Objective:To study the effect of bronchofiberscope airway lavage on respiratory function and inflammatory stress level in adults with severe pneumonia.Methods:80 adults with severe pneumonia treated in our hospital be...Objective:To study the effect of bronchofiberscope airway lavage on respiratory function and inflammatory stress level in adults with severe pneumonia.Methods:80 adults with severe pneumonia treated in our hospital between July 2011 and March 2015 were collected, and after the treatment process and auxiliary examination results were retrospectively analyzed, they were divided into control group (n=45) who accepted conventional treatment and observation group (n=35) who accepted bronchofiberscope airway lavage. Before and after treatment, the spirometer was used to test the respiratory function of two groups of patients;ELISA method was used to detect serum inflammatory factor levels;RIA method was used to detect serum stress index levels.Results:Before treatment, differences in serum levels of inflammatory cytokines and stress indexes were not statistically significant between two groups of patients (P>0.05);after treatment, respiratory function parameters forced expiratory volume in 1 s (FEV1), alveolar ventilation (VA), maximal mid-expiratory flow (FEF25-75), instantaneous late-expiratory flow (FEF50%) and instantaneous late-expiratory flow (FEF75%) levels of observation group were higher than those of control group (P<0.05), serum high mobility group box B1 (HMGB1), interleukin-2 (IL-2), interferonγ (IFN-γ), cortisol (Cor), adrenaline (ADR) and noradrenaline (NADR) levels were significantly lower than those of control group while interleukin-13 (IL-13) level was significantly higher than that of control group (P<0.05). Conclusions: Bronchofiberscope airway lavage can optimize the respiratory function and reduce systemic inflammatory and stress response in adults with severe pneumonia.展开更多
文摘Objective:To study the effect of bronchofiberscope airway lavage on respiratory function and inflammatory stress level in adults with severe pneumonia.Methods:80 adults with severe pneumonia treated in our hospital between July 2011 and March 2015 were collected, and after the treatment process and auxiliary examination results were retrospectively analyzed, they were divided into control group (n=45) who accepted conventional treatment and observation group (n=35) who accepted bronchofiberscope airway lavage. Before and after treatment, the spirometer was used to test the respiratory function of two groups of patients;ELISA method was used to detect serum inflammatory factor levels;RIA method was used to detect serum stress index levels.Results:Before treatment, differences in serum levels of inflammatory cytokines and stress indexes were not statistically significant between two groups of patients (P>0.05);after treatment, respiratory function parameters forced expiratory volume in 1 s (FEV1), alveolar ventilation (VA), maximal mid-expiratory flow (FEF25-75), instantaneous late-expiratory flow (FEF50%) and instantaneous late-expiratory flow (FEF75%) levels of observation group were higher than those of control group (P<0.05), serum high mobility group box B1 (HMGB1), interleukin-2 (IL-2), interferonγ (IFN-γ), cortisol (Cor), adrenaline (ADR) and noradrenaline (NADR) levels were significantly lower than those of control group while interleukin-13 (IL-13) level was significantly higher than that of control group (P<0.05). Conclusions: Bronchofiberscope airway lavage can optimize the respiratory function and reduce systemic inflammatory and stress response in adults with severe pneumonia.
