Objective: This paper aims to study the sociodemographic and clinical aspects of menopausal climacteric syndrome in the city of Kati in Mali. Patients and Methods: This was a quantitative descriptive and cross-section...Objective: This paper aims to study the sociodemographic and clinical aspects of menopausal climacteric syndrome in the city of Kati in Mali. Patients and Methods: This was a quantitative descriptive and cross-sectional study, conducted in the city of Kati from February 1 to July 31, 2021. We included 112 menopausal women. Women were selected from a household survey using the sampling step. We were interested in conjugal, family and professional life, self-esteem and the state of health of women in general. Results: More than half of the women in our study were already postmenopausal (52.2%);the mean age was 50.5 years with the extremes ranging from 41 to 62 years. The majority of them were married (69.9%), housewives (43.4%) and Bambara (53.1%). The most common climacteric syndromes were: joint pain (65.5%), hot flashes (62.8%) and night sweats (56.6%). Genital-urinary syndromes (42.5%) were dominated by decreased libido (41.7%), urinary disorder (23%) and vaginal dryness (14.6%). Genitalia-urinary syndromes increased the frequency of disagreements;Pearson’s Chi-square = 33.63;ddl = 1;P = 0.001. There was a statistically significant relationship between night sweat, genital-urinary syndromes, joint pain, and increased disease frequency with, respectively: Pearson’s chi-square = 4.660;ddl = 1;P = 0.031;Fisher’s exact test, P = 0.001, Pearson’s Chi-square = 8.434;ddl = 1;P = 0.004. There was no statistically significant relationship between climacteric syndrome and family life, work life and self-esteem. Changes in the professional relationship between women and their co-workers included, respectively: arguments (50%);disagreements (25%) and disobedience (25%). Conclusion: Menopause deteriorates the quality of life of women who suffer in silence, hence the need to pay special attention to them.展开更多
To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for tre...To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome were reviewed.The research literatures on acupuncture treatment were major,focusing on the field of acupuncture and moxibustion regulating hypothalamic-pituitary-gonad axis and nerval-endocritic-immune net.Acupuncture and moxibustion could regulate the endocrine environment of menopausal women.Taking advantage of combination biomedicine with multi-sciences,to improve the acupuncture and moxibustion curative effct and probe the mechanism of menopausal pathology and acupuncture and moxibustion function to Women＇s Climacteric Syndrome,is the research direction afterward.展开更多
To evaluate the effects of acupuncture for treatment of climacteric syndrome.Methods:The 65 cases in this series were randomly assigned to the acupuncture group (N=35) and the control group (N=30), with the former tre...To evaluate the effects of acupuncture for treatment of climacteric syndrome.Methods:The 65 cases in this series were randomly assigned to the acupuncture group (N=35) and the control group (N=30), with the former treated by acupuncture and the latter by medication respectively.The therapeutic effects were evaluated by means of the clinical outcome,improvement in the symptom scores and the results of radioimmunoassays.Results:In the acupuncture group,12 cases were cured,16 cases markedly effective,and 6 cases improved,the total effective rate being as high as 97.14%.The decrease in the symptom scores,and especially the elevation of the decreased E_2 level and the decrease of the increased FSH and LH levels, demonstrated that acupuncture therapy was superior to medication.Conclusion:Acupuncture for regulating the mental activities and reinforcing the kidney is an effective therapy for climacteric syndrome.展开更多
Objective: To find out the incidence of high-risk HPV infections on climacteric women within our area of influence;and to typify HPV genotypes on women with normal cytology that come to our hospitalary unit of menopau...Objective: To find out the incidence of high-risk HPV infections on climacteric women within our area of influence;and to typify HPV genotypes on women with normal cytology that come to our hospitalary unit of menopausia. Material and Method: Cross-sectional study;with a random sample of 140 cases of climacteric women of ≥50 years of age, with normal Pap smears for the last 12 months. HPV determination was carried out by PCR for screening, and by hybrid capture for genotype typification. Results: The percentage of climacteric women who are carriers of oncogenic HPV and a normal Pap smear was of 11.43% (16/140 cases). The genotype found most frequently was HPV-16, followed by HPV-58, 51 and 18. Conclusions: We found a high prevalence of women who were carriers of oncogenic HPV in climacteric women with normal Pap smears (latent infections) in our health region. We consider that cervical cancer screening, either by PCR or conventional Pap smear, should not be minimized or ignored from 50 years of age onwards.展开更多
Female climacteric syndrome is a common disease occurring before and after menopause. The author has treated the disease with ear embedding therapy, and achieved satisfactory therapeutic results. The following is a re...Female climacteric syndrome is a common disease occurring before and after menopause. The author has treated the disease with ear embedding therapy, and achieved satisfactory therapeutic results. The following is a report of the clinical observation.展开更多
Melon （Cucumis melo L.） is an important horticultural crop worldwide. Ethylene regulates the ripening process and affects the ripening rate. To screen genes that are differentially expressed at the burst of ethylene...Melon （Cucumis melo L.） is an important horticultural crop worldwide. Ethylene regulates the ripening process and affects the ripening rate. To screen genes that are differentially expressed at the burst of ethylene climacteric in melon fruit, we performed suppression subtractive hybridization （SSH） to generate forward and reverse libraries, for which we sequenced 439 and 445 clones, respectively. Our BLAST analysis showed that the genes from the 2 libraries were involved in metabolism, signal transduction, cell structure, transcription, translation, and defense. Six genes were analyzed by qRT-PCR during the differential developmental stage of melon fruit. Our results provide new insight into the understanding of climacteric ripening of melon fruit.展开更多
Objective To search the effects of the extractive E of Ginseng(EG)on experimental climacteric syndrome in rats.Methods Extirpating the both sides of ovary of rats to turbulence estrogen secretion,induce climacteric sy...Objective To search the effects of the extractive E of Ginseng(EG)on experimental climacteric syndrome in rats.Methods Extirpating the both sides of ovary of rats to turbulence estrogen secretion,induce climacteric syndrome.The weight,bite and sup,substance of bone,blood lipid,calcium urine biochemistry,estrodiol,behavior perfomance were also observed.Results The body weight of ovariotomied rat was controlled,bone density was increased,estradiol level increased,the weight of bone increased.Conclusions EG ameliorated climacteric syndrome.Increase bone density and bone mine content,enhanced the level of estradiol.展开更多
Aim: To search for the best therapeutic method for climacteric syndrome. Methods: A total of 190 cases of climacteric syndrome participants were randomly divided into auricular plus body acupuncture group (treatment g...Aim: To search for the best therapeutic method for climacteric syndrome. Methods: A total of 190 cases of climacteric syndrome participants were randomly divided into auricular plus body acupuncture group (treatment group, n=96) and simple body acupuncture group (control group, n=94). Serum sexual hormone (FSH, LH and E2) and blood lipid (TC, LDL C, HDL C and TG) levels were detected before and after treatment. Results: After 30 sessions of treatment, the total effective rates of treatment and control groups were 82.29% and 76.02% respectively, with the former being significantly higher than the later (P<0.01). In comparison with pre treatment of each group, serum follicle stimulating hormone (FSH) and luterotropic hormone (LH) levels lowered significantly; serum estradiol (E 2) increased remarkably (P<0.05-0.01); serum high density lipoprotein cholesterol (HDL C) of two groups raised significantly (P<0.05-0.01), and low density lipoprotein (LDL) C of treatment group decreased evidently (P<0.05). In addition, the improvement of complaints of hot flushes, sweating, paresthesia, insomnia and emotional irritability in treatment group is significantly better than that of control group. Conclusion: Auricular acupuncture combined with body acupuncture has a better therapeutic effect than that of simple body acupuncture in the treatment of climacteric syndrome.展开更多
Objectives: To estimate the age at natural menopause and the frequency of climacteric symptoms in Chinese women.Design: A cross-sectional study of randomly recruited 788 women, aged 45 to 55 years in Beijing.Results: ...Objectives: To estimate the age at natural menopause and the frequency of climacteric symptoms in Chinese women.Design: A cross-sectional study of randomly recruited 788 women, aged 45 to 55 years in Beijing.Results: The mean age at natural menopause was 48. 2 years. there was a trend that women with more parities, more babies breast fed or longer duration of breastfeeding had a delayed age at natural menopause. Higher socio-economic status was related to a later cessetion of menstruation. Vasomotor and psychological symptoms increased during menopause transition. However, psychological disorders tended to decrease after the menopause. Bone-joint problems were inversely associated with daily activi-ty or physical exercise. Perimenopausal women experienced the most frequent climacteric symptoms.Conclusion: The menopausal age was influenced by reproductive factors and socio-economic status-Vasomotor and psychological symptoms were associated with the menopausal status. However, bone-joint problems was not.展开更多
<strong>Background:</strong> There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle...<strong>Background:</strong> There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle. <strong>Objective: </strong>The aim of this study was to determine the differences in male climacteric symptoms depending on the number of working years and to determine whether lifestyle habits differ depending on the number of working years in rotating shift workers. <strong>Methods:</strong> We collected participant’s data from the manufacturing companies in Japan during the period from March to May in 2017. We conducted a self-administered questionnaire survey in 1561 male rotating night shift workers. Male climacteric symptoms were evaluated by using the Aging Males’ Symptoms (AMS) rating scale. We analyzed 636 rotating shift workers aged over 40 years old whose all AMS data was collected. <strong>Results:</strong> A significant difference in psychological AMS score was found between men who had worked for 10 - 19 years (9.4 ± 3.9) and men who had worked for more than 40 years (7.6 ± 3.0) (p = 0.011). Sexual functional AMS score significantly differed depending on the number of working years (less than 10 years: 8.1 ± 3.9, 10 - 19 years: 9.8 ± 4.1, 20 - 29 years: 7.9 ± 3.3, 30 - 39 years: 9.3 ± 3.5, more than 40 years: 9.3 ± 3.5) (p < 0.001). The proportion of workers with a balanced meal intake was significantly lower in men who had worked for less than 10 years and the proportions of such workers were significantly higher in men who had worked for 10 - 19 years and for more than 40 years. The proportions of men who did not drink alcohol were high in men who had worked for less than 10 years and 20 - 29 years and low in men who had worked more than 30 years. <strong>Conclusion: </strong>Psychological AMS score and sexual functional AMS score are significantly different among the 5 groups according to the number of working years on rotating shift. In addition, well-balanced diet on day shift and reduction of alcohol drinking is a related-factor for long-term rotating night shift workers.展开更多
The diagnosis of climacteric disorders in gynecology is performed on the basis of symptoms rather than hormonal levels. Generally, the follicle-stimulating hormone (FSH) level increases when the 17β-estradiol (E2) le...The diagnosis of climacteric disorders in gynecology is performed on the basis of symptoms rather than hormonal levels. Generally, the follicle-stimulating hormone (FSH) level increases when the 17β-estradiol (E2) level decreases in menopause. However, the problem of these hormones should be determined by strict timing of sampling, and there are individual specificities of decreases of hormone levels. We considered that anti-Mullerian hormone (AMH) can be measured at any time of the menstrual cycle and that it shows ovary functional decline earlier than FSH/E2, and we examined whether AMH would possibly become a good index for climacteric disorders. The subjects were 163 healthy females and 21 patients with climacteric disorders between 20 and 59 years old. We examined AMH, FSH and E2 at the same time. It is understood that in healthy females, AMH decreases with age and a decline in ovary function occurs at a relatively early age. Patients visiting clinics for climacteric disorders often have normal-range serum FSH/E2 levels, and it is clear that these values could not serve as indices of menopause at these inspections. Upon measurement of AMH in patients with climacteric disorders, most showed less than normal range (< 14 pmol/L), suggesting a decline in ovarian function. In addition, AMH was low in females with climacteric disorders compared with those without them. In conclusion, AMH was suggested as an objective index for climacteric disorders and possibly as a new diagnostic marker.展开更多
Background: This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Me...Background: This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Metabolic Syn- drome according to sample characteristics. Methods: A cross-sectional study was conducted with 551 women treated at a clinic in southern Brazil. MetS and its components were defined according to NCEP-ATP III and menopausal status as pre, peri, and post-menopause. Prevalences of menopausal status and of MetS and its components were calculated. Estimates of prevalence ratios crude and adjusted with confidence intervals of 95% were calculated by Poisson Regression with robust variance. Demographic, socioeconomic, behavioral, and reproductive characteristics were considered as potential confounding factors in multivariable models based on a conceptual framework of MetS determination. Results: The prevalence of Metabolic Syndrome in the sample was 56.1% (CI95%: 51.9 to 60.2), being more common among older women (56 to 65 years), with low education, menarche 11 years old, with three or more pregnancies and in the post-menopausal period. In multivariate analysis, there was an increase of prevalence ratios when comparing perimenopause and post-menopause with pre-menopause;however, the confidence intervals include the unit. Regarding the analysis of isolated components in the sample, the most prevalent altered components were: hypertension (84.8%;CI95%: 81.7 to 87.8), waist circumference (66.4%;CI95%: 62.5 to 70.4) and HDL cholesterol (51.7%;CI95%: 47.5 to 55.9). There was a linear increase on mean blood glucose through menopausal status. Conclusions: Our study indicates variation on the distribution of MetS and each component according to menopausal status and other women characteristics. Future studies on MetS should also have foresight to use this type of approach to improve understanding and targeting of actions and programs focusing on women in this period of life.展开更多
Background: With population aging occurring worldwide, promoting climacteric women’s health has become the object of important studies. Purpose: Observing the prevalence of depression in climacteric women and their s...Background: With population aging occurring worldwide, promoting climacteric women’s health has become the object of important studies. Purpose: Observing the prevalence of depression in climacteric women and their self-evaluation of the depression factors is the main goal of this study. Design: This cross-sectional research is enquiry descriptive. Methods: The sample was composed of 48 climacteric women (between 45 and 65 years old) non-selected volunteers, served by the Centers for Psycho and Social Attention (CAPS) of Specialized Mental Medicine, in Sorocaba, via the Beck Depression Inventory (BDI) questionnaire. Results: Checking the mean and frequency distribution, the climacteric women presented a prevalence of 37.5% of moderate depression (BDIindex = 24.39 ± 3.13), and 47.92% of severe depression (BDIindex = 38.13 ± 6.78). Concerning the symptoms, Spearman rank order correlation was found as the highest concerns, hierarchically: indecision (r = 0.72, p Conclusions: The prevalence of depression in these CAPS climacteric women was considered very high (86% ranking from moderate to severe) caused mostly by indecision, anhedonia, guilt, crying and self-esteem, followed by inutility, self-criticism and loss of concentration.展开更多
Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Met...Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor Wang Yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor Wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.展开更多
Objective： To explore the effects of Chinese medicine prescription Zuogui Pill（左归丸, ZGP） on monoamine neurotransmitters and sex hormones in climacteric rats with induced panic attacks. Methods： Forty-eight clim...Objective： To explore the effects of Chinese medicine prescription Zuogui Pill（左归丸, ZGP） on monoamine neurotransmitters and sex hormones in climacteric rats with induced panic attacks. Methods： Forty-eight climacteric female rats were randomized into 6 groups with 8 rats in each group： the control group, the model group, the low-, medium- and high-dose ZGP groups and the alprazolam group. Rats in the low-, medium- and high-dose ZGP groups were administered 4.725, 9.45, or 18.9 g/kg ZGP by gastric perfusion, respectively. The alprazolam group was treated by gastric perfusion with 0.036 mg/kg alprazolam. The control and model groups were treated with distilled water. The animals were pretreated once daily for 8 consecutive weeks. The behaviors of rats in the open field test and the elevated T-maze（ETM） were observed after induced panic attack, and the levels of brain monoamine neurotransmitters and the plasma levels of sex hormones were measured. Results： Compared with the control group, the mean ETM escape time and the levels of 5-hydroxytryptamine（5-HT） and noradrenalin（NE） of the model group were significantly reduced（P〈0.05）, Compared with the model group, the mean ETM escape time and the 5-HT and NE levels of all the ZGP groups increased significantly（P〈0.05 or P〈0.01）. However, no significant difference was observed in the levels of sex hormones between the groups. Conclusion： Pretreatment with ZGP in climacteric rats may improve the behavior of panic attack, which may be related to increased 5-HT and NE in the brain.展开更多
Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities.It culminates in desirable changes in the structural and textural properties and is governed...Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities.It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network.Much is known about ethylene,one of the most important metabolites promoting the ripening of climacteric fruits.However,the dynamic interplay between phytohormones also plays an important part.Additional regulatory factors such as transcription factors(TFs)and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening.Here,we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.展开更多
he levels of estrogen receptor (ER) in human peripheral leucocytes in 22 women withclimacteric syndrome were measured by radioligand method. The results were compared with those of 12healthy women of child-bearing age...he levels of estrogen receptor (ER) in human peripheral leucocytes in 22 women withclimacteric syndrome were measured by radioligand method. The results were compared with those of 12healthy women of child-bearing age. It was found that the contents of leucocytic ER in patients with cli-macteric syndrome were significantly lower than healthy women of child-bearing age (372±149 vs 1143±255 Rs binding sites/cell). The authors used a Chinese prescription---Liuwei Dihuang Pills (LDP) totreat the patients for 2 months. The levels of leucocytic ER were increased affer treatment. The data indi-cate a decrease of ER Ievels in leucocytes may be involved in the pathogenesis of climacteric syndrome.LDP not only increase plasma estradiol levels , but also increase the leucocytic ER levels. This may be thebasis of the therapeutic effect of LDP on climacteric syndrome.展开更多
Perimenopause syndrome refers to the syndrome of the disorders of multiple systems of women around menopause caused by the reduction in secreted estrogen and is also known as menopause syndrome.Its pathogenesis involv...Perimenopause syndrome refers to the syndrome of the disorders of multiple systems of women around menopause caused by the reduction in secreted estrogen and is also known as menopause syndrome.Its pathogenesis involves increasing age,the abatement of ovarian function,and psychological change caused by the increasing life pressure.The above factors lead to physical and mental changes in postmenopausal women.This paper summarizes the pathogenesis of perimenopause from the perspective of gene studies and existing experimental studies and provide some ideas for clinical treatment and research.展开更多
Objective:We aimed to investigate the safety and efficacy of acupuncture in the treatment of climacteric insomnia compared with western medicine through a comprehensive metaanalysis.Methods:Literature retrieval,resear...Objective:We aimed to investigate the safety and efficacy of acupuncture in the treatment of climacteric insomnia compared with western medicine through a comprehensive metaanalysis.Methods:Literature retrieval,research selection and data extraction were done independently and in duplicate.Effect-size estimates are expressed as risk ratio(RR)and 95%confidence interval(CI).Results:Summary data from 27 articles,involving a total of 2349 menopausal women,were meta-analyzed.The overall analysis showed that the clinical cure rate(RR=1.85,95%CI:1.57~2.18,P<0.001)of acupuncture was 1.85 times higher than western medicine,and the markedly effective rate was 1.3 times higher than that of westernmedicine(RR=1.30,95%CI:1.09~1.54,P=0.003).In terms of Pittsburgh Sleep quality Index((PSQI)),simple acupuncture is superior to western medicine in sleep quality,falling asleep time,sleep time,sleep efficiency and daytime dysfunction.In the evaluation of adverse reactions,the incidence of adverse events in the acupuncture-related therapy group(3.5%)was lower than that in the western medicine group(12.5%).Conclusion:The results of metaanalysis show that the clinical efficacy of acupuncture in the treatment of climacteric insomnia is better than that of western medicine which has better efficacy and safety.The acupuncture therapy is suitable for clinical.展开更多
文摘Objective: This paper aims to study the sociodemographic and clinical aspects of menopausal climacteric syndrome in the city of Kati in Mali. Patients and Methods: This was a quantitative descriptive and cross-sectional study, conducted in the city of Kati from February 1 to July 31, 2021. We included 112 menopausal women. Women were selected from a household survey using the sampling step. We were interested in conjugal, family and professional life, self-esteem and the state of health of women in general. Results: More than half of the women in our study were already postmenopausal (52.2%);the mean age was 50.5 years with the extremes ranging from 41 to 62 years. The majority of them were married (69.9%), housewives (43.4%) and Bambara (53.1%). The most common climacteric syndromes were: joint pain (65.5%), hot flashes (62.8%) and night sweats (56.6%). Genital-urinary syndromes (42.5%) were dominated by decreased libido (41.7%), urinary disorder (23%) and vaginal dryness (14.6%). Genitalia-urinary syndromes increased the frequency of disagreements;Pearson’s Chi-square = 33.63;ddl = 1;P = 0.001. There was a statistically significant relationship between night sweat, genital-urinary syndromes, joint pain, and increased disease frequency with, respectively: Pearson’s chi-square = 4.660;ddl = 1;P = 0.031;Fisher’s exact test, P = 0.001, Pearson’s Chi-square = 8.434;ddl = 1;P = 0.004. There was no statistically significant relationship between climacteric syndrome and family life, work life and self-esteem. Changes in the professional relationship between women and their co-workers included, respectively: arguments (50%);disagreements (25%) and disobedience (25%). Conclusion: Menopause deteriorates the quality of life of women who suffer in silence, hence the need to pay special attention to them.
文摘To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome were reviewed.The research literatures on acupuncture treatment were major,focusing on the field of acupuncture and moxibustion regulating hypothalamic-pituitary-gonad axis and nerval-endocritic-immune net.Acupuncture and moxibustion could regulate the endocrine environment of menopausal women.Taking advantage of combination biomedicine with multi-sciences,to improve the acupuncture and moxibustion curative effct and probe the mechanism of menopausal pathology and acupuncture and moxibustion function to Women＇s Climacteric Syndrome,is the research direction afterward.
文摘To evaluate the effects of acupuncture for treatment of climacteric syndrome.Methods:The 65 cases in this series were randomly assigned to the acupuncture group (N=35) and the control group (N=30), with the former treated by acupuncture and the latter by medication respectively.The therapeutic effects were evaluated by means of the clinical outcome,improvement in the symptom scores and the results of radioimmunoassays.Results:In the acupuncture group,12 cases were cured,16 cases markedly effective,and 6 cases improved,the total effective rate being as high as 97.14%.The decrease in the symptom scores,and especially the elevation of the decreased E_2 level and the decrease of the increased FSH and LH levels, demonstrated that acupuncture therapy was superior to medication.Conclusion:Acupuncture for regulating the mental activities and reinforcing the kidney is an effective therapy for climacteric syndrome.
文摘Objective: To find out the incidence of high-risk HPV infections on climacteric women within our area of influence;and to typify HPV genotypes on women with normal cytology that come to our hospitalary unit of menopausia. Material and Method: Cross-sectional study;with a random sample of 140 cases of climacteric women of ≥50 years of age, with normal Pap smears for the last 12 months. HPV determination was carried out by PCR for screening, and by hybrid capture for genotype typification. Results: The percentage of climacteric women who are carriers of oncogenic HPV and a normal Pap smear was of 11.43% (16/140 cases). The genotype found most frequently was HPV-16, followed by HPV-58, 51 and 18. Conclusions: We found a high prevalence of women who were carriers of oncogenic HPV in climacteric women with normal Pap smears (latent infections) in our health region. We consider that cervical cancer screening, either by PCR or conventional Pap smear, should not be minimized or ignored from 50 years of age onwards.
文摘Female climacteric syndrome is a common disease occurring before and after menopause. The author has treated the disease with ear embedding therapy, and achieved satisfactory therapeutic results. The following is a report of the clinical observation.
基金supported by the National Natural Science Foundation of China(30960159)the Specialized Research Foundation for the Doctoral Program of Higher Education(200801260002)
文摘Melon （Cucumis melo L.） is an important horticultural crop worldwide. Ethylene regulates the ripening process and affects the ripening rate. To screen genes that are differentially expressed at the burst of ethylene climacteric in melon fruit, we performed suppression subtractive hybridization （SSH） to generate forward and reverse libraries, for which we sequenced 439 and 445 clones, respectively. Our BLAST analysis showed that the genes from the 2 libraries were involved in metabolism, signal transduction, cell structure, transcription, translation, and defense. Six genes were analyzed by qRT-PCR during the differential developmental stage of melon fruit. Our results provide new insight into the understanding of climacteric ripening of melon fruit.
文摘Objective To search the effects of the extractive E of Ginseng(EG)on experimental climacteric syndrome in rats.Methods Extirpating the both sides of ovary of rats to turbulence estrogen secretion,induce climacteric syndrome.The weight,bite and sup,substance of bone,blood lipid,calcium urine biochemistry,estrodiol,behavior perfomance were also observed.Results The body weight of ovariotomied rat was controlled,bone density was increased,estradiol level increased,the weight of bone increased.Conclusions EG ameliorated climacteric syndrome.Increase bone density and bone mine content,enhanced the level of estradiol.
文摘Aim: To search for the best therapeutic method for climacteric syndrome. Methods: A total of 190 cases of climacteric syndrome participants were randomly divided into auricular plus body acupuncture group (treatment group, n=96) and simple body acupuncture group (control group, n=94). Serum sexual hormone (FSH, LH and E2) and blood lipid (TC, LDL C, HDL C and TG) levels were detected before and after treatment. Results: After 30 sessions of treatment, the total effective rates of treatment and control groups were 82.29% and 76.02% respectively, with the former being significantly higher than the later (P<0.01). In comparison with pre treatment of each group, serum follicle stimulating hormone (FSH) and luterotropic hormone (LH) levels lowered significantly; serum estradiol (E 2) increased remarkably (P<0.05-0.01); serum high density lipoprotein cholesterol (HDL C) of two groups raised significantly (P<0.05-0.01), and low density lipoprotein (LDL) C of treatment group decreased evidently (P<0.05). In addition, the improvement of complaints of hot flushes, sweating, paresthesia, insomnia and emotional irritability in treatment group is significantly better than that of control group. Conclusion: Auricular acupuncture combined with body acupuncture has a better therapeutic effect than that of simple body acupuncture in the treatment of climacteric syndrome.
文摘Objectives: To estimate the age at natural menopause and the frequency of climacteric symptoms in Chinese women.Design: A cross-sectional study of randomly recruited 788 women, aged 45 to 55 years in Beijing.Results: The mean age at natural menopause was 48. 2 years. there was a trend that women with more parities, more babies breast fed or longer duration of breastfeeding had a delayed age at natural menopause. Higher socio-economic status was related to a later cessetion of menstruation. Vasomotor and psychological symptoms increased during menopause transition. However, psychological disorders tended to decrease after the menopause. Bone-joint problems were inversely associated with daily activi-ty or physical exercise. Perimenopausal women experienced the most frequent climacteric symptoms.Conclusion: The menopausal age was influenced by reproductive factors and socio-economic status-Vasomotor and psychological symptoms were associated with the menopausal status. However, bone-joint problems was not.
文摘<strong>Background:</strong> There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle. <strong>Objective: </strong>The aim of this study was to determine the differences in male climacteric symptoms depending on the number of working years and to determine whether lifestyle habits differ depending on the number of working years in rotating shift workers. <strong>Methods:</strong> We collected participant’s data from the manufacturing companies in Japan during the period from March to May in 2017. We conducted a self-administered questionnaire survey in 1561 male rotating night shift workers. Male climacteric symptoms were evaluated by using the Aging Males’ Symptoms (AMS) rating scale. We analyzed 636 rotating shift workers aged over 40 years old whose all AMS data was collected. <strong>Results:</strong> A significant difference in psychological AMS score was found between men who had worked for 10 - 19 years (9.4 ± 3.9) and men who had worked for more than 40 years (7.6 ± 3.0) (p = 0.011). Sexual functional AMS score significantly differed depending on the number of working years (less than 10 years: 8.1 ± 3.9, 10 - 19 years: 9.8 ± 4.1, 20 - 29 years: 7.9 ± 3.3, 30 - 39 years: 9.3 ± 3.5, more than 40 years: 9.3 ± 3.5) (p < 0.001). The proportion of workers with a balanced meal intake was significantly lower in men who had worked for less than 10 years and the proportions of such workers were significantly higher in men who had worked for 10 - 19 years and for more than 40 years. The proportions of men who did not drink alcohol were high in men who had worked for less than 10 years and 20 - 29 years and low in men who had worked more than 30 years. <strong>Conclusion: </strong>Psychological AMS score and sexual functional AMS score are significantly different among the 5 groups according to the number of working years on rotating shift. In addition, well-balanced diet on day shift and reduction of alcohol drinking is a related-factor for long-term rotating night shift workers.
文摘The diagnosis of climacteric disorders in gynecology is performed on the basis of symptoms rather than hormonal levels. Generally, the follicle-stimulating hormone (FSH) level increases when the 17β-estradiol (E2) level decreases in menopause. However, the problem of these hormones should be determined by strict timing of sampling, and there are individual specificities of decreases of hormone levels. We considered that anti-Mullerian hormone (AMH) can be measured at any time of the menstrual cycle and that it shows ovary functional decline earlier than FSH/E2, and we examined whether AMH would possibly become a good index for climacteric disorders. The subjects were 163 healthy females and 21 patients with climacteric disorders between 20 and 59 years old. We examined AMH, FSH and E2 at the same time. It is understood that in healthy females, AMH decreases with age and a decline in ovary function occurs at a relatively early age. Patients visiting clinics for climacteric disorders often have normal-range serum FSH/E2 levels, and it is clear that these values could not serve as indices of menopause at these inspections. Upon measurement of AMH in patients with climacteric disorders, most showed less than normal range (< 14 pmol/L), suggesting a decline in ovarian function. In addition, AMH was low in females with climacteric disorders compared with those without them. In conclusion, AMH was suggested as an objective index for climacteric disorders and possibly as a new diagnostic marker.
文摘Background: This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Metabolic Syn- drome according to sample characteristics. Methods: A cross-sectional study was conducted with 551 women treated at a clinic in southern Brazil. MetS and its components were defined according to NCEP-ATP III and menopausal status as pre, peri, and post-menopause. Prevalences of menopausal status and of MetS and its components were calculated. Estimates of prevalence ratios crude and adjusted with confidence intervals of 95% were calculated by Poisson Regression with robust variance. Demographic, socioeconomic, behavioral, and reproductive characteristics were considered as potential confounding factors in multivariable models based on a conceptual framework of MetS determination. Results: The prevalence of Metabolic Syndrome in the sample was 56.1% (CI95%: 51.9 to 60.2), being more common among older women (56 to 65 years), with low education, menarche 11 years old, with three or more pregnancies and in the post-menopausal period. In multivariate analysis, there was an increase of prevalence ratios when comparing perimenopause and post-menopause with pre-menopause;however, the confidence intervals include the unit. Regarding the analysis of isolated components in the sample, the most prevalent altered components were: hypertension (84.8%;CI95%: 81.7 to 87.8), waist circumference (66.4%;CI95%: 62.5 to 70.4) and HDL cholesterol (51.7%;CI95%: 47.5 to 55.9). There was a linear increase on mean blood glucose through menopausal status. Conclusions: Our study indicates variation on the distribution of MetS and each component according to menopausal status and other women characteristics. Future studies on MetS should also have foresight to use this type of approach to improve understanding and targeting of actions and programs focusing on women in this period of life.
文摘Background: With population aging occurring worldwide, promoting climacteric women’s health has become the object of important studies. Purpose: Observing the prevalence of depression in climacteric women and their self-evaluation of the depression factors is the main goal of this study. Design: This cross-sectional research is enquiry descriptive. Methods: The sample was composed of 48 climacteric women (between 45 and 65 years old) non-selected volunteers, served by the Centers for Psycho and Social Attention (CAPS) of Specialized Mental Medicine, in Sorocaba, via the Beck Depression Inventory (BDI) questionnaire. Results: Checking the mean and frequency distribution, the climacteric women presented a prevalence of 37.5% of moderate depression (BDIindex = 24.39 ± 3.13), and 47.92% of severe depression (BDIindex = 38.13 ± 6.78). Concerning the symptoms, Spearman rank order correlation was found as the highest concerns, hierarchically: indecision (r = 0.72, p Conclusions: The prevalence of depression in these CAPS climacteric women was considered very high (86% ranking from moderate to severe) caused mostly by indecision, anhedonia, guilt, crying and self-esteem, followed by inutility, self-criticism and loss of concentration.
文摘Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor Wang Yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor Wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.
基金Supported by the Natural Science Foundation of Guangdong Province,China(No.8151040701000033)
文摘Objective： To explore the effects of Chinese medicine prescription Zuogui Pill（左归丸, ZGP） on monoamine neurotransmitters and sex hormones in climacteric rats with induced panic attacks. Methods： Forty-eight climacteric female rats were randomized into 6 groups with 8 rats in each group： the control group, the model group, the low-, medium- and high-dose ZGP groups and the alprazolam group. Rats in the low-, medium- and high-dose ZGP groups were administered 4.725, 9.45, or 18.9 g/kg ZGP by gastric perfusion, respectively. The alprazolam group was treated by gastric perfusion with 0.036 mg/kg alprazolam. The control and model groups were treated with distilled water. The animals were pretreated once daily for 8 consecutive weeks. The behaviors of rats in the open field test and the elevated T-maze（ETM） were observed after induced panic attack, and the levels of brain monoamine neurotransmitters and the plasma levels of sex hormones were measured. Results： Compared with the control group, the mean ETM escape time and the levels of 5-hydroxytryptamine（5-HT） and noradrenalin（NE） of the model group were significantly reduced（P〈0.05）, Compared with the model group, the mean ETM escape time and the 5-HT and NE levels of all the ZGP groups increased significantly（P〈0.05 or P〈0.01）. However, no significant difference was observed in the levels of sex hormones between the groups. Conclusion： Pretreatment with ZGP in climacteric rats may improve the behavior of panic attack, which may be related to increased 5-HT and NE in the brain.
基金the National Natural Science Foundation of China(31722047)the Liaoning Revitalization Talents Program(XLYC1802019).
文摘Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities.It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network.Much is known about ethylene,one of the most important metabolites promoting the ripening of climacteric fruits.However,the dynamic interplay between phytohormones also plays an important part.Additional regulatory factors such as transcription factors(TFs)and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening.Here,we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.
文摘he levels of estrogen receptor (ER) in human peripheral leucocytes in 22 women withclimacteric syndrome were measured by radioligand method. The results were compared with those of 12healthy women of child-bearing age. It was found that the contents of leucocytic ER in patients with cli-macteric syndrome were significantly lower than healthy women of child-bearing age (372±149 vs 1143±255 Rs binding sites/cell). The authors used a Chinese prescription---Liuwei Dihuang Pills (LDP) totreat the patients for 2 months. The levels of leucocytic ER were increased affer treatment. The data indi-cate a decrease of ER Ievels in leucocytes may be involved in the pathogenesis of climacteric syndrome.LDP not only increase plasma estradiol levels , but also increase the leucocytic ER levels. This may be thebasis of the therapeutic effect of LDP on climacteric syndrome.
基金National Natural Science Foundation of China(No.81660830)Open Project for Guangxi Key Laboratory of Chinese Medicine Foundation Research of Guangxi(No.15-140-32-06)+3 种基金Open Project for Guangxi First-class Discipline Construction of Guangxi University of Chinese Medicine(No.2019XK038)Project for Improving Basic Capabilities of Middle-aged and Young Teachers in Guangxi Institutions of Higher Learning(No.KY2016YB835,No.KY2016YB833)Funded by Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine(No.2018005)Guangxi first-class discipline construction project(No.Gui Jiao Ke Yan[2018]12)。
文摘Perimenopause syndrome refers to the syndrome of the disorders of multiple systems of women around menopause caused by the reduction in secreted estrogen and is also known as menopause syndrome.Its pathogenesis involves increasing age,the abatement of ovarian function,and psychological change caused by the increasing life pressure.The above factors lead to physical and mental changes in postmenopausal women.This paper summarizes the pathogenesis of perimenopause from the perspective of gene studies and existing experimental studies and provide some ideas for clinical treatment and research.
基金Innovation program of personnel department for returned overseas students(No.2015192)。
文摘Objective:We aimed to investigate the safety and efficacy of acupuncture in the treatment of climacteric insomnia compared with western medicine through a comprehensive metaanalysis.Methods:Literature retrieval,research selection and data extraction were done independently and in duplicate.Effect-size estimates are expressed as risk ratio(RR)and 95%confidence interval(CI).Results:Summary data from 27 articles,involving a total of 2349 menopausal women,were meta-analyzed.The overall analysis showed that the clinical cure rate(RR=1.85,95%CI:1.57~2.18,P<0.001)of acupuncture was 1.85 times higher than western medicine,and the markedly effective rate was 1.3 times higher than that of westernmedicine(RR=1.30,95%CI:1.09~1.54,P=0.003).In terms of Pittsburgh Sleep quality Index((PSQI)),simple acupuncture is superior to western medicine in sleep quality,falling asleep time,sleep time,sleep efficiency and daytime dysfunction.In the evaluation of adverse reactions,the incidence of adverse events in the acupuncture-related therapy group(3.5%)was lower than that in the western medicine group(12.5%).Conclusion:The results of metaanalysis show that the clinical efficacy of acupuncture in the treatment of climacteric insomnia is better than that of western medicine which has better efficacy and safety.The acupuncture therapy is suitable for clinical.
