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Surrogate Role of CD85k on Monocytic Lineage Involved Leukemogenesis Biology and Clinical Aspect
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作者 Hasnaa A. Abo-Elwafa Shereen P. Aziz +2 位作者 Heba A. Ahmed Elsayed Mostafa Ali Doaa S. Elsaied 《Open Journal of Blood Diseases》 2018年第4期61-73,共13页
Background: Unique receptor involved in leukemogenesis is CD85k;an immuneglobulin receptor for immune tolerance, CD36 is glycoprotein mediates cellular adhesion and metastatic spread, CD14, CD15 considered common mono... Background: Unique receptor involved in leukemogenesis is CD85k;an immuneglobulin receptor for immune tolerance, CD36 is glycoprotein mediates cellular adhesion and metastatic spread, CD14, CD15 considered common monocytic markers. Aims: to investigate CD85k with monocytic lineage involved leukemia (MLIL) markers in leukemia pathogenesis and clinical presentation. Patients and Methods: 47 patients (32 diagnosed acute myeloid leukemia (AML);15 non-malignant hematological disease as a control), were included, aged from 2 to 80 years, all subjected to peripheral blood (P.Bl) and bone marrow (B.M) examination, immunophenotyping (IPT) using FASC Canto four color flow cytometer (FCM) Becton Dickenson (BD) USA, for CD13, CD33, MPO, HLA-DR, CD34, CD38, CD117, CD14, CD15 and CD36 the Mo Abs supplied by B.D Bioscience, and anti CD85k Mo Abs by Aveda de Coimbra Flamenco, reference No. 1399990130. Results: Frequency of CD85k is 19/32 (59.37%) of AML;14/14 (M4/M5) 100% positive CD85k, insignificant correlations of CD85k to sex, lymphadenopathy or organomegaly, platelets count and P.Bl blast (P > 0.05), significant to age 50,000 × 109/l, Hb 0.05). Conclusion: Although CD85k is MLIL associated marker, it is not correlated with other MLIL markers with frequency 100% in MLIL and 59.37% in AML, age predisposition is <35 years with no sex variation, significant correlation to progenitor and myeloid markers, it’s a crucial role in leukemogenesis biology, not in clinical presentations, considered good follow up predictor MLIL marker. 展开更多
关键词 cd85k Monocytic LINEAGE LEUKEMIA
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CD85d在急性髓系白血病中的表达及临床意义
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作者 饶若 王述文 +1 位作者 吴莉芳 王照良 《中国热带医学》 CAS 北大核心 2024年第8期978-981,共4页
目的探讨CD85d在急性髓系白血病中表达及其对单核细胞相关性急性髓系白血病诊断的临床意义。方法通过CD45/SSC双参数设门方法,对海南省人民医院血液内科2022年3月至2023年12月收治的46例单核细胞相关性急性髓系白血病(monocyte associat... 目的探讨CD85d在急性髓系白血病中表达及其对单核细胞相关性急性髓系白血病诊断的临床意义。方法通过CD45/SSC双参数设门方法,对海南省人民医院血液内科2022年3月至2023年12月收治的46例单核细胞相关性急性髓系白血病(monocyte associated acute myeloid leukemia,M-AML)和60例非单核细胞相关性急性髓系白血病(non monocyte associated acute myeloid leukemia,NM-AML)患者白血病细胞上CD85d、CD14、CD64进行流式细胞术免疫分析。结果正常粒细胞和正常单核细胞中均表达CD85d,并且单核细胞表达荧光强度强于粒细胞。正常淋巴细胞中不表达CD85d。CD85d在M-AML中表达阳性率为80.4%(37/46),高于在NM-AML中表达阳性率3.3%(2/60),差异有统计学意义(P<0.01);CD85d和CD64、CD14诊断M-AML的敏感度由高到低为CD64(87.0%)>CD85d(80.4%)>CD14(34.8%),诊断M-AML的特异度由高到低为CD14(100%)>CD85d(96.7%)>CD64(56.7%),CD85d联合CD64诊断MAML的敏感度为89.1%,特异度为56.7%。;CD85d+AML异常染色体核型检出率(53.8%)、融合基因阳性率(26.9%)、完全缓解(complete remission,CR)率(78.3%)与CD85d-AML的异常核型检出率(66.0%)、融合基因阳性率(50.0%)、CR率(70.0%)比较差异均无统计学意义(P>0.05)。结论CD85d可作为检测幼稚单核细胞新的高灵敏度和特异度表面标志物,有助于提高M-AML的检出率及与NM-AML亚型的鉴别诊断。 展开更多
关键词 cd85d 急性髓系白血病 流式细胞术
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COPD患者诱导痰中DCs及CCR6的变化及意义 被引量:1
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作者 符丹丹 欧阳瑶 李书光 《贵州医药》 CAS 2012年第2期111-114,共4页
目的检测慢性阻塞性肺疾病(COPD)患者诱导痰中DCs的变化及CCR6的含量,分析DCs及趋化因子受体6(Chemkine receptor 6,CCR6)在COPD发病机制中的作用。方法以COPD患者为研究对象,并以无COPD者健康人作为对照,采用沙丁胺醇加高渗盐水超声雾... 目的检测慢性阻塞性肺疾病(COPD)患者诱导痰中DCs的变化及CCR6的含量,分析DCs及趋化因子受体6(Chemkine receptor 6,CCR6)在COPD发病机制中的作用。方法以COPD患者为研究对象,并以无COPD者健康人作为对照,采用沙丁胺醇加高渗盐水超声雾化吸入方法诱导排痰,以流式细胞技术(FCM)检测痰液中DCs水平,以ELISA检测CCR6的含量。同时,常规方法测定肺功能FEV1%及FEV1/FVC。结果DCs在COPD分期的GOLD I级、GOLDⅡ级以及GOLDⅢ~Ⅳ级均高于正常对照组和吸烟无COPD组,且有显著统计学意义(P<0.01)。CCR6在COPD分期的GOLD I级、GOLDⅡ级以及GOLDⅢ~Ⅳ级均高于正常对照组和吸烟无COPD组,且有显著统计学意义(P<0.01)。DCs与COPD患者FEVl%之间呈负相关关系(P<0.05)。CCR6与COPD患者FEV1%之间呈负相关关系(P<0.01)。结论COPD患者DCs及CCR6显著升高,且与病情的严重程度明显相关,提示DCs及CCR6可能参与了COPD的炎症反应过程。 展开更多
关键词 慢性阻塞性肺疾病 树突状细胞 CD40 CD86 CCR6 诱导痰 肺功能
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英伦三重奏——听雅骏CD92/A85和美声781音响组合
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作者 李英立 《现代音响技术》 2001年第5期32-35,共4页
80年代,英国雅骏(Arcam)以一款Black Box 500名动音响界.此诨名"黑盒"的解码器,由于素质高,当年成为港、澳发烧反争相谈论的话题.有鉴于同期/同档次/同售价对手不多,就连英国洋鬼子天书,一样对"黑盒"频送秋波.从此... 80年代,英国雅骏(Arcam)以一款Black Box 500名动音响界.此诨名"黑盒"的解码器,由于素质高,当年成为港、澳发烧反争相谈论的话题.有鉴于同期/同档次/同售价对手不多,就连英国洋鬼子天书,一样对"黑盒"频送秋波.从此,雅骏奠定了成功的基础. 展开更多
关键词 雅骏CD92/A85 美声781 音响组合
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Inhibitory leukocyte immunoglobulin-like receptors in cancer development 被引量:3
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作者 ZHANG FeiFei ZHENG JunKe +4 位作者 KANG XunLei DENG Mi LU ZhiGang KIM Jaehyup ZHANG ChengCheng 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第12期1216-1225,共10页
Inhibitory leukocyte immunoglobulin-like receptors(LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs(ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, ... Inhibitory leukocyte immunoglobulin-like receptors(LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs(ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase(SHIP) to negatively regulate immune cell activation. These receptors are known to play important regulatory roles in immune and neuronal functions. Recent studies demonstrated that several of these receptors are expressed by cancer cells. Importantly, they may directly regulate development, drug resistance, and relapse of cancer, and the activity of cancer stem cells. Although counterintuitive, these findings are consistent with the generally immune-suppressive and thus tumor-promoting roles of the inhibitory receptors in the immune system. This review focuses on the ligands, expression pattern, signaling, and function of LILRB family in the context of cancer development. Because inhibition of the signaling of certain LILRBs directly blocks cancer growth and stimulates immunity that may suppress tumorigenesis, but does not disturb normal development, LILRB signaling pathways may represent ideal targets for treating hematological malignancies and perhaps other tumors. 展开更多
关键词 immunoreceptor tyrosine-based inhibitory motifs immunoreceptor tyrosine-based activation motif leukocyte immunoglobulin-like receptor subfamily B immunoglobulin-like transcript leukocyte immunoglobulin-like receptor phosphatase ITIM ITAM LILRB cd85 ILT LIR SHP-1 SHP-2 SHIP MHC HLA signal transduction leukemia cancer
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ILT4促进脓毒症炎性反应并介导免疫麻痹 被引量:1
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作者 章德文 丁娴 +3 位作者 刘树雄 夏新宇 朱守朝 何建 《中华急诊医学杂志》 CAS CSCD 北大核心 2017年第10期1160-1163,共4页
目的:探讨脓毒症单核细胞表达ILT4的生物学行为和效应,及对于预后的影响。方法:选取BALB/c、BALB/c ILT4–/–雄性小鼠,CLP复制脓毒症模型。用流式细胞仪定量检测CLP术后24h单核细胞ILT4、MHC-Ⅱ表达水平;用ELISA法检测各组0、6、1... 目的:探讨脓毒症单核细胞表达ILT4的生物学行为和效应,及对于预后的影响。方法:选取BALB/c、BALB/c ILT4–/–雄性小鼠,CLP复制脓毒症模型。用流式细胞仪定量检测CLP术后24h单核细胞ILT4、MHC-Ⅱ表达水平;用ELISA法检测各组0、6、12、24h血清IL-6、TNF-α浓度;并观察168h内生存预后。 结果:CLP术后24小时脓毒症小鼠外周单核细胞高度表达ILT4分子 (193.50 ± 52.54 vs. 1292.00 ± 143.70, p 〈 0.05) ;较WT组ILT4–/–小鼠外周单核细胞表达MHC-Ⅱ比率明显增高(24.25± 6.76% vs. 49.38 ±5.66%, p 〈 0.05) 。CLP术后24h血清IL-6显著增高(54.25± 20.04 vs. 470.75±88.03, p 〈 0.05),ILT4敲除后很大程度的抑制这一趋势(470.75±88.03 vs. 241.25 ± 45.10, p 〈 0.05);但对TNF-α表达无显著性干扰(53.13 ±5.49 vs. 50.88 ±6.38, p〉 0.05)。且ILT4–/–小鼠CLP术后生存率WT明显增加(p 〈 0.05)。结论:脓毒症时单核细胞高表达ILT4,与高IL-6水平及低MHC-Ⅱ表达率相关,导致死亡率增加。 展开更多
关键词 脓毒症 单核细胞ILT4 cd85 MHC-Ⅱ IL-6 TNF—α 免疫麻痹 盲肠结扎穿孔术
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