目的 :研究无创参数SpO_2/FiO_2(S/F)和PaO_2/FiO_2(P/F)之间的关系,探索使用无创参数辨识急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者疾病严重程度的可能性。方法:访问重症医学信息数据库(Medical Information ...目的 :研究无创参数SpO_2/FiO_2(S/F)和PaO_2/FiO_2(P/F)之间的关系,探索使用无创参数辨识急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者疾病严重程度的可能性。方法:访问重症医学信息数据库(Medical Information Mart for Intensive Care,MIMIC-Ⅲ),获取患者相关生理参数,将患者数据随机分为训练集和测试集。使用训练集,利用广义线性回归模型,建立lg(S/F)与lg(P/F)之间的线性关系,选择最优的回归方程作为对数线性回归模型,并将lg(S/F)与lg(P/F)之间的线性关系和S/F与P/F之间的线性关系进行对比研究。使用测试集,比较2种模型对于P/F在100(重度ARDS)、200(中度ARDS)、300(轻度ARDS)处的辨识效果。结果:在训练集(n=61 634)上推导出lg(P/F)与lg(S/F)之间的线性关系:lg(S/F)=1.277+0.437×lg(P/F)(r=0.66,P<0.000 1),并确定了P/F在100、200、300处对应的S/F阈值为131、201、271。在测试集(n=26 758)上使用S/F阈值验证了其辨识效果,且较传统线性回归模型辨识结果有了明显改善。结论:通过研究,认为在患者血气分析结果缺失的情况下,可以使用无创参数SpO_2/FiO_2代替PaO_2/FiO_2作为ARDS患者病情诊断的辅助手段。展开更多
Objective:To explore the easily applicable indicators of practical value to evaluate the prognosis of acute respiratory distress syndrome（ARDS）.Methods:Blood and biochemical tests and bloodgas analyses were performe...Objective:To explore the easily applicable indicators of practical value to evaluate the prognosis of acute respiratory distress syndrome（ARDS）.Methods:Blood and biochemical tests and bloodgas analyses were performed upon entry into the ICUs,12 h,24 h,48 h and 72 h after that in 72 ARDS patients（who were admitted to the ICUs of our hospital from January 2000 to December 2009）.Then APACHEⅡscores were achieved by combining relevant physiological parameters and laboratory results.Results:There was a statistical difference between the death group and survival group at different time points upon entering the ICUs in terms of APACHEⅡscore, alveolar-arterial oxygen difference and arterial blood lactate clearance rate.PaO<sub>2</sub>/FiO<sub>2</sub> values were recorded to be statistically different between the death group and survival group 24 h,48 h and 72 h,respectively after entry into the ICUs.In addition,registered linear regression existed between APACHEⅡscore,alveolar-arterial oxygen difference or PaO<sub>2</sub>/FiO<sub>2</sub> value and time. APACHEⅡscore 24 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve（AUC） standing respectively at 0.919 and 0.9SS.Arterial blood lactate clearance rate 12 h, 24 h,48 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve （AUC） at 0.918,0.918,0.909 and 0.991,respectively.Conclusions:APACHEⅡscore applied in combination with arterial blood lactate clearance rate is of clinical significance in assessing the prognosis of ARDS patients.展开更多
目的探讨气管内滴入不同布地奈德合剂联合经鼻持续气道正压(NCPAP)对呼吸窘迫综合征(RDS)的早期疗效差异。方法按纳入标准随机将RDS高危早产儿91例(预防RDS28例,诊断RDS治疗63例)分为观察组(气管内滴入沐舒坦-布地奈德混合剂)和对照组(...目的探讨气管内滴入不同布地奈德合剂联合经鼻持续气道正压(NCPAP)对呼吸窘迫综合征(RDS)的早期疗效差异。方法按纳入标准随机将RDS高危早产儿91例(预防RDS28例,诊断RDS治疗63例)分为观察组(气管内滴入沐舒坦-布地奈德混合剂)和对照组(气管内滴入固尔苏-布地奈德混合剂),均予NCPAP通气,比较预防病例RDS发生率和RDS治疗病例PaO2/FiO2改善情况。结果两组均无RDS新发病例;两组RDS病例治疗前及治疗后6、12 h PaO2/FiO2无差异(P>0.05),治疗后1小时观察组比对照组低(P<0.01)。结论两种布地奈德混合剂及早气管内滴入均能有效预防RDS、改善RDS肺功能,但观察组显效慢。展开更多
文摘目的 :研究无创参数SpO_2/FiO_2(S/F)和PaO_2/FiO_2(P/F)之间的关系,探索使用无创参数辨识急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者疾病严重程度的可能性。方法:访问重症医学信息数据库(Medical Information Mart for Intensive Care,MIMIC-Ⅲ),获取患者相关生理参数,将患者数据随机分为训练集和测试集。使用训练集,利用广义线性回归模型,建立lg(S/F)与lg(P/F)之间的线性关系,选择最优的回归方程作为对数线性回归模型,并将lg(S/F)与lg(P/F)之间的线性关系和S/F与P/F之间的线性关系进行对比研究。使用测试集,比较2种模型对于P/F在100(重度ARDS)、200(中度ARDS)、300(轻度ARDS)处的辨识效果。结果:在训练集(n=61 634)上推导出lg(P/F)与lg(S/F)之间的线性关系:lg(S/F)=1.277+0.437×lg(P/F)(r=0.66,P<0.000 1),并确定了P/F在100、200、300处对应的S/F阈值为131、201、271。在测试集(n=26 758)上使用S/F阈值验证了其辨识效果,且较传统线性回归模型辨识结果有了明显改善。结论:通过研究,认为在患者血气分析结果缺失的情况下,可以使用无创参数SpO_2/FiO_2代替PaO_2/FiO_2作为ARDS患者病情诊断的辅助手段。
基金sponsored by Guangdong Science and Technology Project(No:2009B03081118)
文摘Objective:To explore the easily applicable indicators of practical value to evaluate the prognosis of acute respiratory distress syndrome（ARDS）.Methods:Blood and biochemical tests and bloodgas analyses were performed upon entry into the ICUs,12 h,24 h,48 h and 72 h after that in 72 ARDS patients（who were admitted to the ICUs of our hospital from January 2000 to December 2009）.Then APACHEⅡscores were achieved by combining relevant physiological parameters and laboratory results.Results:There was a statistical difference between the death group and survival group at different time points upon entering the ICUs in terms of APACHEⅡscore, alveolar-arterial oxygen difference and arterial blood lactate clearance rate.PaO<sub>2</sub>/FiO<sub>2</sub> values were recorded to be statistically different between the death group and survival group 24 h,48 h and 72 h,respectively after entry into the ICUs.In addition,registered linear regression existed between APACHEⅡscore,alveolar-arterial oxygen difference or PaO<sub>2</sub>/FiO<sub>2</sub> value and time. APACHEⅡscore 24 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve（AUC） standing respectively at 0.919 and 0.9SS.Arterial blood lactate clearance rate 12 h, 24 h,48 h and 72 h after entering ICUs predicted mortality with an area under the ROC curve （AUC） at 0.918,0.918,0.909 and 0.991,respectively.Conclusions:APACHEⅡscore applied in combination with arterial blood lactate clearance rate is of clinical significance in assessing the prognosis of ARDS patients.
文摘目的探讨气管内滴入不同布地奈德合剂联合经鼻持续气道正压(NCPAP)对呼吸窘迫综合征(RDS)的早期疗效差异。方法按纳入标准随机将RDS高危早产儿91例(预防RDS28例,诊断RDS治疗63例)分为观察组(气管内滴入沐舒坦-布地奈德混合剂)和对照组(气管内滴入固尔苏-布地奈德混合剂),均予NCPAP通气,比较预防病例RDS发生率和RDS治疗病例PaO2/FiO2改善情况。结果两组均无RDS新发病例;两组RDS病例治疗前及治疗后6、12 h PaO2/FiO2无差异(P>0.05),治疗后1小时观察组比对照组低(P<0.01)。结论两种布地奈德混合剂及早气管内滴入均能有效预防RDS、改善RDS肺功能,但观察组显效慢。
