期刊文献+
共找到98,591篇文章
< 1 2 250 >
每页显示 20 50 100
Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment
1
作者 Mesut Tez 《World Journal of Clinical Oncology》 2024年第10期1264-1268,共5页
The prognosis of colorectal cancer(CRC)patients with peritoneal metastasis remains poor despite advancements in detection and treatment.Preoperative inflammatory and nutritional markers have emerged as significant pre... The prognosis of colorectal cancer(CRC)patients with peritoneal metastasis remains poor despite advancements in detection and treatment.Preoperative inflammatory and nutritional markers have emerged as significant predictors of prognosis in CRC,potentially guiding treatment decisions and improving patient outcomes.This editorial explores the prognostic value of markers such as the neutrophil-to-lymphocyte ratio,hemoglobin,and serum albumin levels.By integrating these markers into prognostic models,clinicians can better stratify patients,personalize treatment strategies,and ultimately enhance clinical outcomes.This review highlights the importance of these markers in providing a comprehensive assessment of patient condition and underscores the need for further research to validate their clinical utility and uncover underlying mecha-nisms. 展开更多
关键词 Colorectal cancer Peritoneal metastasis Neutrophil-to-lymphocyte ratio HEMOGLOBIN Serum albumin Inflammatory markers Nutritional markers prognosis Preoperative markers Personalized treatment
下载PDF
Serum tumor markers (carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, carbohydrate antigen 24-2, ferritin) and gastric cancer prognosis correlation
2
作者 Jie-Wen Zhu Ling-Zhen Gong Qian-Wen Wang 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第9期2808-2814,共7页
BACKGROUND Gastric cancer is a kind of malignant tumor which is prevalent all over the world.Although some progress has been made in the treatment of gastric cancer,its prognosis is still not optimistic,so it is of gr... BACKGROUND Gastric cancer is a kind of malignant tumor which is prevalent all over the world.Although some progress has been made in the treatment of gastric cancer,its prognosis is still not optimistic,so it is of great significance to find reliable prog-nostic indicators to guide the treatment and management of patients with gastric cancer.AIM To explore the relationship between serum levels of five biomarkers[carcinoem-bryonic antigen(CEA),carbohydrate antigen(CA)19-9,CA72-4,CA24-2,and ferritin]and prognosis in patients with gastric cancer.METHODS This study included 200 patients with gastric adenocarcinoma,and conducted an in-depth analysis of their baseline characteristics,relationship between tumor markers and staging,and prognosis.The study found that CA19-9 has a signi-ficant correlation with tumor stage,the average levels of CA24-2,CEA,CA72-4 and ferritin were slightly increased disregarding the stage of tumor.Survival analysis showed that increases in CEA,CA19-9,CA24-2,and ferritin were all associated with shortened overall survival of patients.Further multivariate ana-lysis revealed that elevated serum CA72-4 levels were an inde-pendent adverse prognostic factor.RESULTS This study reveals that there is a significant correlation between the expression levels of serum tumor markers CEA,CA19-9,CA72-4,CA24-2 and ferritin in patients with gastric cancer and prognosis,and can be used as important indicators for prognostic evaluation of gastric cancer.In particular,markers that appear abnormally elevated initially may help identify gastric cancer patients with poor prognosis.CONCLUSION Serum CEA and CA19-9 play an important role in the prognosis assessment of gastric cancer,and are effective tools to guide clinical practice and optimize individualized treatment strategies for gastric cancer patients. 展开更多
关键词 Gastric cancer prognosis Carcinoembryonic antigen Carbohydrate antigen 19-9 Carbohydrate antigen 72-4 Carbohydrate antigen 24-2 FERRITIN Serum markers Retrospective study
下载PDF
Malignant Lymphoma with Initial Symptoms in the Mandibular Region
3
作者 Yumi Mochizuki Hiroyuki Harada +8 位作者 Kei Sakamoto Kou Kayamori Shin Nakamura Minoru Ikuta Yuji Kabasawa Eriko Marukawa Hiroaki Shimamoto Fumihiko Tushima Ken Omura 《Journal of Cancer Therapy》 2015年第7期554-565,共12页
Primary intraosseous lymphoma is rare and there are few case reports manifesting with a mass in the mandible. Thus, we retrospectively reviewed and analyzed the clinical characteristics, treatment, and outcome of extr... Primary intraosseous lymphoma is rare and there are few case reports manifesting with a mass in the mandible. Thus, we retrospectively reviewed and analyzed the clinical characteristics, treatment, and outcome of extranodal non-Hodgkin’s lymphoma (NHL) with initial mandibular symptoms in our department. At initial treatment of dental clinics, dentists had diagnosed as dental or gingival diseases and had performed dental treatment. Neurological disorder to involvement of the inferior alveolar nerve was present in 80.0% of our cases. On dental or panoramic radiography a specific radiolucent lesion in the mandible was not detected, except for dental lesions. On CT, NHL of the mandible region has no widening and no clear destruction but a slit-like the cortex bone destruction pattern with keeping in shape of the mandibular body (62.5% of CT-examined cases), and extraosseous soft tissue mass are clearer on MRI (100.0% of MRI-examined cases). Histopathologically, 80.0% of our cases were diagnosed as diffuse large B cell lymphoma (DLBCL). One case as B-cell lymphoblastic lymphoma and one case as B-cell lymphoma unclassifiable with features intermediate between DLBCL and Burkitt lymphoma were Stage IV (Ann Arbor staging system) and had poor prognosis. The disease-specific survival rate was 77.8% at 5 years. If unexplained non-specific symptoms such as swelling of the jaw, pain, neurological disorder of the inferior alveolar nerve, tooth mobility are observed, oral surgeons and dentists should not perform dental treatments. CT and MRI show disease specific appearance to be able to give a definitive diasnosis as NHL. PET/CT is useful for scaninng of whole body. A deep bone biopsy is preferred for suspected malignant lymphoma. 展开更多
关键词 MANDIBLE Diffuse Large B Cell lymphoma B-CELL lymphoma Unclassifiable with Features Intermediate between DLBCL and BURKITT lymphoma B-CELL LYMPHOBLASTIC lymphoma The Inferior Alveolar Nerve
下载PDF
T lymphocyte proportion in Alzheimer’s disease prognosis
4
作者 Matthew Willman Gopi Patel Brandon Lucke-Wold 《World Journal of Clinical Cases》 SCIE 2024年第26期6001-6003,共3页
Bai et al investigate the predictive value of T lymphocyte proportion in Alzheimer's disease(AD)prognosis.Through a retrospective study involving 62 AD patients,they found that a decrease in T lymphocyte proportio... Bai et al investigate the predictive value of T lymphocyte proportion in Alzheimer's disease(AD)prognosis.Through a retrospective study involving 62 AD patients,they found that a decrease in T lymphocyte proportion correlated with a poorer prognosis,as indicated by higher modified Rankin scale scores.While the study highlights the potential of T lymphocyte proportion as a prognostic marker,it suggests the need for larger,multicenter studies to enhance generalizability and validity.Additionally,future research could use cognitive exams when evaluating prognosis and delve into immune mechanisms underlying AD progression.Despite limitations inherent in retrospective designs,Bai et al's work contributes to understanding the immune system's role in AD prognosis,paving the way for further exploration in this under-researched area. 展开更多
关键词 Alzheimer's disease T lymphocyte T lymphocyte proportion Alzheimer's disease prognosis Modified rankin scale Immune cell count ELECTROENCEPHALOGRAM Immune function
下载PDF
Nomogram model including LATS2 expression was constructed to predict the prognosis of advanced gastric cancer after surgery
5
作者 Nan Sun Bi-Bo Tan Yong Li 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第2期518-528,共11页
BACKGROUND Gastric cancer is a leading cause of cancer-related deaths worldwide.Prognostic assessments are typically based on the tumor-node-metastasis(TNM)staging system,which does not account for the molecular heter... BACKGROUND Gastric cancer is a leading cause of cancer-related deaths worldwide.Prognostic assessments are typically based on the tumor-node-metastasis(TNM)staging system,which does not account for the molecular heterogeneity of this disease.LATS2,a tumor suppressor gene involved in the Hippo signaling pathway,has been identified as a potential prognostic biomarker in gastric cancer.AIM To construct and validate a nomogram model that includes LATS2 expression to predict the survival prognosis of advanced gastric cancer patients following ra-dical surgery,and compare its predictive performance with traditional TNM staging.METHODS A retrospective analysis of 245 advanced gastric cancer patients from the Fourth Hospital of Hebei Medical University was conducted.The patients were divided into a training group(171 patients)and a validation group(74 patients)to deve-lop and test our prognostic model.The performance of the model was determined using C-indices,receiver operating characteristic curves,calibration plots,and decision curves.RESULTS The model demonstrated a high predictive accuracy with C-indices of 0.829 in the training set and 0.862 in the validation set.Area under the curve values for three-year and five-year survival prediction were significantly robust,suggesting an excellent discrimination ability.Calibration plots confirmed the high concordance between the predictions and actual survival outcomes.CONCLUSION We developed a nomogram model incorporating LATS2 expression,which significantly outperformed conven-tional TNM staging in predicting the prognosis of advanced gastric cancer patients postsurgery.This model may serve as a valuable tool for individualized patient management,allowing for more accurate stratification and im-proved clinical outcomes.Further validation in larger patient cohorts will be necessary to establish its generaliza-bility and clinical utility. 展开更多
关键词 Gastric cancer LATS2 Column line graph prognosis Advanced gastric cancer survival Molecular biomarkers Predictive analytics in oncology Survival analysis
下载PDF
Systematic review of risk factors,prognosis,and management of colorectal signet-ring cell carcinoma 被引量:1
6
作者 Frederiek Nuytens Vincent Drubay +2 位作者 Clarisse Eveno Florence Renaud Guillaume Piessen 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第5期2141-2158,共18页
BACKGROUND Colorectal signet-ring cell carcinoma(CSRCC)is a rare clinical entity which accounts for approximately 1%of all colorectal cancers.Although multiple studies concerning this specific topic have been publishe... BACKGROUND Colorectal signet-ring cell carcinoma(CSRCC)is a rare clinical entity which accounts for approximately 1%of all colorectal cancers.Although multiple studies concerning this specific topic have been published in the past decades,the pathogenesis,associated risk factors,and potential implications on treatment are still poorly understood.Besides the low incidence,historically confusing histological criteria have resulted in confusing data.Nevertheless,the rising incidence of CSRCC along with relatively young age at presentation and associated dismal prognosis,highlight the actual interest to synthesize the known literature regarding CSRCC.AIM To provide an updated overview of risk factors,prognosis,and management of CSRCC.METHODS A literature search in the MEDLINE/PubMed database was conducted with the following search terms used:‘Signet ring cell carcinoma’and‘colorectal’.Studies in English language,published after January 1980,were included.Studies included in the qualitative synthesis were evaluated for content concerning epidemiology,risk factors,and clinical,diagnostic,histological,and molecular features,as well as metastatic pattern and therapeutic management.If possible,presented data was extracted in order to present a more detailed overview of the literature.RESULTS In total,67 articles were included for qualitative analysis,of which 54 were eligible for detailed data extraction.CSRCC has a reported incidence between 0.1%-2.4%and frequently presents with advanced disease stage at the time of diagnosis.CSRCC is associated with an impaired overall survival(5-year OS:0%-46%)and a worse stagecorrected outcome compared to mucinous and not otherwise specified adenocarcinoma.The systematic use of exploratory laparoscopy to determine the presence of peritoneal metastases has been advised.Surgery is the mainstay of treatment,although the rates of curative resection in CSRCC(21%-82%)are lower compared to those in other histological types.In case of peritoneal metastasis,cytoreductive surgery with hyperthermic intraperitoneal chemotherapy should only be proposed in selected patients.CONCLUSION CSRCC is a rare clinical entity most often characterized by young age and advanced disease at presentation.As such,diagnostic modalities and therapeutic approach should be tailored accordingly. 展开更多
关键词 Colorectal cancer Signet-ring cell histology Poorly cohesive cells Systematic review Risk factors prognosis Therapeutic management
下载PDF
Nomogram predicting the prognosis of primary liver cancer after radiofrequency ablation combined with transcatheter arterial chemoembolization 被引量:1
7
作者 Hai-Hua Shen Yu-Rong Hong +4 位作者 Wen Xu Lei Chen Jun-Min Chen Zhi-Gen Yang Cai-Hong Chen 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第8期2630-2639,共10页
BACKGROUND The incidence and mortality rates of primary hepatocellular carcinoma(HCC)are high,and the conventional treatment is radiofrequency ablation(RFA)with transcatheter arterial chemoembolization(TACE);however,t... BACKGROUND The incidence and mortality rates of primary hepatocellular carcinoma(HCC)are high,and the conventional treatment is radiofrequency ablation(RFA)with transcatheter arterial chemoembolization(TACE);however,the 3-year survival rate is still low.Further,there are no visual methods to effectively predict their prognosis.AIM To explore the factors influencing the prognosis of HCC after RFA and TACE and develop a nomogram prediction model.METHODS Clinical and follow-up information of 150 patients with HCC treated using RFA and TACE in the Hangzhou Linping Hospital of Traditional Chinese Medicine from May 2020 to December 2022 was retrospectively collected and recorded.We examined their prognostic factors using multivariate logistic regression and created a nomogram prognosis prediction model using the R software(version 4.1.2).Internal verification was performed using the bootstrapping technique.The prognostic efficacy of the nomogram prediction model was evaluated using the concordance index(CI),calibration curve,and receiver operating characteristic RESULTS Of the 150 patients treated with RFA and TACE,92(61.33%)developed recurrence and metastasis.Logistic regression analysis identified six variables,and a predictive model was created.The internal validation results of the model showed a CI of 0.882.The correction curve trend of the prognosis prediction model was always near the diagonal,and the mean absolute error before and after internal validation was 0.021.The area under the curve of the prediction model after internal verification was 0.882[95%confidence interval(95%CI):0.820-0.945],with a specificity of 0.828 and sensitivity of 0.656.According to the Hosmer-Lemeshow test,χ^(2)=3.552 and P=0.895.The predictive model demonstrated a satisfactory calibration,and the decision curve analysis demonstrated its clinical applicability.CONCLUSION The prognosis of patients with HCC after RFA and TACE is affected by several factors.The developed prediction model based on the influencing parameters shows a good prognosis predictive efficacy. 展开更多
关键词 NOMOGRAM Primary liver cancer Radiofrequency ablation Transcatheter arterial chemoembolization prognosis Influencing factors Decision curve analysis
下载PDF
Marginal zone lymphoma with severe rashes: A case report
8
作者 Si-Jun Bai Ye Geng +7 位作者 Yi-Nan Gao Cai-Xia Zhang Qian Mi Chen Zhang Jia-Ling Yang Si-Jie He Zhen-YingYan Jian-Xia He 《World Journal of Clinical Cases》 SCIE 2024年第3期565-574,共10页
BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generaliz... BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL. 展开更多
关键词 Marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab Obinutuzumab Zanubrutinib Case report
下载PDF
Exposure to Hyaluronan and Radon-Containing Water during the Treatment of Periodontal Pockets
9
作者 Ani Gibishvili Mamuka Gogiberidze Marina Nikolaishvili 《Journal of Biosciences and Medicines》 2023年第12期203-217,共15页
Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature undersc... Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices. 展开更多
关键词 Hyaluronic Acid Dental Practice Biological Functions Tissue Water Balance Cell Proliferation Cell Migration Cell Differentiation Tissue Regeneration Synovial Fluid Viscosity Immune System Activation Cartilage Elasticity Radon Water Hormetic Effects Dental Research Intervention Effectiveness Post-Procedural prognosis Risk Factors Inflammatory Periodontal Diseases Chronic Somatic Diseases Gastrointestinal Tract Disorders Respiratory Susceptibility Hereditary Predisposition Lifestyle Factors Smoking Dietary Preferences
下载PDF
Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report
10
作者 Makoto Saito Zen-Ichi Tanei +7 位作者 Masumi Tsuda Toma Suzuki Emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第10期4281-4288,共8页
BACKGROUND Helicobacter pylori(H.pylori)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been established.However,t(11;18)(q21;q21)/API2-MALT1 translocation-positive... BACKGROUND Helicobacter pylori(H.pylori)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been established.However,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to achieve.In addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT lymphoma.CASE SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and biopsy.Two years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for H.pylori,and eradication treatment was administered.Two years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the fundus.One year later(4 years and 3 months after H.pylori eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of DLBCL.Both MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also detected.After 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 years.In addition,both the colonic and gastric lesions were proven to have the same clonality.CONCLUSION Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of H.pylori infection and progressed. 展开更多
关键词 Gastric mucosa-associated lymphoid tissue lymphoma TRANSFORM Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report
下载PDF
HCV infection, B-cell non-Hodgkin's lymphoma and immunochemotherapy: Evidence and open questions 被引量:1
11
作者 Maria Christina Cox Maria Antonietta Aloe-Spiriti +6 位作者 Elena Cavalieri Eleonora Alma Elia Gigante Paola Begini Caterina Rebecchini Gianfranco Delle Fave Massimo Marignani 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2012年第3期46-53,共8页
There is plenty of data confirming that hepatitis C virus (HCV) infection is a predisposing factor for a B-cell non-Hodgkin's lymphoma (B-NHL) outbreak, while relatively few reports have addressed the role of HCV ... There is plenty of data confirming that hepatitis C virus (HCV) infection is a predisposing factor for a B-cell non-Hodgkin's lymphoma (B-NHL) outbreak, while relatively few reports have addressed the role of HCV in affecting B-NHL patients' outcome. HCV infection may influence the short-term outcome of B-NHL because of the emergence of severe hepatic toxicity (HT) during immunochemotherapy. Furthermore, the long term outcome of HCV-related liver disease and patients' quality of life will possibly be affected by Rituximab maintenance, multiple-lines of toxicity during chemotherapy and hematopoietic stem cell transplantation. In this review, data dealing with aggressive and low-grade B-NHL were separately analyzed. The few retrospective papers reporting on aggressive B-NHL patients showed that HCV infection is a risk factor for the outbreak of severe HT during treatment. This adverse event not infrequently leads to the reduction of treatment density and intensity. Existing papers report that low-grade B-NHL patients with HCV infection may have a more widespread disease, more frequent relapses or a lower ORR compared to HCV-negative patients. Notwithstanding, there is no statistical evidence that the prognosis of HCV-positive patients is inferior to that of HCV-negative subjects. HCV-positive prospective studies and longer follow-up are necessary to ascertain if HCV-positive B-NHL patients have inferior outcomes and if there are long term sequels of immunochemotherapies on the progression of liver disease. 展开更多
关键词 Marginal zone lymphoma Diffuse large B cell lymphoma Hepatitis C virus Non-Hodgkins lymphomaS HEPATOTOXICITY Chemotherapy IMMUNOCHEMOTHERAPY prognosis RITUXIMAB
下载PDF
Glycogen metabolism-mediated intercellular communication in the tumor microenvironment influences liver cancer prognosis
12
作者 YANG ZHANG NANNAN QIN +6 位作者 XIJUN WANG RUI LIANG QUAN LIU RUOYI GENG TIANXIAO JIANG YUNFEI LIU JINWEI LI 《Oncology Research》 SCIE 2024年第3期563-576,共14页
Glycogen metabolism plays a key role in the development of hepatoellular carcinoma(HCC),but the function of glycogen metabolism genes in the tumor microenvironment(TME)is still to be elucidated.Single cell RNA-seq dat... Glycogen metabolism plays a key role in the development of hepatoellular carcinoma(HCC),but the function of glycogen metabolism genes in the tumor microenvironment(TME)is still to be elucidated.Single cell RNA-seq data were obtained from ten HCC tumor samples totaling 64,545 cells and 65 glycogen metabolism genes were analyzed bya nonnegative matrix factorization(NMF).The prognosis and immune response of new glycogen TME cell dusters were predicted by using HCC and immunotherapy cohorts from public databases.HOC single cell analysis was divided into fibroblasts,NT T cells,macrophages,endothelial clls,and B cells,which were separately divided into new cell clusters by glycogen metabolism gene annotation.Pseudo temporal trajectory analysis demonstrated the temporal differentiation trajectory of different glycogen subtype cell dusters.Cellular communication analysis revealed extensive interactions between endothelial cells with glycogen metabolizing TME cell.related subtypes and diferent glycogen subtype cell clusters.SCENIC analysis of transcription factors upstream of TME cell clusters with different glycogen metabolism.In addition,TME cell dusters of glycogen metabolism were found to be enriched in expression in CAF subtypes,CD8 depleted,M1,and M2 types.Bulk seq analysis showed the prognostic signifcance of glycogen metabolism.mediated TME cell dusters in HCC,while a significant immune response was found in the immunotherapy cohort in patients treated with immune checkpoint blockade(ICB),especially for CAFs,T cells,and macrophages In summary,our study reveals for the first time that glycogen metabolism mediates intercellular communication in the hepatocellular carcinoma microenvironment while elucidating the anti-tumor mechanisms and immune prognostic responses of different subtypes of cell dusters. 展开更多
关键词 Glycogen metabolism Metabolic map Single cell Tumor microenvironment Liver cancer prognosis IMMUNOTHERAPY
下载PDF
Primary pancreatic lymphoma:A case report and review of literature
13
作者 Marko M Stojanovic Vesna Brzacki +8 位作者 Goran Marjanovic Milica Nestorovic Jelena Zivadinovic Miljan Krstic Marko Gmijovic Ilija Golubovic Svetlana Jovanovic Miroslav P Stojanovic Katarina Terzic 《World Journal of Clinical Oncology》 2024年第11期1444-1453,共10页
BACKGROUND Primary pancreatic lymphoma(PPL)is a rare tumor that mimics pancreatic adenocarcinoma,leading to diagnostic and therapeutic challenges.PPL accounts for 0.2%of all pancreatic tumors and is typically treated ... BACKGROUND Primary pancreatic lymphoma(PPL)is a rare tumor that mimics pancreatic adenocarcinoma,leading to diagnostic and therapeutic challenges.PPL accounts for 0.2%of all pancreatic tumors and is typically treated with chemotherapy.However,the long-term survival rates for PPL with chemotherapy and radiotherapy alone are unsatisfactory.Due to the improvements in pancreatic surgery,there is a need to reevaluate the treatment strategies for PPL.CASE SUMMARY A 62-year-old male presented to our clinic.A biopsy was unsuccessful,and the imaging was suggestive of pancreatic adenocarcinoma.Therefore,subtotal splenopancreatectomy was performed and histopathology was performed.He was then diagnosed with primary pancreatic diffuse large B-cell lymphoma.He received adjuvant chemotherapy and radiotherapy.Currently,the patient is alive with no evidence of disease 36 months after surgery.CONCLUSION The potential role of surgery in the treatment of PPL should be emphasized and added in the management protocol of early stage lymphoma. 展开更多
关键词 lymphoma PRIMARY PANCREAS Treatment STRATEGY SURGERY Case report
下载PDF
Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma
14
作者 Qi-Feng Wang Zong-Wei Li +4 位作者 Hai-Feng Zhou Kun-Zhong Zhu Ya-Jing Wang Ya-Qin Wang Yue-Wei Zhang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第6期2380-2393,共14页
Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy varies.This review summarized the ability of various markers to pred... Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy varies.This review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical applications.As of October 25,2023,51 articles have been retrieved based on keyword predictions and HAIC.Sixteen eligible articles were selected for inclusion in this study.Comprehensive literature analysis found that methods used to predict the efficacy of HAIC include serological testing,gene testing,and imaging testing.The above indicators and their combined forms showed excellent predictive effects in retrospective studies.This review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC,analyzed each marker's ability to predict HAIC efficacy,and provided a reference for the clinical application of the prediction system. 展开更多
关键词 Hepatocellular carcinoma Hepatic artery infusion chemotherapy PREDICTION prognosis IMAGING Biomarkers GENOMICS
下载PDF
Gallbladder carcinosarcoma with a poor prognosis: A case report
15
作者 Yi Dai Min Meng +3 位作者 Qi-Zhi Luo Yuan-Jun Liu Fan Xiao Chun-Hua Wang 《World Journal of Clinical Cases》 SCIE 2024年第10期1817-1823,共7页
BACKGROUND Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor prognosis.To date,only approximately 100 patients have been reported in the English literature.The prognosis of this tumor type i... BACKGROUND Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor prognosis.To date,only approximately 100 patients have been reported in the English literature.The prognosis of this tumor type is poor,the preoperative diagnosis is difficult,and there is a possibility of a misdiagnosis.We present an unsuccessful case of carcinosarcoma of the gallbladder with a preoperative misdiagnosis and rapid early postoperative recurrence.Therefore,we have a deeper understanding of the poor prognosis of gallbladder carcinosarcoma(GBC)patients.CASE SUMMARY The patient is a 65-year-old male.He was admitted to the hospital because of right upper abdomen distending pain and discomfort for half a month.Abdominal magnetic resonance imaging revealed a polycystic mass in the right lobe of the liver and the fossa of the gallbladder.After admission,the patient was diagnosed with a liver abscess,which was treated by abscess puncture drainage.Obviously,this treatment was unsuccessful.Hepatectomy and cholecystectomy were performed one month after the puncture.Postoperative pathologic examination revealed carcinosarcoma of the gallbladder,and the resected specimen contained two tumor components.One month after surgery,the patient's tumor recurred in situ and started to compress the duodenum,resulting in duodenal obstruction and bleeding.The treatment was not effective.The patient died of gastrointestinal hemorrhage and hypovolemic shock.CONCLUSION Carcinosarcoma of the gallbladder is a rare malignant tumor that is easily misdiagnosed preoperatively and has a poor prognosis. 展开更多
关键词 Gallbladder disease CARCINOSARCOMA MISDIAGNOSIS Poor prognosis Pathological diagnosis RECURRENCE Case report
下载PDF
Predictors of prognosis in Alzheimer’s disease: The role of cognitive dysfunction, immune abnormalities, and advanced neuroimaging
16
作者 Hafsa Arshad Raja Abdulqadir J Nashwan 《World Journal of Clinical Cases》 SCIE 2024年第27期6004-6006,共3页
Alzheimer’s disease(AD)is a grave illness that results in cognitive and social issues.A recent study examined the association between neuroimaging results,cognitive dysfunction,atypical cellular immune function,and p... Alzheimer’s disease(AD)is a grave illness that results in cognitive and social issues.A recent study examined the association between neuroimaging results,cognitive dysfunction,atypical cellular immune function,and poor prognostic factors in AD patients who demonstrated poor prognosis.Poor prognosis was associated with abnormal cellular immune function,extrapyramidal symptoms,altered consciousness,abnormal electroencephalogram,modified Rankin scale,increased neutrophil lymphocyte ratio,and severe pneumonia.The impaired cellular immune function characterized by a reduction in the blood T lym-phocytes’proportion predicted poor prognosis as an independent risk factor in AD.Early initiation and maintenance of AD medications is associated with better outcomes. 展开更多
关键词 Amyloid beta peptide Alzheimer's disease DEMENTIA Cellular immunity prognosis T lymphocytes Magnetic resonance spectroscopy
下载PDF
Prediction of pathological complete response and prognosis in locally advanced rectal cancer
17
作者 Yi-Jun Xu Dan Tao +6 位作者 Song-Bing Qin Xiao-Yan Xu Kai-Wen Yang Zhong-Xu Xing Ju-Ying Zhou Yang Jiao Li-Li Wang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第6期2520-2530,共11页
BACKGROUND Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death worldwide.Neoadjuvant chemoradiotherapy(nCRT)is standard for locally advanced rectal... BACKGROUND Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death worldwide.Neoadjuvant chemoradiotherapy(nCRT)is standard for locally advanced rectal cancer(LARC).Except for pathological examination after resection,it is not known exactly whether LARC patients have achieved pathological complete response(pCR)before surgery.To date,there are no clear clinical indicators that can predict the efficacy of nCRT and patient outcomes.AIM To investigate the indicators that can predict pCR and long-term outcomes following nCRT in patients with LARC.METHODS Clinical data of 128 LARC patients admitted to our hospital between September 2013 and November 2022 were retrospectively analyzed.Patients were categorized into pCR and non-pCR groups.Univariate analysis(using the χ^(2) test or Fisher’s exact test)and logistic multivariate regression analysis were used to study clinical predictors affecting pCR.The 5-year disease-free survival(DFS)and overall survival(OS)rates were calculated using Kaplan-Meier analysis,and differences in survival curves were assessed with the log-rank test.RESULTS Univariate analysis showed that pretreatment carcinoembryonic antigen(CEA)level,lymphocyte-monocyte ratio(LMR),time interval between neoadjuvant therapy completion and total mesorectal excision,and tumor size were correlated with pCR.Multivariate results showed that CEA≤5 ng/mL(P=0.039),LMR>2.73(P=0.023),and time interval>10 wk(P=0.039)were independent predictors for pCR.Survival analysis demonstrated that patients in the pCR group had significantly higher 5-year DFS rates(94.7%vs 59.7%,P=0.002)and 5-year OS rates(95.8%vs 80.1%,P=0.019)compared to the non-pCR group.Tumor deposits(TDs)were significantly correlated with shorter DFS(P=0.002)and OS(P<0.001).CONCLUSION Pretreatment CEA,LMR,and time interval contribute to predicting nCRT efficacy in LARC patients.Achieving pCR demonstrates longer DFS and OS.TDs correlate with poor prognosis. 展开更多
关键词 Locally advanced rectal cancer Neoadjuvant chemoradiotherapy Pathological complete response Carcinoembryonic antigen Inflammation-related markers Tumor deposit prognosis
下载PDF
Contributing to the prediction of prognosis for treated hepatocellular carcinoma: Imaging aspects that sculpt the future
18
作者 Cristian Lindner 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第10期3377-3380,共4页
A novel nomogram model to predict the prognosis of hepatocellular carcinoma(HCC)treated with radiofrequency ablation and transarterial chemoembolization was recently published in the World Journal of Gastrointestinal ... A novel nomogram model to predict the prognosis of hepatocellular carcinoma(HCC)treated with radiofrequency ablation and transarterial chemoembolization was recently published in the World Journal of Gastrointestinal Surgery.This model includes clinical and laboratory factors,but emerging imaging aspects,partic-ularly from magnetic resonance imaging(MRI)and radiomics,could enhance the predictive accuracy thereof.Multiparametric MRI and deep learning radiomics models significantly improve prognostic predictions for the treatment of HCC.In-corporating advanced imaging features,such as peritumoral hypointensity and radiomics scores,alongside clinical factors,can refine prognostic models,aiding in personalized treatment and better predicting outcomes.This letter underscores the importance of integrating novel imaging techniques into prognostic tools to better manage and treat HCC. 展开更多
关键词 Hepatocellular carcinoma Radiofrequency ablation Transcatheter arterial chemoembolization prognosis Magnetic resonance imaging Radiomics Artificial intelligence
下载PDF
Chinese guidelines for diagnosis and treatment of malignant lymphoma 2018(English version) 被引量:4
19
作者 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2019年第4期557-577,共21页
1. Overview2. Diagnosis of lymphoma2.1 Clinical manifestations2.2 Physical examination2.3 Laboratory examination2.4 Imaging examination2.4.1 CT2.4.2 MRI2.4.3 PET-CT2.4.4 Ultrasound2.4.5 Isotope bone scan2.5 Other spec... 1. Overview2. Diagnosis of lymphoma2.1 Clinical manifestations2.2 Physical examination2.3 Laboratory examination2.4 Imaging examination2.4.1 CT2.4.2 MRI2.4.3 PET-CT2.4.4 Ultrasound2.4.5 Isotope bone scan2.5 Other specific examinations2.6 Pathological examinations2.6.1 Morphology2.6.2 IHC2.6.3 Fluorescence in situ hybridization (FISH)2.6.4 Antigen receptor gene rearrangement of lymphocytes2.6.5 Others. 展开更多
关键词 EBV AHSCT HDC II DLBCL CHINESE GUIDELINES for diagnosis and treatment of MALIGNANT lymphoma 2018 English version
下载PDF
Changes of serum CEA, CA125, LDH andβ2-MG in patients with malignant lymphoma and their clinical staging and prognosis
20
作者 Ya-Bin Chen Jiang Zhang 《Journal of Hainan Medical University》 2018年第20期65-68,共4页
Objective:To investigate the changes of serum carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), lactate dehydrogenase (LDH) andβ2-microglobulin (β2-MG) in patients with malignant lymphoma.Methods: A ... Objective:To investigate the changes of serum carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), lactate dehydrogenase (LDH) andβ2-microglobulin (β2-MG) in patients with malignant lymphoma.Methods: A total of 71 patients with malignant lymphoma treated in our hospital from April 2015 to April 2017 were selected. All patients were treated with first-line chemotherapy CHOP, with 28 d as the 1 cycle and continuous chemotherapy for 4 cycles. CEA andβ2-MG were detected by fluorescence immunoassay, CA125 by enzyme-linked immunosorbent assay and LHD by rate method. The changes of serum CEA, CA125, LDH andβ2-MG levels were compared in patients with different stages, different curative effects and 1-year survival and death.Results: The levels of serum CEA, CA125, LDH andβ2-MG in stage III-IV were higher than those in stage I-II. The levels of serum CEA, CA125, LDH andβ2-MG in the ineffective patients were significantly higher than those in the effective patients. The levels of serum CEA, CA125, LDH andβ2-MG in the death group were higher than those in the survival group.Conclusion: The serum levels of CEA, CA125, LDH andβ2-MG in patients with malignant lymphoma increase with the increase of clinical stages and poor prognosis, which can be used as an effective indicator for the condition, treatment and prognosis of patients with malignant lymphoma. 展开更多
关键词 Malignant lymphoma Carcinoembryonic ANTIGEN CARBOHYDRATE ANTIGEN 125 LACTATE dehydrogenaseβ2 MICROGLOBULIN Stage prognosis
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部