Objective： To study, through blood oxygen level dependent functional magnetic resonance imaging （BOLD fMRI）, the cerebral activated areas evoked by electro-acupuncturing （EA） the right Hegu point （LI4） or non-a...Objective： To study, through blood oxygen level dependent functional magnetic resonance imaging （BOLD fMRI）, the cerebral activated areas evoked by electro-acupuncturing （EA） the right Hegu point （LI4） or non-acupoint points on the face, and through comparing their similarities and differences, to speculate on the specific cerebral areas activated by stimulating LI4, for exploring the mechanism of its effect in potential clinical application. Methods： EA was applied at volunteers＇ right LI4 （of 9 subjects in the LI4 group） and facial non-acupoint points （of 5 subjects in the control group）, and whole brain 3-dimensional T1 anatomical imaging of high resolution 1 × 1 × 1 mm^3 used was performed with clustered stimulatory mode adopted by BOLD fMRI. Pretreatment and statistical t-test were conducted on the data by SPM2 software, then the statistical parameters were superimposed to the 3-dimensional anatomical imaging. Results： Data from 3 testees of the 9 subjects in the LI4 group were given up eventually because they were unfit to the demand due to different causes such as movement of patients＇ location or machinery factors. Statistical analysis showed that signal activation or deactivation was found in multiple cerebral areas in 6 subjects of LI4 group and 5 subjects of the control group （P〈0.01）. In the LI4 group, the areas which showed signal activation were： midline nuclear group of thalamus, left supra marginal gyrus, left supra temporal gyrus, right precuneous lobe, bilateral temporal pole, left precentral gyrus and left cerebellum; those which showed signal deactivation were： bilateral hippocampus, parahippocampal gyrus, amygdala body area, rostral side/audal side of cingulate gyrus, prefrontal lobe and occipital lobe as well as left infratemporal gyrus. In the control group, areas which showed signal activation were： bilateral frontal lobe, postcentral gyrus, Reil＇s island lobe, primary somato-sensory cortex, cingulate gyrus, superior temporal gyrus, occipital cuneiform gyrus and/or precuneus gyrus and right brainstem; and the area that showed deactivation was left median frontal lobe. Conclusion： The effects of EA LI4 in regulating cerebral activities could be displayed and recorded through BOLD fMRI, the distribution of signally deactivated area evoked by EA LI4 was similar to the known distribution of anatomical orientation of pain in brain, and closely related to the anatomic structure of limbic system, which areas are possibly the acupuncture analgesic effect＇s cerebral regulating area. Furthermore, activated portion of left central anterior gyrus, which represent the movement of oral facial muscles, and the activated portion of cerebellum are possibly related with the effect of using EA LI4 in treating facial palsy and facial muscle spasm. As for the mechanism of signal deactivation of cerebral activities exhibited in the present study that is unable to be elucidated, it awaits for further research.展开更多
Purpose： To investigate the influence of needling bilateral points Hegu （LI 4） before colonoscopy on the examined patients and the time of inserting colonoscope. Methods： 185 patients to receive colonoscopy were r...Purpose： To investigate the influence of needling bilateral points Hegu （LI 4） before colonoscopy on the examined patients and the time of inserting colonoscope. Methods： 185 patients to receive colonoscopy were randomly divided into an acupuncture group （93 cases） and a control group （92 cases） in order of examination. Bilateral points Hegu （LI 4） were needled before colonoscopy in the acupuncture group. No preventive measures were taken in the control group. Pain grades during the period that colonoscope passes the sigmoid and transverse colons were observed and the time of inserting colonoscope was recorded. Results.. One hundred and sixty-five patients underwent colonoscopic insertion successfully, which were taken as the effective cases. Of them, 84 cases were in the acupuncture group and 81 cases in the control group. Statistics indicated that pain grades during colonoscope＇s passing the sigmoid and transverse colons were significantly lower in the acupuncture group than in the control group （P 〈 0.01）; the time of inserting colonoscope was significantly shorter in the acupuncture group than in the control group （P〈 0.05）. Conclusion. Needling bilateral points Hegu（LI 4） before colonoscopy can effectively relieve the patients＇discomfort and shorten the colonoseopic time during the examination.展开更多
Objective： To observe the changes of metabolic intensity value of points on the face before and after needling bilateral Hegu （LI 4） in healthy people and provide scientific basis for association between Hegu （LI ...Objective： To observe the changes of metabolic intensity value of points on the face before and after needling bilateral Hegu （LI 4） in healthy people and provide scientific basis for association between Hegu （LI 4） and face/mouth. Methods： A total of 45 healthy college students were selected in this study. Using medical thermography and Pennes bio-heat transfer model, the infrared thermograph images on the face before and after needling bilateral Hegu （LI 4） were collected to observe the distribution of metabolic intensity value on the face before acupuncture and changes in these values after needling bilateral Hegu （LI 4）. Results： Before acupuncture, Cuanzhu （BL 2） had the maximal metabolic intensity value. Its mean value was （0.71±0.23） W. Quanliao （SI 28） had the minimal metabolic intensity value. There were no left-right statistical significances in metabolic intensity values. After needling bilateral Hegu （LI 4）, the metabolic intensity values of most points on the face were increased. Kouheliao （LI 19） obtained the maximal increase： 0.35 W on average; and Yangbai （GB 24） obtained the minimal increase： 0.08 W on average. Conclusion： Points on both sides in healthy people have good symmetry in metabolic intensity value. After needling bilateral Hegu （LI 4）, the metabolic intensity values of points on the face were increased, especially points around the lips, which accords with the pathway of the Large Intestine Meridian on the head and face. This provided some scientific foundation for the association between Hegu （LI 4） and face/mouth.展开更多
Pain of supra-orbital bone is very common in clinic The author achieved significant effect in treating 56 cases of pain of supra-orbital bone by puncturing Siguan （four gates） points. The report is as follows.
Hegu （LI 4） and Taichong （LR 3） are the Yuan- Primary acupoints of the Large Intestine and Liver Meridian, and are collectively named as Si Guan （four gates） point. Combined use of these two acupoints can harmon...Hegu （LI 4） and Taichong （LR 3） are the Yuan- Primary acupoints of the Large Intestine and Liver Meridian, and are collectively named as Si Guan （four gates） point. Combined use of these two acupoints can harmonize yin and yang, regulate qi and blood, and balance ascending or descending. This paper attempts to study the effects of Si Guan point on the vascular dilation and constriction in migraine patients from the perspective of its feature.展开更多
OBJECTIVE:To study the effects of temperature on different facial areas by suspended moxibustion at two points,Zusanli(ST 36) and Hegu(LI 4),and probe the phenomena underlying self-regulation in the human body after t...OBJECTIVE:To study the effects of temperature on different facial areas by suspended moxibustion at two points,Zusanli(ST 36) and Hegu(LI 4),and probe the phenomena underlying self-regulation in the human body after thermal stimulation.METHODS:Thirty healthy volunteers accepted moxibustion over Zusanli(ST 36) and Hegu(LI 4),and the order of moxibustion points was randomly determined.Moxibustion method:suspension of moxibustion over Zusanli(ST 36) and Hegu(LI 4) on both sides was performed using an ignited moxa stick stuck in a support for 20 min.Observation method:An infrared thermal image of the face was taken before and after suspended moxibustion using a CK350 medical infrared thermal imaging instrument.Data analysis:A thermal microscopic section view system(TMTSys) was used to analyze the change in temperature in special facial areas.Statistical analysis was carried out using SPSS 14.0 software.RESULTS:Before moxibustion was suspended,the facial thermal image showed a T-shaped thermal area related to the vascular distribution with even temperature and good symmetry on both sides.Suspended moxibustion over Zusanli(ST 36) have a very significant increase in temperature at the forehead,around the nose,at the corners of the mouth,and at the cheeks and lips(P<0.01).Suspended moxibustion over Hegu(LI 4) also have a significant(P<0.05) increase in temperature around the nose,the corners of the mouth,the cheeks,and lips,where has a new high temperature area was formed(P<0.01).Suspended moxibustion over Hegu(LI 4) raised the temperature at the middle point of the lips more obviously than did Zusanli(ST 36) in the same person,(P<0.05).After 10 min of moxibustion over Zusanli(ST 36) and Hegu(LI 4),the change in temperature in the facial area reached its peak value.CONCLUSIONS:Facial infrared thermography of healthy people revealed a T-shaped thermal area reflecting a physiological thermal area.Moxibustion over Zusanli(ST 36) or Hegu(LI 4) raised the temperature in this facial T-shaped thermal area.Hegu(LI 4) led to the formation of a new thermal area in the lips.The time required for moxibustion to regulate human body temperature was 10 min.展开更多
OBJECTIVE: To investigate the effect of electroacupuncture(EA) at acupoints on the pericardium meridian on the expression of phosphorylated Akt(p-Akt) protein in rat myocardium after ischemia and reperfusion.METHODS: ...OBJECTIVE: To investigate the effect of electroacupuncture(EA) at acupoints on the pericardium meridian on the expression of phosphorylated Akt(p-Akt) protein in rat myocardium after ischemia and reperfusion.METHODS: Seventy Wistar rats were evenly randomized into seven groups: the sham operation group(group A), ischemia-reperfusion model Ⅰgroup(group B), ischemia-reperfusion model Ⅱgroup(group C), EA at Neiguan(PC 6) group(group D), EA at Ximen(PC 4) group(group E), EA at Hegu(LI 4) group(group F), and LY294002 + EA at Neiguan(PC 6) group(group G). All processes were monitored by electrocardiography. In group A, the left anterior descending coronary artery was only threaded without ligation for 100 min. In group B,the left anterior descending coronary artery was ligated for 40 min and reperfused for 60 min. The left anterior descending coronary artery in group C was ligated for 40 min and reperfused for 100 min.Groups D, E, and F received EA for 20 min before undergoing ischemia for 40 min, and then received EA for 20 min before undergoing reperfusion for 60 min. Before modeling, group G was injected with LY294002(0.3 mg/kg) into the tail vein, and then underwent the same intervention as the other EA groups. After reperfusion, myocardial tissue from the left cardiac ventricle was collected to enable Western blot analysis of the p-Akt level, and analysis of electrocardiographic changes.RESULTS: In groups B and C, electrocardiography showed obvious elevation of the ST-segment Ⅱlead(ECG-STⅡ), while the ECG-STⅡvalues were significantly lower in groups D, E, and G(P < 0.01). The p-Akt levels in groups D and E were significantly greater than those in groups B and C(P < 0.01).Compared with all other groups, group G showed a significantly different expression of p-Akt(P < 0.01).CONCLUSION: The expression of p-Akt protein in cardiomyocytes was significantly greater in rats that were injected with LY294002 and received EA at Ximen(PC 4) compared with all other groups.This suggests that EA at Ximen(PC 4) resulted in activation of the phosphoinositide 3-kinase/Akt signaling pathway and phosphorylation of Akt.展开更多
To observe the clinical effect in the treatment of toothache by puncturing Hegu（LI 4）. Methods： Two hundred and seventy-eight cases of the patients were randomly divided into the treatment group （139 cases） and t...To observe the clinical effect in the treatment of toothache by puncturing Hegu（LI 4）. Methods： Two hundred and seventy-eight cases of the patients were randomly divided into the treatment group （139 cases） and the control group （139 cases）. The treatment group was treated by puncturing Hegu （LI 4） with electric stimulation and the control group, by puncturing Chenshan （BL 57） with electric stimulation, for 3 days as one course of the treatment, to grade pain and observe the anesthetic effect respectively. Results： There was no significant difference in the remarkable effective rate between the two groups before withdrawal of the needle in the treatment for one day （P〉0.05）. In the other times, the remarkable effective rate was obviously higher in the treatment group than in the control group （P〈0.05）, Conclusion： Acupuncture on Hegu （LI 4） is effective in treating toothache.展开更多
Epigastric pain, also known as stomach pain, is presented with fi＇equently recurrent pain in the upper abdomen or stomach area, which is mainly caused by exogenous pathogen, improper diet or internal injuries due to ...Epigastric pain, also known as stomach pain, is presented with fi＇equently recurrent pain in the upper abdomen or stomach area, which is mainly caused by exogenous pathogen, improper diet or internal injuries due to seven emotions. All 45 cases with epigastric pain caused by various fitctors were treated with mainly needling Hegu （LI 4） between November 2010 and November 2012, and the report is given as follows.展开更多
OBJECTIVE: To observe the analgesic effect of acupuncture at Hegu (LI 4) in vitro fertilization-embryo transfer (IVF-ET) transvaginal oocyte retrieval using ultrasonography and explore its mechanism. METHODS: Ninety p...OBJECTIVE: To observe the analgesic effect of acupuncture at Hegu (LI 4) in vitro fertilization-embryo transfer (IVF-ET) transvaginal oocyte retrieval using ultrasonography and explore its mechanism. METHODS: Ninety patients undergoing IVF-EF oocyte retrieval were randomly divided into three groups: an acupuncture group with needles inserted into bilateral Hegu (LI 4) points, a placebo group given placebo needles, and a control group with routine oocyte retrieval. Each group had an indometacin enema 30 min before the operation. We compared the pain-rated index (PRI), visual analogy scale (VAS), and present pain intensity (PPI) immediately after operation and 1 h after operation. We also determined the neuropeptide Y (NPY) level of the follicular fluid. RESULTS: PRI, VAS, and PPI after operation and 1 hafter operation in the acupuncture group were significantly lower than those in the control group (P< 0.01). No obvious difference (P>0.05) was observed in PRI,VAS, and PPI after operation and 1 h after operation between the placebo group and the control group.The NPY level of the follicular fluid in the acupuncture group was significantly higher than that in the control group (P<0.01). No obvious difference (P>0.05) was observed in the NPY level of the follicular fluid between the placebo group and the control group. CONCLUSION: The analgesic effect of acupuncture at Hegu in transvaginal oocyte retrieval using ultrasonography may be related to the increase in the NPY level of the follicular fluid.展开更多
To investigate the safety of electroacupuncture plus oxytocin for uterine contraction of puerperants. Methods： 276 puerperants with difficult labor were randomly divided into a medication group, treated with intraven...To investigate the safety of electroacupuncture plus oxytocin for uterine contraction of puerperants. Methods： 276 puerperants with difficult labor were randomly divided into a medication group, treated with intravenous dripping of oxytocin, and an acupuncture plus medication group, in the medication group, intravenous dripping of oxytocin was given, and in the other group, acupuncture at bilateral Hegu （LI 4） was added. Heart rate, respiratory frequency, blood pressure of puerperants, fetal heart rate and birth process were observed. Results： During laboring, the indices observed, including heart rate, respiratory frequency, blood pressure, fetal heart rate and birth process, were all in normal range in all of the 276 cases, with better effects in acupuncture plus medication Group M. Conclusions： Electroacupuncture at bilateral Hegu （LI 4） plus intravenous dripping of oxytocin can intensify the uterine contraction, shorten the birth process to avoid probable systemic exhaustion due to excessive consumption, and with no side effects on life signs of the puernerants and newborns.展开更多
基金Supported by the National Natural Science Foundation (No. 90209031)
文摘Objective： To study, through blood oxygen level dependent functional magnetic resonance imaging （BOLD fMRI）, the cerebral activated areas evoked by electro-acupuncturing （EA） the right Hegu point （LI4） or non-acupoint points on the face, and through comparing their similarities and differences, to speculate on the specific cerebral areas activated by stimulating LI4, for exploring the mechanism of its effect in potential clinical application. Methods： EA was applied at volunteers＇ right LI4 （of 9 subjects in the LI4 group） and facial non-acupoint points （of 5 subjects in the control group）, and whole brain 3-dimensional T1 anatomical imaging of high resolution 1 × 1 × 1 mm^3 used was performed with clustered stimulatory mode adopted by BOLD fMRI. Pretreatment and statistical t-test were conducted on the data by SPM2 software, then the statistical parameters were superimposed to the 3-dimensional anatomical imaging. Results： Data from 3 testees of the 9 subjects in the LI4 group were given up eventually because they were unfit to the demand due to different causes such as movement of patients＇ location or machinery factors. Statistical analysis showed that signal activation or deactivation was found in multiple cerebral areas in 6 subjects of LI4 group and 5 subjects of the control group （P〈0.01）. In the LI4 group, the areas which showed signal activation were： midline nuclear group of thalamus, left supra marginal gyrus, left supra temporal gyrus, right precuneous lobe, bilateral temporal pole, left precentral gyrus and left cerebellum; those which showed signal deactivation were： bilateral hippocampus, parahippocampal gyrus, amygdala body area, rostral side/audal side of cingulate gyrus, prefrontal lobe and occipital lobe as well as left infratemporal gyrus. In the control group, areas which showed signal activation were： bilateral frontal lobe, postcentral gyrus, Reil＇s island lobe, primary somato-sensory cortex, cingulate gyrus, superior temporal gyrus, occipital cuneiform gyrus and/or precuneus gyrus and right brainstem; and the area that showed deactivation was left median frontal lobe. Conclusion： The effects of EA LI4 in regulating cerebral activities could be displayed and recorded through BOLD fMRI, the distribution of signally deactivated area evoked by EA LI4 was similar to the known distribution of anatomical orientation of pain in brain, and closely related to the anatomic structure of limbic system, which areas are possibly the acupuncture analgesic effect＇s cerebral regulating area. Furthermore, activated portion of left central anterior gyrus, which represent the movement of oral facial muscles, and the activated portion of cerebellum are possibly related with the effect of using EA LI4 in treating facial palsy and facial muscle spasm. As for the mechanism of signal deactivation of cerebral activities exhibited in the present study that is unable to be elucidated, it awaits for further research.
文摘Purpose： To investigate the influence of needling bilateral points Hegu （LI 4） before colonoscopy on the examined patients and the time of inserting colonoscope. Methods： 185 patients to receive colonoscopy were randomly divided into an acupuncture group （93 cases） and a control group （92 cases） in order of examination. Bilateral points Hegu （LI 4） were needled before colonoscopy in the acupuncture group. No preventive measures were taken in the control group. Pain grades during the period that colonoscope passes the sigmoid and transverse colons were observed and the time of inserting colonoscope was recorded. Results.. One hundred and sixty-five patients underwent colonoscopic insertion successfully, which were taken as the effective cases. Of them, 84 cases were in the acupuncture group and 81 cases in the control group. Statistics indicated that pain grades during colonoscope＇s passing the sigmoid and transverse colons were significantly lower in the acupuncture group than in the control group （P 〈 0.01）; the time of inserting colonoscope was significantly shorter in the acupuncture group than in the control group （P〈 0.05）. Conclusion. Needling bilateral points Hegu（LI 4） before colonoscopy can effectively relieve the patients＇discomfort and shorten the colonoseopic time during the examination.
基金supported by the National Key Scientific Instrument and Equipment Development Projects~~
文摘Objective： To observe the changes of metabolic intensity value of points on the face before and after needling bilateral Hegu （LI 4） in healthy people and provide scientific basis for association between Hegu （LI 4） and face/mouth. Methods： A total of 45 healthy college students were selected in this study. Using medical thermography and Pennes bio-heat transfer model, the infrared thermograph images on the face before and after needling bilateral Hegu （LI 4） were collected to observe the distribution of metabolic intensity value on the face before acupuncture and changes in these values after needling bilateral Hegu （LI 4）. Results： Before acupuncture, Cuanzhu （BL 2） had the maximal metabolic intensity value. Its mean value was （0.71±0.23） W. Quanliao （SI 28） had the minimal metabolic intensity value. There were no left-right statistical significances in metabolic intensity values. After needling bilateral Hegu （LI 4）, the metabolic intensity values of most points on the face were increased. Kouheliao （LI 19） obtained the maximal increase： 0.35 W on average; and Yangbai （GB 24） obtained the minimal increase： 0.08 W on average. Conclusion： Points on both sides in healthy people have good symmetry in metabolic intensity value. After needling bilateral Hegu （LI 4）, the metabolic intensity values of points on the face were increased, especially points around the lips, which accords with the pathway of the Large Intestine Meridian on the head and face. This provided some scientific foundation for the association between Hegu （LI 4） and face/mouth.
文摘Pain of supra-orbital bone is very common in clinic The author achieved significant effect in treating 56 cases of pain of supra-orbital bone by puncturing Siguan （four gates） points. The report is as follows.
基金Scientific Research Foundation of Zhejiang Education Department (Y200805946)Open Foundation of Top Priority Projects of Zhejiang Universities (Acupuncturemoxibustion and Tuina) (ZJZZ-0902)
文摘Hegu （LI 4） and Taichong （LR 3） are the Yuan- Primary acupoints of the Large Intestine and Liver Meridian, and are collectively named as Si Guan （four gates） point. Combined use of these two acupoints can harmonize yin and yang, regulate qi and blood, and balance ascending or descending. This paper attempts to study the effects of Si Guan point on the vascular dilation and constriction in migraine patients from the perspective of its feature.
基金Supported by the National Natural Science Foundation (No.30973795)
文摘OBJECTIVE:To study the effects of temperature on different facial areas by suspended moxibustion at two points,Zusanli(ST 36) and Hegu(LI 4),and probe the phenomena underlying self-regulation in the human body after thermal stimulation.METHODS:Thirty healthy volunteers accepted moxibustion over Zusanli(ST 36) and Hegu(LI 4),and the order of moxibustion points was randomly determined.Moxibustion method:suspension of moxibustion over Zusanli(ST 36) and Hegu(LI 4) on both sides was performed using an ignited moxa stick stuck in a support for 20 min.Observation method:An infrared thermal image of the face was taken before and after suspended moxibustion using a CK350 medical infrared thermal imaging instrument.Data analysis:A thermal microscopic section view system(TMTSys) was used to analyze the change in temperature in special facial areas.Statistical analysis was carried out using SPSS 14.0 software.RESULTS:Before moxibustion was suspended,the facial thermal image showed a T-shaped thermal area related to the vascular distribution with even temperature and good symmetry on both sides.Suspended moxibustion over Zusanli(ST 36) have a very significant increase in temperature at the forehead,around the nose,at the corners of the mouth,and at the cheeks and lips(P<0.01).Suspended moxibustion over Hegu(LI 4) also have a significant(P<0.05) increase in temperature around the nose,the corners of the mouth,the cheeks,and lips,where has a new high temperature area was formed(P<0.01).Suspended moxibustion over Hegu(LI 4) raised the temperature at the middle point of the lips more obviously than did Zusanli(ST 36) in the same person,(P<0.05).After 10 min of moxibustion over Zusanli(ST 36) and Hegu(LI 4),the change in temperature in the facial area reached its peak value.CONCLUSIONS:Facial infrared thermography of healthy people revealed a T-shaped thermal area reflecting a physiological thermal area.Moxibustion over Zusanli(ST 36) or Hegu(LI 4) raised the temperature in this facial T-shaped thermal area.Hegu(LI 4) led to the formation of a new thermal area in the lips.The time required for moxibustion to regulate human body temperature was 10 min.
基金Supported by"Effects of acupuncture at the points of the Pericardium Meridian on Ca2+ signal transduction in Myocardial Ischemia and Reperfusion Injury"from the National Natural Science Foundation of China(No.30371803)"Study on the intervention mechanism on Akt signaling pathway activated by acupuncture in reperfusion injury myocardial cell apoptosis"(Nature Science Foundation of Shanxi Province,No.2010011056-1)
文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) at acupoints on the pericardium meridian on the expression of phosphorylated Akt(p-Akt) protein in rat myocardium after ischemia and reperfusion.METHODS: Seventy Wistar rats were evenly randomized into seven groups: the sham operation group(group A), ischemia-reperfusion model Ⅰgroup(group B), ischemia-reperfusion model Ⅱgroup(group C), EA at Neiguan(PC 6) group(group D), EA at Ximen(PC 4) group(group E), EA at Hegu(LI 4) group(group F), and LY294002 + EA at Neiguan(PC 6) group(group G). All processes were monitored by electrocardiography. In group A, the left anterior descending coronary artery was only threaded without ligation for 100 min. In group B,the left anterior descending coronary artery was ligated for 40 min and reperfused for 60 min. The left anterior descending coronary artery in group C was ligated for 40 min and reperfused for 100 min.Groups D, E, and F received EA for 20 min before undergoing ischemia for 40 min, and then received EA for 20 min before undergoing reperfusion for 60 min. Before modeling, group G was injected with LY294002(0.3 mg/kg) into the tail vein, and then underwent the same intervention as the other EA groups. After reperfusion, myocardial tissue from the left cardiac ventricle was collected to enable Western blot analysis of the p-Akt level, and analysis of electrocardiographic changes.RESULTS: In groups B and C, electrocardiography showed obvious elevation of the ST-segment Ⅱlead(ECG-STⅡ), while the ECG-STⅡvalues were significantly lower in groups D, E, and G(P < 0.01). The p-Akt levels in groups D and E were significantly greater than those in groups B and C(P < 0.01).Compared with all other groups, group G showed a significantly different expression of p-Akt(P < 0.01).CONCLUSION: The expression of p-Akt protein in cardiomyocytes was significantly greater in rats that were injected with LY294002 and received EA at Ximen(PC 4) compared with all other groups.This suggests that EA at Ximen(PC 4) resulted in activation of the phosphoinositide 3-kinase/Akt signaling pathway and phosphorylation of Akt.
文摘To observe the clinical effect in the treatment of toothache by puncturing Hegu（LI 4）. Methods： Two hundred and seventy-eight cases of the patients were randomly divided into the treatment group （139 cases） and the control group （139 cases）. The treatment group was treated by puncturing Hegu （LI 4） with electric stimulation and the control group, by puncturing Chenshan （BL 57） with electric stimulation, for 3 days as one course of the treatment, to grade pain and observe the anesthetic effect respectively. Results： There was no significant difference in the remarkable effective rate between the two groups before withdrawal of the needle in the treatment for one day （P〉0.05）. In the other times, the remarkable effective rate was obviously higher in the treatment group than in the control group （P〈0.05）, Conclusion： Acupuncture on Hegu （LI 4） is effective in treating toothache.
文摘Epigastric pain, also known as stomach pain, is presented with fi＇equently recurrent pain in the upper abdomen or stomach area, which is mainly caused by exogenous pathogen, improper diet or internal injuries due to seven emotions. All 45 cases with epigastric pain caused by various fitctors were treated with mainly needling Hegu （LI 4） between November 2010 and November 2012, and the report is given as follows.
文摘OBJECTIVE: To observe the analgesic effect of acupuncture at Hegu (LI 4) in vitro fertilization-embryo transfer (IVF-ET) transvaginal oocyte retrieval using ultrasonography and explore its mechanism. METHODS: Ninety patients undergoing IVF-EF oocyte retrieval were randomly divided into three groups: an acupuncture group with needles inserted into bilateral Hegu (LI 4) points, a placebo group given placebo needles, and a control group with routine oocyte retrieval. Each group had an indometacin enema 30 min before the operation. We compared the pain-rated index (PRI), visual analogy scale (VAS), and present pain intensity (PPI) immediately after operation and 1 h after operation. We also determined the neuropeptide Y (NPY) level of the follicular fluid. RESULTS: PRI, VAS, and PPI after operation and 1 hafter operation in the acupuncture group were significantly lower than those in the control group (P< 0.01). No obvious difference (P>0.05) was observed in PRI,VAS, and PPI after operation and 1 h after operation between the placebo group and the control group.The NPY level of the follicular fluid in the acupuncture group was significantly higher than that in the control group (P<0.01). No obvious difference (P>0.05) was observed in the NPY level of the follicular fluid between the placebo group and the control group. CONCLUSION: The analgesic effect of acupuncture at Hegu in transvaginal oocyte retrieval using ultrasonography may be related to the increase in the NPY level of the follicular fluid.
文摘To investigate the safety of electroacupuncture plus oxytocin for uterine contraction of puerperants. Methods： 276 puerperants with difficult labor were randomly divided into a medication group, treated with intravenous dripping of oxytocin, and an acupuncture plus medication group, in the medication group, intravenous dripping of oxytocin was given, and in the other group, acupuncture at bilateral Hegu （LI 4） was added. Heart rate, respiratory frequency, blood pressure of puerperants, fetal heart rate and birth process were observed. Results： During laboring, the indices observed, including heart rate, respiratory frequency, blood pressure, fetal heart rate and birth process, were all in normal range in all of the 276 cases, with better effects in acupuncture plus medication Group M. Conclusions： Electroacupuncture at bilateral Hegu （LI 4） plus intravenous dripping of oxytocin can intensify the uterine contraction, shorten the birth process to avoid probable systemic exhaustion due to excessive consumption, and with no side effects on life signs of the puernerants and newborns.
