Objective To explore the the effect of the changes of ghrelin and its receptor(GHSR1a)on accelerating diabetic encephalopathy by blood glucose fluctuation in GK rats.Methods Eight male wistar rats were set as normal c...Objective To explore the the effect of the changes of ghrelin and its receptor(GHSR1a)on accelerating diabetic encephalopathy by blood glucose fluctuation in GK rats.Methods Eight male wistar rats were set as normal control group(NC).16 male GK rats were randomly divided into sustained hyperglycemia group(MS)and blood glucose fluctuation group(MF).MF group展开更多
The Goto-Kakizaki(GK) rat is a spontaneous type 2 diabetic animal model,which is characterized by a progressive loss of beta islet cells with fibrosis.In the present study,the hypoglycemic effect of asiatic acid(AA) i...The Goto-Kakizaki(GK) rat is a spontaneous type 2 diabetic animal model,which is characterized by a progressive loss of beta islet cells with fibrosis.In the present study,the hypoglycemic effect of asiatic acid(AA) in GK rats was examined.GK rats receiving AA at a daily dose of 25 mg·kg-1 for four weeks showed a significant reduction in blood glucose levels.Age-matched normal Wistar rats were given 0.5% sodium carboxymethyl cellulose(CMC-Na) solution for the same periods and used as control.Compared to the normal Wistar rats,GK rats treated with AA showed improvement in insulin resistance partially through decreasing glucose level(P < 0.01) and insulin level(P < 0.05).Furthermore,the results of immunohistochemistry indicate that AA treatment reduced islet fibrosis in GK rats.Fibronectin,a key protein related to islet fibrosis,was over-expressed in GK rats,which was reversed significantly by AA treatment(P < 0.05).These findings suggest that AA has a beneficial effect on lowering blood glucose levels in GK rats and improves fibrosis of islets in diabetes,which may play a role in the prevention of islets展开更多
文摘Objective To explore the the effect of the changes of ghrelin and its receptor(GHSR1a)on accelerating diabetic encephalopathy by blood glucose fluctuation in GK rats.Methods Eight male wistar rats were set as normal control group(NC).16 male GK rats were randomly divided into sustained hyperglycemia group(MS)and blood glucose fluctuation group(MF).MF group
基金supported by the Fundamental Research Funds for the Central Universities(No.JKP2011004)
文摘The Goto-Kakizaki(GK) rat is a spontaneous type 2 diabetic animal model,which is characterized by a progressive loss of beta islet cells with fibrosis.In the present study,the hypoglycemic effect of asiatic acid(AA) in GK rats was examined.GK rats receiving AA at a daily dose of 25 mg·kg-1 for four weeks showed a significant reduction in blood glucose levels.Age-matched normal Wistar rats were given 0.5% sodium carboxymethyl cellulose(CMC-Na) solution for the same periods and used as control.Compared to the normal Wistar rats,GK rats treated with AA showed improvement in insulin resistance partially through decreasing glucose level(P < 0.01) and insulin level(P < 0.05).Furthermore,the results of immunohistochemistry indicate that AA treatment reduced islet fibrosis in GK rats.Fibronectin,a key protein related to islet fibrosis,was over-expressed in GK rats,which was reversed significantly by AA treatment(P < 0.05).These findings suggest that AA has a beneficial effect on lowering blood glucose levels in GK rats and improves fibrosis of islets in diabetes,which may play a role in the prevention of islets
