生物鲁棒性是生物系统抵抗外界扰动或内部参数摄动引起系统行为变化的一种能力。电磁场是一种外界物理因素,可以对生物体产生影响。为了建立一种电磁场扰动下生物系统稳定鲁棒性的研究方法,以Lyapunov理论为基础,用电磁场细胞暴露系统...生物鲁棒性是生物系统抵抗外界扰动或内部参数摄动引起系统行为变化的一种能力。电磁场是一种外界物理因素,可以对生物体产生影响。为了建立一种电磁场扰动下生物系统稳定鲁棒性的研究方法,以Lyapunov理论为基础,用电磁场细胞暴露系统实时记录了在磁感应强度B为0、0.09、0.38、0.76、7.33、14.78 m T的电磁场暴露下细胞内活性氧自由基（ROS）和钙离子（Ca2＋）的含量,分析了电磁场扰动前的细胞状态稳态点和稳定域,以及电磁场扰动后的状态转移和稳定鲁棒域。结果表明：（1）细胞无扰时ROS的稳态点是46.157~120.913,Ca2＋的稳态点是25.430~55.686,ROS的稳定域半径是1.688~10.278,Ca2＋的稳定域半径是2.782~13.345;（2）B〈7.33 m T的电磁场扰动没有提高胞内ROS含量,B为14.78 m T的电磁场扰动可阶跃性提高胞内ROS含量,B为0和0.09 m T的电磁场扰动没有提高胞内Ca2＋含量,B为0.38 m T的电磁场扰动可持续性提高胞内Ca2＋含量。结论是：（1）无电磁场扰动时,细胞内ROS和Ca2＋状态可以保持稳定;（2）电磁场扰动在较高水平（如B为14.78 m T）时,才能改变细胞内ROS和Ca2＋的状态;（3）细胞的鲁棒域与电磁场的磁感应强度无关。展开更多
The present study is aimed to test whether exposure to electromagnetic fields of very weak intensity (≤1 mT) and low frequency (≤100 Hz) may influence reproductive performance and induce teratogenesis in mice. We sp...The present study is aimed to test whether exposure to electromagnetic fields of very weak intensity (≤1 mT) and low frequency (≤100 Hz) may influence reproductive performance and induce teratogenesis in mice. We speculate that a resonant effect occur when the applied frequency matches the cyclotron frequency of Mg<sup>2+</sup> (≈60 Hz) involved in the cell duplication. Four groups of mice (four dams and one male each) were exposed to ?50 μT electromagnetic field continuous irradiation of for 100 days. A control group (four dams and one male) was also examined. The exposed dams exhibited a significantly lower number of offspring per birth than the control ones (11.0 vs. 11.6;P = 0.006). A significantly lower average daily gain of body weight per mouse was observed (0.74 vs. 0.77 g/d;P = 0.002), resulting in a reduction of the average body weight per nest at 11 days of age (404 vs. 463 g;P = 0.048). Post mortem examinations revealed a significant increase in mild chronic hepatic inflammatory findings (28 vs. 0%;P = 0.001) in the offspring and myocardial hypertrophy (25 vs. 0%;P = 0.023) in the dams. The exposure of mice to an electromagnetic field with the cyclotron frequency of Mg2+ during pregnancy caused a measurable effect on the reproductive performance in terms of offspring per birth. This finding may be considered as a warning about the environmental effects of the electromagnetic fields on the stability of individual species and ecosystems.展开更多
文摘生物鲁棒性是生物系统抵抗外界扰动或内部参数摄动引起系统行为变化的一种能力。电磁场是一种外界物理因素,可以对生物体产生影响。为了建立一种电磁场扰动下生物系统稳定鲁棒性的研究方法,以Lyapunov理论为基础,用电磁场细胞暴露系统实时记录了在磁感应强度B为0、0.09、0.38、0.76、7.33、14.78 m T的电磁场暴露下细胞内活性氧自由基（ROS）和钙离子（Ca2＋）的含量,分析了电磁场扰动前的细胞状态稳态点和稳定域,以及电磁场扰动后的状态转移和稳定鲁棒域。结果表明：（1）细胞无扰时ROS的稳态点是46.157~120.913,Ca2＋的稳态点是25.430~55.686,ROS的稳定域半径是1.688~10.278,Ca2＋的稳定域半径是2.782~13.345;（2）B〈7.33 m T的电磁场扰动没有提高胞内ROS含量,B为14.78 m T的电磁场扰动可阶跃性提高胞内ROS含量,B为0和0.09 m T的电磁场扰动没有提高胞内Ca2＋含量,B为0.38 m T的电磁场扰动可持续性提高胞内Ca2＋含量。结论是：（1）无电磁场扰动时,细胞内ROS和Ca2＋状态可以保持稳定;（2）电磁场扰动在较高水平（如B为14.78 m T）时,才能改变细胞内ROS和Ca2＋的状态;（3）细胞的鲁棒域与电磁场的磁感应强度无关。
文摘The present study is aimed to test whether exposure to electromagnetic fields of very weak intensity (≤1 mT) and low frequency (≤100 Hz) may influence reproductive performance and induce teratogenesis in mice. We speculate that a resonant effect occur when the applied frequency matches the cyclotron frequency of Mg<sup>2+</sup> (≈60 Hz) involved in the cell duplication. Four groups of mice (four dams and one male each) were exposed to ?50 μT electromagnetic field continuous irradiation of for 100 days. A control group (four dams and one male) was also examined. The exposed dams exhibited a significantly lower number of offspring per birth than the control ones (11.0 vs. 11.6;P = 0.006). A significantly lower average daily gain of body weight per mouse was observed (0.74 vs. 0.77 g/d;P = 0.002), resulting in a reduction of the average body weight per nest at 11 days of age (404 vs. 463 g;P = 0.048). Post mortem examinations revealed a significant increase in mild chronic hepatic inflammatory findings (28 vs. 0%;P = 0.001) in the offspring and myocardial hypertrophy (25 vs. 0%;P = 0.023) in the dams. The exposure of mice to an electromagnetic field with the cyclotron frequency of Mg2+ during pregnancy caused a measurable effect on the reproductive performance in terms of offspring per birth. This finding may be considered as a warning about the environmental effects of the electromagnetic fields on the stability of individual species and ecosystems.
