It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in...It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in the dermal structure actually affect the dermal function. The objective of this study was to clarify the relationship between dermal structural parameters and dermal functional parameters in overweight and obese Japanese males. A cross-sectional, observational study was conducted on Japanese male volunteers. Two ultrasound scanners, a 20-MHz Dermascan C<sup>®</sup> and an 18-MHz Mylab<sup>TM</sup> five<sup>®</sup> were used to evaluate dermal structure. Echogenicity of the lower dermis and dermal thickness of the participants’ abdomens and thighs were measured. A Cutometer<sup>®</sup> MPA580 was used to evaluate skin viscoelasticity, skin deformation (R0) and elasticity (R2, R7). The correlation between dermal structural parameters and skin viscoelasticity were validated using Pearson’s correlation coefficient or Spearman’s correlation coefficient by rank test. A total of 79 male volunteers were recruited of which 43 were control subjects with BMI <25 (age, 22 - 63 years), 25 were overweight subjects with BMI ≥ 25 to <30 (age, 23 - 64 years) and the 11 obese subjects had a BMI ≥ 30 (age, 26 - 47 years). There was no correlation between dermal structural parameters and skin viscoelasticity in the abdomens or thighs of all 79 participants. On the other hand, in the 36 overweight and obese participants, thigh dermal echogenicity was significantly and negatively correlated with R0 (r = -0.456, p < 0.01) and dermal thickness in the abdomen was significantly and positively correlated with R0 (r = 0.464, p < 0.01). The dermal functional parameter was significantly correlated with dermal structural parameters in overweight and obese males;in other words, a decrease in dermal function may be caused by structural changes in the dermis during obesity.展开更多
High-fat diet(HFD)could induce obese and microbial dysbiosis,the latter of which has great impact on host health.Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health.In t...High-fat diet(HFD)could induce obese and microbial dysbiosis,the latter of which has great impact on host health.Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health.In this study,we investigated the effects of rapeseed polysaccharide(RSP)on overweight and gut microbiota in highfat-diet(HFD)fed rats.RSP effectively alleviated the hyperglycemia and lipid metabolic disorder in serum,which was found closely related to the modulation of intestinal microbiota.Supplementation of RSP regulated the intestinal microbiome by increasing the proportion of butyrate acid producer Blautia(P<0.05),Dorea(P<0.01)and Akkermansia genus and inhibiting the growth of bacterial species associated with inflammation such as unclassified Ruminococcaceae(P<0.05).Moreover,the restoration of total short-chain fatty acids(SCFAs),especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders.Our results suggested that RSP is a potential prebiotic for preventing obese induced HFD through regulating the gut microbiota.展开更多
文摘It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in the dermal structure actually affect the dermal function. The objective of this study was to clarify the relationship between dermal structural parameters and dermal functional parameters in overweight and obese Japanese males. A cross-sectional, observational study was conducted on Japanese male volunteers. Two ultrasound scanners, a 20-MHz Dermascan C<sup>®</sup> and an 18-MHz Mylab<sup>TM</sup> five<sup>®</sup> were used to evaluate dermal structure. Echogenicity of the lower dermis and dermal thickness of the participants’ abdomens and thighs were measured. A Cutometer<sup>®</sup> MPA580 was used to evaluate skin viscoelasticity, skin deformation (R0) and elasticity (R2, R7). The correlation between dermal structural parameters and skin viscoelasticity were validated using Pearson’s correlation coefficient or Spearman’s correlation coefficient by rank test. A total of 79 male volunteers were recruited of which 43 were control subjects with BMI <25 (age, 22 - 63 years), 25 were overweight subjects with BMI ≥ 25 to <30 (age, 23 - 64 years) and the 11 obese subjects had a BMI ≥ 30 (age, 26 - 47 years). There was no correlation between dermal structural parameters and skin viscoelasticity in the abdomens or thighs of all 79 participants. On the other hand, in the 36 overweight and obese participants, thigh dermal echogenicity was significantly and negatively correlated with R0 (r = -0.456, p < 0.01) and dermal thickness in the abdomen was significantly and positively correlated with R0 (r = 0.464, p < 0.01). The dermal functional parameter was significantly correlated with dermal structural parameters in overweight and obese males;in other words, a decrease in dermal function may be caused by structural changes in the dermis during obesity.
基金supported by the Earmarked Fund for China Agriculture Research System(CARS-13)the Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2013-OCRI).
文摘High-fat diet(HFD)could induce obese and microbial dysbiosis,the latter of which has great impact on host health.Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health.In this study,we investigated the effects of rapeseed polysaccharide(RSP)on overweight and gut microbiota in highfat-diet(HFD)fed rats.RSP effectively alleviated the hyperglycemia and lipid metabolic disorder in serum,which was found closely related to the modulation of intestinal microbiota.Supplementation of RSP regulated the intestinal microbiome by increasing the proportion of butyrate acid producer Blautia(P<0.05),Dorea(P<0.01)and Akkermansia genus and inhibiting the growth of bacterial species associated with inflammation such as unclassified Ruminococcaceae(P<0.05).Moreover,the restoration of total short-chain fatty acids(SCFAs),especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders.Our results suggested that RSP is a potential prebiotic for preventing obese induced HFD through regulating the gut microbiota.
