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A Mixed-Variable Experimental Design Method
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作者 Zili Wan Qi Wang 《Open Journal of Applied Sciences》 2024年第2期343-352,共10页
Mixed-variable problems are inevitable in engineering. However, few researches pay attention to discrete variables. This paper proposed a mixed-variable experimental design method (ODCD): first, the design variables w... Mixed-variable problems are inevitable in engineering. However, few researches pay attention to discrete variables. This paper proposed a mixed-variable experimental design method (ODCD): first, the design variables were divided into discrete variables and continuous variables;then, the DVD method was employed for handling discrete variables, the LHD method was applied for continuous variables, and finally, a Columnwise-Pairwise Algorithm was used for the overall optimization of the design matrix. Experimental results demonstrated that the ODCD method outperforms in terms of the sample space coverage performance. 展开更多
关键词 OPTIMIZATION experimental design Methods Discrete Variable
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Designing an Experimental Device for Swinging Excitation Spray Cooling
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作者 Long Huang Yujiao Wang 《Journal of Electronic Research and Application》 2024年第2期151-157,共7页
In this paper,we introduce the design principle of the oscillating excited spray cooling experimental device.We then designed an oscillating excited spray cooling experimental device.By using the device,the swaying mo... In this paper,we introduce the design principle of the oscillating excited spray cooling experimental device.We then designed an oscillating excited spray cooling experimental device.By using the device,the swaying motion can be realized through the control system,and the motion of the droplet under different vibration frequencies can be observed.By measuring the liquid flow rate and pressure,the changes in liquid flow rate,pressure,and temperature with time under different vibration frequencies were studied.The trajectory of the droplet and the temperature distribution of the droplet under different vibration frequencies could be observed.The device has a simple structure,is easy to control,and can achieve continuous observation of the spray cooling process. 展开更多
关键词 Oscillating excitation spray cooling experimental device design
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Optimization of Center of Gravity Position and Anti-Wave Plate Angle of Amphibious Unmanned Vehicle Based on Orthogonal Experimental Method
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作者 Deyong Shang Xi Zhang +3 位作者 Fengqi Liang Chunde Zhai Hang Yang Yanqi Niu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期2027-2041,共15页
When the amphibious vehicle navigates in water,the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics.In the relevant research on reducing the navig... When the amphibious vehicle navigates in water,the angle of the anti-wave plate and the position of the center of gravity greatly influence the navigation characteristics.In the relevant research on reducing the navigation resistance of amphibious vehicles by adjusting the angle of the anti-wave plate,there is a lack of scientific selection of parameters and reasonable research of simulation results by using mathematical methods,and the influence of the center of gravity position on navigation characteristics is not considered at the same time.To study the influence of the combinations of the angle of the anti-wave plate and the position of the center of gravity on the resistance reduction characteristics,a numerical calculation model of the amphibious unmanned vehicle was established by using the theory of computational fluid dynamics,and the experimental data verified the correctness of the numerical model.Based on this numerical model,the navigation characteristics of the amphibious unmanned vehicle were studied when the center of gravity was located at different positions,and the orthogonal experimental design method was used to optimize the parameters of the angle of the anti-wave plate and the position of the center of gravity.The results show that through the parameter optimization analysis based on the orthogonal experimental method,the combination of the optimal angle of the anti-wave plate and the position of the center of gravity is obtained.And the numerical simulation result of resistance is consistent with the predicted optimal solution.Compared with the maximum navigational resistance,the parameter optimization reduces the navigational resistance of the amphibious unmanned vehicle by 24%. 展开更多
关键词 Amphibious unmanned vehicle orthogonal experimental design anti-wave plate center of gravity resistance characteristic
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Box-Behnken Design响应面法优化银杏叶提取物醇提水沉工艺
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作者 毕艳艳 姜佳峰 +5 位作者 孙绍明 刘健 郭田甜 孙艳 张兰 郝大伟 《中国药业》 CAS 2024年第7期59-64,共6页
目的优化银杏叶提取物的醇提水沉工艺。方法在单因素试验基础上,以总黄酮醇苷转移率、萜类内酯转移率及干物质得率为综合评价指标,通过Box-Behnken Design(BBD)响应面法对液料比、提取时间、提取次数、提取液浓缩倍数、加水倍数、冷沉... 目的优化银杏叶提取物的醇提水沉工艺。方法在单因素试验基础上,以总黄酮醇苷转移率、萜类内酯转移率及干物质得率为综合评价指标,通过Box-Behnken Design(BBD)响应面法对液料比、提取时间、提取次数、提取液浓缩倍数、加水倍数、冷沉时间进行考察。结果醇提水沉最佳工艺为液料比8∶1(V/m),提取时间1.0 h,提取次数3次,浓缩倍数3倍,加水倍数3倍,冷沉时间28.0 h。结论BBD响应面法优化得到的银杏叶提取物醇提水沉工艺科学、合理、稳定、可行。 展开更多
关键词 银杏叶提取物 醇提水沉工艺 box-behnken design响应面法 总黄酮醇苷转移率 萜类内酯转移率 干物质得率
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A Spider Monkey Optimization Algorithm Combining Opposition-Based Learning and Orthogonal Experimental Design
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作者 Weizhi Liao Xiaoyun Xia +3 位作者 Xiaojun Jia Shigen Shen Helin Zhuang Xianchao Zhang 《Computers, Materials & Continua》 SCIE EI 2023年第9期3297-3323,共27页
As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the... As a new bionic algorithm,Spider Monkey Optimization(SMO)has been widely used in various complex optimization problems in recent years.However,the new space exploration power of SMO is limited and the diversity of the population in SMO is not abundant.Thus,this paper focuses on how to reconstruct SMO to improve its performance,and a novel spider monkey optimization algorithm with opposition-based learning and orthogonal experimental design(SMO^(3))is developed.A position updatingmethod based on the historical optimal domain and particle swarmfor Local Leader Phase(LLP)andGlobal Leader Phase(GLP)is presented to improve the diversity of the population of SMO.Moreover,an opposition-based learning strategy based on self-extremum is proposed to avoid suffering from premature convergence and getting stuck at locally optimal values.Also,a local worst individual elimination method based on orthogonal experimental design is used for helping the SMO algorithm eliminate the poor individuals in time.Furthermore,an extended SMO^(3)named CSMO^(3)is investigated to deal with constrained optimization problems.The proposed algorithm is applied to both unconstrained and constrained functions which include the CEC2006 benchmark set and three engineering problems.Experimental results show that the performance of the proposed algorithm is better than three well-known SMO algorithms and other evolutionary algorithms in unconstrained and constrained problems. 展开更多
关键词 Spider monkey optimization opposition-based learning orthogonal experimental design particle swarm
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Factorial Experimental Design to Study the Effects of Layers and Fiber Content on Concrete Flexural Behavior
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作者 Dumbiri H. Odia 《Open Journal of Civil Engineering》 CAS 2023年第1期83-102,共20页
Experimentation has come a long in helping researchers achieve breakthroughs in their different scientific areas and engineering happens to be one of those areas with the most impact from experimental advancement. The... Experimentation has come a long in helping researchers achieve breakthroughs in their different scientific areas and engineering happens to be one of those areas with the most impact from experimental advancement. The need for valid experimental results free from biases and confounding conclusions has prompted the development of new experimental techniques that takes consideration of all applicable factor and combinations in providing answers on a research topic, and the Factorial Experimental design credited to Sir Ronald Fisher is one technique yielding highly valid results. This paper uses the factorial design of experiments to research the flexural impact of polyvinyl acetate fiber and layered concrete in construction. The experiment considered two levels of fiber contents and two levels of layers, and prepared samples with all combinations of the variable factors. The samples were tested after 7 days from casting for flexural strength and an advance statistical analysis was performed on the flexural responses of the samples using R-program. The results from the analyses revealed the significance of the variables to the flexural strength of the samples, as well as their interactions. The experiment concluded that based on the number of layers and fiber content used for the experiment, casting concrete in layers does have a significant negative effect on the flexural strength of concrete, and the failure pattern of concrete members under flexural load in evidently influenced by the material composition of the concrete, and that it can be evidently influenced by casting the concrete in layers. 展开更多
关键词 experimental design Concrete Flexural Strength Factorial design of experiments Concrete Fibers Concrete Layers
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The Study of Optimizing Reservoir Model Using Experimental Design in Stochastic Models
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作者 Huan Wang Xiaojun Jiang 《Journal of Civil Engineering and Architecture》 2023年第3期145-151,共7页
In response to the main problems in commonly used model selection methods,a method was proposed to apply the concept of experimental design to the optimization of uncertain reservoir models.Firstly,based on the actual... In response to the main problems in commonly used model selection methods,a method was proposed to apply the concept of experimental design to the optimization of uncertain reservoir models.Firstly,based on the actual situation of the oil field,the uncertain variables were determined that affect the geological reserves of the model and their possible range of variation,and experimental design was used to determine the modeling plan.Then,multiple geological models were established and reserves were calculated,and multiple regression was performed between uncertain variables and the corresponding geological reserves of the model.Finally,Monte Carlo simulation technology was applied to determine the parameters of the P10,P50,and P90 models for probabilistic reserves,and P10,P50,and P90 models were established.This method is not only more objective and time-saving in the application process,but also can determine the main geological variables that affect geological reserves,providing a new idea for evaluating the uncertainty of geological reserves. 展开更多
关键词 Uncertainty evaluation experimental design random modeling model optimization
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Design and Application of Experimental Teaching in Consumer Behavior Courses
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作者 Shiyu Liu 《Journal of Contemporary Educational Research》 2023年第4期67-71,共5页
This article mainly elaborates on the design and application of experimental teaching in the teaching of consumer behavior.To study consumer behavior,it is necessary to understand their information collection activiti... This article mainly elaborates on the design and application of experimental teaching in the teaching of consumer behavior.To study consumer behavior,it is necessary to understand their information collection activities before acquiring goods and services,as well as the evaluation and selection of goods,services,or brands.It is also important to pay attention to how they handle products and activities based on their satisfaction after purchasing products or services.In addition,through inquiry experiments,the learning effects of students can be improved,thereby highlighting the significance of inquiry experiments. 展开更多
关键词 Consumer behavior experimental teaching Instructional design
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Experimental Design for Computer System Platform Course
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作者 Li Zhang Qing Zhu Xuejun Yu 《Journal of Contemporary Educational Research》 2023年第8期119-124,共6页
The computer system platform course is a comprehensive platform course formed by modifying and optimizing the content of the relevant basic courses of computer major to meet the requirement for basic computer knowledg... The computer system platform course is a comprehensive platform course formed by modifying and optimizing the content of the relevant basic courses of computer major to meet the requirement for basic computer knowledge in digital media technology major.The scope and extent of the course content make its experimental design more challenging.By considering the scope of contents,the difficulty of experiments,and the rationality of intrinsic logic,the experiments covering from operating system to computer network are designed.The relevance and continuity of the experiments are ensured,so as to achieve the goals of promoting students’understanding of key concepts,improving their hands-on ability,cultivating their interest,and guiding their self-learning within the limited class time. 展开更多
关键词 Digital media technology experimental design Computer fundamentals Intrinsic logic
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Optimization of rheological parameter for micro-bubble drilling fluids by multiple regression experimental design 被引量:2
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作者 郑力会 王金凤 +2 位作者 李潇鹏 张燕 李都 《Journal of Central South University》 SCIE EI CAS 2008年第S1期424-428,共5页
In order to optimize plastic viscosity of 18 mPa·s circulating micro-bubble drilling fluid formula,orthogonal and uniform experimental design methods were applied,and the plastic viscosities of 36 and 24 groups o... In order to optimize plastic viscosity of 18 mPa·s circulating micro-bubble drilling fluid formula,orthogonal and uniform experimental design methods were applied,and the plastic viscosities of 36 and 24 groups of agent were tested,respectively.It is found that these two experimental design methods show drawbacks,that is,the amount of agent is difficult to determine,and the results are not fully optimized.Therefore,multiple regression experimental method was used to design experimental formula.By randomly selecting arbitrary agent with the amount within the recommended range,17 groups of drilling fluid formula were designed,and the plastic viscosity of each experiment formula was measured.Set plastic viscosity as the objective function,through multiple regressions,then quadratic regression model is obtained,whose correlation coefficient meets the requirement.Set target values of plastic viscosity to be 18,20 and 22 mPa·s,respectively,with the trial method,5 drilling fluid formulas are obtained with accuracy of 0.000 3,0.000 1 and 0.000 3.Arbitrarily select target value of each of the two groups under the formula for experimental verification of drilling fluid,then the measurement errors between theoretical and tested plastic viscosity are less than 5%,confirming that regression model can be applied to optimizing the circulating of plastic-foam drilling fluid viscosity.In accordance with the precision of different formulations of drilling fluid for other constraints,the methods result in the optimization of the circulating micro-bubble drilling fluid parameters. 展开更多
关键词 orthogonal experimental design uniform experimental design CIRCULATING micro-bubbles plastic viscosity multiple regression experimental design
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Application of Uniform Experimental Design in Optimizing Excitation Parameters for Magnetic Frequency Mixing Measurements 被引量:2
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作者 Yu Chang Jingpin Jiao +3 位作者 Xiucheng Liu Guanghai Li Cunfu He Bin Wu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2020年第1期197-209,共13页
Excitation parameter preferences are key factors a ecting the performance of magnetic frequency mixing detection.A uniform experimental design method was used to analyze this influence.Using fuzzy theory,a comprehensi... Excitation parameter preferences are key factors a ecting the performance of magnetic frequency mixing detection.A uniform experimental design method was used to analyze this influence.Using fuzzy theory,a comprehensive model is established for evaluating the e ect of magnetic frequency mixing.A polynomial is selected as the regression function to express explicitly the correlation between the excitation parameters and the frequency-mixing e ect.The excitation parameters were then optimized using genetic algorithm.Magnetic frequency mixing experiments were conducted to measure the surface hardness of some ferromagnetic materials.Frequency mixing is further enhanced under the optimal settings,resulting in an improvement in the measurement sensitivity.The results of this study support the application of the magnetic frequency mixing technique in non-destructive testing. 展开更多
关键词 MAGNETIC frequency MIXING technology EXCITATION parameters UNIFORM experimental design Regression STATISTICAL method Surface HARDNESS measurement
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The Adsorption of Pb(II)Using Silica Gel Synthesized from Chemical Bottle Waste:Optimization Using Box-Behnken Design
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作者 Yatim Lailun Ni’mah Nabila Eka Yuningsih Suprapto Suprapto 《Journal of Renewable Materials》 SCIE EI 2023年第6期2913-2924,共12页
The adsorption of Pb(II)on silica gel synthesized from chemical glass bottle waste has been studied.The effect of independent variables(adsorbent dose,initial concentration of Pb(II),contact time,and pH)on the Pb(II)r... The adsorption of Pb(II)on silica gel synthesized from chemical glass bottle waste has been studied.The effect of independent variables(adsorbent dose,initial concentration of Pb(II),contact time,and pH)on the Pb(II)removal from water was evaluated and optimized using the Response Surface Methodology(RSM).Under optimized conditions(adsorbent dose:20 mg;contact time:30 min;initial Pb(II)concentration:120 mg.L^(−1);and pH:8),the removal of Pb(II)was 99.77%.The adsorption equilibrium data obtained from the batch experiment were investigated using different isotherm models.The Langmuir isotherm model fits the experimental data.This shows that the surface of the silica gel synthesized from chemical bottles waste was covered by a Pb(II)monolayer.XRF analysis showed that the synthesized silica gel had a SiO_(2) content of 75.63%.Amorphous silica was observed from XRD analysis.SEM-EDX characterization showed that Pb was adsorbed on the silica gel surface.SEM analysis showed that silica gel has irregular particles with a surface area of 297.08 m2.g^(−1) with a pore radius of 15.74 nm calculated from BET analysis. 展开更多
关键词 Chemical bottle waste silica gel ADSORPTION box-behnken design response surface methodology
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Electro-Chemical Impedance Spectral (EIS) Study of Patinated Bronze Corrosion in Sulfate Media: Experimental Design Approach 被引量:2
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作者 Aymen Chaabani Safa Aouadi +1 位作者 Nébil Souissi X. Ramón Nóvoa 《Journal of Materials Science and Chemical Engineering》 2017年第10期44-54,共11页
The aim of the present investigation was to model the experimental conditions of tin bronze patination using full factorial experimental design. In this sense, a full factorial design approach was developed to model t... The aim of the present investigation was to model the experimental conditions of tin bronze patination using full factorial experimental design. In this sense, a full factorial design approach was developed to model the corrosion behavior of patinated tin bronze alloy in sulfate electrolyte. Three experimental factors (the immersion time in the chloride electrolyte, the potential limit for the anodic sweep Elim, and the potential scan rate) were chosen to identify the significant factor on the patina growth process at the bronze substrate. The experimental responses were the kinetic parameters extracted from the electro-chemical spectra (EIS) for eight different experiments. An equivalent electrical circuit containing an electrolyte resistance (Re), a double layer capacitance (CPEdl), a charge transfer resistance (Rt) and Gerischer element (G), was developed to model the patinated bronze corrosion process. The electro-chemical spectra (EIS) show that the corrosion process of the patinated bronze alloy occurred from a chemical reaction is followed by an electrochemical one. Analysis of the experimental responses showed that while the scan rate is the most influent factor for the corrosion potential (Ecorr), the electrolyte resistance (Re), and the double layer capacitance CPEdl variation, the potential limit is the significant factor for charge transfer resistance Rt, reciprocal of the admittance parameter Y0 and the effective transfer rate of the chemical reaction k variation. 展开更多
关键词 BRONZE CORROSION experimental design Electrochemical IMPEDANCE Spectroscopy Gerischer IMPEDANCE
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Process Characterization of the Transesterification of Rapeseed Oil to Biodiesel Using Design of Experiments and Infrared Spectroscopy
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作者 Tobias Drieschner Andreas Kandelbauer +1 位作者 Bernd Hitzmann Karsten Rebner 《Journal of Renewable Materials》 SCIE EI 2023年第4期1643-1660,共18页
For optimization of production processes and product quality,often knowledge of the factors influencing the process outcome is compulsory.Thus,process analytical technology(PAT)that allows deeper insight into the proc... For optimization of production processes and product quality,often knowledge of the factors influencing the process outcome is compulsory.Thus,process analytical technology(PAT)that allows deeper insight into the process and results in a mathematical description of the process behavior as a simple function based on the most important process factors can help to achieve higher production efficiency and quality.The present study aims at characterizing a well-known industrial process,the transesterification reaction of rapeseed oil with methanol to produce fatty acid methyl esters(FAME)for usage as biodiesel in a continuous micro reactor set-up.To this end,a design of experiment approach is applied,where the effects of two process factors,the molar ratio and the total flow rate of the reactants,are investigated.The optimized process target response is the FAME mass fraction in the purified nonpolar phase of the product as a measure of reaction yield.The quantification is performed using attenuated total reflection infrared spectroscopy in combination with partial least squares regression.The data retrieved during the conduction of the DoE experimental plan were used for statistical analysis.A non-linear model indicating a synergistic interaction between the studied factors describes the reactor behavior with a high coefficient of determination(R^(2))of 0.9608.Thus,we applied a PAT approach to generate further insight into this established industrial process. 展开更多
关键词 Process analytical technology TRANSESTERIFICATION design of experiment attenuated total reflection infrared spectroscopy partial least square regression
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An iterated local coordinate-exchange algorithm for constructing experimental designs for multi-dimensional constrained spaces 被引量:1
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作者 YOU Yang JIN Guang +1 位作者 PAN Zhengqiang GUO Rui 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第5期1212-1220,共9页
Iterated local search(ILS)is used to construct the optimal experimental designs for multi-dimensional constrained spaces,in which the inner loop is based on the stochastic coordinate-exchange(SCE)algorithm.Every time ... Iterated local search(ILS)is used to construct the optimal experimental designs for multi-dimensional constrained spaces,in which the inner loop is based on the stochastic coordinate-exchange(SCE)algorithm.Every time a local optimal solution is found by the SCE algorithm,the perturbation operator is applied to it,and then a new solution is explored in the areas where the exchange of coordinates may produce improvement,so as to retain the features and attributes of the current optimal solution and avoid the defects of random restart.We implement the iterated local coordinate-exchange algorithm for experimental designs in the multi-dimensional constrained spaces.In addition,sensitivity analysis was conducted to analyze the impacts of the parameters on the performance of the proposed algorithm.Also we compared the performance of the proposed algorithm to the SCE algorithm using the random restart strategy.The analysis shows that the proposed algorithm is better than the SCE algorithm in terms of efficiency and quality,especially in the experimental designs for high-dimensional constrained space. 展开更多
关键词 constrained space experimental design coordinate-exchange iterated local search(ILS)
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Application of orthogonal experimental design and Tikhonov regularization method for the identification of parameters in the casting solidification process 被引量:4
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作者 Dashan SUI Zhenshan CUI 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2009年第1期13-21,共9页
The inverse heat conduction method is one of methods to identify the casting simu- lation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized fun... The inverse heat conduction method is one of methods to identify the casting simu- lation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized functional was established, and the functional was solved by the sensitivity coeffcient and Newton-Raphson iteration method. Moreover, the orthogonal experimental design was used to estimate the ap- propriate initial value and variation domain of each variable to decrease the number of iteration and improve the identification accuracy and effciency. It illustrated a detailed case of AlSi7Mg sand mold casting and the temperature measurement ex- periment was done. The physical properties of sand mold and the interfacial heat transfer coeffcient were identified at the meantime. The results indicated that the new regularization method was effcient in overcoming the ill-posedness of the inverse heat conduction problem and improving the stability and accuracy of the solutions. 展开更多
关键词 TIKHONOV正则化方法 正交试验设计 铸件凝固过程 逆热传导问题 应用 砂型铸造 界面传热系数 模拟参数
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Ideological and Political Teaching Case Design and Research Based on the Course Simulation Electronic Technology Experiment
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作者 Meiyi Chen Wei Yang +2 位作者 Xin Hao Shunyu Long Pengfei Zhong 《Journal of Contemporary Educational Research》 2023年第2期37-45,共9页
As critical measures to educate and cultivate people’s morality,“Ideology and Politics of Course”has gradually become the focus in actual undergraduate education research in universities.Targeting the single ideolo... As critical measures to educate and cultivate people’s morality,“Ideology and Politics of Course”has gradually become the focus in actual undergraduate education research in universities.Targeting the single ideological and political education mode and students’lack of interest in experimental courses,this paper,through various links,including pre-class preview,in-class teaching,and after-class data analysis,takes the common emitter single tube amplifier experiment as an example to organically integrate the excavated ideological and political elements with practical operation and carry out teaching case design and practice;realize the improvement of students’learning initiative and problem-analysis ability;and achieve the purpose of cultivating people throughout the whole process and in a comprehensive direction. 展开更多
关键词 Ideology and politics Simulation electronic technology experiment Teaching design
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Key design parameters and optimum method of medium- and high-velocity synchronous induction coilgun based on orthogonal experimental design
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作者 刘开培 牛小波 +3 位作者 张亚东 季曾超 冯建源 李文琦 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第2期202-209,共8页
The energy conversion efficiency of a multistage synchronous induction coilgun(MSSICG) has become one of the key factors that restricts its industrialization. To improve the launch efficiency of medium-and high-veloci... The energy conversion efficiency of a multistage synchronous induction coilgun(MSSICG) has become one of the key factors that restricts its industrialization. To improve the launch efficiency of medium-and high-velocity MSSICG,we propose an optimization design scheme combining orthogonal experimental design(OED) and self-consistent design method in this paper. The OED is introduced to reduce the number of iterations and improve the identification accuracy and efficiency. A self-consistent design model is established to overcome a defect that the parameters that need to be optimized will multiply as the number of coil stages increases. The influence of six factors(radial thickness of armature, axial length of armature, axial length of coil, capacitance, wire diameter, and slip speed) on the launch efficiency are then evaluated by range analysis. This work presents a valuable reference for optimizing medium-and high-velocity MSSICG. 展开更多
关键词 MULTISTAGE SYNCHRONOUS induction coilgun(MSSICG) SELF-CONSISTENT design orthogonal experimental design(OED) range analysis
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Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis
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作者 Prakash Thapa Du Hyung Choi +1 位作者 Min Soo Kim Seong Hoon Jeong 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2019年第3期287-304,共18页
The current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets. The knowledge gained was intended to be used for Quality-by-Design based pro... The current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets. The knowledge gained was intended to be used for Quality-by-Design based process design and optimization. The variables were selected based on the risk assessment as impeller speed, liquid addition rate, and wet massing time. Formulation compositions were kept constant to minimize their influence on granules properties. Multiple linear regression models were built providing understanding of the impact of each variable on granule hardness, Carr’s index, tablet tensile strength, surface mean diameter of granules, and compression behavior. The experimental results showed that the impact of impeller speed was more dominant compared to wet massing time and water addition rate. The results also revealed that quality of granules and tablets could be optimized by adjusting specific process variables(impeller speed 1193 rpm, water spray rate 3.7 ml/min, and wet massing time 2.84 min). Overall desirability was 0.84 suggesting that the response values were closer to the target one. The SEM image of granules showed that spherical and smooth granules produced at higher impeller speed, whereas rough and irregular shape granules at lower speed. Moreover, multivariate data analysis demonstrated that impeller speed and massing time had strong correlation with the granule and tablet properties. In overall, the combined experimental design and principal component analysis approach allowed to better understand the correlation between process variables and granules and tablet attributes. 展开更多
关键词 experimental design Principal COMPONENT analysis High SHEAR GRANULATION Process PARAMETER
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Application of experimental design in optimization of crude oil adsorption from saline waste water using raw bagasse 被引量:1
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作者 M.Behnood B.Nasernejad M.Nikazar 《Journal of Central South University》 SCIE EI CAS 2014年第2期684-693,共10页
Experimental design was applied in the optimization of crude oil adsorption from saline waste water using raw bagasse.The application of response surface methodology(RSM) was presented with temperature,salinity of wat... Experimental design was applied in the optimization of crude oil adsorption from saline waste water using raw bagasse.The application of response surface methodology(RSM) was presented with temperature,salinity of water,pH,adsorbent dose,and initial oil content as factors.A quadratic model could be used to approximate the mathematical relationship of crude oil removal on the five significant independent variables.Predicted values and experimental values are found to be in good agreement with R2 of 97.44%.The result of optimization shows that the maximum crude oil removal is equal to 67.38% under the optimal condition of temperature of 46.53 °C,salinity of 37.2 g/L,pH of 3,adsorbent dose of 9 g/L and initial oil content of 300×10-6. 展开更多
关键词 优化利用 实验设计 废水利用 吸附剂 原油 应用 原料 蔗渣
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