy of small dose of TH. Methods A total of 120 healthy old persons were randomly divided...Objectives To observe the relationship between Thyroid Hormone (TH) level and blood lipid level in the healthy elderly with therapy of small dose of TH. Methods A total of 120 healthy old persons were randomly divided into two groups: 60 old persons as treatment group and other 60 persons as control group. Each person in the treatment group took a thyroid tablet 10 mg daily continuously for six months while the control group took VitB1 30 mg daily instead of thyroid tablet. The level of TH, M -TSH, FT3, FT4, TT4, rT3, TC, TG, LDL - C, HDL-C, ApoA1 were measured in two groups before and after receiving TH or Vit. B1 treatment. Results In the treatment group the level of TH increased obviously. And TC, TG, LDL - C levels decreased also to some extent while HDL - C, ApoAl levels increased slightly which was significant when compared with the control group and pre - treatment group. Conclusions To use small dose of TH as supplement treatment can increase the TH level of healthy old persons and decrease展开更多
In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis ...In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis (AS) in the rabbit. An experimental model of atherosclerosis was established in cholesterol-fed rabbits. In the 2nd, 4th, 8th and 12th week, the parametersmentioned above were determined and the pathological changes of the aorta examined. It was found that serum triglyceride (TG)was increased in the 4th week and total serum cholesterol (TCh) was significantly higher in the 4th, 8th and 12th week than thatin the control. Erythrocytic Na+ -K+ -ATPase activity decreased progressively and it was negatively correlated to TCh in the 4thand 12th week (r = - 0.67 and - 0.51, P < 0.01 and 0.05). G’ was significantly increased in the 4th week only when theshear rate was 0. 190 Hz whereas G and η’ increased progressively from the 8th to 12th week. It is believed that the determinationof blood lipids, Na+ -K+ -ATPase activity and viscoelastic parameters of the whole blood is useful for the prediction of the propession of the pathological changes in different stages of AS.展开更多
OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network Meta-analysis.METH...OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network Meta-analysis.METHODS:Randomized controlled trials(RCTs)on clinical efficacy of CHD angina pectoris with interaction of phlegm and blood stasis were searched in PubMed,Springer,the Cochrane Library and Chinese-language databases China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data from their inception to December 2021.Literature was screened and literature bias risk was assessed by RevMan5.4 software.The overall response rate,the duration of angina attack,the levels of serum lipids such as total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C),and expression of hypersensitive C-reactive protein(hs-CRP)were selected as outcome indicators for network Meta-analysis and mapped using Stata15.1 software.RESULTS:Totally,26 RCTs were included,involving 2098 participants.There were 6 TCM formulas with the effects of dispelling phlegm and removing blood stasis.Taking conventional Western Medicine as the common intervention measures,the results showed that the overall response improvement rate from high to low was displayed as modified Xiaoxianxiong decoction(小陷胸汤,MXD),Danlou tablet(丹蒌片,DT),modified Gualou Xiebai Banxia decoction(瓜蒌薤白半夏汤,MGXBD),modified Wendan decoction(温胆汤,MWD),modified Zhishi Xiebai Guizhi decoction(枳实薤白桂枝汤,MZXGD),and modified Erchen decoction(二陈汤,MED).The sequence of angina attack duration improvement from high to low was MZXGD,MGXBD,DT,MWD,MXD.The sequence of TC improvement from high to low was MZXGD,MED,DT,and MGXBD.Sequence of improving TG from high to low was MED,MZXGD,MGXBD,and DT.For LDL-C improvement,the effect from good to poor was MZXGD,MGXBD,DT,and MED.With regard to HDL-C improvement,the effect was ranked as MED,MZXGD,MGXBD,and DT from good to poor.hs-CRP expression from high to low was MZXGD,MXD,MED,MWD,and MGXBD.CONCLUSION:TCM formula with the effects of dispelling phlegm and removing blood stasis combined with conventional Western Medicine has obvious advantages in treating CHD angina pectoris with interaction of phlegm and blood stasis.MZXGD has great potential in increasing the overall response rate,reducing Duration of angina attack improving blood lipids,and reducing inflammatory factors.However,due to the limitations of extant studies,the conclusions of this study need to be confirmed by numerous reasonably-designed RCTs.展开更多
基金Supported by the National Innovation Planning Project for University Students in 2022 in Guangxi(S202210599012).
文摘[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.
文摘Objectives:According to the findings of randomized controlled trials,blood lipid levels in patients with coronary heart disease(CHD)can be significantly decreased through a combination of pitavastatin and ezetimibe;however,the effects and clinical applications of this treatment remain controversial.This meta-analysis was aimed at objectively assessing the efficacy and safety of pitavastatin and ezetimibe in lowering blood lipid levels.Design:Relevant studies were retrieved from electronic databases,including PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure,VIP,and WanFang Data,from database inception to June 8,2022.The lev-els of low-density lipoprotein cholesterol,total cholesterol,triglycerides,and high-density lipoprotein cholesterol in patients’serum after treatment were the primary endpoint.Results:Nine randomized controlled trials(2586 patients)met the inclusion criteria.The meta-analysis indi-cated that pitavastatin plus ezetimibe resulted in significantly lower levels of LDL-C[standardized mean difference(SMD)=−0.86,95%confidence interval(CI)(−1.15 to−0.58),P<0.01],TC[SMD=−0.84,95%CI(−1.10 to−0.59),P<0.01],and TG[SMD=−0.59,95%CI(−0.89 to−0.28),P<0.01]than pitavastatin alone.Conclusions:Pitavastatin plus ezetimibe significantly decreased serum LDL-C,TC,and TG levels in patients with CHD.
基金This work was supported by National Natural Science Foundation of China(NO.81603695).
文摘Objective:To observe the effects of moxibustion at different temperatures(38℃,46℃)on blood lipids,endothelial morphology of the thoracic aorta,serum endothelin-1(ET-1),calcitonin gene-related peptide(CGRP),nitric oxide(NO),and endothelial NO synthase(eNOS)in hyperlipidemic rats.Methods:Using the random number table method,60 Sprague Dawley rats were randomly and evenly divided into blank,model,38℃-moxibustion,and 46℃-moxibustion groups.Rats in the 3 experimental groups were fed a high-fat feed to model hyperlipidemia in rats.Rats in the 38℃-moxibustion and 46℃-moxibustion groups were moxibustion on the Shenque and bilateral Zusanli acupoints for 10 minutes each,once every other day for 4 weeks,at temperatures of 38±1℃ and 46±1℃.After that,rat blood samples were collected to detect blood lipids and ET-1,CGRP,eNOS and NO.Take the endotheal tissue of the thoracic aorta to do HE staining.Results:(1)The serum total cholesterol,triglycerides,and low-density lipoprotein cholesterol of rats in the 46℃-moxibustion group were significantly lower than those in the model and 38℃-moxibustion groups.(2)Revealed by hematoxylin and eosin staining,showed necrosis in the local vascular endothelial cells and mild inflammatory cell infiltration in the tunica adventitia of the hyperlipidemic rats.These endothelial morphologies did not improve significantly after moxibustion at 38℃ but did improve at 46℃.(3)Compared with the blank group,serum ET-1 was significantly higher and serum CGRP,NO,eNOS were significantly lower in the model group.Compared with the model and the 38℃-moxibustion groups,serum ET-1 was significantly lower and serum CGRP,NO,eNOS were significantly higher in 46℃-moxibustion groups.Conclusion:Moxibustion at 46℃ effectively regulated blood lipids,improved the morphology of the vascular endothelium,and protected vascular endothelial function.
文摘AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrhosis were enrolled into the study. The values of triglyceride (TG), cholesterol (TC), high density lipoproteins (HDL) and low density lipoprotein (LDL) of each patient on the fi rst day of admission were retrieved from the medical records, and MELD was calculated. All the patients were followed up for 1 year. The relationship between the change of blood lipid level and the value of MELD score was studied by analysis of variance. The prognostic factors were screened by multivariate Cox proportional hazard model. Draw Kaplan-Meier survival curves were drawn. RESULTS: Forty-f ive patients died within 3 mo and 83 patients died within 1 year. The levels of TG, TC, HDL and LDL of the death group were all lower than those of the survivors. The serum TG, TC, HDL and LDL levels were lowered with the increase of the MELD score. Multivariate Cox proportional hazard model showed that MELD ≥18 and TC ≤2.8 mmol/L were independent risk factors for prognosis of decompensated cirrhosis. Survival analysis showed that MELD ≥18 combined with TC ≤ 2.8 mmol/L can clearly discriminate between the patients who would survive and die in 1 year. CONCLUSION: MELD ≥18 and TC ≤2.8 mmol/L are two important indexes to predict the prognosis of patients with decompensated cirrhosis. Their combination can effectively predict the long-term prognosis of patients with decompensated cirrhosis.
基金the Ministry of Education of the People’s Republic of China(NO:201210026044)supervised by Beijing University of Chinese Medicine.
文摘Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats were fed a normal diet,and bilateral acu-point Fenglong(equivalent to ST40 in humans)on the hind legs were covered with a placebo(general mucilage)for 2 hours each day.Model group rats were fed a high-lipid diet for 2 weeks.Therapy group rats were fed a high-lipid diet for 2 weeks and then administered crude-herb moxibustion at ST40 for 2 hours each day for the next 2 weeks.Prevention group rats were administered crude-herb moxibustion 2 hours a day for 2 weeks and then fed a high-lipid diet for the subsequent 2 weeks.Prevention/Therapy group rats were each administered crude-herb moxibustion at ST40 for 2 hours each day for 2 weeks,followed by a high-lipid diet for the next 2 weeks,and then crude-herb moxibustion again at ST40 for another 2 weeks.Simvastatin group rats were fed a high-lipid diet for 2 weeks and then treated with simvastatin for the next 2 weeks.Blood lipids,hepatosomatic indices(HSIs)and epididymal fat pad weights of all rats were examined.Results:Compared with the Model group,levels of total cholesterol(TC),glycerinate,lowdensity lipoprotein cholesterol(LDL-C)and very low-density lipoprotein cholesterol(VLDL-C)in plasma collected from the Therapy group,the Prevention/Therapy group,and the Simvastatin group were decreased.Moreover,compared with the Model group,HSIs in Therapy group rats were also decreased following administration of crude-herb moxibustion,but TC,TG,HDLC,LDL-C,and VLDL-C levels in the Prevention group were higher than those in the Model group.Conclusion:The results reveal that blood lipids and HSIs appear to be modulated by the effect of crude-herb moxibustion and suggest therapeutic strategies for the treatment of dyslipidemia.
基金This work was supported by National Natural Science Foundation of China(No.81360684)Guangxi Key Research and Development Plan Project(Gui Ke AB18221095)+3 种基金Teaching Teacher Training Project from Youjiang Medical University for Nationalities-National Teaching Teacher Training Project(You Hospital Zi[2018]No.98)High-level Talent Research Projects from Youjiang Medical University For Nationalities(No.01002018079)China National and Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599022)China Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599073).
文摘Objective:The study aims to explore the interventional effect of Abrus cantonensis and Armeniaca mume Sieb and their compatibility on blood glucose and blood lipid in diabetic mice and to explore the optimal ratio of efficacy of their compatibility.Methods:SPF Kunming male mice were fed with high sugar and high fat diet for 6 weeks and then intraperitoneally injected with STZ solution to establish a diabetes model.The successfully modeled mice were randomly divided into 6 groups according to their body weight:model group,Abrus Cantoniensis group,Armeniaca mume Sieb group,as well as Abrus Cantoniensis and Armeniaca mume Sieb group divided into 1:2,1:1 and 2:1 groups according to volume ratio with 10 mice in each group.Another 10 healthy mice were taken as blank group and intraperitoneally injected with sodium citrate buffer.The corresponding solution was given intragastric administration by body mass once a day for 20 days.After the last administration,fasting was performed for 12 hours.Serum was collected by the method of eyeball blood collection to determine the contents of fasting blood glucose,total cholesterol Triacylglycerol,triglyceride,low density lipoprotein and high-density lipoprotein.Results:Compared with Abrus Cantoniensis and Armeniaca mume Sieb groups,Glu,TG,TC and LDL-C of the three compatibility groups significantly decreased,with the most significant decrease in the compatibility group 1:2,while there was no significant difference in HDL-C among all groups.Conclusion:Abrus Cantoniensis and Armeniaca mume Sieb and their combination have synergistic effects on the improvement of blood glucose and lipid levels in mice with high glucose and high fat combined with STZ-induced diabetes mellitus model.Among all the experimental groups,the compatibility 1:2 group had the best effect.
文摘Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular risk.Methods Eighty three subjects with high risk factors of cardiovascular diseases were enrolled into the study and randomized to two groups,i.e.,the ZBT group(n =44,treated with ZBT 0.48 g twice per day) and the atorvastatin(ATO) group(n =39,treated with ATO 10 mg per day).The levels of fasting serum lipids including total cholesterol(TC),triglyceride(TG),high and low density lipoprotein cholesterol(HDL-C and LDL-C) and pulse wave velocity(PWV) were investigated before and eight weeks after treatment.Results The serum levels of TG,TC,LDL-C,femoral-ankle PWV(FAPWV) and carotid-radial PWV(CRPWV) were markedly decreased after the therapy with ZBT or ATO for 8 weeks(P <0.05).There was no significant alteration in HDL-C and carotid-femoral PWV(CFPWV) levels in both ZBT and ATO groups(P >0.05) after eight-week's treatment.Conclusion ZBT could reduce the levels of FAPWV and CRPWV,thus improve the elasticity of medium-sized peripheral muscular arteries in addition to its lipids lowering effect.The efficacy of ZBT is similar to that of ATO.
基金the Wuhan Municipal Health Commission Foundation(No.wx21Q38).
文摘Background:Yangxin Dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and neurasthenia.However,it is unclear whether YDHP can suppress the development of atherosclerosis.The aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential mechanisms.Methods:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or rosuvastatin.After feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were measured.Serum metabolic profiles were detected by an automatic biochemical analyser.Serum inflammatory cytokines were quantified by enzyme-linked immunosorbent assay kits.Atherosclerotic plaque areas were analysed using Oil Red O staining.Results:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model group.YDHP inhibited the area of atherosclerotic lesions.In addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and tumor necrosis factorα(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group).Conclusion:Our study demonstrated that YDHP showed considerable activity in alleviating the formation of atherosclerotic plaques in ApoE^(-/-)mice by reducing blood lipids and exerting anti-inflammatory activity.
基金Distinguished Professor Project of Liaoning Province([2018]No.35)。
文摘Objective:To explore the possible mechanism of Soufeng Qutan traditional Chinese medicine in the treatment of atherosclerosis.Methods:Mice of six weeks old which were knocked out gene ApoE and fed with a high-fat diet for 13 weeks to establish a model of atherosclerotic unstable plaque,and they were randomly divided into the model group,the atorvastatin group and the low,medium,and high-dose Shoufeng Qutan groups.In addition,six weeks old C57BL/6J mice were set as the blank con?trol group. Both the blank control group and the model group were given 0.9% normal saline by gavage. The low,medium,and high-dose groups of Soufeng Qutangroup and the atorvastatin group were given different doses of Soufeng Qutan Chinese Medicine Decoction and atorvastatin. After 13 weeks,the mice were sacrificed,and the abdominal aortic blood vessels were observed by HE staining. Total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C). and high-density lipopro?tein cholesterol(HDL-C)content were detected by a biochemical automatic analyzer and IL-1β levels were detected by ELISA.Results:Compared with the blank control group,a large number of foam cells could be seen in the model group with obvious plaques;serum TC,TG,LDL-C,and IL-1β levels were significantly increased(P<0.05),and HDL-C level was markedly de?creased (P<0.05). Compared with the model group,the Soufeng Qutangroup at all doses and the atorvastatin group had a small amount of foam cells and reduced plaque area;serum TC,TG,LDL-C,and IL-1β levels were significantly decreased (P<0.05),and the level of HDL-C was significantly increased (P<0.05).Conclusion:Soufeng Qutan Chinesemedicine can inhibit the pro?gression of cellular inflammation,downregulate the expression of IL-1β,reduce plaques,and improve blood lipids. This may be one of the molecular mechanisms of Soufeng Qutan Chinese medicine in the early treatment of atherosclerosis.
文摘Objectives To investigate prevalence of blood lipid level among 1401 residents aged≥60 years in rong-gui community.Methods 1401 ones(579 males,822 females, (68.12±6.64)years Of total 1503 residents aged≥60 years in the 2 villages which were randomly exampled in rong-gui community were investigated.867 ones aged among 60-69 years(61.9%),430 ones aged among 70-79 years (30.7%),104 ones aged≥60 years(7.4%).Investigative items included age,sex,total cholesterol(TC),triglyceride (TG),body height,body weight,waist circumference(WC), hip circumference(HC),fasting plasma glucose(FG),blood pressure,history of past illness,body mass index(BMI), waist hip ratio(WHR),waist height ratio(WHtR).Results (l)Of total 1401 residents,Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male(P【0.01), The difference among three age groups were not significant, the combined prevalence of hyperlipemia and borderline hyperlipemia was 80.1%.(2)The FG、BMI、SBP、DBP、WC、WHR、WHtR of residents with hyperlipemia were higher than ones with normal blood lipid level(P【0.01).(3)By Pearson correlation analysis,we found that hyperlipemia was obviously correlated with FG,BMI,WC,WHR,WHtR, SBP,DBP.Conclusions(1)Prevalence of hyperlipemia were 42.8%,female were signifleanfly higher than male.(2) hyperlipemia were obviously correlated with higher FG、BMI、WC、WHR、WHtR、SBP、DBP.
文摘<b><span style="font-family:Verdana;">Objective</span></b><span style="font-family:Verdana;">:</span><span><span style="font-family:Verdana;"> To explore the effects of Danqi Yishen Capsule (Danqi Capsule for Tonifying Kidney) on blood lipid levels and hemorheological indicators of hyperlipidemia patients. </span><span><span style="font-family:Verdana;"><b></b></span><b><b><span style="font-family:Verdana;">Methods</span></b></b></span></span><b><span style="font-family:Verdana;">:</span></b><b><span> </span></b><span style="font-family:Verdana;">A total of 96 patients </span><span style="font-family:Verdana;">with</span><span style="font-family:Verdana;"> hyperlipidemia were randomly divided into </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group and observation group of 48 cases respectively. The control group was given by simvastatin in oral administration of 10 mg half an hour after dinner, once a day, while the observation group based on the treatment of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group, was orally given Danshen Yishen Capsule of three capsules each time, three times a day. The treatment of both groups lasted for two months. Then the comparison focused on blood lipid levels, hemorheological indicators</span><span style="font-family:Verdana;">,</span><span><span style="font-family:Verdana;"> and adverse reactions between both groups before and after the treatment. </span><span><span style="font-family:Verdana;"><b></b></span><b><b><span style="font-family:Verdana;">Results</span></b></b></span></span><b><span style="font-family:Verdana;">:</span></b><span> </span><span style="font-family:Verdana;">There was no significant difference</span><span><span style="font-family:Verdana;"> in blood lipid levels and hemorheological indicators between both groups before the treatment (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i></span><i><span> </span></i><span><span style="font-family:Verdana;">> 0.05). The symptoms of both groups were significantly improved after the treatment, and the difference before and after the treatment was statistically significant (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i></span><span> </span><span><span style="font-family:Verdana;">< 0.05), and the difference between both groups was also statistically significant (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i></span><span style="font-family:Verdana;"> < 0.05). There was no significant difference in the incidence rate of adverse reactions between both groups (<i></i></span><i><i><span style="font-family:Verdana;">P</span></i><span style="font-family:Verdana;"></span></i><span> </span><span><span style="font-family:Verdana;">> 0.05). </span><span><span style="font-family:Verdana;"><b></b></span><b><b><span style="font-family:Verdana;">Conclusion</span></b></b></span></span><b><span style="font-family:Verdana;">:</span></b><b><span> </span></b><span style="font-family:Verdana;">Danqi Yishen Capsule has a significant value in clinical applications, which can optimize clinical efficacy, improve blood lipid levels and hemorheological indicators of hyperlipidemia patients, as well as reduce the probability of adverse reactions in patients.</span>
文摘Objective:To explore the effects of compound danshen dripping pills on the levels of serum inflammatory factors,brain natriuretic peptide(BNP)and blood lipid in CABG postoperative patients.Methods:156 cases of patients who were given CABG from January 2015 to January 2018 in Baogang Hospital were chosen and randomly divided into the observation group(n=78)and the control group(n=78).Both groups were given conventional drugs,simultaneously,the observation group was given compound danshen dripping pills.The treatment lasted 3 months.The clinical efficacy was compared between two groups of patients,and the levels of serum inflammatory factors,plasma BNP and blood lipid before and after treatment in two groups of patients were detected in order to make a comparison in the incidence of adverse cardiac events between two groups of patients.Results:After treatment,the total effective rate of treatment in the observation group was significantly higher than that in the control group;in the two groups,the levels of serum interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein and plasma BNP after treatment were obviously lower than those before treatment,and these indicators in the observation group were lower than those in the control group(p<.05);the levels of TG,TC and LDL-C in two groups were obviously lower(p<.05)with the level of HDL-C significantly higher(all p<.05),and the descending or ascending range of each indicator in the observation group was obviously larger than that in the control group(p<.05);in the follow-up visit,the incidence of adverse cardiac events in the observation group of patients was significantly lower than that in the control group of patients(p<.05).Conclusions:Compound danshen dripping pills can effectively reduce the levels of serum inflammatory factors and BNP,regulate blood lipid metabolism and reduce the incidence of adverse cardiac events in CABG postoperative patients.
基金supported by grants from the National Natural Sciences Foundation of China (No. 30525031 and No.30430590)
文摘Associations between "lipid-related" candidate genes,blood lipid concentrations and coronary artery disease(CHD) risk are not clear.We aimed to investigate the effect of three newly identified lipids loci from genome-wide association studies on CHD and blood lipid levels in Chinese Han population.The genotypes of SNPs at three newly identified lipid loci and blood lipids concentrations were examined in 1360 CHD patients and 1360 age-and sex-frequency matched controls from an unrelated Chinese Han population.Allele T of rs16996148 occurred less frequently in CHD patients with the odds ratio(OR) being 0.64(95% CI 0.50 to 0.81),after adjusting for conventional risk factors and was associated with a 33% decreased CHD risk(P<0.01) comparing with the major allele G.Individuals with GT genotype had the lowest CHD risk.No associations were found between the polymorphisms of other two loci with CHD risk and all three SNPs had no effect on lipid profile in this population.SNP rs16996148 on chromosome 19p13 is significantly associated with lower risk for CHD in Chinese Han population.However,it remains unresolved why these lipid-related loci had significantly less effects than the correspondingly expected effects on blood lipids levels in this population.
基金a grant from Zhangjiakou Bureau of Technology,No. 060132
文摘BACKGROUND:The severity of cerebral infarction is associated with the increase of blood viscosity caused by hyperfibrinogenemia and hyperlipidemia,etc.Thus it has become one of the target for treating cerebral infarction to decrease blood viscosity by integrated Chinese and western medicine.OBJECTIVE:To investigate the influence and clinical therapeutic effects of cinepazide maleate combined with tanshinone Ⅱ A sodium sulfonate on the hemorrheologic indexes and blood lipids of patients with acute cerebral infarction,and compare the results with those of simple cinepazide maleate treatment.DESIGN:A non-randomized case-controlled observation.SETTINGS:Hebei North University;the Second Affiliated Hospitals of Hebei North University;the Third Affiliated Hospitals of Hebei North University.PARTICIPANTS:Eighty-six inpatients with cerebral infarction were selected from the infirmary,the Second and Third Affiliated Hospitals of Hebei North University from September 2004 to October 2006.They were all diagnosed to have acute cerebral infarction by CT or MRI,and accorded with the diagnostic standards for acute cerebral infarction set by the Fourth National Academic Meeting for Cerebrovascular Disease in 1995.Meanwhile,40 teachers and medical staff of voluntary physical examinees were selected as the control group.Informed contents were obtained from all the patients and their relatives.METHODS:The patients were divided into combined treatment group(n=43)and simple treatment group(n=43).In the combined treatment group,the patients were administrated with 160 mg cinepazide maleate injection(Beijing Four-ring Pharmaceutical,Co.,Ltd,No.H200220125;80 mg/2 mL)added in 5% glucose,and 40 mg tanshinone Ⅱ sodium sulfonate(Shanghai No.1 Biochemical & Pharmaceutical Co.,Ltd.,No.H31022558,10 mg/2 mL)added in 250 mL normal saline.In the simple treatment group,the patients were only administrated with cinepazide maleate 320 mg added in 5% glucose or 250 mL normal saline.They were treated for 1 or 2 courses,once a day,and 14 days as a course.The patients were detected before treatment and at 14 and 28 days after treatment respectively.① Determination of hemorrheologic indexes:Whole blood viscosity was determined with LBY-N6B automatic hemorrheologic meter;Plasma viscosity with LBY-F200B automatic plasma viscosity meter;Volume of fibrinogen was determined by the method of 12.5% sodium nitrate depositing biuret reaction.② Determination of blood lipids:The serum levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were determined.③ Severity of neurological deficit:The total score of neurological deficit score(NDS)ranged from 0 to 45 points,0-15 points was taken as mild,16-30 points as moderate and 31-45 points as severe.④ Evaluation of curative effects:Generally cured:NDS decreased by 91%-100%,and disabled severity of grade 0;Significantly improved:NDS decreased by 46%-90%,and disabled severity of grades 1-3;Improved:NDS decreased by 18%-45%;No change:NDS decreased by less than 18%;Aggravated:NDS increased by more than 18%.Generally cured and significant improved were taken as significant effect.⑤ The adverse events and side effects after medication were observed.MAIN OUTCOME MEASURES:① Results of hemorrheologic indexes and blood lipids;② NDS results in the combined treatment group and simple treatment group;③ Therapeutic effects and adverse events.RESULTS:All the 86 patients with cerebral infarction and 40 healthy controls were involved in the analysis of results.① Results of hemorrheologic indexes and blood lipids:The hemorrheologic indexes and blood lipids before treatment were manifested as abnormalities to different extents in both the combined treatment group and simple treatment group;The hemorrheologic indexes after treatment were obviously improved in both groups.But the hemorrheologic indexes were improved more obviously in the combined treatment group as compared with those in the simple treatment group(P < 0.05);The levels of TC,TG and LDL-Cafter treatment in the combined treatment group were obviously lowered(P < 0.05),whereas those in the simple treatment group were not significantly changed(P > 0.05).② NDS results:The NDS scores at 14 and 28 days after treatment in the combined treatment group(6.23±2.34),(4.27±1.83)points were obviously lower than those in the simple treatment group(8.76±3.41),(6.65±2.49)points,P < 0.05.③ Therapeutic effects and side effects:The total significant effective rates in the combined treatment group and simple treatment group were 93% and 81% respectively.In the combined treatment group,1 case suffered from palpitation,dizziness and agrypnia.In the simple treatment group,1 case suffered from palpitation,dizziness and agrypnia,1 case had itch of skin.All the above symptoms disappeared gradually after the transfusing speed was adjusted to be slower.No drug withdrawal occurred in the patients due to the adverse events.CONCLUSION:Cinepazide maleate combined with tanshinon can obviously improve the abnormalities of hemorrheologic indexes and blood lipids and nerve function in patients with acute cerebral infarction,and its curative effect is faster than that of simple cinepazide maleate treatment.
基金supported by the "Food Functionality Evaluation Program" under the Ministry of Agriculture, Food and Rural Affairspartly Korea Food Research Institute(G2015)
文摘Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases,the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated.SpragueDawley rats were fed a diet containing the oils or trans-fat,and then body weights,blood lipids,and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion(MCAO) were analyzed.All the oils and trans-fat,except perilla oil,significantly increased body fats and body weight gain.Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides,respectively,while perilla oil decreased both cholesterols and triglycerides.Perilla oil not only attenuated cerebral infarction,but also restored locomotor activity and rota-rod performances of MCAO rats.It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke.
基金supported by research grants from the National Natural Science Foundation of China (30872102)the Diet Nutrition Research & Communication Grant of Danone Institute China (DIC2008‐12)
文摘Objective To investigate the relationships between erythrocyte membrane n‐6:n‐3 PUFAs ratio and blood lipids and high sensitivity C‐reactive protein (hs‐CRP).Methods The observational study consisted of a population‐based cross‐sectional study of 456 Chinese and a subsequent 1‐year follow‐up study of 171 subjects with the fasting plasma total cholesterol of 5.13‐8.00 mmol/L.Results In the cross‐sectional analysis,plasma low‐density lipoprotein cholesterol (LDL‐c) had a significant and negative association with the erythrocyte membrane n‐6:n‐3 PUFAs ratio (P for trend=0.019) after adjusting for sex,age and total PUFA percentage.In the follow‐up study,171 subjects were categorized into quartiles by the changes of n‐6:n‐3 ratio in erythrocyte membrane (△=month 12‐month 0).In the top quartile whose ratios of n‐6:n‐3 increased by an average of 1.25 during the follow‐up,the LDL‐c‐lowering extent was 3.3 times of that in the lowest quartile whose ratios of n‐6:n‐3 decreased by an average of 1.13 (‐1.07 mmol/L v.s.‐0.32 mmol/L).The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile (P for difference=0.052).Conclusion Our results suggested that the balance between n‐6 and n‐3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.
文摘Objectives To observe the relationship between Thyroid Hormone (TH) level and blood lipid level in the healthy elderly with therapy of small dose of TH. Methods A total of 120 healthy old persons were randomly divided into two groups: 60 old persons as treatment group and other 60 persons as control group. Each person in the treatment group took a thyroid tablet 10 mg daily continuously for six months while the control group took VitB1 30 mg daily instead of thyroid tablet. The level of TH, M -TSH, FT3, FT4, TT4, rT3, TC, TG, LDL - C, HDL-C, ApoA1 were measured in two groups before and after receiving TH or Vit. B1 treatment. Results In the treatment group the level of TH increased obviously. And TC, TG, LDL - C levels decreased also to some extent while HDL - C, ApoAl levels increased slightly which was significant when compared with the control group and pre - treatment group. Conclusions To use small dose of TH as supplement treatment can increase the TH level of healthy old persons and decrease
文摘In this work the changes of blood lipids, erythrocytic Na+ -K+ -ATPase activity, and dynamic viscosity(η’) and dynamic modulus(G’) of whole blood were determined in different satges of experimental atherosclerosis (AS) in the rabbit. An experimental model of atherosclerosis was established in cholesterol-fed rabbits. In the 2nd, 4th, 8th and 12th week, the parametersmentioned above were determined and the pathological changes of the aorta examined. It was found that serum triglyceride (TG)was increased in the 4th week and total serum cholesterol (TCh) was significantly higher in the 4th, 8th and 12th week than thatin the control. Erythrocytic Na+ -K+ -ATPase activity decreased progressively and it was negatively correlated to TCh in the 4thand 12th week (r = - 0.67 and - 0.51, P < 0.01 and 0.05). G’ was significantly increased in the 4th week only when theshear rate was 0. 190 Hz whereas G and η’ increased progressively from the 8th to 12th week. It is believed that the determinationof blood lipids, Na+ -K+ -ATPase activity and viscoelastic parameters of the whole blood is useful for the prediction of the propession of the pathological changes in different stages of AS.
基金the Fundamental Research Funds for the Central Public Welfare Research Institutes:Theoretical Study of Combination of Facial Color and Pulses Mode in Traditional Chinese Medicine(No.KJ-202013)Objective Study of“Wei Qi”in Pulse Based on Color Doppler Flow Imaging(CDFI)Technology(No.YZ-202124)。
文摘OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network Meta-analysis.METHODS:Randomized controlled trials(RCTs)on clinical efficacy of CHD angina pectoris with interaction of phlegm and blood stasis were searched in PubMed,Springer,the Cochrane Library and Chinese-language databases China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data from their inception to December 2021.Literature was screened and literature bias risk was assessed by RevMan5.4 software.The overall response rate,the duration of angina attack,the levels of serum lipids such as total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C),and expression of hypersensitive C-reactive protein(hs-CRP)were selected as outcome indicators for network Meta-analysis and mapped using Stata15.1 software.RESULTS:Totally,26 RCTs were included,involving 2098 participants.There were 6 TCM formulas with the effects of dispelling phlegm and removing blood stasis.Taking conventional Western Medicine as the common intervention measures,the results showed that the overall response improvement rate from high to low was displayed as modified Xiaoxianxiong decoction(小陷胸汤,MXD),Danlou tablet(丹蒌片,DT),modified Gualou Xiebai Banxia decoction(瓜蒌薤白半夏汤,MGXBD),modified Wendan decoction(温胆汤,MWD),modified Zhishi Xiebai Guizhi decoction(枳实薤白桂枝汤,MZXGD),and modified Erchen decoction(二陈汤,MED).The sequence of angina attack duration improvement from high to low was MZXGD,MGXBD,DT,MWD,MXD.The sequence of TC improvement from high to low was MZXGD,MED,DT,and MGXBD.Sequence of improving TG from high to low was MED,MZXGD,MGXBD,and DT.For LDL-C improvement,the effect from good to poor was MZXGD,MGXBD,DT,and MED.With regard to HDL-C improvement,the effect was ranked as MED,MZXGD,MGXBD,and DT from good to poor.hs-CRP expression from high to low was MZXGD,MXD,MED,MWD,and MGXBD.CONCLUSION:TCM formula with the effects of dispelling phlegm and removing blood stasis combined with conventional Western Medicine has obvious advantages in treating CHD angina pectoris with interaction of phlegm and blood stasis.MZXGD has great potential in increasing the overall response rate,reducing Duration of angina attack improving blood lipids,and reducing inflammatory factors.However,due to the limitations of extant studies,the conclusions of this study need to be confirmed by numerous reasonably-designed RCTs.
