Moldy sugarcane poisoning, an acute fatal food poisoning of unknown etiology, has occurred in 13 provinces in China. The epidemiological characteristics and clinical features were described. Evidence from laboratory s...Moldy sugarcane poisoning, an acute fatal food poisoning of unknown etiology, has occurred in 13 provinces in China. The epidemiological characteristics and clinical features were described. Evidence from laboratory studies indicates that 3-nitropropionic acid roduced by the fungus Arthrinium Spp. is the etiological factor of this food poisoning.展开更多
Lead is a toxic metal that affects many organ systems and functions in humans. In the majority of adults, chronic lead poisoning comes from exposures to work places and can occur in numerous work settings, such as man...Lead is a toxic metal that affects many organ systems and functions in humans. In the majority of adults, chronic lead poisoning comes from exposures to work places and can occur in numerous work settings, such as manufacturing, lead smelting and refinement, or due to use of batteries, pigments, solder, ammunitions, paint, car radiators, cable and wires, certain cosmetics. In some countries, lead is added to petrol. We present a rare case of gastric dilation caused by long-term petrol ingestion. A 16-year-old young man was admitted to our hospital due to a 6-mo history of exhaustion, dizziness, nausea, abdominal cramps and constipation. X-ray examination revealed dilated stomach descending into the pelvis and small bowel distension. After a long clinical observation, we found that the reason for the chronic lead poisoning of the patient was due to a 3-year history of petrol ingestion. The patient spontaneously recovered and stomach returned to its normal position and size. Lead poisoning should be taken into consideration in all unexplained cases of gastric dilation.展开更多
[ Objective] To investigate the effects of Newcastle disease vaccination and lead exposure on growth and development of egg yellow feather quail. [ Method] Ninety 14-day-old quails were assigned randomly to 10 groups ...[ Objective] To investigate the effects of Newcastle disease vaccination and lead exposure on growth and development of egg yellow feather quail. [ Method] Ninety 14-day-old quails were assigned randomly to 10 groups （ n = 9）, and they fed and drunk at liberty. A 2 ×5 factorial design was used. The quail immunized with ND vaccine and those non-immunized were exposed to lead at a dosage of 0, 50,500, 1 000 and 2 000 mg/L, respectively. [Result] The ND immunization reduced body weight significantly （ P 〈 0.01 ） and increased liver index and serum levels of hy- aluronic acid in quail within 1 -2 weeks post inoculation. The quail exposed to 2 000 mg/L lead acetate had significantly lower body weight than the control （ P 〈 0.01 ）. From 7 weeks old, the same inhibitory effect was observed in the quail＇exposed to lead at different dosages （ P 〈 0.01 ）. In addition, the lead poisoning could cause decreased feed intake, depilation, gonadal dysgenesis, and increased serum levels of hyaluronic acid. [ Conduslon] The inhibitory effect of ND vaccination on growth of quail occurs within 1 -2 weeks post inoculation; thus, the effects of immune stress should not be worried in quail production. The lead poisoning has significant effects on body weight and feed intake of quail, and lead dosage and duration affect the inhibitory effects of lead. Gonadal dysgenesis is an important indicator of lead poisoning in. quail. The serum levels of hyaluronic acid can be used to determine whether the quail have been immunized with ND vaccine or have contacted lead pollutants.展开更多
Carbon monoxide （CO） is an odorless, colorless gas produced by incomplete combustion of carbonbased compounds. Exposure to CO can cause various adverse health effects ranging from headache and fatigue to coma and de...Carbon monoxide （CO） is an odorless, colorless gas produced by incomplete combustion of carbonbased compounds. Exposure to CO can cause various adverse health effects ranging from headache and fatigue to coma and death. Thousands of illnesses and deaths have been documented through CO poisoning surveillance systems and accident investigations each year.展开更多
Lead poisoning caused by a foreign body is rare. Foreign bodies that are ingested typically pass without consequence or awareness by the patient [1]. There are few documented cases of lead poisoning from an ingested f...Lead poisoning caused by a foreign body is rare. Foreign bodies that are ingested typically pass without consequence or awareness by the patient [1]. There are few documented cases of lead poisoning from an ingested foreign body lodged in the appendix. Screening for lead poisoning is mandated by New York State at annual well person exams for children ages 6 months to 6 years [2]. We present a case of a 2-year-old male who was found to have elevated lead levels during a routine well-child visit. An abdominal X-ray was obtained as part of routine follow up for elevated lead levels and a foreign body was found in the right lower quadrant. After unsuccessful attempt to flush the foreign body out with golytely, a CT abdomen/ pelvis was obtained. The foreign body was localized in the appendix. The patient was subsequently taken to surgery for an appendectomy to remove the foreign body. This case is a demonstration of the positive effects of the lead screening guidelines of New York.展开更多
This study explored the association between the lncRNA HOTAIR polymorphism and susceptibility to lead poisoning in a Chinese population. We speculated that lead poisoning caused elevated levels of oxidative stress, wh...This study explored the association between the lncRNA HOTAIR polymorphism and susceptibility to lead poisoning in a Chinese population. We speculated that lead poisoning caused elevated levels of oxidative stress, which, in turn, activate the HOTAIR gene to cause apoptosis. Three lncRNA HOTAIR tagSNPs（rs7958904, rs4759314, and rs874945） were genotyped by TaqM an genotyping technology in 113 lead-sensitive and 113 lead-resistant Chinese workers exposed to lead. Rs7958904 was significantly associated with susceptibility to lead poisoning（P = 0.047）. The rs7958904 G allele had a protective effect compared with the C allele and reduced the risk of lead poisoning（P = 0.016）. Rs7958904 may act as a potential biomarker for predicting the risk of lead poisoning and distinguishing lead-sensitive individuals from lead-resistant individuals.展开更多
Objective To investigate the blood lead level in children aged 0-6 years in urban areas of China. Methods Fourteen cities were selected as sites under surveillance. A total of 44 045 peripheral blood specimens were co...Objective To investigate the blood lead level in children aged 0-6 years in urban areas of China. Methods Fourteen cities were selected as sites under surveillance. A total of 44 045 peripheral blood specimens were collected from 2004 to 2006, during which 15 727, 14 737, and 13 584 specimens were tested in 2004, 2005, and 2006, respectively. Tungsten atomizer absorption spectrophotometer was employed to determine blood lead level. Results The geometric mean blood lead level in the tested children was 47.10 μg/L with 10.10% ≥100 μg/L, 46.17 μg/L with 7.78% ≥100 μg/L, and 47.03 μg/L with 7.30% ≥ 100μg/L in 2004, 2005, and 2006, respectively. The blood lead levels seemed to tend to rise in parallel with the increase of age of the children and were higher in boys （48.84 μg/L, 47.56μg/L, and 47.78 μg/L in the 3 respective years） than in girls （45.00 μg/L, 44.53μg/L, and 46.13 μg/L）. Conclusion The blood lead levels in children in cities of China are lower than those in previous national studies, but higher than those in developed countries. Childhood lead poisoning remains a public health problem in China.展开更多
Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes,public health decision making,and primary prevention synthesis.Lead is one of the neuro...Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes,public health decision making,and primary prevention synthesis.Lead is one of the neurotoxicants that seems to be involved in the etiology of psychologies.Biomarkers are generally classified into three groups:biomarkers of exposure,effect,and susceptibility.The main body compartments that store lead are the blood,soft tissues,and bone;the half-life of lead in these tissues is measured in weeks for blood,months for soft tissues,and years for bone.Within the brain,lead-induced damage in the prefrontal cerebral cortex,hippocampus,and cerebellum can lead to a variety of neurological disorders,such as brain damage,mental retardation,behavioral problems,nerve damage,and possibly Alzheimer’s disease,Parkinson’s disease,and schizophrenia.This paper presents an overview of biomarkers of lead exposure and discusses the neurotoxic effects of lead with regard to children and adults.展开更多
Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory d...Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol（0.1, 1.0, 10.0 mg/kg） was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.展开更多
文摘Moldy sugarcane poisoning, an acute fatal food poisoning of unknown etiology, has occurred in 13 provinces in China. The epidemiological characteristics and clinical features were described. Evidence from laboratory studies indicates that 3-nitropropionic acid roduced by the fungus Arthrinium Spp. is the etiological factor of this food poisoning.
文摘Lead is a toxic metal that affects many organ systems and functions in humans. In the majority of adults, chronic lead poisoning comes from exposures to work places and can occur in numerous work settings, such as manufacturing, lead smelting and refinement, or due to use of batteries, pigments, solder, ammunitions, paint, car radiators, cable and wires, certain cosmetics. In some countries, lead is added to petrol. We present a rare case of gastric dilation caused by long-term petrol ingestion. A 16-year-old young man was admitted to our hospital due to a 6-mo history of exhaustion, dizziness, nausea, abdominal cramps and constipation. X-ray examination revealed dilated stomach descending into the pelvis and small bowel distension. After a long clinical observation, we found that the reason for the chronic lead poisoning of the patient was due to a 3-year history of petrol ingestion. The patient spontaneously recovered and stomach returned to its normal position and size. Lead poisoning should be taken into consideration in all unexplained cases of gastric dilation.
基金funded by the Key Scientific and Technological Project of Henan Province ( 082102130002)
文摘[ Objective] To investigate the effects of Newcastle disease vaccination and lead exposure on growth and development of egg yellow feather quail. [ Method] Ninety 14-day-old quails were assigned randomly to 10 groups （ n = 9）, and they fed and drunk at liberty. A 2 ×5 factorial design was used. The quail immunized with ND vaccine and those non-immunized were exposed to lead at a dosage of 0, 50,500, 1 000 and 2 000 mg/L, respectively. [Result] The ND immunization reduced body weight significantly （ P 〈 0.01 ） and increased liver index and serum levels of hy- aluronic acid in quail within 1 -2 weeks post inoculation. The quail exposed to 2 000 mg/L lead acetate had significantly lower body weight than the control （ P 〈 0.01 ）. From 7 weeks old, the same inhibitory effect was observed in the quail＇exposed to lead at different dosages （ P 〈 0.01 ）. In addition, the lead poisoning could cause decreased feed intake, depilation, gonadal dysgenesis, and increased serum levels of hyaluronic acid. [ Conduslon] The inhibitory effect of ND vaccination on growth of quail occurs within 1 -2 weeks post inoculation; thus, the effects of immune stress should not be worried in quail production. The lead poisoning has significant effects on body weight and feed intake of quail, and lead dosage and duration affect the inhibitory effects of lead. Gonadal dysgenesis is an important indicator of lead poisoning in. quail. The serum levels of hyaluronic acid can be used to determine whether the quail have been immunized with ND vaccine or have contacted lead pollutants.
基金supported by the Medicine and Technology Development Plan Project of Shandong Province(2016WS0119)
文摘Carbon monoxide （CO） is an odorless, colorless gas produced by incomplete combustion of carbonbased compounds. Exposure to CO can cause various adverse health effects ranging from headache and fatigue to coma and death. Thousands of illnesses and deaths have been documented through CO poisoning surveillance systems and accident investigations each year.
文摘Lead poisoning caused by a foreign body is rare. Foreign bodies that are ingested typically pass without consequence or awareness by the patient [1]. There are few documented cases of lead poisoning from an ingested foreign body lodged in the appendix. Screening for lead poisoning is mandated by New York State at annual well person exams for children ages 6 months to 6 years [2]. We present a case of a 2-year-old male who was found to have elevated lead levels during a routine well-child visit. An abdominal X-ray was obtained as part of routine follow up for elevated lead levels and a foreign body was found in the right lower quadrant. After unsuccessful attempt to flush the foreign body out with golytely, a CT abdomen/ pelvis was obtained. The foreign body was localized in the appendix. The patient was subsequently taken to surgery for an appendectomy to remove the foreign body. This case is a demonstration of the positive effects of the lead screening guidelines of New York.
基金financially supported by Jiangsu Province Special Project of Clinical Science and Technology[grant project number BL2014082]supported by the Fundamental Research Funds for the Central UniversitiesJiangsu Province Ordinary University Graduate Student Scientific Research Innovation Projects[grant project number SJZZ16-0035]
文摘This study explored the association between the lncRNA HOTAIR polymorphism and susceptibility to lead poisoning in a Chinese population. We speculated that lead poisoning caused elevated levels of oxidative stress, which, in turn, activate the HOTAIR gene to cause apoptosis. Three lncRNA HOTAIR tagSNPs（rs7958904, rs4759314, and rs874945） were genotyped by TaqM an genotyping technology in 113 lead-sensitive and 113 lead-resistant Chinese workers exposed to lead. Rs7958904 was significantly associated with susceptibility to lead poisoning（P = 0.047）. The rs7958904 G allele had a protective effect compared with the C allele and reduced the risk of lead poisoning（P = 0.016）. Rs7958904 may act as a potential biomarker for predicting the risk of lead poisoning and distinguishing lead-sensitive individuals from lead-resistant individuals.
文摘Objective To investigate the blood lead level in children aged 0-6 years in urban areas of China. Methods Fourteen cities were selected as sites under surveillance. A total of 44 045 peripheral blood specimens were collected from 2004 to 2006, during which 15 727, 14 737, and 13 584 specimens were tested in 2004, 2005, and 2006, respectively. Tungsten atomizer absorption spectrophotometer was employed to determine blood lead level. Results The geometric mean blood lead level in the tested children was 47.10 μg/L with 10.10% ≥100 μg/L, 46.17 μg/L with 7.78% ≥100 μg/L, and 47.03 μg/L with 7.30% ≥ 100μg/L in 2004, 2005, and 2006, respectively. The blood lead levels seemed to tend to rise in parallel with the increase of age of the children and were higher in boys （48.84 μg/L, 47.56μg/L, and 47.78 μg/L in the 3 respective years） than in girls （45.00 μg/L, 44.53μg/L, and 46.13 μg/L）. Conclusion The blood lead levels in children in cities of China are lower than those in previous national studies, but higher than those in developed countries. Childhood lead poisoning remains a public health problem in China.
文摘Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes,public health decision making,and primary prevention synthesis.Lead is one of the neurotoxicants that seems to be involved in the etiology of psychologies.Biomarkers are generally classified into three groups:biomarkers of exposure,effect,and susceptibility.The main body compartments that store lead are the blood,soft tissues,and bone;the half-life of lead in these tissues is measured in weeks for blood,months for soft tissues,and years for bone.Within the brain,lead-induced damage in the prefrontal cerebral cortex,hippocampus,and cerebellum can lead to a variety of neurological disorders,such as brain damage,mental retardation,behavioral problems,nerve damage,and possibly Alzheimer’s disease,Parkinson’s disease,and schizophrenia.This paper presents an overview of biomarkers of lead exposure and discusses the neurotoxic effects of lead with regard to children and adults.
基金financially supported by the Science and Technology Commission Foundation of Zhangjiakou City,No.1021098Dthe Medical Scientific Research Project of Health Bureau of Hebei Province,No.20100144+2 种基金the Natural Science Foundation of Hebei Province,No.H2012405016the Innovative Talents Project of Hebei North University,No.CXRC1325the Major Projects of Hebei North University,No.ZD201310
文摘Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol（0.1, 1.0, 10.0 mg/kg） was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.
