Objective:To analyze the diagnostic value of frozen section pathology in the diagnosis of breast cancer.Methods:A total of 50 patients with breast tumors treated between July 2021 and February 2023 were randomly selec...Objective:To analyze the diagnostic value of frozen section pathology in the diagnosis of breast cancer.Methods:A total of 50 patients with breast tumors treated between July 2021 and February 2023 were randomly selected as samples.Both paraffin section and frozen section diagnoses were conducted.The paraffin section results served as the gold standard for evaluating the value of frozen section examination.Results:Among the frozen section diagnoses,48 cases(96.00%)were confirmed,1 case was misdiagnosed(2.00%),and 1 case was delayed(2.00%).Among the confirmed patients,45 cases(90.00%)were entirely consistent,and 3 cases(6.00%)were basically consistent.The diagnostic rate of the frozen section was 96.00%,compared with 100.00%for the paraffin section(P>0.05).The diagnostic time of the frozen section(35.25±2.11 min)was significantly shorter than that for the paraffin section(6911.36±58.36 min;P<0.05).Conclusion:Frozen section diagnosis is rapid and demonstrates relatively high diagnostic accuracy.It can guide doctors in determining whether to pursue breast-conserving treatment and aid in selecting appropriate surgical methods.This is beneficial for preventing unnecessary medical interventions and reducing the need for secondary surgeries in breast cancer patients.展开更多
We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prost...We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate cancer.The study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral preservation.Intraoperative frozen sections of the periurethra,dorsal vein,and bladder neck were analyzed.The ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic regression.Of 271 patients,108(39.9%)had PSM and 163(60.1%)had negative margins.Pathologic Gleason score^8(18.9%vs 7.5%,P=0.015)and T stage≥T3a(51.9%vs 24.6%,P<0.001)were significantly more frequent in the PSM group.Multivariate analysis showed that Gleason pattern≥4(vs<4;hazard ratio:4.386;P=0.0004)was the only significant predictor of BCR in the PSM cohort.Periurethral frozen sections had a sensitivity of 83.3%and a specificity of 84.2%in detecting PSM with Gleason pattern≥4.Multivariate analysis showed that membranous urethra length(odds ratio[OR]:0.79,P=0.0376)and extracapsular extension of the apex(OR:4.58,P=0.0226)on magnetic resonance imaging(MRI)and positive periurethral tissue(OR:17.85,P<0.0001)were associated with PSM of the apex.PSM with Gleason pattern≥4 is significantly predictive of BCR.Intraoperative frozen sections of periurethral tissue can independently predict PSM,whereas sections of the bladder neck and dorsal vein could not.Pathologic examination of these samples may help predict significant PSM in patients undergoing robot-assisted laparoscopic prostatectomy with preservation of functional outcomes.展开更多
文摘Objective:To analyze the diagnostic value of frozen section pathology in the diagnosis of breast cancer.Methods:A total of 50 patients with breast tumors treated between July 2021 and February 2023 were randomly selected as samples.Both paraffin section and frozen section diagnoses were conducted.The paraffin section results served as the gold standard for evaluating the value of frozen section examination.Results:Among the frozen section diagnoses,48 cases(96.00%)were confirmed,1 case was misdiagnosed(2.00%),and 1 case was delayed(2.00%).Among the confirmed patients,45 cases(90.00%)were entirely consistent,and 3 cases(6.00%)were basically consistent.The diagnostic rate of the frozen section was 96.00%,compared with 100.00%for the paraffin section(P>0.05).The diagnostic time of the frozen section(35.25±2.11 min)was significantly shorter than that for the paraffin section(6911.36±58.36 min;P<0.05).Conclusion:Frozen section diagnosis is rapid and demonstrates relatively high diagnostic accuracy.It can guide doctors in determining whether to pursue breast-conserving treatment and aid in selecting appropriate surgical methods.This is beneficial for preventing unnecessary medical interventions and reducing the need for secondary surgeries in breast cancer patients.
基金This research was supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT&Future Planning(NRF-2019R1C1C1005170)Korea Health Technology R&D Project,the Korea Health Industry Development Institute(H16C2193).
文摘We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate cancer.The study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral preservation.Intraoperative frozen sections of the periurethra,dorsal vein,and bladder neck were analyzed.The ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic regression.Of 271 patients,108(39.9%)had PSM and 163(60.1%)had negative margins.Pathologic Gleason score^8(18.9%vs 7.5%,P=0.015)and T stage≥T3a(51.9%vs 24.6%,P<0.001)were significantly more frequent in the PSM group.Multivariate analysis showed that Gleason pattern≥4(vs<4;hazard ratio:4.386;P=0.0004)was the only significant predictor of BCR in the PSM cohort.Periurethral frozen sections had a sensitivity of 83.3%and a specificity of 84.2%in detecting PSM with Gleason pattern≥4.Multivariate analysis showed that membranous urethra length(odds ratio[OR]:0.79,P=0.0376)and extracapsular extension of the apex(OR:4.58,P=0.0226)on magnetic resonance imaging(MRI)and positive periurethral tissue(OR:17.85,P<0.0001)were associated with PSM of the apex.PSM with Gleason pattern≥4 is significantly predictive of BCR.Intraoperative frozen sections of periurethral tissue can independently predict PSM,whereas sections of the bladder neck and dorsal vein could not.Pathologic examination of these samples may help predict significant PSM in patients undergoing robot-assisted laparoscopic prostatectomy with preservation of functional outcomes.
