In the present paper, the authors make an analysis on the therapeutic effect of acupunc-ture at Sanyinjiao(SP 6) alone for treatment of 120 cases of primary dysmenorrhea. Results show atotal effective rate of 96.7%.
Objective: To explore the analgesic effects and uterine hemodynamics of perpendicular needling(PN)and transverse needling(TN) at SP 6 in patients with primary dysmenorrhea(PD).Methods: In this randomized controlled tr...Objective: To explore the analgesic effects and uterine hemodynamics of perpendicular needling(PN)and transverse needling(TN) at SP 6 in patients with primary dysmenorrhea(PD).Methods: In this randomized controlled trial, patients with PD diagnosed with cold-dampness congealing pattern were randomly assigned in a ratio of 1:1 to receive PN or TN at bilateral SP 6 for 10 min.Acupuncture was performed when the menstrual pain score was over 40 mm on the first day of menstruation, as measured using the visual analog scale for pain(VAS-P). The primary outcome was average menstrual pain(VAS-P). Secondary outcomes included the pulsatility index(PI), resistance index(RI), and systolic-diastolic peaks ratio(S/D) in uterine arteries as measured using color Doppler ultrasonography;anxiety as assessed using the Hamilton Anxiety Rating Scale(HAMA), blood pressure(BP),and heart rate(HR).Results: Forty-eight patients completed the study. The TN group exhibited a significant reduction in VAS-P scores(-5.71 mm, 95% confidence interval(CI): -8.78, -2.63, P =.001), RI values(-0.05, 95% CI:-0.09, -0.01, P=.015), and HAMA values(-2.50, 95% CI: -4.78, -0.22, P=.032) when compared with the PN group. No significant differences in PI, S/D, BP, or HR values were observed between the two groups(P >.05).Conclusion: TN at SP 6 was superior to PN in alleviating menstrual pain and anxiety in patients with PD.This analgesic effect of TN may be due to its better ability to improve uterine arterial blood flow via decreases in RI values.展开更多
Objective: To study the central mechanism of acupuncture stimulation of Sanyinjiao (三阴交 SP 6) in relieving dysmenorrhea. Methods: A total of 6 dysmenorrhea volunteer patients were subjected into this study. On the ...Objective: To study the central mechanism of acupuncture stimulation of Sanyinjiao (三阴交 SP 6) in relieving dysmenorrhea. Methods: A total of 6 dysmenorrhea volunteer patients were subjected into this study. On the first positron emission tomography (PET) scan examination, they were assigned to pseudo-acupuncture group by using the acupuncture needle just to prick the skin of Sanyinjiao (SP 6); while on the second PET scans, they were assigned to acupuncture group by inserting the needle into the same acupoint. 18F fluorodeoxyglucose ( 18F-FDG) PET of the whole brain was performed during pseudo-acupuncture and real acupuncture of Sanyinjiao (SP 6). The acquired PET data were analyzed by using statistical parametric mapping (SPM) software to determine changes of glucose metabolism in different cerebral regions. The patient’s pain intensity was rated by using 0-10 numerical pain intensity scale. Results: After pseudo-acupuncture stimulation of Sanyinjiao (SP 6), no significant changes were found in the pain intensity (P>0.05), while after real-acupuncture stimulation, the pain intensity declined significantly (P<0.01). Following acupuncture of the right Sanyinjiao (SP 6), multiple cerebral regions involving pain were activated (increase of glucose metabolism), including ipsilateral lenticular nucleus (globus pallidus, putamen), ipsilateral cerebellum and insular lobe, bilateral dorsal thalamus, ipsilateral paracentral lobule, bilateral amygdaloid bodies, contralateral substantia nigra of the midbrain, bilateral second somatosensory (SⅡ) areas, ispsilateral hippocampal gyrus, frontal part of the ipsilateral cingulated gyrus, and bilateral mammary bodies of the hypothalamus. In addition, fewer regions of the cerebral cortex responded with decrease of the glucose metabolism after real acupuncture.展开更多
OBJECTIVE: To investigate the effects of electroacupuncture(EA) at the Guanyuan(CV 4) or Sanyinjiao(SP 6) acupoints on the hypothalamus-pituitary-ovary(HPO) axis and spatial learning and memory in female mice.METHODS:...OBJECTIVE: To investigate the effects of electroacupuncture(EA) at the Guanyuan(CV 4) or Sanyinjiao(SP 6) acupoints on the hypothalamus-pituitary-ovary(HPO) axis and spatial learning and memory in female mice.METHODS: Nine-month-old female mice with senescence-accelerated mouse prone 8(SAMP8)were divided into three groups: the disease model,EA-Guanyuan and EA-Sanyinjiao groups. Concurrently, 9-month old female mice with senescence-accelerated mouse resistance 1(SAMR1)were set as the control model group. The two treatment groups were given the same pattern of EA stimulation. Gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone(FSH) and Serum estradiol levels in the Hypothalamus-pituitary-ovary axis were assessed by enzyme-linked immunosorbent assay to determinethe HPO axis function level. Spatial learning and memory were assessed by the Morris Water Maze(MWM) test.RESULTS:(a) HPO axis: compared with the control model group, the disease model group displayed a decrease in E2 levels(P < 0.01), and an increase in Gn RH, LH and FSH levels(P < 0.01). E2 levels were increased in EA treatment groups compared with the disease model group(P < 0.05). In contrast,Gn RH and LH and FSH levels were reduced(P <0.05). EA-Sanyinjiao group was superior than EA-Guanyuan group on increasing E2 and declining Gn RH levels(P < 0.01).(b) The MWM test demonstrated that the response latency in the EA-Sanyinjiao treatment group declined from day 2 to day5 compared with the disease model group(P <0.05), whereas the EA-Guanyuan treatment group showed no significant difference.CONCLUSION: EA can regulate hormone(E2, FSH,LH, Gn RH) levels in the HPO axis and the spatial learning and memory ability in female SAMP8 mice. Moreover, this effect may have been more pronounced in the EA-Sanyinjiao group than the EA-Guanyuan group. The underlying mechanism of the EA-induced changes may be related to gonadal hormone shifts in the HPO axis, followed by an improvement in spatial learning and memory.展开更多
Objective To observe the effects of moxibustion at'Guanyuan'(CV 4) and'Sanyinjiao'(SP 6) on bone morphology,metabolism and ERαof bone marrow mesenchymal stem cells (MSCs) in the ovariectomized rats an...Objective To observe the effects of moxibustion at'Guanyuan'(CV 4) and'Sanyinjiao'(SP 6) on bone morphology,metabolism and ERαof bone marrow mesenchymal stem cells (MSCs) in the ovariectomized rats and explore the underlying mechanism of moxibustion at Guanyuan (CV 4) and Sanyinjiao (SP 6) on the regulationof bone metabolism. Methods A total of 60 SD ratswere randomized into a normal group (20 rats) and anovariectomy group (40 rats).展开更多
目的探究三阴交穴位按摩联合低频脉冲反馈电刺激对产后压力性尿失禁患者盆底功能、尿失禁次数的影响。方法选取2018年6月—2020年6月期间在南京中医药大学太仓附属医院进行产后压力性尿失禁治疗的患者110例,根据随机数字表法分为按摩组...目的探究三阴交穴位按摩联合低频脉冲反馈电刺激对产后压力性尿失禁患者盆底功能、尿失禁次数的影响。方法选取2018年6月—2020年6月期间在南京中医药大学太仓附属医院进行产后压力性尿失禁治疗的患者110例,根据随机数字表法分为按摩组和联合组,每组各55例。两组患者均进行常规治疗,适当减少水分摄入,及时排尿,进行膀胱功能训练,按摩组在常规治疗的基础上进行三阴交穴位按摩治疗,联合组在按摩组的基础上,进行低频脉冲反馈电刺激治疗。治疗6周后,观察比较两组患者临床疗效,治疗前后尿流动力学指标[腹压漏尿点压力(Abdominal leak point pressure,ALPP)、最大尿流率(The maximum flow rate,Qmax)、最大尿道闭合压(Maximum urethral closure pressure,MUCP)];膀胱颈活动度、尿道旋转角水平;盆底功能水平(阴道收缩压、阴道静息压、阴道收缩持续时间);ICI-Q-SF评分(总排尿量、总排尿次数、总漏尿次数、总分)。结果治疗后两组患者尿流动力学指标ALPP、Qmax、MUCP水平较治疗前升高,差异有统计学意义(P<0.05),且联合组高于按摩组,差异有统计学意义(P<0.05)。治疗后两组患者膀胱颈活动度、尿道旋转角水平较治疗前降低,差异有统计学意义(P<0.05);且联合组低于按摩组,差异有统计学意义(P<0.05)。治疗后两组患者阴道收缩压、阴道静息压、阴道收缩持续时间水平较治疗前升高,差异有统计学意义(P<0.05);且联合组高于按摩组,差异有统计学意义(P<0.05)。治疗后两组患者ICI-Q-SF评分总分及总排尿次数、总漏尿次数较治疗前降低,总排尿量较治疗前升高,差异有统计学意义(P>0.05);且联合组ICI-Q-SF评分总分及总排尿次数、总漏尿次数低于按摩组,总排尿量高于按摩组,差异有统计学意义(P<0.05)。治疗后联合组临床疗效总有效率92.73%(51/55)明显高于按摩组70.91%(39/55),差异有统计学意义(P<0.05)。结论经三阴交穴位按摩联合低频脉冲反馈电刺激联合治疗后,产后压力性尿失禁患者尿流动力学指标水平提高,盆底功能改善,ICI-Q-SF评分降低,尿失禁症状明显减轻,联合治疗效果显著。展开更多
文摘In the present paper, the authors make an analysis on the therapeutic effect of acupunc-ture at Sanyinjiao(SP 6) alone for treatment of 120 cases of primary dysmenorrhea. Results show atotal effective rate of 96.7%.
基金funded by the Longitudinal Research Project of BUCM (2018-ZXFZJJ-010)。
文摘Objective: To explore the analgesic effects and uterine hemodynamics of perpendicular needling(PN)and transverse needling(TN) at SP 6 in patients with primary dysmenorrhea(PD).Methods: In this randomized controlled trial, patients with PD diagnosed with cold-dampness congealing pattern were randomly assigned in a ratio of 1:1 to receive PN or TN at bilateral SP 6 for 10 min.Acupuncture was performed when the menstrual pain score was over 40 mm on the first day of menstruation, as measured using the visual analog scale for pain(VAS-P). The primary outcome was average menstrual pain(VAS-P). Secondary outcomes included the pulsatility index(PI), resistance index(RI), and systolic-diastolic peaks ratio(S/D) in uterine arteries as measured using color Doppler ultrasonography;anxiety as assessed using the Hamilton Anxiety Rating Scale(HAMA), blood pressure(BP),and heart rate(HR).Results: Forty-eight patients completed the study. The TN group exhibited a significant reduction in VAS-P scores(-5.71 mm, 95% confidence interval(CI): -8.78, -2.63, P =.001), RI values(-0.05, 95% CI:-0.09, -0.01, P=.015), and HAMA values(-2.50, 95% CI: -4.78, -0.22, P=.032) when compared with the PN group. No significant differences in PI, S/D, BP, or HR values were observed between the two groups(P >.05).Conclusion: TN at SP 6 was superior to PN in alleviating menstrual pain and anxiety in patients with PD.This analgesic effect of TN may be due to its better ability to improve uterine arterial blood flow via decreases in RI values.
文摘Objective: To study the central mechanism of acupuncture stimulation of Sanyinjiao (三阴交 SP 6) in relieving dysmenorrhea. Methods: A total of 6 dysmenorrhea volunteer patients were subjected into this study. On the first positron emission tomography (PET) scan examination, they were assigned to pseudo-acupuncture group by using the acupuncture needle just to prick the skin of Sanyinjiao (SP 6); while on the second PET scans, they were assigned to acupuncture group by inserting the needle into the same acupoint. 18F fluorodeoxyglucose ( 18F-FDG) PET of the whole brain was performed during pseudo-acupuncture and real acupuncture of Sanyinjiao (SP 6). The acquired PET data were analyzed by using statistical parametric mapping (SPM) software to determine changes of glucose metabolism in different cerebral regions. The patient’s pain intensity was rated by using 0-10 numerical pain intensity scale. Results: After pseudo-acupuncture stimulation of Sanyinjiao (SP 6), no significant changes were found in the pain intensity (P>0.05), while after real-acupuncture stimulation, the pain intensity declined significantly (P<0.01). Following acupuncture of the right Sanyinjiao (SP 6), multiple cerebral regions involving pain were activated (increase of glucose metabolism), including ipsilateral lenticular nucleus (globus pallidus, putamen), ipsilateral cerebellum and insular lobe, bilateral dorsal thalamus, ipsilateral paracentral lobule, bilateral amygdaloid bodies, contralateral substantia nigra of the midbrain, bilateral second somatosensory (SⅡ) areas, ispsilateral hippocampal gyrus, frontal part of the ipsilateral cingulated gyrus, and bilateral mammary bodies of the hypothalamus. In addition, fewer regions of the cerebral cortex responded with decrease of the glucose metabolism after real acupuncture.
基金the National Science Foundation of China(the Experimental Research on Acupuncture for Prevention and Treatment Alzheimer's Disease Based on the Adjustment Imbalances of NIM,No.81072768)
文摘OBJECTIVE: To investigate the effects of electroacupuncture(EA) at the Guanyuan(CV 4) or Sanyinjiao(SP 6) acupoints on the hypothalamus-pituitary-ovary(HPO) axis and spatial learning and memory in female mice.METHODS: Nine-month-old female mice with senescence-accelerated mouse prone 8(SAMP8)were divided into three groups: the disease model,EA-Guanyuan and EA-Sanyinjiao groups. Concurrently, 9-month old female mice with senescence-accelerated mouse resistance 1(SAMR1)were set as the control model group. The two treatment groups were given the same pattern of EA stimulation. Gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone(FSH) and Serum estradiol levels in the Hypothalamus-pituitary-ovary axis were assessed by enzyme-linked immunosorbent assay to determinethe HPO axis function level. Spatial learning and memory were assessed by the Morris Water Maze(MWM) test.RESULTS:(a) HPO axis: compared with the control model group, the disease model group displayed a decrease in E2 levels(P < 0.01), and an increase in Gn RH, LH and FSH levels(P < 0.01). E2 levels were increased in EA treatment groups compared with the disease model group(P < 0.05). In contrast,Gn RH and LH and FSH levels were reduced(P <0.05). EA-Sanyinjiao group was superior than EA-Guanyuan group on increasing E2 and declining Gn RH levels(P < 0.01).(b) The MWM test demonstrated that the response latency in the EA-Sanyinjiao treatment group declined from day 2 to day5 compared with the disease model group(P <0.05), whereas the EA-Guanyuan treatment group showed no significant difference.CONCLUSION: EA can regulate hormone(E2, FSH,LH, Gn RH) levels in the HPO axis and the spatial learning and memory ability in female SAMP8 mice. Moreover, this effect may have been more pronounced in the EA-Sanyinjiao group than the EA-Guanyuan group. The underlying mechanism of the EA-induced changes may be related to gonadal hormone shifts in the HPO axis, followed by an improvement in spatial learning and memory.
文摘Objective To observe the effects of moxibustion at'Guanyuan'(CV 4) and'Sanyinjiao'(SP 6) on bone morphology,metabolism and ERαof bone marrow mesenchymal stem cells (MSCs) in the ovariectomized rats and explore the underlying mechanism of moxibustion at Guanyuan (CV 4) and Sanyinjiao (SP 6) on the regulationof bone metabolism. Methods A total of 60 SD ratswere randomized into a normal group (20 rats) and anovariectomy group (40 rats).
文摘目的探究三阴交穴位按摩联合低频脉冲反馈电刺激对产后压力性尿失禁患者盆底功能、尿失禁次数的影响。方法选取2018年6月—2020年6月期间在南京中医药大学太仓附属医院进行产后压力性尿失禁治疗的患者110例,根据随机数字表法分为按摩组和联合组,每组各55例。两组患者均进行常规治疗,适当减少水分摄入,及时排尿,进行膀胱功能训练,按摩组在常规治疗的基础上进行三阴交穴位按摩治疗,联合组在按摩组的基础上,进行低频脉冲反馈电刺激治疗。治疗6周后,观察比较两组患者临床疗效,治疗前后尿流动力学指标[腹压漏尿点压力(Abdominal leak point pressure,ALPP)、最大尿流率(The maximum flow rate,Qmax)、最大尿道闭合压(Maximum urethral closure pressure,MUCP)];膀胱颈活动度、尿道旋转角水平;盆底功能水平(阴道收缩压、阴道静息压、阴道收缩持续时间);ICI-Q-SF评分(总排尿量、总排尿次数、总漏尿次数、总分)。结果治疗后两组患者尿流动力学指标ALPP、Qmax、MUCP水平较治疗前升高,差异有统计学意义(P<0.05),且联合组高于按摩组,差异有统计学意义(P<0.05)。治疗后两组患者膀胱颈活动度、尿道旋转角水平较治疗前降低,差异有统计学意义(P<0.05);且联合组低于按摩组,差异有统计学意义(P<0.05)。治疗后两组患者阴道收缩压、阴道静息压、阴道收缩持续时间水平较治疗前升高,差异有统计学意义(P<0.05);且联合组高于按摩组,差异有统计学意义(P<0.05)。治疗后两组患者ICI-Q-SF评分总分及总排尿次数、总漏尿次数较治疗前降低,总排尿量较治疗前升高,差异有统计学意义(P>0.05);且联合组ICI-Q-SF评分总分及总排尿次数、总漏尿次数低于按摩组,总排尿量高于按摩组,差异有统计学意义(P<0.05)。治疗后联合组临床疗效总有效率92.73%(51/55)明显高于按摩组70.91%(39/55),差异有统计学意义(P<0.05)。结论经三阴交穴位按摩联合低频脉冲反馈电刺激联合治疗后,产后压力性尿失禁患者尿流动力学指标水平提高,盆底功能改善,ICI-Q-SF评分降低,尿失禁症状明显减轻,联合治疗效果显著。
