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Correlation between the gut microbiome and neurodegenerative diseases:a review of metagenomics evidence 被引量:5
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作者 Xiaoyan Liu Yi Liu +7 位作者 Junlin Liu Hantao Zhang Chaofan Shan Yinglu Guo Xun Gong Mengmeng Cui Xiubin Li Min Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期833-845,共13页
A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis.As a contributing factor,microbiota dysbiosis always occurs in... A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis.As a contributing factor,microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral sclerosis.High-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms,and for both neuroimmune and neuroendocrine systems.Here,we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases,with an emphasis on multi-omics studies and the gut virome.The pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also elucidated.Finally,we discuss the role of diet,prebiotics,probiotics,postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases. 展开更多
关键词 biomarker diet pattern gut microbiota gut-brain axis METAGENOMICS mitochondrial dysfunction multi-omics neurodegenerative disease NEUROINFLAMMATION probiotic
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Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations 被引量:4
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作者 Shun Wang Peng Zhang +12 位作者 Fan Fei Tianyang Tong Xiujuan Zhou Yajie Zhou Jing Zhang Mengke Wei Yanqi Zhang Lei Zhang Yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie 《Zoological Research》 SCIE CSCD 2024年第1期69-78,共10页
Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity i... Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions. 展开更多
关键词 Homing and migration Animal navigation Magnetoreceptor(MagR) Diverse navigation pattern Conserved protein
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Corrigendum to“Migration pattern of a population of Barn Swallows(Hirundo rustica)breeding in East Asian tropical region”[Avian Res.15(2024)100192] 被引量:1
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作者 Li Tian Yu Liu +3 位作者 Yang Wu Zimei Feng Dan Hu Zhengwang Zhang 《Avian Research》 SCIE CSCD 2024年第3期402-402,共1页
The authors regret that the caption of Fig.4 should be replaced as below.
关键词 BREEDING pattern TROPICAL
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Plastid phylogenomics provides new insights into the systematics,diversification,and biogeography of Cymbidium(Orchidaceae) 被引量:1
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作者 Hai-Yao Chen Zhi-Rong Zhang +7 位作者 Xin Yao Ji-Dong Ya Xiao-Hua Jin Lin Wang Lu Lu De-Zhu Li Jun-Bo Yang Wen-Bin Yu 《Plant Diversity》 SCIE CAS CSCD 2024年第4期448-461,共14页
Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the region.However,... Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the region.However,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this genus.In this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate analyses.Molecular dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle Miocene.Cymbidium spp.migration to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene period.Our analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon intensity.Favorable hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle Miocene.The transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification rates.This study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia. 展开更多
关键词 CYMBIDIUM East Asia Asian monsoons Climate change Biogeographical patterns
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Clinical manifestation,lifestyle,and treatment patterns of chronic erosive gastritis:A multicenter real-world study in China 被引量:1
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作者 Ying-Yun Yang Ke-Min Li +18 位作者 Gui-Fang Xu Cheng-Dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-Wei Wang Jing-Nan Li 《World Journal of Gastroenterology》 SCIE CAS 2024年第9期1108-1120,共13页
BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To ex... BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in China.METHODS We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology.Patients and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.RESULTS Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included.Epigastric pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting symptoms.Gastritis was classified as chronic non-atrophic in 69.9%of patients.Among those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat lesions.In patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more effective.For those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more promising.CONCLUSION CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms.Gastroscopy may play a major role in its detection and diagnosis.Treatment should be individualized based on symptom profile. 展开更多
关键词 Chronic erosive gastritis SYMPTOM Endoscopic findings Treatment pattern Real-world
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A strategy for strengthening chaotic mixing of dual shaft eccentric mixers by changing non-Newtonian fluids kinetic energy distribution 被引量:1
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作者 Songsong Wang Tong Meng +4 位作者 Qian Zhang Changyuan Tao Yundong Wang Zequan Li Zuohua Liu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第5期122-134,共13页
Efficiently modulating the velocity distribution and flow pattern of non-Newtonian fluids is a critical challenge in the context of dual shaft eccentric mixers for process intensification,posing a significant barrier ... Efficiently modulating the velocity distribution and flow pattern of non-Newtonian fluids is a critical challenge in the context of dual shaft eccentric mixers for process intensification,posing a significant barrier for the existing technologies.Accordingly,this work reports a convenient strategy that changes the kinetic energy to controllably regulate the flow patterns from radial flow to axial flow.Results showed that the desired velocity distribution and flow patterns could be effectively obtained by varying the number and structure of baffles to change kinetic energy,and a more uniform velocity distribution,which could not be reached normally in standard baffle dual shaft mixers,was easily obtained.Furthermore,a comparative analysis of velocity and shear rate distributions is employed to elucidate the mechanism behind the generation of flow patterns in various dual-shaft eccentric mixers.Importantly,there is little difference in the power number of the laminar flow at the same Reynolds number,meaning that the baffle type has no effect on the power consumption,while the power number of both unbaffle and U-shaped baffle mixing systems decreases compared with the standard baffle mixing system in the transition flow.Finally,at the same rotational condition,the dimensionless mixing time of the U-shaped baffle mixing system is 15.3%and 7.9%shorter than that of the standard baffle and the unbaffle mixing system,respectively,which shows the advantage of the U-shaped baffle in stirring rate. 展开更多
关键词 Dual shaft “U-shaped”baffle Flow pattern Mixing time Power demand
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Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process 被引量:1
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作者 Chong-Zheng Sun Yu-Xing Li +2 位作者 Hui Han Xiao-Yi Geng Xiao Lu 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1369-1384,共16页
Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat ... Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat exchanger.The results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow. 展开更多
关键词 Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition Falling film flow
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Knockdown of the atypical protein kinase genes GhABC1K2-A05 and GhABC1K12-A07 make cotton more sensitive to salt and PEG stress 被引量:1
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作者 Caixiang Wang Meili Li +3 位作者 Dingguo Zhang Xueli Zhang Juanjuan Liu Junji Su 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第10期3370-3386,共17页
Activity of bc1 complex kinase(ABC1K)is an atypical protein kinase(aPK)that plays a crucial role in plant mitochondrial and plastid stress responses,but little is known about the responses of ABC1Ks to stress in cotto... Activity of bc1 complex kinase(ABC1K)is an atypical protein kinase(aPK)that plays a crucial role in plant mitochondrial and plastid stress responses,but little is known about the responses of ABC1Ks to stress in cotton(Gossypium spp.).Here,we identified 40 ABC1Ks in upland cotton(Gossypium hirsutum L.)and found that the Gh ABC1Ks were unevenly distributed across 17 chromosomes.The GhABC1K family members included 35 paralogous gene pairs and were expanded by segmental duplication.The GhABC1K promoter sequences contained diverse cis-acting regulatory elements relevant to hormone or stress responses.The qRT-PCR results revealed that most Gh ABC1Ks were upregulated by exposure to different stresses.Gh ABC1K2-A05 and Gh ABC1K12-A07 expression levels were upregulated by at least three stress treatments.These genes were further functionally characterized by virus-induced gene silencing(VIGS).Compared with the controls,the Gh ABC1K2-A05-and Gh ABC1K12-A07-silenced cotton lines exhibited higher malondialdehyde(MDA)contents,lower catalase(CAT),peroxidase(POD)and superoxide dismutase(SOD)activities and reduced chlorophyll and soluble sugar contents under NaCl and PEG stress.In addition,the expression levels of six stress marker genes(Gh DREB2A,Gh SOS1,Gh CIPK6,Gh SOS2,Gh WRKY33,and Gh RD29A)were significantly downregulated after stress in the Gh ABC1K2-A05-and Gh ABC1K12-A07-silenced lines.The results indicate that knockdown of Gh ABC1K2-A05 and Gh ABC1K12-A07 make cotton more sensitive to salt and PEG stress.These findings can provide valuable information for intensive studies of Gh ABC1Ks in the responses and resistance of cotton to abiotic stresses. 展开更多
关键词 COTTON ABC1K abiotic stress responses expression patterns virus-induced gene silencing(VIGS)
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A deep convolutional neural network for diabetic retinopathy detection via mining local and long-range dependence 被引量:1
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作者 Xiaoling Luo Wei Wang +4 位作者 Yong Xu Zhihui Lai Xiaopeng Jin Bob Zhang David Zhang 《CAAI Transactions on Intelligence Technology》 SCIE EI 2024年第1期153-166,共14页
Diabetic retinopathy(DR),the main cause of irreversible blindness,is one of the most common complications of diabetes.At present,deep convolutional neural networks have achieved promising performance in automatic DR d... Diabetic retinopathy(DR),the main cause of irreversible blindness,is one of the most common complications of diabetes.At present,deep convolutional neural networks have achieved promising performance in automatic DR detection tasks.The convolution operation of methods is a local cross-correlation operation,whose receptive field de-termines the size of the local neighbourhood for processing.However,for retinal fundus photographs,there is not only the local information but also long-distance dependence between the lesion features(e.g.hemorrhages and exudates)scattered throughout the whole image.The proposed method incorporates correlations between long-range patches into the deep learning framework to improve DR detection.Patch-wise re-lationships are used to enhance the local patch features since lesions of DR usually appear as plaques.The Long-Range unit in the proposed network with a residual structure can be flexibly embedded into other trained networks.Extensive experimental results demon-strate that the proposed approach can achieve higher accuracy than existing state-of-the-art models on Messidor and EyePACS datasets. 展开更多
关键词 image classification medical image processing pattern recognition
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Surface Patterning of Metal Zinc Electrode with an In‑Region Zincophilic Interface for High‑Rate and Long‑Cycle‑Life Zinc Metal Anode 被引量:1
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作者 Tian Wang Qiao Xi +8 位作者 Kai Yao Yuhang Liu Hao Fu Venkata Siva Kavarthapu Jun Kyu Lee Shaocong Tang Dina Fattakhova‑Rohlfing Wei Ai Jae Su Yu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第6期192-209,共18页
The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially im... The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the microchannels.The accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current densities.Meanwhile,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array surface.Consequently,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs. 展开更多
关键词 Zn metal anode Surface patterning Directional Zn deposition Aqueous Zn-I_(2)batteries
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Venous Doppler flow patterns,venous congestion,heart disease and renal dysfunction:A complex liaison 被引量:1
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作者 Alessio Di Maria Rossella Siligato +1 位作者 Marta Bondanelli Fabio Fabbian 《World Journal of Cardiology》 2024年第1期5-9,共5页
The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted... The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of investigation.Evaluating venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its efficacy.Renal dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney diseases.Fluid overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart disease.Organ congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney disease.Ultrasonography and abnormal Doppler flow patterns diagnose clinically significant systemic venous congestion.Cardiologists and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices. 展开更多
关键词 Cardio-renal syndrome Fluid overload Venous congestion Acute kidney injury ULTRASOUND Doppler flow patterns
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不同编织方式下陶瓷基复合材料表面流动特性数值计算研究 被引量:1
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作者 张金月 杨荣菲 +1 位作者 吴兴爽 葛宁 《风机技术》 2024年第2期38-43,共6页
Ceramic matrix composites(CMCs) are one of the most promising materials in the field of gas turbines,with superior weight and thermal properties. Its surface morphology is different from the traditional casting airfoi... Ceramic matrix composites(CMCs) are one of the most promising materials in the field of gas turbines,with superior weight and thermal properties. Its surface morphology is different from the traditional casting airfoil components, which mainly comes from different weaving methods and different braided tow thickness. However, few people have studied the influence of surface morphology of ceramic matrix composites(CMCs) on the development of boundary layer and the resulting flow loss. In this paper, Tex Gen is used to generate different surface morphology structures of ceramic matrix composites(CMCs), and the surface flow characteristics of corresponding CMCs plates are numerically studied. It is found that the slope of the displacement thickness of the woven surface first increases and then decreases in the whole transition interval. Thicker braided tow thickness and denser braiding method will induce earlier flow transition phenomenon and produce greater flow loss;The flow loss on the surface of CMCs plate is mainly composed of the vortex loss in the pit and the boundary layer loss outside the pit, and the boundary layer loss is dominant. The weaving methods has a greater influence on the flow state and flow loss of the boundary layer. 展开更多
关键词 Ceramic Matrix Composites Weave Pattern Boundary Layer Transition PIT Flow Loss
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Pedestrian flow through exit:Study focused on evacuation pattern
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作者 张博思 余志红 +2 位作者 孙柏林 郭紫钰 陈默 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期755-764,共10页
Experiments are conducted on the evacuation rate of pedestrians through exits with queued evacuation pattern and random evacuation pattern. The experimental results show that the flow rate of pedestrians is larger wit... Experiments are conducted on the evacuation rate of pedestrians through exits with queued evacuation pattern and random evacuation pattern. The experimental results show that the flow rate of pedestrians is larger with the random evacuation pattern than with the queued evacuation pattern. Therefore, the exit width calculated based on the minimum evacuation clear width for every 100 persons, which is on the assumption that the pedestrians pass through the exit in one queue or several queues, is conservative. The number of people crossing the exit simultaneously is greater in the random evacuation experiments than in the queued evacuation experiments, and the time interval between the front row and rear row of people is shortened in large-exit conditions when pedestrians evacuate randomly. The difference between the flow rate with a queued evacuation pattern and the flow rate with a random evacuation pattern is related to the surplus width of the exit, which is greater than the total width of all accommodated people streams. Two dimensionless quantities are defined to explore this relationship. It is found that the difference in flow rate between the two evacuation patterns is stable at a low level when the surplus width of the exit is no more than 45% of the width of a single pedestrian stream. There is a great difference between the flow rate with the queued evacuation pattern and the flow rate with the random evacuation pattern in a scenario with a larger surplus width of the exit. Meanwhile, the pedestrians crowd extraordinarily at the exit in these conditions as well, since the number of pedestrians who want to evacuate through exit simultaneously greatly exceeds the accommodated level. Therefore, the surplus width of exit should be limited especially in the narrow exit condition, and the relationship between the two dimensionless quantities mentioned above could provide the basis to some extent. 展开更多
关键词 EVACUATION exit width flow rate queued evacuation pattern random evacuation pattern
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A Quarterly High RFM Mining Algorithm for Big Data Management
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作者 Cuiwei Peng Jiahui Chen +1 位作者 Shicheng Wan Guotao Xu 《Computers, Materials & Continua》 SCIE EI 2024年第9期4341-4360,共20页
In today’s highly competitive retail industry,offline stores face increasing pressure on profitability.They hope to improve their ability in shelf management with the help of big data technology.For this,on-shelf ava... In today’s highly competitive retail industry,offline stores face increasing pressure on profitability.They hope to improve their ability in shelf management with the help of big data technology.For this,on-shelf availability is an essential indicator of shelf data management and closely relates to customer purchase behavior.RFM(recency,frequency,andmonetary)patternmining is a powerful tool to evaluate the value of customer behavior.However,the existing RFM patternmining algorithms do not consider the quarterly nature of goods,resulting in unreasonable shelf availability and difficulty in profit-making.To solve this problem,we propose a quarterly RFM mining algorithmfor On-shelf products named OS-RFM.Our algorithmmines the high recency,high frequency,and high monetary patterns and considers the period of the on-shelf goods in quarterly units.We conducted experiments using two real datasets for numerical and graphical analysis to prove the algorithm’s effectiveness.Compared with the state-of-the-art RFM mining algorithm,our algorithm can identify more patterns and performs well in terms of precision,recall,and F1-score,with the recall rate nearing 100%.Also,the novel algorithm operates with significantly shorter running times and more stable memory usage than existing mining algorithms.Additionally,we analyze the sales trends of products in different quarters and seasonal variations.The analysis assists businesses in maintaining reasonable on-shelf availability and achieving greater profitability. 展开更多
关键词 Data mining recency pattern high-utility itemset RFM pattern mining on-shelf management
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A divergent pattern in functional connectivity: a transdiagnostic perspective
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作者 Lu Zhang Lorenzo Pini 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1885-1886,共2页
Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at rest.The physics b... Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at rest.The physics beyond this approach is based on the analysis of the blood oxygenation level-dependent signal. 展开更多
关键词 PATTERN CONNECTIVITY FUNCTIONAL
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Recent Advances in Patterning Strategies for Full‑Color Perovskite Light‑Emitting Diodes
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作者 Gwang Heon Lee Kiwook Kim +2 位作者 Yunho Kim Jiwoong Yang Moon Kee Choi 《Nano-Micro Letters》 SCIE EI CSCD 2024年第3期99-137,共39页
Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with rem... Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with remarkably narrow bandwidths,high quantum yield,and solution processability.Despite recent advances have pushed the luminance efficiency of monochromic perovskite light-emitting diodes(PeLEDs)to their theoretical limits,their current fabrication using the spincoating process poses limitations for fabrication of full-color displays.To integrate PeLEDs into full-color display panels,it is crucial to pattern red–green–blue(RGB)perovskite pixels,while mitigating issues such as cross-contamination and reductions in luminous efficiency.Herein,we present state-of-the-art patterning technologies for the development of full-color PeLEDs.First,we highlight recent advances in the development of efficient PeLEDs.Second,we discuss various patterning techniques of MPHs(i.e.,photolithography,inkjet printing,electron beam lithography and laserassisted lithography,electrohydrodynamic jet printing,thermal evaporation,and transfer printing)for fabrication of RGB pixelated displays.These patterning techniques can be classified into two distinct approaches:in situ crystallization patterning using perovskite precursors and patterning of colloidal perovskite nanocrystals.This review highlights advancements and limitations in patterning techniques for PeLEDs,paving the way for integrating PeLEDs into full-color panels. 展开更多
关键词 PEROVSKITE Light-emitting diode Full-color display High-resolution patterning ELECTROLUMINESCENCE
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Memristors-coupled neuron models with multiple firing patterns and homogeneous and heterogeneous multistability
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作者 Xuan Wang Santo Banerjee +1 位作者 Yinghong Cao Jun Mou 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第10期176-189,共14页
Memristors are extensively used to estimate the external electromagnetic stimulation and synapses for neurons.In this paper,two distinct scenarios,i.e.,an ideal memristor serves as external electromagnetic stimulation... Memristors are extensively used to estimate the external electromagnetic stimulation and synapses for neurons.In this paper,two distinct scenarios,i.e.,an ideal memristor serves as external electromagnetic stimulation and a locally active memristor serves as a synapse,are formulated to investigate the impact of a memristor on a two-dimensional Hindmarsh-Rose neuron model.Numerical simulations show that the neuronal models in different scenarios have multiple burst firing patterns.The introduction of the memristor makes the neuronal model exhibit complex dynamical behaviors.Finally,the simulation circuit and DSP hardware implementation results validate the physical mechanism,as well as the reliability of the biological neuron model. 展开更多
关键词 MEMRISTOR MULTISTABILITY Hamilton energy firing pattern Neuron model hardware implementation
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Dissolvable temporary barrier:a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models
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作者 Ding Wang Qinyu Li +5 位作者 Chenyang Zhou Zhangjie Li Kangyi Lu Yijun Liu Lian Xuan Xiaolin Wang 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第2期153-166,共14页
A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as organ-on-a-chipmodels.The hydrogel patterningwith awell-controlled... A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as organ-on-a-chipmodels.The hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a boundary.However,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo conditions.Herein,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular hydrogels.The key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the DTB.Single and multiple tissue compartments with different geometries can be established using either straight or curved DTB structures.The effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor model.As a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan chips.Therefore,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies. 展开更多
关键词 Dissolvable temporary barrier Hydrogel patterning Microfluidics Organ-on-a-chip Vascularization
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Coupling of RANS and BEM Solvers for Simulation of Propeller Behind the Hull in Full Appended Model
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作者 Saeed NAJAFI Mehdi POURMOSTAFA LIU Peng-fei 《China Ocean Engineering》 SCIE EI CSCD 2024年第3期424-438,共15页
To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this pap... To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this paper,a coupled BEM(Boundary Element Method)/RANS(Renolds-Averaged Navier−Stokes)solver is used to simulate propeller behind the hull in the self-propulsion test.The motivation of this work is to develop a practical tool to design marine propulsion system without suffering long computational time.An unsteady boundary element method which is also known as panel method is chosen to estimate the propeller forces.Propeller wakes are treated using a time marching wake alignment method.Also,a RANS code coupled with VoF equation is developed to consider the ship motions and wake field effects in the problem.A coupling algorithm is developed to interchange ship wake field to the potential flow solver and propeller thrust to the RANS code.Based on the difference between hull resistance and the propeller thrust,a PI controller is developed to compute the propeller RPM in every time step.Verification of the solver is carried out using the towing tank test report of a 50 m oceanography research vessel.Wake factor and trust deduction coefficient are estimated numerically.Also,the wake rollup pattern of the propeller in open water is compared with the propeller in real wake field. 展开更多
关键词 RANS BEM coupled method ship propeller SELF-PROPULSION wake sheet pattern
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Spatiotemporal pattern of climate change in the China-Myanmar Economic Corridor from 1901 to 2018
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作者 YANG Xiaoliu LI Yungang GAO Lu 《Journal of Mountain Science》 SCIE CSCD 2024年第1期131-145,共15页
The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal p... The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security. 展开更多
关键词 China-Myanmar Economic Corridor CRU Air temperature PRECIPITATION Spatiotemporal pattern
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