<strong>Background</strong><span><span><span style="font-family:;" "=""> <b><span style="font-family:Verdana;">and</span></b> &l...<strong>Background</strong><span><span><span style="font-family:;" "=""> <b><span style="font-family:Verdana;">and</span></b> <b><span style="font-family:Verdana;">Objectives:</span></b><span style="font-family:Verdana;"> Candida colonization in neonates with low birth weight is reported to be the first step for invasive candidiasis. This study was designed to describe the patterns of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonizing neonates with low birth weight in Mwanza, Tanzania to provide baseline information for future studies in this field. </span><b><span style="font-family:Verdana;">Methodology:</span></b><span style="font-family:Verdana;"> The hospital based cross sectional study was conducted between January 2019 and April 2019 among neonates with low birth weight. Clinical and social demographic data were collected using interview guide questionnaire. Oral and umbilical</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">rectal swabs were collected on </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">the </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">first and seventh day of life to assess </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonization status. Data were analyzed using STATA version 13 following the study objectives. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> A total of 320 neonates with median body weight of 1600 [IQR 1000 - 2000] grams were enrolled. Prevalence of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonization on either oral, umbilical or rectum was 16.2% (52/320). A total of 34 (10.6%) and 41 (12.8%) neonates were colonized by </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. on </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">the </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">first day and seventh day of life, respectively. Of 34 neonates colonized on the first day of life, 23 (67.7%) were still being colonized on the seventh day. </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>albicans</i></span><span style="font-family:Verdana;"> 38 (73.1%), was the predominant specie</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> detected followed by </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>glabrata</i></span><span style="font-family:Verdana;"> 10 (19.2%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The prevalence of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonization among neonates with low birth weight is within the reported range and is mainly due to </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>albicans</i></span><span style="font-family:Verdana;">. Future studies are highly needed to explore the role of colonization and subsequent </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. infections.</span></span></span></span>展开更多
文摘<strong>Background</strong><span><span><span style="font-family:;" "=""> <b><span style="font-family:Verdana;">and</span></b> <b><span style="font-family:Verdana;">Objectives:</span></b><span style="font-family:Verdana;"> Candida colonization in neonates with low birth weight is reported to be the first step for invasive candidiasis. This study was designed to describe the patterns of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonizing neonates with low birth weight in Mwanza, Tanzania to provide baseline information for future studies in this field. </span><b><span style="font-family:Verdana;">Methodology:</span></b><span style="font-family:Verdana;"> The hospital based cross sectional study was conducted between January 2019 and April 2019 among neonates with low birth weight. Clinical and social demographic data were collected using interview guide questionnaire. Oral and umbilical</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">rectal swabs were collected on </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">the </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">first and seventh day of life to assess </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonization status. Data were analyzed using STATA version 13 following the study objectives. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> A total of 320 neonates with median body weight of 1600 [IQR 1000 - 2000] grams were enrolled. Prevalence of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonization on either oral, umbilical or rectum was 16.2% (52/320). A total of 34 (10.6%) and 41 (12.8%) neonates were colonized by </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. on </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">the </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">first day and seventh day of life, respectively. Of 34 neonates colonized on the first day of life, 23 (67.7%) were still being colonized on the seventh day. </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>albicans</i></span><span style="font-family:Verdana;"> 38 (73.1%), was the predominant specie</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> detected followed by </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>glabrata</i></span><span style="font-family:Verdana;"> 10 (19.2%). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The prevalence of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. colonization among neonates with low birth weight is within the reported range and is mainly due to </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> <i>albicans</i></span><span style="font-family:Verdana;">. Future studies are highly needed to explore the role of colonization and subsequent </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp. infections.</span></span></span></span>
