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Antiparkinsonian treatment for depression in Parkinson's disease: Are selective serotonin reuptake inhibitors recommended? 被引量:4
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作者 Philippe De Deurwaerdère Yuqiang Ding 《Translational Neuroscience and Clinics》 2016年第2期138-149,共12页
Depression is a frequent comorbid syndrome in Parkinson's disease. It is a difficult symptom to manage, as patients continuously receive antiparkinsonian medication and may also have to be treated for the ameliora... Depression is a frequent comorbid syndrome in Parkinson's disease. It is a difficult symptom to manage, as patients continuously receive antiparkinsonian medication and may also have to be treated for the amelioration of the side-effects of antiparkinsonian therapy. The first-line treatment for depression in Parkinson's disease is the use of selective serotonin reuptake inhibitors(SSRIs). The clinical efficacy of these medications in patients with Parkinson's disease is questionable. In fact, based on their mechanism of action, which requires at least a functional serotonergic system, it is predicted that SSRIs will have lower efficacy in patients with Parkinson's disease. Here, we consider the mechanism of action of SSRIs in the context of Parkinson's disease by investigating the fall in the levels of serotonergic markers and the inhibitory outcomes of antiparkinsonian treatment on serotonergic nerve activity. Because certain classes of antidepressant drugs are widely available, it is necessary to perform translational research to address different strategies used to manage depression in Parkinson's disease. 展开更多
关键词 ANTIDEPRESSANT drugs animal behavior HIGH-FREQUENCY stimulation of the subthalamic NUCLEUS L-DOPA MONOAMINE neurochemistry
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Harpagide Inhibits Microglial Activation and Protects Dopaminergic Neurons as Revealed by Nanoelectrode Amperometry
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作者 Fu-Li Zhang Yun Tang +2 位作者 Hong Jiang Xiao-Ke Yang Wei-Hua Huang 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2021年第8期2188-2194,共7页
Parkinson's disease(PD)is one of the most comm on n euroge nerative diseases(NDDs),characterized as less n eurotra nsmitter release and loss of dopaminergic(DAergic)neurons with microglial inflammatory response as... Parkinson's disease(PD)is one of the most comm on n euroge nerative diseases(NDDs),characterized as less n eurotra nsmitter release and loss of dopaminergic(DAergic)neurons with microglial inflammatory response as a key player.Natural product harpagide with anti-inflammatory function is a potential therapeutic drug of PD,but its role towards microglial activation and inflammation-mediated neuronal injury remained unsure. 展开更多
关键词 Nanotechnology Reactive oxygen species Vesicles HARPAGIDE neurochemistry
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