针对局部遮阴环境下传统灰狼优化(Gray wolf optimization,GWO)算法在跟踪最大功率点时P-U特性曲线出现多峰值、后期收敛速度慢、稳态精度低等问题,结合灰狼优化算法和扰动观察法(Perturbation and observation,P&O)各自的优势,提...针对局部遮阴环境下传统灰狼优化(Gray wolf optimization,GWO)算法在跟踪最大功率点时P-U特性曲线出现多峰值、后期收敛速度慢、稳态精度低等问题,结合灰狼优化算法和扰动观察法(Perturbation and observation,P&O)各自的优势,提出了基于GWO-P&O的混合优化最大功率点跟踪(Maximum power point tracking,MPPT)算法。首先,采用灰狼优化算法逐渐向光伏的全局最大功率点靠近。其次,在灰狼优化算法收敛后期引入P&O法,既保持了灰狼优化算法较高的稳态精度,又能以较快速度寻找到局部最大功率点。最后,在不同环境工况下,将所提出的GWO-P&O方法与传统GWO算法进行对比。结果表明,改进的GWO-P&O算法在保证良好稳态性能的同时,一定程度上提高了GWO算法后期跟踪最大功率时的收敛速度。展开更多
To investigate the effect of Dachengqi decoction on NF-κB p65 expression in lung of rats with partial intestinal obstruction and the underlying mechanism, 30 SD rats were randomly divided into three groups： sham-ope...To investigate the effect of Dachengqi decoction on NF-κB p65 expression in lung of rats with partial intestinal obstruction and the underlying mechanism, 30 SD rats were randomly divided into three groups： sham-operation group, model group and Dachengqi decoction treatment group （Dachengqi group）, with 10 animals in each group. The models were made by partially ligating their large intestines outside the body. The pathological changes were analyzed by HE staining. The expression of NF-κB p65 in rats lung were measured by using real-time polymerase chain reaction and immunohistochemistry respectively. Moreover, the expression of caveolin-1 in rats lung was also measured to. Increased edema, interstitial thickening, hemorrhage, and infiltration of inflammatory cells were found in the model group. In contrast, this change was significantly reduced in Dachengqi group as compared with model group. In addition, the up-regulated caveolin-1 and NF-κB p65 were also suppressed by Dachengqi decoction in lung of rats with partial intestinal obstruction. We are led to concluded that the caveolin-l-NF-κB pathway plays an important role in the development of lung injury of rats with partial intestinal obstruction and Dachengqi decoction could down-regulate the expression of caveolin-1 and NF-κB p65 in lung of rats with partial intestinal obstruction.展开更多
The mutation of p53 gene was detected in Syrian hamster embryo(SHE) cells neoplastically initiated with a particles.The level of the p53 mRNA in transformant was obviously higher than that in non-irradiated counterpar...The mutation of p53 gene was detected in Syrian hamster embryo(SHE) cells neoplastically initiated with a particles.The level of the p53 mRNA in transformant was obviously higher than that in non-irradiated counterpart,as measured by Northern blot analysis of total RNA.A pair of primers were designed based on p53 cDNA sequence to produce the whole length of coding sequence about 1.2 kilobase(Kb) by reverse transcription of mRNA followed by the polymerase chain reaction(RTPCR),but the length of fragment amplified from transformant mRNA was about 0.3Kb,remarkably shorter than that from normal SHE cells.Imrnunohistochemical analysis of p53 protein showed that no heavy staining was found on slice of tumor derived from transformant inoculated in nude mice with hamster specific p53 monocloned antibody HD200.The results implied that p53 gene had been mutated by deletion,which might lead to loss of p53 protein expression but the increased expression of p53 remained in a particle-induced SHE transformant.展开更多
Mental retardation is defined by significant limitations in intellectual function and adaptive behavior that occur before 18 years of age.Many chromosomal diseases come with mental retardation.We reported two Chinese ...Mental retardation is defined by significant limitations in intellectual function and adaptive behavior that occur before 18 years of age.Many chromosomal diseases come with mental retardation.We reported two Chinese families with partial trisomy 9p and other chromosome partial monosomy,clinical features of mental retardation and mild facial and pinkie anomalies.In the family 1,we showed that the proband carried a trisomy 9p21.3→pter and monosomy 21q22.3→qter by using fluorescence in situ hybridization analysis.Molecular genetic analysis defined the precise breakpoint on chromosome 9p between markers D9S1846 and D9S171,an interval of about 2.9 Mb on 9p21.3,and the breakpoint on chromosome 21q between markers D21S1897 and D21S1446,a region of about 1.5 Mb on 21q22.3.In the family 2,a patient with trisomy 9p21.3→pter and monosomy 5p15.33→pter,and a de novo maternal balanced translocation between chromosomes 5 and 9 was identified in his mother.Cytogenetic and molecular genetic analysis defined the precise breakpoints on chromosome 9p21.3 and chromosome 5p15.33.Further clinical investigation found that any individual had no refractoriness eczema disease except the proband in this family.These results further implicate that trisomy 9p is associated with mental retardation,and that there may be key gene duplication on chromosome 9p21.3→9pter responsible for mental retardation and mild facial anomaly.This result has been applied successfully in prenatal diagnosis of the second family.展开更多
Let {Xn, n≥1} be a martingale difference sequence and {a nk , 1?k?n,n?1} an array of constant real numbers. The limiting behavior of weighted partial sums ∑ k=1 n a nk X k is investigated and some new results are ob...Let {Xn, n≥1} be a martingale difference sequence and {a nk , 1?k?n,n?1} an array of constant real numbers. The limiting behavior of weighted partial sums ∑ k=1 n a nk X k is investigated and some new results are obtained.展开更多
光伏系统在部分遮挡条件下的输出功率-电压(P-V)特性曲线呈多峰状,此时传统的最大功率点跟踪(Maximum Power Point Tracking,MPPT)算法失效,极大地降低了光伏系统能量转换效率。通过对光伏阵列在部分遮挡条件下的P-V特性进行较为深入的...光伏系统在部分遮挡条件下的输出功率-电压(P-V)特性曲线呈多峰状,此时传统的最大功率点跟踪(Maximum Power Point Tracking,MPPT)算法失效,极大地降低了光伏系统能量转换效率。通过对光伏阵列在部分遮挡条件下的P-V特性进行较为深入的实验分析及研究,基于实验分析及研究结果,设计并提出一种全局最大功率点跟踪(Global Maximum Power Point Tracking,GMPPT)算法以弥补传统M PPT算法的缺陷和不足。测试结果表明该算法可以快速实现在部分遮挡条件下全局最大功率点的追踪。展开更多
黄酮类化合物对P糖蛋白外泵作用的抑制效果越来越引起人们的关注.使用偏最小二乘法(PLS)和M o lconnZ分子参数计算程序,首次成功地构建了特异性地结合到P糖蛋白NBD 2位点的黄酮类抑制剂的二维定量构效关系(2D-Q SAR)模型.所得到的模型(...黄酮类化合物对P糖蛋白外泵作用的抑制效果越来越引起人们的关注.使用偏最小二乘法(PLS)和M o lconnZ分子参数计算程序,首次成功地构建了特异性地结合到P糖蛋白NBD 2位点的黄酮类抑制剂的二维定量构效关系(2D-Q SAR)模型.所得到的模型(尤其是模型D)表现出良好的可靠性和预测性,较好地关联了该类化合物结构特点和其对P糖蛋白抑制活性.这些模型对进一步合成和开发黄酮类P糖蛋白抑制剂有指导作用.展开更多
变压器能否稳定工作直接关系到变电站是否安全运行,其工作重心是检测出变压器局部放电产生的超声波信号。介绍了一种光纤F-P腔传感器,并在此基础上搭建了调制解调系统,分别通过对无超声波源、有超声波源和浸入变压器油中3种情况进行了...变压器能否稳定工作直接关系到变电站是否安全运行,其工作重心是检测出变压器局部放电产生的超声波信号。介绍了一种光纤F-P腔传感器,并在此基础上搭建了调制解调系统,分别通过对无超声波源、有超声波源和浸入变压器油中3种情况进行了实验测试,并在距离超声波源20,40,60,80,90,100 cm处进行了损耗特性测试,测试结果表明:此传感器受外界噪声干扰较小,且在变压器油中能实时地检测出超声波信号,精度高,损耗度为25.8 m V/cm,符合传感器在油浸式变压器中持续稳定工作的条件。当变压器出现故障时,能够及时发现问题,保证变压器安全运行。展开更多
基金supported by National Natural Science Foundation of China(No.52067013)Natural Science Foundation of Gansu Province(No.21JR7RA280)。
文摘针对局部遮阴环境下传统灰狼优化(Gray wolf optimization,GWO)算法在跟踪最大功率点时P-U特性曲线出现多峰值、后期收敛速度慢、稳态精度低等问题,结合灰狼优化算法和扰动观察法(Perturbation and observation,P&O)各自的优势,提出了基于GWO-P&O的混合优化最大功率点跟踪(Maximum power point tracking,MPPT)算法。首先,采用灰狼优化算法逐渐向光伏的全局最大功率点靠近。其次,在灰狼优化算法收敛后期引入P&O法,既保持了灰狼优化算法较高的稳态精度,又能以较快速度寻找到局部最大功率点。最后,在不同环境工况下,将所提出的GWO-P&O方法与传统GWO算法进行对比。结果表明,改进的GWO-P&O算法在保证良好稳态性能的同时,一定程度上提高了GWO算法后期跟踪最大功率时的收敛速度。
基金supported by a grant from the National Natural Sciences Foundation of China (No. 30873225)
文摘To investigate the effect of Dachengqi decoction on NF-κB p65 expression in lung of rats with partial intestinal obstruction and the underlying mechanism, 30 SD rats were randomly divided into three groups： sham-operation group, model group and Dachengqi decoction treatment group （Dachengqi group）, with 10 animals in each group. The models were made by partially ligating their large intestines outside the body. The pathological changes were analyzed by HE staining. The expression of NF-κB p65 in rats lung were measured by using real-time polymerase chain reaction and immunohistochemistry respectively. Moreover, the expression of caveolin-1 in rats lung was also measured to. Increased edema, interstitial thickening, hemorrhage, and infiltration of inflammatory cells were found in the model group. In contrast, this change was significantly reduced in Dachengqi group as compared with model group. In addition, the up-regulated caveolin-1 and NF-κB p65 were also suppressed by Dachengqi decoction in lung of rats with partial intestinal obstruction. We are led to concluded that the caveolin-l-NF-κB pathway plays an important role in the development of lung injury of rats with partial intestinal obstruction and Dachengqi decoction could down-regulate the expression of caveolin-1 and NF-κB p65 in lung of rats with partial intestinal obstruction.
文摘The mutation of p53 gene was detected in Syrian hamster embryo(SHE) cells neoplastically initiated with a particles.The level of the p53 mRNA in transformant was obviously higher than that in non-irradiated counterpart,as measured by Northern blot analysis of total RNA.A pair of primers were designed based on p53 cDNA sequence to produce the whole length of coding sequence about 1.2 kilobase(Kb) by reverse transcription of mRNA followed by the polymerase chain reaction(RTPCR),but the length of fragment amplified from transformant mRNA was about 0.3Kb,remarkably shorter than that from normal SHE cells.Imrnunohistochemical analysis of p53 protein showed that no heavy staining was found on slice of tumor derived from transformant inoculated in nude mice with hamster specific p53 monocloned antibody HD200.The results implied that p53 gene had been mutated by deletion,which might lead to loss of p53 protein expression but the increased expression of p53 remained in a particle-induced SHE transformant.
基金supported by grants from National Natural Sciences Foundation of China [No. 30670736 and No.30972655 (J.Y.L.)]
文摘Mental retardation is defined by significant limitations in intellectual function and adaptive behavior that occur before 18 years of age.Many chromosomal diseases come with mental retardation.We reported two Chinese families with partial trisomy 9p and other chromosome partial monosomy,clinical features of mental retardation and mild facial and pinkie anomalies.In the family 1,we showed that the proband carried a trisomy 9p21.3→pter and monosomy 21q22.3→qter by using fluorescence in situ hybridization analysis.Molecular genetic analysis defined the precise breakpoint on chromosome 9p between markers D9S1846 and D9S171,an interval of about 2.9 Mb on 9p21.3,and the breakpoint on chromosome 21q between markers D21S1897 and D21S1446,a region of about 1.5 Mb on 21q22.3.In the family 2,a patient with trisomy 9p21.3→pter and monosomy 5p15.33→pter,and a de novo maternal balanced translocation between chromosomes 5 and 9 was identified in his mother.Cytogenetic and molecular genetic analysis defined the precise breakpoints on chromosome 9p21.3 and chromosome 5p15.33.Further clinical investigation found that any individual had no refractoriness eczema disease except the proband in this family.These results further implicate that trisomy 9p is associated with mental retardation,and that there may be key gene duplication on chromosome 9p21.3→9pter responsible for mental retardation and mild facial anomaly.This result has been applied successfully in prenatal diagnosis of the second family.
基金SupportedbytheNationalNaturalScienceFoundationofChina (No .10 0 710 5 8)and (No .10 0 710 19)
文摘Let {Xn, n≥1} be a martingale difference sequence and {a nk , 1?k?n,n?1} an array of constant real numbers. The limiting behavior of weighted partial sums ∑ k=1 n a nk X k is investigated and some new results are obtained.
文摘光伏系统在部分遮挡条件下的输出功率-电压(P-V)特性曲线呈多峰状,此时传统的最大功率点跟踪(Maximum Power Point Tracking,MPPT)算法失效,极大地降低了光伏系统能量转换效率。通过对光伏阵列在部分遮挡条件下的P-V特性进行较为深入的实验分析及研究,基于实验分析及研究结果,设计并提出一种全局最大功率点跟踪(Global Maximum Power Point Tracking,GMPPT)算法以弥补传统M PPT算法的缺陷和不足。测试结果表明该算法可以快速实现在部分遮挡条件下全局最大功率点的追踪。
文摘黄酮类化合物对P糖蛋白外泵作用的抑制效果越来越引起人们的关注.使用偏最小二乘法(PLS)和M o lconnZ分子参数计算程序,首次成功地构建了特异性地结合到P糖蛋白NBD 2位点的黄酮类抑制剂的二维定量构效关系(2D-Q SAR)模型.所得到的模型(尤其是模型D)表现出良好的可靠性和预测性,较好地关联了该类化合物结构特点和其对P糖蛋白抑制活性.这些模型对进一步合成和开发黄酮类P糖蛋白抑制剂有指导作用.
文摘变压器能否稳定工作直接关系到变电站是否安全运行,其工作重心是检测出变压器局部放电产生的超声波信号。介绍了一种光纤F-P腔传感器,并在此基础上搭建了调制解调系统,分别通过对无超声波源、有超声波源和浸入变压器油中3种情况进行了实验测试,并在距离超声波源20,40,60,80,90,100 cm处进行了损耗特性测试,测试结果表明:此传感器受外界噪声干扰较小,且在变压器油中能实时地检测出超声波信号,精度高,损耗度为25.8 m V/cm,符合传感器在油浸式变压器中持续稳定工作的条件。当变压器出现故障时,能够及时发现问题,保证变压器安全运行。
