Considering the pivotal role of single-wavelength anomalous diffraction(SAD) in macromolecular crystallography,our objective was to introduce DSAS,a novel program designed for efficient anomalous scattering substructu...Considering the pivotal role of single-wavelength anomalous diffraction(SAD) in macromolecular crystallography,our objective was to introduce DSAS,a novel program designed for efficient anomalous scattering substructure determination.DSAS stands out with its core components:a modified phase-retrieval algorithm and automated parameter tuning.The software boasts an intuitive graphical user interface(GUI),facilitating seamless input of essential data and real-time monitoring.Extensive testing on DSAS has involved diverse datasets,encompassing proteins,nucleic acids,and various anomalous scatters such as sulfur(S),selenium(Se),metals,and halogens.The results confirm DSAS’s exceptional performance in accurately determining heavy atom positions,making it a highly effective tool in the field.展开更多
目的:探究数字减影血管造影(Digital subtraction angiography,DSA)辅助下神经介入取栓术治疗缺血性脑卒中的效果。方法:选择2019年10月至2022年10月本院收治的缺血性脑卒中患者130例作为研究对象。随机将患者分为对照组和观察组,各65...目的:探究数字减影血管造影(Digital subtraction angiography,DSA)辅助下神经介入取栓术治疗缺血性脑卒中的效果。方法:选择2019年10月至2022年10月本院收治的缺血性脑卒中患者130例作为研究对象。随机将患者分为对照组和观察组,各65例。对照组接受静脉溶栓治疗;观察组实施DSA辅助下神经介入取栓术治疗。在术后1 w,分析对比两组的治疗效果。结果:观察组总有效率高于对照组(P<0.05)。治疗前,两组国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)无显著差异(P>0.05)。治疗后,观察组NIHSS评分低于对照组(P<0.05)。观察组血管再通率高于对照组(P<0.05)。结论:对缺血性脑卒中采用DSA辅助下神经介入取栓术治疗能改善患者的神经功能,提高其血管再通率,提高治疗效果。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.32371280 and T2350011)。
文摘Considering the pivotal role of single-wavelength anomalous diffraction(SAD) in macromolecular crystallography,our objective was to introduce DSAS,a novel program designed for efficient anomalous scattering substructure determination.DSAS stands out with its core components:a modified phase-retrieval algorithm and automated parameter tuning.The software boasts an intuitive graphical user interface(GUI),facilitating seamless input of essential data and real-time monitoring.Extensive testing on DSAS has involved diverse datasets,encompassing proteins,nucleic acids,and various anomalous scatters such as sulfur(S),selenium(Se),metals,and halogens.The results confirm DSAS’s exceptional performance in accurately determining heavy atom positions,making it a highly effective tool in the field.
文摘目的:探究数字减影血管造影(Digital subtraction angiography,DSA)辅助下神经介入取栓术治疗缺血性脑卒中的效果。方法:选择2019年10月至2022年10月本院收治的缺血性脑卒中患者130例作为研究对象。随机将患者分为对照组和观察组,各65例。对照组接受静脉溶栓治疗;观察组实施DSA辅助下神经介入取栓术治疗。在术后1 w,分析对比两组的治疗效果。结果:观察组总有效率高于对照组(P<0.05)。治疗前,两组国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)无显著差异(P>0.05)。治疗后,观察组NIHSS评分低于对照组(P<0.05)。观察组血管再通率高于对照组(P<0.05)。结论:对缺血性脑卒中采用DSA辅助下神经介入取栓术治疗能改善患者的神经功能,提高其血管再通率,提高治疗效果。
