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Overall clinical course of indeterminate dendritic cell tumor patients without skin lesions:A rare case report
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作者 Hao Liang Yun-Fei Zhao +1 位作者 Liu-Ping Zhang Ya-Kun Wu 《World Journal of Clinical Cases》 SCIE 2024年第19期4022-4028,共7页
BACKGROUND Indeterminate dendritic cell tumor(IDCT)is a rare tumor of immune cells,and IDCT patients without skin lesions are rarely reported.Therefore,the clinical course in this type of patient is unclear,and furthe... BACKGROUND Indeterminate dendritic cell tumor(IDCT)is a rare tumor of immune cells,and IDCT patients without skin lesions are rarely reported.Therefore,the clinical course in this type of patient is unclear,and further research on the underlying pathological mechanisms and appropriate treatments is needed.CASE SUMMARY This study describes a female IDCT patient with bile duct lesions.The strong mimicry of IDCT lesions confused doctors,and consequently,this patient,who had no skin lesions,was first diagnosed with cholangiocarcinoma.Then,she presented with persistent abdominal distension without jaundice.Enlarged mesenteric lymph nodes along with massive ascites were observed in the subsequent imaging examination.However,no tumor cells or pathogens were found in the three subsequent ascites analyses.It took 2 years to reach the correct diagnosis,which was eventually obtained by performing surgery for biopsy of the patient’s abdominal lymph nodes.However,by then,she was already in a cachexic state.Finally,she received a cycle of cyclophosphamide therapy and was advised to visit a hospital specializing in rare diseases.CONCLUSION For IDCT patients without skin lesions,early biopsy is the key to obtaining a correct diagnosis.Moreover,the collective management of IDCT patients is important.Further histological and molecular biology studies based on human specimens are critical for understanding the pathological mechanism of dendritic cell tumors in the future. 展开更多
关键词 Indeterminate dendritic cell tumor clinical development Surgical biopsy Collective management Dendritic cell Case report
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Immune checkpoints in targetedi-mmunotherapy of pancreatic cancer:New hope for clinical development 被引量:5
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作者 Seyed Hossein Kiaie Mohammad Javad Sanaei +5 位作者 Masoud Heshmati Zahra Asadzadeh Iman Azimi Saleh Hadidi Reza Jafari Behzad Baradaran 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第5期1083-1097,共15页
Immunotherapy has been recently considered as a promising alternative for cancer treatment.Indeed,targeting of immune checkpoint(ICP)strategies have shown significant success in human malignancies.However,despite rema... Immunotherapy has been recently considered as a promising alternative for cancer treatment.Indeed,targeting of immune checkpoint(ICP)strategies have shown significant success in human malignancies.However,despite remarkable success of cancer immunotherapy in pancreatic cancer(PCa),many of the developed immunotherapy methods show poor therapeutic outcomes in PCa with no or few effective treatment options thus far.In this process,immunosuppression in the tumor microenvironment(TME)is found to be the main obstacle to the effectiveness of antitumor immune response induced by an immunotherapy method.In this paper,the latest findings on the ICPs,which mediate immunosuppression in the TME have been reviewed.In addition,different approaches for targeting ICPs in the TME of PCa have been discussed.This review has also synopsized the cutting-edge advances in the latest studies to clinical applications of ICP-targeted therapy in PCa. 展开更多
关键词 Immune checkpoint Pancreatic cancer Tumor microenvironment IMMUNOTHERAPY clinical development
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Artificial blood——RBC Substitute :Research & development and clinical trials
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《中国输血杂志》 CAS CSCD 2001年第S1期306-314,共9页
关键词 RBC Substitute development and clinical trials RESEARCH Artificial blood
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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment
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作者 ABHISHEK WAHI MAMTA BISHNOI +6 位作者 NEHA RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR HARDEEP SINGH TULI MADHU GUPTA 《Oncology Research》 SCIE 2024年第1期19-47,共29页
Cancer is a leading cause of death globally,with limited treatment options and several limitations.Chemotherapeutic agents often result in toxicity which long-term conventional treatment.Phytochemicals are natural con... Cancer is a leading cause of death globally,with limited treatment options and several limitations.Chemotherapeutic agents often result in toxicity which long-term conventional treatment.Phytochemicals are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the resistance.These phytoconstituents act in several ways and deliver optimum effectiveness against cancer.Nevertheless,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and stability.Nanotechnology presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective effects.This holds significant potential for future advancements in cancer management.Herein,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in cancer.Moreover,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo settings.Lastly,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future. 展开更多
关键词 Phyto-formulations CANCER NANOCARRIERS NANOTECHNOLOGY clinical development
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Helicobacter pylori neutrophil-activating protein:From molecular pathogenesis to clinical applications 被引量:10
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作者 Hua-Wen Fu 《World Journal of Gastroenterology》 SCIE CAS 2014年第18期5294-5301,共8页
Helicobacter pylori (H. pylori) neutrophil-activating protein (HP-NAP) was originally identified as a virulence factor of H. pylori for its ability to activate neutrophils to generate respiratory burst by releasing re... Helicobacter pylori (H. pylori) neutrophil-activating protein (HP-NAP) was originally identified as a virulence factor of H. pylori for its ability to activate neutrophils to generate respiratory burst by releasing reactive oxygen species. Later on, HP-NAP was also found to be involved in the protection of H. pylori from DNA damage, supporting the survival of H. pylori under oxidative stress. This protein is highly conserved and expressed by virtually all clinical isolates of H. pylori. The majority of patients infected with H. pylori produced antibodies specific for HP-NAP, suggesting its important role in immunity. In addition to acting as a pathogenic factor by activating the innate immunity through a wide range of human leukocytes, including neutrophils, monocytes, and mast cells, HP-NAP also mediates adaptive immunity through the induction of T helper cell type&#x02005;I&#x02005;responses. The pro-inflammatory and immunomodulatory properties of HP-NAP not only make it play an important role in disease pathogenesis but also make it a potential candidate for clinical use. Even though there is no convincing evidence to link HP-NAP to a disease outcome, recent findings supporting the pathogenic role of HP-NAP will be reviewed. In addition, the potential clinical applications of HP-NAP in vaccine development, clinical diagnosis, and drug development will be discussed. 展开更多
关键词 Helicobacter pylori Helicobacter pylori neutrophil-activating protein clinical application Vaccine Diagnosis Drug development Immunotherapy Immunomodulation T helper cell type  I/II
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Improving Clinical Practice Guideline Development in Integration of Traditional Chinese Medicine and Western Medicine 被引量:3
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作者 吕爱平 陈可冀 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第3期163-165,共3页
Integration of traditional Chinese medicine (TCM) and Western medicine (WM), or called as integrative medicine (IM) in China, came into being in 1950s as a new form of medicine. IM emphasizes the combination of ... Integration of traditional Chinese medicine (TCM) and Western medicine (WM), or called as integrative medicine (IM) in China, came into being in 1950s as a new form of medicine. IM emphasizes the combination of both conventional WM and TCM alternative approaches to address all aspects of health and illness.(1) The major practice in IM includes the integration of disease diagnosis in WM and pattern classification (or syndrome differentiation) in TCM, and the integration of WM interventions and TCM interventions. 展开更多
关键词 CPG Improving clinical Practice Guideline development in Integration of Traditional Chinese Medicine and Western Medicine
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