<strong><em>Objective</em></strong><span style="font-family:Verdana;">: </span><span style="font-family:Verdana;">To explore the relation</span><s...<strong><em>Objective</em></strong><span style="font-family:Verdana;">: </span><span style="font-family:Verdana;">To explore the relation</span><span style="font-family:Verdana;">ship</span><span style="font-family:Verdana;"> between serum ferritin</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">(SF) and gestational diabetes mellitus (GDM), for providing new ideas to the prevention and treatment of GDM. </span><b><i><span style="font-family:Verdana;">Methods</span></i></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> All the pregnant women were selected in Yinan Maternal and Child Health-Care Hospital</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">from December, 2015 to March, 2018 when they were having routine prenatal examination, According to the diagnostic criteria of GDM, 72 patients with GDM were selected as the case group and 72 normal preg</span><span style="font-family:Verdana;">na</span><span style="font-family:Verdana;">nt women were randomly selected as </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group. Fasting venous blood was drawn from all subjects during the first trimester of pregnancy (11</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">13 weeks) and the second trimester of pregnancy (24</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">28 weeks). </span><span style="font-family:Verdana;">F</span><span style="font-family:;" "=""><span style="font-family:Verdana;">asting plasma glucose was measured by glucose oxidase assay and the expression level of SF was determined by electrochemical method. The application value of SF in GDM diagnosis was evaluated by ROC curve. </span><b><i><span style="font-family:Verdana;">Results</span></i></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> The level</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> of SF in the case group at early and middle stages</span><span style="font-family:Verdana;"> are</span><span style="font-family:Verdana;"> 49.6 ± 18.8 (μg/ml) and 39.8 ± 21.5 (μg/ml), which </span><span style="font-family:Verdana;">re</span><span style="font-family:Verdana;"> 39.4 ± 15.2 (μg/ml)</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">and 32.2 ± 17.6</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(μg/ml) in the control group. The levels of SF in </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">case group were higher than those in </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group</span><span style="font-family:Verdana;"> (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> < 0.05</span><span style="font-family:Verdana;">) </span><span style="font-family:Verdana;">at early and middle stages. The curve (AUC) of SF level in </span><span style="font-family:Verdana;">the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">diagnosis of GDM was 0.895, </span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> < 0.001;</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">the Youden index was 0.651 and the optimum threshold was 38.6</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">ng/ml, with a sensitivity of 97.8% and a specificity of 67.3%. </span><b><i><span style="font-family:Verdana;">Conclusion</span></i></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> The expression level of SF in early pregnancy is correlated with the occurrence of GDM, which may be an important indicator for the prevention and monitoring of GDM.</span>展开更多
BACKGROUND The association between pretreatment serum ferritin concentration(SFC)and long-term survival in lung cancer remains unclear now.AIM To identify the prognostic value of pretreatment SFC in lung cancer patien...BACKGROUND The association between pretreatment serum ferritin concentration(SFC)and long-term survival in lung cancer remains unclear now.AIM To identify the prognostic value of pretreatment SFC in lung cancer patients based on current evidence.METHODS The PubMed,EMBASE and Web of Science databases were searched from inception to May 29,2022 for relevant studies.The primary endpoint was overall survival(OS)and the hazard ratios(HRs)with corresponding 95%confidence intervals(CIs)were combined to assess the predictive role of pretreatment SFC for long-term survival of lung cancer patients.The data were then extracted and assessed on the basis of the Reference Citation Analysis(https://www.reference citationanalysis.com/).RESULTS Twelve retrospective studies involving 1654 patients were analyzed.The results manifested that increased pretreatment SFC was associated with worse OS(HR=1.09,95%CI:1.03-1.15,P=0.004).Subgroup analysis stratified by the country(China vs non-China)showed similar results.However,subgroup analysis stratified by tumor type revealed inconsistent results(lung cancer:HR=1.39,P=0.008;small cell lung cancer:HR=1.99,P=0.175;non-small cell lung cancer:HR=1.03,P=0.281).CONCLUSION Pretreatment SFC might serve as a promising prognostic indicator in lung cancer patients and elevated pretreatment SFC predicts worse prognosis.However,more high-quality studies with big sample sizes are still needed to further verify its prognostic value in lung cancer.展开更多
BACKGROUND Iron plays an important role in neurodevelopmental functions in the brain.Serum ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy child...BACKGROUND Iron plays an important role in neurodevelopmental functions in the brain.Serum ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy children.AIM To explore the current status of iron deficiency in children with neurodevelopmental disorders and its sex and age effects.METHODS A total of 1565 children with attention deficit hyperactivity disorder(ADHD),1694 children with tic disorder(TD),93 children with ASD and 1997 healthy control children were included between January 1,2020,and December 31,2021 at Beijing Children's Hospital.We describe the differences in age levels and ferritin levels between different disease groups and their sex differences.The differences between the sexes in each disease were analyzed using the t test.The incidence rate of low serum ferritin was used to describe the differences between different diseases and different age groups.A chi-square test was used to analyze the difference in the incidence of low serum ferritin between the disease group and the control group.Analysis of variance was used for comparisons between subgroups,and regression analysis was used for confounding factor control.RESULTS A total of 1565 ADHD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 36.82±20.64μg/L and 35.64±18.56μg/L,respectively.A total of 1694 TD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 35.72±20.15μg/L and 34.54±22.12μg/L,respectively.As age increased,the incidence of low serum ferritin in ADHD and TD first decreased and then increased,and 10 years old was the turning point of rising levels.The incidence of ADHD with low serum ferritin was 8.37%,the incidence of TD with low serum ferritin was 11.04%,and the incidence of the healthy control group with low serum ferritin was 8.61%,among which male children with TD accounted for 9.25%and female children with TD accounted for 11.62%.There was a significant difference among the three groups(P<0.05).In addition,there were 93 children with ASD with an average serum ferritin level of 30.99±18.11μg/L and a serum ferritin incidence of 15.05%.CONCLUSION In conclusion,low serum ferritin is not a risk factor for ADHD or TD.The incidence of low serum ferritin levels in children with ADHD and TD between 5 and 12 years old decreases first and then increases with age.展开更多
<strong>Objective: </strong>To investigate the concentration and clinical significance of serum ferritin (SF) in patients diagnosed with advanced gastric cancer before and after treatment. <strong>Me...<strong>Objective: </strong>To investigate the concentration and clinical significance of serum ferritin (SF) in patients diagnosed with advanced gastric cancer before and after treatment. <strong>Methods:</strong> Forty patients with advanced gastric cancer diagnosed by cytology or pathology in our hospital were selected, including 25 males and 15 females, aged from 48 to 85 years, and the median age was 61.0 years. 40 healthy volunteers matched with age and education were selected as the control group. In order to study the changes of SF level in the treatment of advanced gastric cancer, we divided the patients into effective group (efficacy evaluation as partial remission or complete remission), ineffective group (efficacy evaluation as no remission) and recurrence group according to the efficacy after treatment. Then the difference of SF level between different groups and the relationship between SF level and curative effect were analyzed. There was no significant difference in gender and age among all groups. <strong>Results</strong>: The SF levels in the newly diagnosed group, stage III patient group and stage IV patient group were significantly higher than those in the control group. The level of SF in stage IV patients was significantly higher than that in stage III patients. There were significant differences in SF level between the effective treatment group, the newly diagnosed group and the ineffective treatment group, but there was no significant difference in SF level between the newly diagnosed group and the ineffective treatment group. <strong>Conclusion: </strong>SF level has a certain value in the auxiliary diagnosis of gastric cancer, and it also has a certain guiding significance for the evaluation of curative effect and prognosis after treatment.展开更多
Objective To establish and evaluate a protein microarray method for combined measurement of serum ferritin(SF) and soluble transferrin receptor(sTfR).Methods Microarrayer was used to print both anti-SF antibodies I an...Objective To establish and evaluate a protein microarray method for combined measurement of serum ferritin(SF) and soluble transferrin receptor(sTfR).Methods Microarrayer was used to print both anti-SF antibodies I and anti-sTfR antibodies I on each protein microarray.Anti-SF antibodies II and anti-sTfR antibodies II were used as detection antibodies and goat antibodies coupled to Cy3 were used as antibodies III.The detection conditions of the quantitative analysis method for simultaneous measurement of SF and sTfR with protein microarray were optimized and evaluated.The protein microarray was compared with commercially available traditional tests with 26 serum samples.Results By comparison experiment,mouse monoclonal antibodies were chosen as the probes and contact printing was chosen as the printing method.The concentrations of SF and sTfR probes were 0.5 mg/mL and 0.5 mg/mL respectively,while those of SF and sTfR detection antibodies were 5 μg/mL and 0.36 μg/mL respectively.Intra-and inter-assay variability was between 3.26% and 18.38% for all tests.The regression coefficients comparing protein microarray with traditional test assays were better than 0.81 for SF and sTfR.Conclusion The present study has established a protein microarray method for combined measurement of SF and sTfR.展开更多
Objective The present study aimed to investigate the association of red meat usual intake with metabolic syndrome(Met S),and explore the contribution of red meat usual intake to serum ferritin.Methods Based on the dat...Objective The present study aimed to investigate the association of red meat usual intake with metabolic syndrome(Met S),and explore the contribution of red meat usual intake to serum ferritin.Methods Based on the data from the longitudinal China Health and Nutrition Survey(CHNS),2,797 healthy adults aged 18–75 years without hypertension,diabetes,and Met S were selected in 2009 as subjects and follow-up studies were carried out till 2015.We used the National Cancer Institute(NCI)method to estimate the usual intake of foods.Multivariable logistic regressions were performed to evaluate the association between red meat usual intake and the risk of Met S.Quantile regression analysis was used to study the relationship between red meat consumption and serum ferritin levels.Results After adjusting for potential confounders,red meat,and fresh red meat were positively associated with the risk of Met S(RR=1.41,95%CI:1.05–1.90 and RR=1.37,95%CI:1.02–1.85,respectively).These relationships showed increasing trend(P<0.05).The level of serum ferritin increased significantly with the number of Met S components(P<0.05).The quantile regression analysis showed that red meat and fresh red meat usual intake had a significant positive association with serum ferritin levels across the entire conditional serum ferritin distribution(P<0.05).Processed red meat did not exhibit a similar association.Conclusion Higher red meat usual intake was associated with an increased risk of Met S and elevated serum ferritin levels.展开更多
The purpose of this study was to assess the correlation between iron deficiency and recurrent aphthous ulceration (RAU). Radioimmunoassay was used to examine the serum ferritin level (SFL) in 52 patients with RAU and ...The purpose of this study was to assess the correlation between iron deficiency and recurrent aphthous ulceration (RAU). Radioimmunoassay was used to examine the serum ferritin level (SFL) in 52 patients with RAU and in 54 controls. Both were divided into 2 groups in accordance with sex. The 36 female patients were subdivided into 3 age-groups as follows: 8 aged 22-24, 10 aged 25-34, and 18 aged 35-50 while the male patients were gathered as one single group aged 26-57. The subdivision was adapted similarly for the normal age-grouts. Although no significant difference in SFL was found between the male control and the male patient groups, differences between the female control and female patient groups showed highly significant which levels, with the ascendance of age, were P【0.001, P【0.005 and P【0.001, respectively. Also the difference between male and female control groups were significant (P【0.05). However, no significant differences in SFL were discovered among the 3 patient groups. 10 female patients with SFL【12ng/ml were tested with ferrous sulfate for one month, then their SFL was reexamined one week after the treatment. A highly significant difference in SFL was noted between the pre-ad post-treatment (P【0.001). 9 of them showed that the interval of recurrences were prolonged, the number of ulcers reduced, the pain less intensive and its duration shorter than those before the treatment. This study demonstrated that a singificant decrease in iron-storage occurred in female RAU patients. The authors concluded that the decrease SFL was possibly related to menstruation and child bearing.展开更多
Background: Significant iron deficiency anaemia is a major concern in children with helminthiasis, because it may eventually contribute to the growing health challenges of severe anaemia This descriptive cross section...Background: Significant iron deficiency anaemia is a major concern in children with helminthiasis, because it may eventually contribute to the growing health challenges of severe anaemia This descriptive cross sectional study was carried out to determine the association between serum ferritin levels and intestinal helminthiasis among school children. Methods: A structured questionnaire was used to collect the study population data. Stool specimens were obtained and examined on the same day using the sedimentation method for identification of the parasite. Blood samples were also obtained for full blood count and serum ferritin measurement. Results: A total of 246 school children were studied with a response rate of 82%. The prevalence of intestinal helminthiasis was 29.7%. The different helminthes identified included Ascaris lumbricoides, Necator americanus, Trichuris trichiura, Strongyloides stercoralis. Of the population studied, 36.2% were anaemic, 15.9% had microcytosis, and 47.6% had hypochromia. The prevalence of ex-hausted iron stores was 3.7%. Serum ferritin levels were significantly lower in children with intestinal helminthiasis compared with controls. Conclusions: The findings in this study demonstrate an inverse re-lationship between intestinal helminthiasis and serum ferritin levels and this is more marked in pupils with hookworm infections. The control of intestinal hel-minthiasis and prevention of iron deficiency anaemia should be given high priority in the implementation of the school health programme.展开更多
Background An increasing number of studies have shown that iron,one of the indispensable trace elements in the human body,is closely related to the occurrence and development of cancer.However,few studies have clearly...Background An increasing number of studies have shown that iron,one of the indispensable trace elements in the human body,is closely related to the occurrence and development of cancer.However,few studies have clearly demonstrated the role of the iron levels in lung cancer patients,or the potential effects of inflammation on iron levels.Methods The clinical data for lung cancer patients and non-lung cancer participants were retrospectively analyzed.The serum iron and ferritin levels were measured and compared using a rank-sum test.The correlation between the serum iron/ferritin and C-reactive protein(CRP)was analyzed by rank correlation.The cut-off values for continuous variables were obtained by the receiver operating characteristic curve(ROC)method.An analysis of potential prognostic factors in lung cancer patients was conducted by univariate and multivariate survival analyses.Results The serum iron levels in patients with extensive small-cell lung cancer(SCLC)were lower than those with limited-stage SCLC,and the levels of serum ferritin and CRP in those with extensive SCLC were higher than those with limited-stage SCLC.Similarly,the serum iron levels in patients with stage IV non-small cell lung cancer(NSCLC)were lower than those of patients with stageⅠ-Ⅲdisease,and the levels of serum ferritin and CRP in those with stage IV NSCLC were higher than those in stagesⅠ-Ⅲ.The serum iron level was negatively correlated with the level of CRP,while the serum ferritin level was positively correlated with CRP.The stage of lung cancer,but not the serum iron/ferritin level,was an independent prognostic factor in lung cancer patients.Conclusions The serum iron and ferritin levels are associated with the staging of lung cancer.The later stages of lung cancer are associated with a lower serum iron level,a higher serum ferritin level,and a higher CRP level.Inflammation may play an important role in regulating the serum iron and ferritin levels in lung cancer patients.展开更多
AIM: To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level. METHODS: One hundred and twenty-four consecutive patients ...AIM: To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level. METHODS: One hundred and twenty-four consecutive patients with hyperferritinemia (male > 300 ng/mL, female > 200 ng/mL) were evaluated; clinical, biochemical and serological data, iron status parameters, HFE gene mutations and homeostasis model assessment score were obtained. Steatosis was graded by ultrasound as absent or present. Histology was available in 53 patients only. RESULTS: Mean level of ferritin was 881 ± 77 ng/mL in men and 549 ± 82 ng/mL in women. The diagnosis was chronic hepatitis C in 53 (42.7%), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in 57 (45.9%), and cryptogenic liver damage in 14 (11.3%). None was diagnosed as hereditary hemochromatosis (HH). Hepatic siderosis on liver biopsy was present in 17 of 54 (32%) patients; grade 1 in eight and grade 2 in nine. Overall, 92 patients (74.2%) had steatosis. By logistic regression, ferritin and γ-glutamyltransferase were independent predictors of steatosis. Ferritin levels were signifi cantly related to low platelet count, steatosis and hepatitis C virus infection. CONCLUSION: In a non-obese cohort of non-alcoholic patients with chronically abnormal LFTs without HH, high serum ferritin level is a risk factor for steatosis.展开更多
文摘<strong><em>Objective</em></strong><span style="font-family:Verdana;">: </span><span style="font-family:Verdana;">To explore the relation</span><span style="font-family:Verdana;">ship</span><span style="font-family:Verdana;"> between serum ferritin</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">(SF) and gestational diabetes mellitus (GDM), for providing new ideas to the prevention and treatment of GDM. </span><b><i><span style="font-family:Verdana;">Methods</span></i></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> All the pregnant women were selected in Yinan Maternal and Child Health-Care Hospital</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">from December, 2015 to March, 2018 when they were having routine prenatal examination, According to the diagnostic criteria of GDM, 72 patients with GDM were selected as the case group and 72 normal preg</span><span style="font-family:Verdana;">na</span><span style="font-family:Verdana;">nt women were randomly selected as </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group. Fasting venous blood was drawn from all subjects during the first trimester of pregnancy (11</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">13 weeks) and the second trimester of pregnancy (24</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">28 weeks). </span><span style="font-family:Verdana;">F</span><span style="font-family:;" "=""><span style="font-family:Verdana;">asting plasma glucose was measured by glucose oxidase assay and the expression level of SF was determined by electrochemical method. The application value of SF in GDM diagnosis was evaluated by ROC curve. </span><b><i><span style="font-family:Verdana;">Results</span></i></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> The level</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> of SF in the case group at early and middle stages</span><span style="font-family:Verdana;"> are</span><span style="font-family:Verdana;"> 49.6 ± 18.8 (μg/ml) and 39.8 ± 21.5 (μg/ml), which </span><span style="font-family:Verdana;">re</span><span style="font-family:Verdana;"> 39.4 ± 15.2 (μg/ml)</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">and 32.2 ± 17.6</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(μg/ml) in the control group. The levels of SF in </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">case group were higher than those in </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">control group</span><span style="font-family:Verdana;"> (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> < 0.05</span><span style="font-family:Verdana;">) </span><span style="font-family:Verdana;">at early and middle stages. The curve (AUC) of SF level in </span><span style="font-family:Verdana;">the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">diagnosis of GDM was 0.895, </span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> < 0.001;</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">the Youden index was 0.651 and the optimum threshold was 38.6</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">ng/ml, with a sensitivity of 97.8% and a specificity of 67.3%. </span><b><i><span style="font-family:Verdana;">Conclusion</span></i></b></span><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> The expression level of SF in early pregnancy is correlated with the occurrence of GDM, which may be an important indicator for the prevention and monitoring of GDM.</span>
文摘BACKGROUND The association between pretreatment serum ferritin concentration(SFC)and long-term survival in lung cancer remains unclear now.AIM To identify the prognostic value of pretreatment SFC in lung cancer patients based on current evidence.METHODS The PubMed,EMBASE and Web of Science databases were searched from inception to May 29,2022 for relevant studies.The primary endpoint was overall survival(OS)and the hazard ratios(HRs)with corresponding 95%confidence intervals(CIs)were combined to assess the predictive role of pretreatment SFC for long-term survival of lung cancer patients.The data were then extracted and assessed on the basis of the Reference Citation Analysis(https://www.reference citationanalysis.com/).RESULTS Twelve retrospective studies involving 1654 patients were analyzed.The results manifested that increased pretreatment SFC was associated with worse OS(HR=1.09,95%CI:1.03-1.15,P=0.004).Subgroup analysis stratified by the country(China vs non-China)showed similar results.However,subgroup analysis stratified by tumor type revealed inconsistent results(lung cancer:HR=1.39,P=0.008;small cell lung cancer:HR=1.99,P=0.175;non-small cell lung cancer:HR=1.03,P=0.281).CONCLUSION Pretreatment SFC might serve as a promising prognostic indicator in lung cancer patients and elevated pretreatment SFC predicts worse prognosis.However,more high-quality studies with big sample sizes are still needed to further verify its prognostic value in lung cancer.
文摘BACKGROUND Iron plays an important role in neurodevelopmental functions in the brain.Serum ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy children.AIM To explore the current status of iron deficiency in children with neurodevelopmental disorders and its sex and age effects.METHODS A total of 1565 children with attention deficit hyperactivity disorder(ADHD),1694 children with tic disorder(TD),93 children with ASD and 1997 healthy control children were included between January 1,2020,and December 31,2021 at Beijing Children's Hospital.We describe the differences in age levels and ferritin levels between different disease groups and their sex differences.The differences between the sexes in each disease were analyzed using the t test.The incidence rate of low serum ferritin was used to describe the differences between different diseases and different age groups.A chi-square test was used to analyze the difference in the incidence of low serum ferritin between the disease group and the control group.Analysis of variance was used for comparisons between subgroups,and regression analysis was used for confounding factor control.RESULTS A total of 1565 ADHD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 36.82±20.64μg/L and 35.64±18.56μg/L,respectively.A total of 1694 TD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 35.72±20.15μg/L and 34.54±22.12μg/L,respectively.As age increased,the incidence of low serum ferritin in ADHD and TD first decreased and then increased,and 10 years old was the turning point of rising levels.The incidence of ADHD with low serum ferritin was 8.37%,the incidence of TD with low serum ferritin was 11.04%,and the incidence of the healthy control group with low serum ferritin was 8.61%,among which male children with TD accounted for 9.25%and female children with TD accounted for 11.62%.There was a significant difference among the three groups(P<0.05).In addition,there were 93 children with ASD with an average serum ferritin level of 30.99±18.11μg/L and a serum ferritin incidence of 15.05%.CONCLUSION In conclusion,low serum ferritin is not a risk factor for ADHD or TD.The incidence of low serum ferritin levels in children with ADHD and TD between 5 and 12 years old decreases first and then increases with age.
文摘<strong>Objective: </strong>To investigate the concentration and clinical significance of serum ferritin (SF) in patients diagnosed with advanced gastric cancer before and after treatment. <strong>Methods:</strong> Forty patients with advanced gastric cancer diagnosed by cytology or pathology in our hospital were selected, including 25 males and 15 females, aged from 48 to 85 years, and the median age was 61.0 years. 40 healthy volunteers matched with age and education were selected as the control group. In order to study the changes of SF level in the treatment of advanced gastric cancer, we divided the patients into effective group (efficacy evaluation as partial remission or complete remission), ineffective group (efficacy evaluation as no remission) and recurrence group according to the efficacy after treatment. Then the difference of SF level between different groups and the relationship between SF level and curative effect were analyzed. There was no significant difference in gender and age among all groups. <strong>Results</strong>: The SF levels in the newly diagnosed group, stage III patient group and stage IV patient group were significantly higher than those in the control group. The level of SF in stage IV patients was significantly higher than that in stage III patients. There were significant differences in SF level between the effective treatment group, the newly diagnosed group and the ineffective treatment group, but there was no significant difference in SF level between the newly diagnosed group and the ineffective treatment group. <strong>Conclusion: </strong>SF level has a certain value in the auxiliary diagnosis of gastric cancer, and it also has a certain guiding significance for the evaluation of curative effect and prognosis after treatment.
基金funded by the 863 Program entitled as"The research and exploration of nutrition fortified food for improving growth and development(2010AA023004)"performed by the Trace Elements Nutrition Key Laboratory of the Ministry of Health
文摘Objective To establish and evaluate a protein microarray method for combined measurement of serum ferritin(SF) and soluble transferrin receptor(sTfR).Methods Microarrayer was used to print both anti-SF antibodies I and anti-sTfR antibodies I on each protein microarray.Anti-SF antibodies II and anti-sTfR antibodies II were used as detection antibodies and goat antibodies coupled to Cy3 were used as antibodies III.The detection conditions of the quantitative analysis method for simultaneous measurement of SF and sTfR with protein microarray were optimized and evaluated.The protein microarray was compared with commercially available traditional tests with 26 serum samples.Results By comparison experiment,mouse monoclonal antibodies were chosen as the probes and contact printing was chosen as the printing method.The concentrations of SF and sTfR probes were 0.5 mg/mL and 0.5 mg/mL respectively,while those of SF and sTfR detection antibodies were 5 μg/mL and 0.36 μg/mL respectively.Intra-and inter-assay variability was between 3.26% and 18.38% for all tests.The regression coefficients comparing protein microarray with traditional test assays were better than 0.81 for SF and sTfR.Conclusion The present study has established a protein microarray method for combined measurement of SF and sTfR.
基金funded by the Ministry of Finance of the People’s Republic of China[No.13103110700015005]Carolina Population Center[No.P2CHD050924,T32 HD007168]+1 种基金the University of North Carolina at Chapel Hill,the NIH[No.R01-HD30880,DK056350,R24 HD050924,and R01-HD38700]the NIH Fogarty International Center[No.D43TW009077,D43 TW007709].
文摘Objective The present study aimed to investigate the association of red meat usual intake with metabolic syndrome(Met S),and explore the contribution of red meat usual intake to serum ferritin.Methods Based on the data from the longitudinal China Health and Nutrition Survey(CHNS),2,797 healthy adults aged 18–75 years without hypertension,diabetes,and Met S were selected in 2009 as subjects and follow-up studies were carried out till 2015.We used the National Cancer Institute(NCI)method to estimate the usual intake of foods.Multivariable logistic regressions were performed to evaluate the association between red meat usual intake and the risk of Met S.Quantile regression analysis was used to study the relationship between red meat consumption and serum ferritin levels.Results After adjusting for potential confounders,red meat,and fresh red meat were positively associated with the risk of Met S(RR=1.41,95%CI:1.05–1.90 and RR=1.37,95%CI:1.02–1.85,respectively).These relationships showed increasing trend(P<0.05).The level of serum ferritin increased significantly with the number of Met S components(P<0.05).The quantile regression analysis showed that red meat and fresh red meat usual intake had a significant positive association with serum ferritin levels across the entire conditional serum ferritin distribution(P<0.05).Processed red meat did not exhibit a similar association.Conclusion Higher red meat usual intake was associated with an increased risk of Met S and elevated serum ferritin levels.
文摘The purpose of this study was to assess the correlation between iron deficiency and recurrent aphthous ulceration (RAU). Radioimmunoassay was used to examine the serum ferritin level (SFL) in 52 patients with RAU and in 54 controls. Both were divided into 2 groups in accordance with sex. The 36 female patients were subdivided into 3 age-groups as follows: 8 aged 22-24, 10 aged 25-34, and 18 aged 35-50 while the male patients were gathered as one single group aged 26-57. The subdivision was adapted similarly for the normal age-grouts. Although no significant difference in SFL was found between the male control and the male patient groups, differences between the female control and female patient groups showed highly significant which levels, with the ascendance of age, were P【0.001, P【0.005 and P【0.001, respectively. Also the difference between male and female control groups were significant (P【0.05). However, no significant differences in SFL were discovered among the 3 patient groups. 10 female patients with SFL【12ng/ml were tested with ferrous sulfate for one month, then their SFL was reexamined one week after the treatment. A highly significant difference in SFL was noted between the pre-ad post-treatment (P【0.001). 9 of them showed that the interval of recurrences were prolonged, the number of ulcers reduced, the pain less intensive and its duration shorter than those before the treatment. This study demonstrated that a singificant decrease in iron-storage occurred in female RAU patients. The authors concluded that the decrease SFL was possibly related to menstruation and child bearing.
文摘Background: Significant iron deficiency anaemia is a major concern in children with helminthiasis, because it may eventually contribute to the growing health challenges of severe anaemia This descriptive cross sectional study was carried out to determine the association between serum ferritin levels and intestinal helminthiasis among school children. Methods: A structured questionnaire was used to collect the study population data. Stool specimens were obtained and examined on the same day using the sedimentation method for identification of the parasite. Blood samples were also obtained for full blood count and serum ferritin measurement. Results: A total of 246 school children were studied with a response rate of 82%. The prevalence of intestinal helminthiasis was 29.7%. The different helminthes identified included Ascaris lumbricoides, Necator americanus, Trichuris trichiura, Strongyloides stercoralis. Of the population studied, 36.2% were anaemic, 15.9% had microcytosis, and 47.6% had hypochromia. The prevalence of ex-hausted iron stores was 3.7%. Serum ferritin levels were significantly lower in children with intestinal helminthiasis compared with controls. Conclusions: The findings in this study demonstrate an inverse re-lationship between intestinal helminthiasis and serum ferritin levels and this is more marked in pupils with hookworm infections. The control of intestinal hel-minthiasis and prevention of iron deficiency anaemia should be given high priority in the implementation of the school health programme.
文摘Background An increasing number of studies have shown that iron,one of the indispensable trace elements in the human body,is closely related to the occurrence and development of cancer.However,few studies have clearly demonstrated the role of the iron levels in lung cancer patients,or the potential effects of inflammation on iron levels.Methods The clinical data for lung cancer patients and non-lung cancer participants were retrospectively analyzed.The serum iron and ferritin levels were measured and compared using a rank-sum test.The correlation between the serum iron/ferritin and C-reactive protein(CRP)was analyzed by rank correlation.The cut-off values for continuous variables were obtained by the receiver operating characteristic curve(ROC)method.An analysis of potential prognostic factors in lung cancer patients was conducted by univariate and multivariate survival analyses.Results The serum iron levels in patients with extensive small-cell lung cancer(SCLC)were lower than those with limited-stage SCLC,and the levels of serum ferritin and CRP in those with extensive SCLC were higher than those with limited-stage SCLC.Similarly,the serum iron levels in patients with stage IV non-small cell lung cancer(NSCLC)were lower than those of patients with stageⅠ-Ⅲdisease,and the levels of serum ferritin and CRP in those with stage IV NSCLC were higher than those in stagesⅠ-Ⅲ.The serum iron level was negatively correlated with the level of CRP,while the serum ferritin level was positively correlated with CRP.The stage of lung cancer,but not the serum iron/ferritin level,was an independent prognostic factor in lung cancer patients.Conclusions The serum iron and ferritin levels are associated with the staging of lung cancer.The later stages of lung cancer are associated with a lower serum iron level,a higher serum ferritin level,and a higher CRP level.Inflammation may play an important role in regulating the serum iron and ferritin levels in lung cancer patients.
文摘AIM: To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level. METHODS: One hundred and twenty-four consecutive patients with hyperferritinemia (male > 300 ng/mL, female > 200 ng/mL) were evaluated; clinical, biochemical and serological data, iron status parameters, HFE gene mutations and homeostasis model assessment score were obtained. Steatosis was graded by ultrasound as absent or present. Histology was available in 53 patients only. RESULTS: Mean level of ferritin was 881 ± 77 ng/mL in men and 549 ± 82 ng/mL in women. The diagnosis was chronic hepatitis C in 53 (42.7%), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in 57 (45.9%), and cryptogenic liver damage in 14 (11.3%). None was diagnosed as hereditary hemochromatosis (HH). Hepatic siderosis on liver biopsy was present in 17 of 54 (32%) patients; grade 1 in eight and grade 2 in nine. Overall, 92 patients (74.2%) had steatosis. By logistic regression, ferritin and γ-glutamyltransferase were independent predictors of steatosis. Ferritin levels were signifi cantly related to low platelet count, steatosis and hepatitis C virus infection. CONCLUSION: In a non-obese cohort of non-alcoholic patients with chronically abnormal LFTs without HH, high serum ferritin level is a risk factor for steatosis.
