In the present study, computational fluid dynamics （CFD） is used to investigate inspiratory and expiratory airflow characteristics in the human upper respiratory tract for the purpose of identifying the probable loc...In the present study, computational fluid dynamics （CFD） is used to investigate inspiratory and expiratory airflow characteristics in the human upper respiratory tract for the purpose of identifying the probable locations of particle deposition and the wall injury. Computed tomography （CT） scan data was used to reconstruct a three dimensional respiratory tract from trachea to first generation bronchi. To compare, a simplified model of respiratory tract based on Weibel was also used in the study. The steady state results are obtained for an airflow rate of 45 L/min, corresponding to the heavy breathing condition. The velocity distribution, wall shear stress, static pressure and particle deposition are compared for inspiratory flows in simplified and realistic models and expiratory flows in realistic model only. The results show that the location of cartilaginous rings is susceptible to wall injury and local particle deposition.展开更多
The deposition of spherical nanoparticles by convection and Brownian diffusion in a pipe with a cartilaginous ring structure is studied. Analytical results for a fully developed flow are found for small amplitude ring...The deposition of spherical nanoparticles by convection and Brownian diffusion in a pipe with a cartilaginous ring structure is studied. Analytical results for a fully developed flow are found for small amplitude rings using the interactive boundary layer theory. It is found that the local deposition rate is at maximum at a position approximately one twelfth of the spacing between the rings before the minimum cross section of the tube. For larger ring amplitudes the problem is solved numerically and separation then takes place in the depressions between the rings, and maximum deposition is found at the point of reattachment of the flow approximately at the same point as in the analytical theory. Cumulative deposition results are also provided with larger deposition rates with the inclusion of the cartilaginous rings. Deposition results for a developing flow are also provided. For the same volume flux as for fully developed flow the deposition is about 25% larger. In general conclusions about the position of maximum deposition rate from the analytic theory of fully developed flow also applies qualitatively to the case of developing flow.展开更多
基金funded by Department of Science & Technology Government of India through the DST-FIST grant
文摘In the present study, computational fluid dynamics （CFD） is used to investigate inspiratory and expiratory airflow characteristics in the human upper respiratory tract for the purpose of identifying the probable locations of particle deposition and the wall injury. Computed tomography （CT） scan data was used to reconstruct a three dimensional respiratory tract from trachea to first generation bronchi. To compare, a simplified model of respiratory tract based on Weibel was also used in the study. The steady state results are obtained for an airflow rate of 45 L/min, corresponding to the heavy breathing condition. The velocity distribution, wall shear stress, static pressure and particle deposition are compared for inspiratory flows in simplified and realistic models and expiratory flows in realistic model only. The results show that the location of cartilaginous rings is susceptible to wall injury and local particle deposition.
文摘The deposition of spherical nanoparticles by convection and Brownian diffusion in a pipe with a cartilaginous ring structure is studied. Analytical results for a fully developed flow are found for small amplitude rings using the interactive boundary layer theory. It is found that the local deposition rate is at maximum at a position approximately one twelfth of the spacing between the rings before the minimum cross section of the tube. For larger ring amplitudes the problem is solved numerically and separation then takes place in the depressions between the rings, and maximum deposition is found at the point of reattachment of the flow approximately at the same point as in the analytical theory. Cumulative deposition results are also provided with larger deposition rates with the inclusion of the cartilaginous rings. Deposition results for a developing flow are also provided. For the same volume flux as for fully developed flow the deposition is about 25% larger. In general conclusions about the position of maximum deposition rate from the analytic theory of fully developed flow also applies qualitatively to the case of developing flow.
