The accuracy and repeatability of computer aided cervical vertebra landmarking (CACVL) were investigated in cephalogram.120 adolescents (60 boys,60 girls) aged from 9.1 to 17.2 years old were randomly selected.Twenty-...The accuracy and repeatability of computer aided cervical vertebra landmarking (CACVL) were investigated in cephalogram.120 adolescents (60 boys,60 girls) aged from 9.1 to 17.2 years old were randomly selected.Twenty-seven landmarks from the second to fifth cervical vertebrae on the lat-eral cephalogram were identified.In this study,the system of CACVL was developed and used to iden-tify and calculate the landmarks by fast marching method and parabolic curve fitting.The accuracy and repeatability in CACVL group were compared with those in two manual landmarking groups [orthodon-tic experts (OE) group and orthodontic novices (ON) group].The results showed that,as for the accu-racy,there was no significant difference between CACVL group and OE group no matter in x-axis or y-axis (P>0.05),but there was significant difference between CACVL group and ON group,as well as OE group and ON group in both axes (P<0.05).As for the repeatability,CACVL group was more reli-able than OE group and ON group in both axes.It is concluded that CACVL has the same or higher ac-curacy,better repeatability and less workload than manual landmarking methods.It’s reliable for cervi-cal parameters identification on the lateral cephalogram and cervical vertebral maturation prediction in orthodontic practice and research.展开更多
Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer.Methods:Thirteen patients with locally advan...Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer.Methods:Thirteen patients with locally advanced cervical cancer who had been proved by pathobiology were randomly divided into two groups:the ultraselection uterine artery group(group A, n = 6) and the peripheral vein(group B, n = 7).Carboplatin was administered by infusing into artery or vein in both groups at the dosage of 300 mg/m2.Tissues from the cervical tumor were collected at different times after infusion in both groups and then analyzed.Results:The peak concentration of platinum in tumor tissue was about 2.79 times higher in group A than that of group B(P < 0.05).The platinum concentrations in tumor in group A reached its peak levels immediately after infusion.But, group B had delayed time.While, for the time point of 0 min, when the administration finished immediately, the platinum concentration in tumor was significantly higher when compared with group B(P < 0.05).The tumor tissue area under the concentration(AUC) of carboplatin was about 2 times higher in group A than that of group B(P < 0.05).Conclusion:We observed the pharmacological advantages of chemotherapy by using ultraselection uterine artery administration of chemotherapeutic agent carboplatin in tumor tissue which provided theoretical basis and laboratory parameters of the intra-arterial chemotherapy for gynecologic malignancy.展开更多
基金supported by grants from National Natural Sciences Foundation of China (No. 30801314)China Hubei Provincial Science and Technology Department (No.2008CBD088)
文摘The accuracy and repeatability of computer aided cervical vertebra landmarking (CACVL) were investigated in cephalogram.120 adolescents (60 boys,60 girls) aged from 9.1 to 17.2 years old were randomly selected.Twenty-seven landmarks from the second to fifth cervical vertebrae on the lat-eral cephalogram were identified.In this study,the system of CACVL was developed and used to iden-tify and calculate the landmarks by fast marching method and parabolic curve fitting.The accuracy and repeatability in CACVL group were compared with those in two manual landmarking groups [orthodon-tic experts (OE) group and orthodontic novices (ON) group].The results showed that,as for the accu-racy,there was no significant difference between CACVL group and OE group no matter in x-axis or y-axis (P>0.05),but there was significant difference between CACVL group and ON group,as well as OE group and ON group in both axes (P<0.05).As for the repeatability,CACVL group was more reli-able than OE group and ON group in both axes.It is concluded that CACVL has the same or higher ac-curacy,better repeatability and less workload than manual landmarking methods.It’s reliable for cervi-cal parameters identification on the lateral cephalogram and cervical vertebral maturation prediction in orthodontic practice and research.
基金Supported by a grant from the Nature Sciences of Guangdong Province(No. 06024389).
文摘Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer.Methods:Thirteen patients with locally advanced cervical cancer who had been proved by pathobiology were randomly divided into two groups:the ultraselection uterine artery group(group A, n = 6) and the peripheral vein(group B, n = 7).Carboplatin was administered by infusing into artery or vein in both groups at the dosage of 300 mg/m2.Tissues from the cervical tumor were collected at different times after infusion in both groups and then analyzed.Results:The peak concentration of platinum in tumor tissue was about 2.79 times higher in group A than that of group B(P < 0.05).The platinum concentrations in tumor in group A reached its peak levels immediately after infusion.But, group B had delayed time.While, for the time point of 0 min, when the administration finished immediately, the platinum concentration in tumor was significantly higher when compared with group B(P < 0.05).The tumor tissue area under the concentration(AUC) of carboplatin was about 2 times higher in group A than that of group B(P < 0.05).Conclusion:We observed the pharmacological advantages of chemotherapy by using ultraselection uterine artery administration of chemotherapeutic agent carboplatin in tumor tissue which provided theoretical basis and laboratory parameters of the intra-arterial chemotherapy for gynecologic malignancy.
