Based on the introduction of the connotation of marginalization,the index of diagnosing the marginalization degree is put forward.According to the 685 copies of questionnaires on peasant households in Tongcheng County...Based on the introduction of the connotation of marginalization,the index of diagnosing the marginalization degree is put forward.According to the 685 copies of questionnaires on peasant households in Tongcheng County of Hubei Province and the statistical data of local government,marginalization of arable land and its correlation with rural labor migration in Tongcheng County are studied by using aggregative indicator method,clustering analysis method and correlation analysis method.Result shows that marginalization of arable land has happened two times in Tongcheng County since 1985.Dry land has severer marginalization degree than paddy field.There is significant correlation between marginalization degree of arable land and rural labor migration;and the correlation between marginalization degree and rural labor migration in paddy field is greater than that in dry land.Marginalization of arable land will advance the rural labor migration,while in response to the poor current circulation of lands;the rural labor migration will further deepen the marginalization degree.Marginalization of arable land is one of the important factors affecting the labor migration in rural areas.展开更多
Ethnic sentiments are usually dictated by political and socio-economic factors and they derive from manipulation of minority interests and groups who are in the face of discrimination and marginalization jostle for at...Ethnic sentiments are usually dictated by political and socio-economic factors and they derive from manipulation of minority interests and groups who are in the face of discrimination and marginalization jostle for attention and relevance within a geopolitical setting in a society. Most often, such political situation which promotes domination by one group and socio-economic subordination of another, usually results in ethnic crisis which arises from, and also leads to serious suspicion, anger, civil unrest, and sometimes war. It is not in doubt, that in times of ethno-political crisis and war, women and children are the main victims as they account for an estimated 80% of refugees and displaced persons worldwide. It is in view of this that this paper examines the politics of ethnic conflicts and discusses some of its painful outcomes, such as marginalization and dehumanization of women and children. The essay uses J. P. Clark＇s The Wives Revolt （1991） and Ahmed Yerima＇s Little Drops （2009） for illustration to point out the importance of democratic principles and increased representation of woman in governance and advocating against discriminatory policies in respect of women and children.展开更多
Chinese American writer Celeste Ng has portrayed images of ＂marginal man＂ in her novel Everything I Never Told You. Centering the narration on the death of Lydia, with her own immigrant identity and cross-ethnical m...Chinese American writer Celeste Ng has portrayed images of ＂marginal man＂ in her novel Everything I Never Told You. Centering the narration on the death of Lydia, with her own immigrant identity and cross-ethnical marriage, Celeste Ng has penetrated into the marginal culture in American society 1970s, exposing characters＇ marginal condition caused by ethnical identity, gender and sexual orientation.展开更多
The city government of Solo has made a decision that street vendors operating in the city＇s Revolution Monument in Banjarsari Square for years must be relocated to the new built traditional market, called Pasar Notoh...The city government of Solo has made a decision that street vendors operating in the city＇s Revolution Monument in Banjarsari Square for years must be relocated to the new built traditional market, called Pasar Notoharjo. This study utilized ethnographic methods, a combination of methods including observation, in-depth interview, focus group and the unobtrusive method including collecting written information. The study showed that the decision of Solo city government which tended to privilege street vendors＇ interests resulted in the life chance of prostitution was deteriorated and marginalized. The city government has accommodated street vendors＇ demand to remove ,the organized prostitution community operating in Silir-Semanggi of Solo since 1960s as one of requirements for their relocation to this area, where the new built traditional market with more than one thousand kiosks was provided for street vendors. The procuresses＇ demand to obtain their rights of the land they occupied for more than 20 years on behalf of their legal ownership failed due to administrative, bureaucratic and legal obstacles. Prostitutes were inhumanly chased away by the city government apparatuses in collaboration with the police from the site of operation in 2006 and it resulted that the social and economic lives of procuresses and prostitutes got worse since their prostitution activities in this location were totally forbidden and unfinished. Both procuresses and prostitutes were marginalized because they did not have links to the powerful stakeholder who were able to protect their rights. Their health was in danger because the city government＇s concern to their activities was limited in particularly since 1998 when the location was formally closed by Solo mayor of the new order.展开更多
With migrant workers pouring out into cities together with their family,their problems become more and more prominent.By means of field study,the paper investigated the language problems and social problems of migrant...With migrant workers pouring out into cities together with their family,their problems become more and more prominent.By means of field study,the paper investigated the language problems and social problems of migrant workers,and confirmed the hypothesis that language problems cause migrant workers marginalized in the mainstream of the society.展开更多
Farmland resources in mountainous areas are important for regional food security and ecological secu- rity. Studies concerning changes in farmland use in mountainous areas are of considerable significance in China. He...Farmland resources in mountainous areas are important for regional food security and ecological secu- rity. Studies concerning changes in farmland use in mountainous areas are of considerable significance in China. Here, we analyzed marginalization characteristics of farmland in Renhuai city from 2005 to 2011 and driving factors using land information systems, surveys of farmer households and statistical data. Our results indicate that from 2005 to 2011, 3095.76 hm2 of farmland was converted to forest land and natural reserve, accounting for 5.45% of the total farmland area. This suggests significant marginalization of farmland. Marginalization of farmland in mountainous areas was affected by topography, labor forces and effectiveness of land management. Farmland with a greater slope gradient was more likely to be abandoned; among marginalized land in Renhuai, a slope greater than 15~ accounted for 62.26%. A high non-agricultural employment rate of rural labor force and annual income per capita of farmer households in mountainous areas were consistent with high speed farmland marginalization. Low land management benefits were the key reason for farmland marginalization. Although farmland marginalization was advantageous for eco-environment protection and sustainable development in mountainous areas, it resulted in inefficient land resource utilization. A win-win model for the exploitation and utilization of sloping farmland should be explored for production development and environmental protection.展开更多
Based on SPOT-5 images, 1：1 million topographic maps, the maps of the returning farmland to forest project and the Chongqing forest project, social and economic statistics, etc., this paper identifies the features an...Based on SPOT-5 images, 1：1 million topographic maps, the maps of the returning farmland to forest project and the Chongqing forest project, social and economic statistics, etc., this paper identifies the features and factors influencing farmland marginalization. The results showed： （1） During 2002-2012, the rate of farmland marginalization was 16.18%, which was mainly found in the high areas of northern Qiyao mountains and the medium-altitude areas of southern Qiyao mountains. And this farmland marginalization will increase, associated with non-agriculturalization of rural labourers and aging of the remaining labourers. （2） Elevation, distance radius from villages and road connections had a great in- fluence on farmland marginalization. Farmland marginalization rates showed an increasing trend with the increase of elevation, and 60.88% of the total farmland marginalization area is found at an altitude greater than 1000 m above sea level. The marginalization trend also increases with slope and distance from the distribution network. （3） Farmland area per labourer and the average age of farm labourers were major factors driving farmland marginalization. Farmland transfer and small agricultural machinery sets affect farmland marginalization with respect to management and productivity efficiency. （4） Farmland with ＂comparative-disadvantage-dominated marginalization＂ accounted for 55.32% of the total farmland marginalization area, followed by ＂location-dominated marginalization＂ （33.80%）. （5） According to the specifics of each real situation, different policies are suggested to mitigate the margin- alization. A ＂continuous marginalization＂ policy will encourage the return of farmland to forest in ＂terrain-dominated marginalization＂. An ＂anti-marginalization＂ policy is suggested to create new rural accommodation and improve the rural road system to counteract ＂terrain-dominated marginalization＂. And another ＂anti-marginalization＂ policy is planned to improve management and micro-mechanization for ＂comparative-disadvantage-dominated marginalization＂. A new idea was developed to integrate high resolution remote sensing and statistical data with survey information to identify land marginalization and its driving forces in mountainous areas.展开更多
The sandstones of the Late miocene–Pliocene Dibdibba Formation in the Najaf–Karbala Plateau and Basra were examined to determine their source rocks and origin. The rare earth elements(REE) and trace elements(Sc, Co,...The sandstones of the Late miocene–Pliocene Dibdibba Formation in the Najaf–Karbala Plateau and Basra were examined to determine their source rocks and origin. The rare earth elements(REE) and trace elements(Sc, Co, V, and Th) concentrations in these sandstones revealed that they likely derived from a single source. The steep light rare earth elements(LREE) and flat, heavy rare earth element(HREE) patterns, negative Eu anomaly, and high ΣREE contents in sandstones suggest its derivation from a suggests that a passive continental margin environment and originated from felsic source rocks. The average concentration of ΣREE is 93.5 ppm, which is lower than that of the average crustal compositions like Upper Continental Crust and Post Archean Australian Shale. The higher proportion of LREE compared to HREE implies that these sandstones were recycled and derived from a distal source. The Th/Co, Th/Sc, La/Sc, La/Co, Eu/Eu*and(La/Lu)cn elemental ratios indicated that these Late Miocene–Pliocene sandstones were derived from felsic rocks located in the marginal region of the Arabian Shield.展开更多
Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin,SW China,the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbo...Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin,SW China,the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbon accumulation elements,especially the source rock.The hydrocarbon accumulation characteristics of each whole petroleum system are analyzed,the patterns of integrated conventional and unconventional hydrocarbon accumulation are summarized,and the favorable exploration targets are proposed.Under the control of multiple extensional-convergent tectonic cycles,the marine carbonate rocks of the Sichuan Basin contain three sets of regional source rocks and three sets of regional cap rocks,and can be divided into the Cambrian,Silurian and Permian whole petroleum systems.These whole petroleum systems present mainly independent hydrocarbon accumulation,containing natural gas of affinity individually.Locally,large fault zones run through multiple whole petroleum systems,forming a fault-controlled complex whole petroleum system.The hydrocarbon accumulation sequence of continental shelf facies shale gas accumulation,marginal platform facies-controlled gas reservoirs,and intra-platform fault-and facies-controlled gas reservoirs is common in the whole petroleum system,with a stereoscopic accumulation and orderly distribution pattern.High-quality source rock is fundamental to the formation of large gas fields,and natural gas in a whole petroleum system is generally enriched near and within the source rocks.The development and maintenance of large-scale reservoirs are essential for natural gas enrichment,multiple sources,oil and gas transformation,and dynamic adjustment are the characteristics of marine petroleum accumulation,and good preservation conditions are critical to natural gas accumulation.Large-scale marginal-platform reef-bank facies zones,deep shale gas,and large-scale lithological complexes related to source-connected faults are future marine hydrocarbon exploration targets in the Sichuan Basin.展开更多
On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of t...On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault.展开更多
Farmland marginalization has become the main trend of land-use change in the mountainous areas of China. Using annual survey data of major agricultural production costs and earnings at national and provincial levels i...Farmland marginalization has become the main trend of land-use change in the mountainous areas of China. Using annual survey data of major agricultural production costs and earnings at national and provincial levels in China, this study aims to analyze the reasons and mechanism behind farmland marginalization in mountainous areas. We find that farmers on plains are able to reduce their per mu labor input effectively through intensive use of agricultural machinery, which has minimized the impact of the increase in labor price. However, it is extremely challenging for farmers in mountainous areas to use the same method owing to the rough terrain. Thus, per laborer farming area in these areas has increased relatively slowly, causing a widening gap in agricultural labor productivity between the two regions. With the rapid rise in labor costs since 2003, the marginalization of cultivated land in mountainous areas is evident. In 2013, the net profit of agricultural production in mountainous China fell below zero. Since 2000, the land-use and land-cover change in these areas was characterized by the reduction of farmland area, reforestation, and the enhancement of the NDVI value. The high correlation between the NDVI change rate and the ratio of change in farmland(r = –0.70) and forest(r = 0.91) in mountainous areas at provincial level further attests to the trend of farmland marginalization there. Finally, we summarize the mechanism of such marginalization against the backdrop of the rapid increase in the opportunity cost of farming and the rapid fall of agricultural labor forces in mountainous areas. This study contributes to a deep understanding of the development process of farmland marginalization and abandonment as well as forest transition in Chinese mountainous areas.展开更多
BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generaliz...BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.展开更多
Marine heatwaves(MHWs)caused by anthropogenic climate change are becoming a key driver of change at the ecosystem level.Thermal conditions experienced by marine organisms across their distribution,particularly towards...Marine heatwaves(MHWs)caused by anthropogenic climate change are becoming a key driver of change at the ecosystem level.Thermal conditions experienced by marine organisms across their distribution,particularly towards the equator,are likely to approach their physiological limits,resulting in extensive mortality and subsequent changes at the population level.Populations at the margins of their species’distribution are thought to be more sensitive to climate-induced environmental pressures than central populations,but our understanding of variability in fitness-related physiological traits in trailing versus leading-edge populations is limited.In a laboratory simulation study,we tested whether two leading(Iceland)and two trailing(Spain)peripheral populations of the intertidal macroalga Corallina officinalis display different levels of maximum potential quantum efficiency(Fv/Fm)resilience to current and future winter MHWs scenarios.Our study revealed that ongoing and future local winter MHWs will not negatively affect leading-edge populations of C.officinalis,which exhibited stable photosynthetic efficiency throughout the study.Trailing edge populations showed a positive though non-significant trend in photosynthetic efficiency throughout winter MHWs exposure.Poleward and equatorward populations did not produce significantly different results,with winter MHWs having no negative affect on Fv/Fm of either population.Additionally,we found no long-term regional or population-level influence of a winter MHWs on this species’photosynthetic efficiency.Thus,we found no statistically significant difference in thermal stress responses between leading and trailing populations.Nonetheless,C.officinalis showed a trend towards higher stress responses in southern than northern populations.Because responses rest on a variety of local population traits,they are difficult to predict based solely on thermal pressures.展开更多
This paper systematically introduces and reviews a scientific exploration of reliability called the belief reliability.Beginning with the origin of reliability engineering,the problems of present theories for reliabil...This paper systematically introduces and reviews a scientific exploration of reliability called the belief reliability.Beginning with the origin of reliability engineering,the problems of present theories for reliability engineering are summarized as a query,a dilemma,and a puzzle.Then,through philosophical reflection,we introduce the theoretical solutions given by belief reliability theory,including scientific principles,basic equations,reliability science experiments,and mathematical measures.The basic methods and technologies of belief reliability,namely,belief reliability analysis,function-oriented belief reliability design,belief reliability evaluation,and several newly developed methods and technologies are sequentially elaborated and overviewed.Based on the above investigations,we summarize the significance of belief reliability theory and make some prospects about future research,aiming to promote the development of reliability science and engineering.展开更多
The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,t...The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,tropical cyclones,the Kuroshio intrusion,and water exchange through the Luzon Strait(LS).展开更多
Forests,the largest terrestrial carbon sinks,play an important role in carbon sequestration and climate change mitigation.Although forest attributes and environmental factors have been shown to impact aboveground biom...Forests,the largest terrestrial carbon sinks,play an important role in carbon sequestration and climate change mitigation.Although forest attributes and environmental factors have been shown to impact aboveground biomass,their influence on biomass stocks in species-rich forests in southern China,a biodiversity hotspot,has rarely been investigated.In this study,we characterized the effects of environmental factors,forest structure,and species diversity on aboveground biomass stocks of 30 plots(1 ha each) in natural forests located within seven nature reserves distributed across subtropical and marginal tropical zones in Guangxi,China.Our results indicate that forest aboveground biomass stocks in this region are lower than those in mature tropical and subtropical forests in other regions.Furthermore,we found that aboveground biomass was positively correlated with stand age,mean annual precipitation,elevation,structural attributes and species richness,although not with species evenness.When we compared stands with the same basal area,we found that aboveground biomass stock was higher in communities with a higher coefficient of variation of diameter at breast height.These findings highlight the importance of maintaining forest structural diversity and species richness to promote aboveground biomass accumulation and reveal the potential impacts of precipitation changes resulting from climate warming on the ecosystem services of subtropical and northern tropical forests in China.Notably,many natural forests in southern China are not fully stocked.Therefore,their continued growth will increase their carbon storage over time.展开更多
Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional p...Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain lateral comparison profile and seismic reflection structures in the 2D seismic section, which can provide references for future worldwide exploration. Microbial mounds with larger buildups and thicker vertical reservoirs are typically targeted on the windward margin, while small-sized microbial mounds and flats with better lateral connections are typically focused on the leeward margin.展开更多
The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is u...The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate change.The water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing factors.In this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)isotopes.We analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor sources.The results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study area.Temperature significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O value.Through the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study area.The hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air mass.In addition,the results of PSCF and CWT analysis showed that the water vapor source areas were primarily distributed in the south and northwest direction of the study area.展开更多
Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced re...Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more diverse.Following tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal function.However, there is currently no consensus on the specific distance of distal resection margin.展开更多
Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one tria...Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one trial has evaluated frontline BR prospectively in EMZL.This retrospective study reports outcomes among EMZL patients receiving frontline BR.Twenty-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ disease.The median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)individuals.Overall response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not reached.The estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to BR.BR is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.展开更多
基金Supported by the Project of Excellent Middle-aged People and Young People Team in Colleges and Universities of Hubei Province(T200708)the Humanity and Social Science Project of Hubei Provincial Department of Education(2009y149)
文摘Based on the introduction of the connotation of marginalization,the index of diagnosing the marginalization degree is put forward.According to the 685 copies of questionnaires on peasant households in Tongcheng County of Hubei Province and the statistical data of local government,marginalization of arable land and its correlation with rural labor migration in Tongcheng County are studied by using aggregative indicator method,clustering analysis method and correlation analysis method.Result shows that marginalization of arable land has happened two times in Tongcheng County since 1985.Dry land has severer marginalization degree than paddy field.There is significant correlation between marginalization degree of arable land and rural labor migration;and the correlation between marginalization degree and rural labor migration in paddy field is greater than that in dry land.Marginalization of arable land will advance the rural labor migration,while in response to the poor current circulation of lands;the rural labor migration will further deepen the marginalization degree.Marginalization of arable land is one of the important factors affecting the labor migration in rural areas.
文摘Ethnic sentiments are usually dictated by political and socio-economic factors and they derive from manipulation of minority interests and groups who are in the face of discrimination and marginalization jostle for attention and relevance within a geopolitical setting in a society. Most often, such political situation which promotes domination by one group and socio-economic subordination of another, usually results in ethnic crisis which arises from, and also leads to serious suspicion, anger, civil unrest, and sometimes war. It is not in doubt, that in times of ethno-political crisis and war, women and children are the main victims as they account for an estimated 80% of refugees and displaced persons worldwide. It is in view of this that this paper examines the politics of ethnic conflicts and discusses some of its painful outcomes, such as marginalization and dehumanization of women and children. The essay uses J. P. Clark＇s The Wives Revolt （1991） and Ahmed Yerima＇s Little Drops （2009） for illustration to point out the importance of democratic principles and increased representation of woman in governance and advocating against discriminatory policies in respect of women and children.
文摘Chinese American writer Celeste Ng has portrayed images of ＂marginal man＂ in her novel Everything I Never Told You. Centering the narration on the death of Lydia, with her own immigrant identity and cross-ethnical marriage, Celeste Ng has penetrated into the marginal culture in American society 1970s, exposing characters＇ marginal condition caused by ethnical identity, gender and sexual orientation.
文摘The city government of Solo has made a decision that street vendors operating in the city＇s Revolution Monument in Banjarsari Square for years must be relocated to the new built traditional market, called Pasar Notoharjo. This study utilized ethnographic methods, a combination of methods including observation, in-depth interview, focus group and the unobtrusive method including collecting written information. The study showed that the decision of Solo city government which tended to privilege street vendors＇ interests resulted in the life chance of prostitution was deteriorated and marginalized. The city government has accommodated street vendors＇ demand to remove ,the organized prostitution community operating in Silir-Semanggi of Solo since 1960s as one of requirements for their relocation to this area, where the new built traditional market with more than one thousand kiosks was provided for street vendors. The procuresses＇ demand to obtain their rights of the land they occupied for more than 20 years on behalf of their legal ownership failed due to administrative, bureaucratic and legal obstacles. Prostitutes were inhumanly chased away by the city government apparatuses in collaboration with the police from the site of operation in 2006 and it resulted that the social and economic lives of procuresses and prostitutes got worse since their prostitution activities in this location were totally forbidden and unfinished. Both procuresses and prostitutes were marginalized because they did not have links to the powerful stakeholder who were able to protect their rights. Their health was in danger because the city government＇s concern to their activities was limited in particularly since 1998 when the location was formally closed by Solo mayor of the new order.
文摘With migrant workers pouring out into cities together with their family,their problems become more and more prominent.By means of field study,the paper investigated the language problems and social problems of migrant workers,and confirmed the hypothesis that language problems cause migrant workers marginalized in the mainstream of the society.
基金National key basic research and development program(2015CB452706)National Natural Science Foundation of China(41361021)Science and Technology Foundation of Guizhou(Q J LKS[2013]17)
文摘Farmland resources in mountainous areas are important for regional food security and ecological secu- rity. Studies concerning changes in farmland use in mountainous areas are of considerable significance in China. Here, we analyzed marginalization characteristics of farmland in Renhuai city from 2005 to 2011 and driving factors using land information systems, surveys of farmer households and statistical data. Our results indicate that from 2005 to 2011, 3095.76 hm2 of farmland was converted to forest land and natural reserve, accounting for 5.45% of the total farmland area. This suggests significant marginalization of farmland. Marginalization of farmland in mountainous areas was affected by topography, labor forces and effectiveness of land management. Farmland with a greater slope gradient was more likely to be abandoned; among marginalized land in Renhuai, a slope greater than 15~ accounted for 62.26%. A high non-agricultural employment rate of rural labor force and annual income per capita of farmer households in mountainous areas were consistent with high speed farmland marginalization. Low land management benefits were the key reason for farmland marginalization. Although farmland marginalization was advantageous for eco-environment protection and sustainable development in mountainous areas, it resulted in inefficient land resource utilization. A win-win model for the exploitation and utilization of sloping farmland should be explored for production development and environmental protection.
基金The NSFC-IIASA Major International Joint Research Project, No.41161140352 Natural Science Foundation of Chongqing, No.2010JJ0069 Science and Technology Great Special Project on Controlling and Fathering Water Pollution during the National 12th Five-year Plan, No.2012ZX07104-003
文摘Based on SPOT-5 images, 1：1 million topographic maps, the maps of the returning farmland to forest project and the Chongqing forest project, social and economic statistics, etc., this paper identifies the features and factors influencing farmland marginalization. The results showed： （1） During 2002-2012, the rate of farmland marginalization was 16.18%, which was mainly found in the high areas of northern Qiyao mountains and the medium-altitude areas of southern Qiyao mountains. And this farmland marginalization will increase, associated with non-agriculturalization of rural labourers and aging of the remaining labourers. （2） Elevation, distance radius from villages and road connections had a great in- fluence on farmland marginalization. Farmland marginalization rates showed an increasing trend with the increase of elevation, and 60.88% of the total farmland marginalization area is found at an altitude greater than 1000 m above sea level. The marginalization trend also increases with slope and distance from the distribution network. （3） Farmland area per labourer and the average age of farm labourers were major factors driving farmland marginalization. Farmland transfer and small agricultural machinery sets affect farmland marginalization with respect to management and productivity efficiency. （4） Farmland with ＂comparative-disadvantage-dominated marginalization＂ accounted for 55.32% of the total farmland marginalization area, followed by ＂location-dominated marginalization＂ （33.80%）. （5） According to the specifics of each real situation, different policies are suggested to mitigate the margin- alization. A ＂continuous marginalization＂ policy will encourage the return of farmland to forest in ＂terrain-dominated marginalization＂. An ＂anti-marginalization＂ policy is suggested to create new rural accommodation and improve the rural road system to counteract ＂terrain-dominated marginalization＂. And another ＂anti-marginalization＂ policy is planned to improve management and micro-mechanization for ＂comparative-disadvantage-dominated marginalization＂. A new idea was developed to integrate high resolution remote sensing and statistical data with survey information to identify land marginalization and its driving forces in mountainous areas.
文摘The sandstones of the Late miocene–Pliocene Dibdibba Formation in the Najaf–Karbala Plateau and Basra were examined to determine their source rocks and origin. The rare earth elements(REE) and trace elements(Sc, Co, V, and Th) concentrations in these sandstones revealed that they likely derived from a single source. The steep light rare earth elements(LREE) and flat, heavy rare earth element(HREE) patterns, negative Eu anomaly, and high ΣREE contents in sandstones suggest its derivation from a suggests that a passive continental margin environment and originated from felsic source rocks. The average concentration of ΣREE is 93.5 ppm, which is lower than that of the average crustal compositions like Upper Continental Crust and Post Archean Australian Shale. The higher proportion of LREE compared to HREE implies that these sandstones were recycled and derived from a distal source. The Th/Co, Th/Sc, La/Sc, La/Co, Eu/Eu*and(La/Lu)cn elemental ratios indicated that these Late Miocene–Pliocene sandstones were derived from felsic rocks located in the marginal region of the Arabian Shield.
基金Supported by the National Natural Science Foundation of China(42090022)。
文摘Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin,SW China,the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbon accumulation elements,especially the source rock.The hydrocarbon accumulation characteristics of each whole petroleum system are analyzed,the patterns of integrated conventional and unconventional hydrocarbon accumulation are summarized,and the favorable exploration targets are proposed.Under the control of multiple extensional-convergent tectonic cycles,the marine carbonate rocks of the Sichuan Basin contain three sets of regional source rocks and three sets of regional cap rocks,and can be divided into the Cambrian,Silurian and Permian whole petroleum systems.These whole petroleum systems present mainly independent hydrocarbon accumulation,containing natural gas of affinity individually.Locally,large fault zones run through multiple whole petroleum systems,forming a fault-controlled complex whole petroleum system.The hydrocarbon accumulation sequence of continental shelf facies shale gas accumulation,marginal platform facies-controlled gas reservoirs,and intra-platform fault-and facies-controlled gas reservoirs is common in the whole petroleum system,with a stereoscopic accumulation and orderly distribution pattern.High-quality source rock is fundamental to the formation of large gas fields,and natural gas in a whole petroleum system is generally enriched near and within the source rocks.The development and maintenance of large-scale reservoirs are essential for natural gas enrichment,multiple sources,oil and gas transformation,and dynamic adjustment are the characteristics of marine petroleum accumulation,and good preservation conditions are critical to natural gas accumulation.Large-scale marginal-platform reef-bank facies zones,deep shale gas,and large-scale lithological complexes related to source-connected faults are future marine hydrocarbon exploration targets in the Sichuan Basin.
基金the National Natural Science Foundation of China(Project Nos.41804046 and 41974050)the Special Fund of the Key Laboratory of Earthquake Prediction,China Earthquake Administration(No.CEAIEF2022010100).
文摘On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault.
基金GDAS'Project of Science and Technology Development,No.2018GDASCX-0903,No.2017GDASCX-0101,No.2018GDASCX-0101National Basic Research Program of China(973 Program),No.2015CB452706National Natural Science Foundation of China,No.41801101,No.41161140352.
文摘Farmland marginalization has become the main trend of land-use change in the mountainous areas of China. Using annual survey data of major agricultural production costs and earnings at national and provincial levels in China, this study aims to analyze the reasons and mechanism behind farmland marginalization in mountainous areas. We find that farmers on plains are able to reduce their per mu labor input effectively through intensive use of agricultural machinery, which has minimized the impact of the increase in labor price. However, it is extremely challenging for farmers in mountainous areas to use the same method owing to the rough terrain. Thus, per laborer farming area in these areas has increased relatively slowly, causing a widening gap in agricultural labor productivity between the two regions. With the rapid rise in labor costs since 2003, the marginalization of cultivated land in mountainous areas is evident. In 2013, the net profit of agricultural production in mountainous China fell below zero. Since 2000, the land-use and land-cover change in these areas was characterized by the reduction of farmland area, reforestation, and the enhancement of the NDVI value. The high correlation between the NDVI change rate and the ratio of change in farmland(r = –0.70) and forest(r = 0.91) in mountainous areas at provincial level further attests to the trend of farmland marginalization there. Finally, we summarize the mechanism of such marginalization against the backdrop of the rapid increase in the opportunity cost of farming and the rapid fall of agricultural labor forces in mountainous areas. This study contributes to a deep understanding of the development process of farmland marginalization and abandonment as well as forest transition in Chinese mountainous areas.
文摘BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.
基金The Fundação para a Ciência e Tecnologia(FCT-MEC,Portugal)under contract No.UIDB/04326/2020 awarded to Gerardo Zardithe South African Research Chairs Initiative(SARChI)of the Department of Science and Technology and the National Research Foundation of South Africa under contract No.64801 awarded to Christopher McQuaid+1 种基金the Fund of European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie contract No.101034329the WINNINGNormandy Program supported by the Normandy Region for Gerardo Zardi.
文摘Marine heatwaves(MHWs)caused by anthropogenic climate change are becoming a key driver of change at the ecosystem level.Thermal conditions experienced by marine organisms across their distribution,particularly towards the equator,are likely to approach their physiological limits,resulting in extensive mortality and subsequent changes at the population level.Populations at the margins of their species’distribution are thought to be more sensitive to climate-induced environmental pressures than central populations,but our understanding of variability in fitness-related physiological traits in trailing versus leading-edge populations is limited.In a laboratory simulation study,we tested whether two leading(Iceland)and two trailing(Spain)peripheral populations of the intertidal macroalga Corallina officinalis display different levels of maximum potential quantum efficiency(Fv/Fm)resilience to current and future winter MHWs scenarios.Our study revealed that ongoing and future local winter MHWs will not negatively affect leading-edge populations of C.officinalis,which exhibited stable photosynthetic efficiency throughout the study.Trailing edge populations showed a positive though non-significant trend in photosynthetic efficiency throughout winter MHWs exposure.Poleward and equatorward populations did not produce significantly different results,with winter MHWs having no negative affect on Fv/Fm of either population.Additionally,we found no long-term regional or population-level influence of a winter MHWs on this species’photosynthetic efficiency.Thus,we found no statistically significant difference in thermal stress responses between leading and trailing populations.Nonetheless,C.officinalis showed a trend towards higher stress responses in southern than northern populations.Because responses rest on a variety of local population traits,they are difficult to predict based solely on thermal pressures.
基金supported by the National Natural Science Foundation of China(62073009,52775020,72201013)the China Postdoctoral Science Foundation(2022M710314)the Funding of Science&Technology on Reliability&Environmental Engineering Laboratory(6142004210102)。
文摘This paper systematically introduces and reviews a scientific exploration of reliability called the belief reliability.Beginning with the origin of reliability engineering,the problems of present theories for reliability engineering are summarized as a query,a dilemma,and a puzzle.Then,through philosophical reflection,we introduce the theoretical solutions given by belief reliability theory,including scientific principles,basic equations,reliability science experiments,and mathematical measures.The basic methods and technologies of belief reliability,namely,belief reliability analysis,function-oriented belief reliability design,belief reliability evaluation,and several newly developed methods and technologies are sequentially elaborated and overviewed.Based on the above investigations,we summarize the significance of belief reliability theory and make some prospects about future research,aiming to promote the development of reliability science and engineering.
基金The National Natural Science Foundation of China under contract Nos 41920104006the Scientific Research Fund of Second Institute of Oceanography+3 种基金Ministry of Natural Resources under contract Nos JZ2001,XRJH2410,and QNYC2102the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University under contract No.SL2021MS021the Global Climate Changes and Air-sea Interaction Program under contract No.GASI-02-PAC-ST-Wwinthe Taishan Scholars Program under contract No.tsqn202306282。
文摘The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,tropical cyclones,the Kuroshio intrusion,and water exchange through the Luzon Strait(LS).
基金supported by the Guangxi Key R&D Program (project No. AB16380254)a research project of Guangxi Forestry Department (Guilinkezi [2015] No.5)supported a grant for Bagui Senior Fellow (C33600992001)。
文摘Forests,the largest terrestrial carbon sinks,play an important role in carbon sequestration and climate change mitigation.Although forest attributes and environmental factors have been shown to impact aboveground biomass,their influence on biomass stocks in species-rich forests in southern China,a biodiversity hotspot,has rarely been investigated.In this study,we characterized the effects of environmental factors,forest structure,and species diversity on aboveground biomass stocks of 30 plots(1 ha each) in natural forests located within seven nature reserves distributed across subtropical and marginal tropical zones in Guangxi,China.Our results indicate that forest aboveground biomass stocks in this region are lower than those in mature tropical and subtropical forests in other regions.Furthermore,we found that aboveground biomass was positively correlated with stand age,mean annual precipitation,elevation,structural attributes and species richness,although not with species evenness.When we compared stands with the same basal area,we found that aboveground biomass stock was higher in communities with a higher coefficient of variation of diameter at breast height.These findings highlight the importance of maintaining forest structural diversity and species richness to promote aboveground biomass accumulation and reveal the potential impacts of precipitation changes resulting from climate warming on the ecosystem services of subtropical and northern tropical forests in China.Notably,many natural forests in southern China are not fully stocked.Therefore,their continued growth will increase their carbon storage over time.
基金jointly funded by projects supported by the National Natural Science Foundation of China(Grant No.41872150)the Joint Funds of the National Natural Science Foundation of China(Grant No.U19B6003)Major Scientific and Technological Projects of CNPC during the 13th five-year plan(No.2019A-02-10)。
文摘Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain lateral comparison profile and seismic reflection structures in the 2D seismic section, which can provide references for future worldwide exploration. Microbial mounds with larger buildups and thicker vertical reservoirs are typically targeted on the windward margin, while small-sized microbial mounds and flats with better lateral connections are typically focused on the leeward margin.
基金supported by the National Natural Science Foundation of China(42161007)the Scientific Research Program for Higher Education Institutions of Gansu Province(2021B-081)the Natural Science Foundation of Gansu Province(22JR5RA074).
文摘The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate change.The water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing factors.In this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)isotopes.We analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor sources.The results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study area.Temperature significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O value.Through the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study area.The hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air mass.In addition,the results of PSCF and CWT analysis showed that the water vapor source areas were primarily distributed in the south and northwest direction of the study area.
基金supported by “San Ming” Project of Shenzhen, China (No. SZSM201612051)National Natural Science Foundation of China (No. 81972240)。
文摘Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more diverse.Following tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal function.However, there is currently no consensus on the specific distance of distal resection margin.
文摘Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one trial has evaluated frontline BR prospectively in EMZL.This retrospective study reports outcomes among EMZL patients receiving frontline BR.Twenty-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ disease.The median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)individuals.Overall response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not reached.The estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to BR.BR is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.
