Morbidity associated with conjunctivitis is higher in developing countries,particularly among children,because of the poorer standards of living（Azari and Barney,2013;Yetman and Coody,1997）.Presently,little is known...Morbidity associated with conjunctivitis is higher in developing countries,particularly among children,because of the poorer standards of living（Azari and Barney,2013;Yetman and Coody,1997）.Presently,little is known regarding the microorganisms that cause conjunctivitis in the remote area of Chinese Tibet.In particular,it is difficult to monitor and control the occurrence of conjunctivitis in children from this area.展开更多
Plant diseases severely reduce crop yields and threaten global food security.Broad-spectrum resistance(BSR)is a desirable trait because it confers resistance against more than one pathogen species or the majority of r...Plant diseases severely reduce crop yields and threaten global food security.Broad-spectrum resistance(BSR)is a desirable trait because it confers resistance against more than one pathogen species or the majority of races/strains of the same pathogen.To control plant diseases,breeders have selected BSR to reduce disease occurrence and prolong the life-span of newly released cultivars in the last several decades(Mundt,Phytopathology 108(7):792–802,2018).Although effective,breeding of BSR cultivars in crop plants is still time-consuming and technically challenging.Recently,new gene-editing technologies such as CRISPR/Cas9 have dramatically accelerated the process of plant breeding and provided an approach for rapidly creating new varieties with BSR and other beneficial traits(Borrelli et al.,Front Plant Sci 9:1245,2018).In addition,close surveillance of pathogen populations in the field can provide useful information for the deployment of appropriate resistance genes in the target regions.In this mini-review,we focus on the significance and application of the exciting results from two recent companion papers published in Nature Biotechnology that provide new strategies to develop crop plants with BSR against pathogens through targeted promoter editing of susceptibility genes in plants as well as pathogen population monitoring.展开更多
文摘Morbidity associated with conjunctivitis is higher in developing countries,particularly among children,because of the poorer standards of living（Azari and Barney,2013;Yetman and Coody,1997）.Presently,little is known regarding the microorganisms that cause conjunctivitis in the remote area of Chinese Tibet.In particular,it is difficult to monitor and control the occurrence of conjunctivitis in children from this area.
基金We gratefully acknowledge grant supports from the National Natural Science Foundation of China(#31901829)the China Postdoctoral Science Foundation(2019M660894)to J.W.
文摘Plant diseases severely reduce crop yields and threaten global food security.Broad-spectrum resistance(BSR)is a desirable trait because it confers resistance against more than one pathogen species or the majority of races/strains of the same pathogen.To control plant diseases,breeders have selected BSR to reduce disease occurrence and prolong the life-span of newly released cultivars in the last several decades(Mundt,Phytopathology 108(7):792–802,2018).Although effective,breeding of BSR cultivars in crop plants is still time-consuming and technically challenging.Recently,new gene-editing technologies such as CRISPR/Cas9 have dramatically accelerated the process of plant breeding and provided an approach for rapidly creating new varieties with BSR and other beneficial traits(Borrelli et al.,Front Plant Sci 9:1245,2018).In addition,close surveillance of pathogen populations in the field can provide useful information for the deployment of appropriate resistance genes in the target regions.In this mini-review,we focus on the significance and application of the exciting results from two recent companion papers published in Nature Biotechnology that provide new strategies to develop crop plants with BSR against pathogens through targeted promoter editing of susceptibility genes in plants as well as pathogen population monitoring.
