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Transdermal delivery of fluorescein isothiocyanate-dextrans using the combination of microneedles and low-frequency sonophoresis 被引量:1
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作者 Boonnada Pamornpathomkul Sureewan Duangjit +3 位作者 Suvida Laohapatarapant Theerasak Rojanarata Praneet Opanasopit Tanasait Ngawhirunpat 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2015年第5期415-424,共10页
This study aimed to evaluate the patient-friendly methods that are used in the delivery of hydrophilic macromolecules into deep skin layers,in particular,the combination of microneedles patch(MNs patch)and low-frequen... This study aimed to evaluate the patient-friendly methods that are used in the delivery of hydrophilic macromolecules into deep skin layers,in particular,the combination of microneedles patch(MNs patch)and low-frequency sonophoresis(SN).The hydrophilic macromolecule drug fluorescein isothiocyanate(FITC)-dextrans(FD-4:MW 4.4 kDa)was used as the model drug in our experimental design.In this study,excised porcine skin was used to investigate and optimize the key parameters that determine effective MNs-and SNfacilitated FD-4 delivery.In vitro skin permeation experiments revealed that the combination of MNs patch with SN had a superior enhancing effect of skin permeation for FD-4 compared to MNs alone,SN alone or untreated skin,respectively.The optimal parameters for the combination of MNs and SN included the following:10 N insertion force of MNs,4 W/cm^(2)SN intensity,6 mm radiation diameter of the SN probe,2 min application time,and the continuous mode duty cycle of SN.In addition,vertical sections of skin,clearly observed under a confocal microscope,confirmed that the combination of MNs and SN enhanced permeation of FD-4 into the deep skin layers.These studies suggest that the combination of MNs and SN techniques could have great potential in the delivery of hydrophilic macromolecules into deep skin. 展开更多
关键词 MICRONEEDLE sonophoresis Fluorescein isothiocyanate-dextran Transdermal drug delivery
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Topical Delivery of Modified Da-Cheng-Qi Decoction(加味大承气汤) Using Low-Frequency Ultrasound Sonophoresis for Refractory Metastatic Malignant Bowel Obstruction:An Open-Label Single-Arm Clinical Trial 被引量:2
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作者 TIAN Ai-ping YIN Yu-kun +7 位作者 YU Lei YANG Bo-yan LI Ning LI Jian-ying BIAN Zhi-min HU Shang-ying WENG Chun-xiao FENG Li 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2020年第5期382-387,共6页
Objective:To evaluate the efficacy and safety of topical delivery of modified Da-Cheng-Qi Decoction(加味大承气汤,MDCQD)by low-frequency ultrasound sonophoresis(LFUS)in patients with refractory metastatic malignant bow... Objective:To evaluate the efficacy and safety of topical delivery of modified Da-Cheng-Qi Decoction(加味大承气汤,MDCQD)by low-frequency ultrasound sonophoresis(LFUS)in patients with refractory metastatic malignant bowel obstruction(MBO)using an objective performance criteria(OPC)design.Methods:Fifty patients with refractory metastatic MBO were enrolled in this open-label single-arm clinical trial.Alongside fasting,gastrointestinal decompression,glycerol enema,intravenous nutrition and antisecretory therapy,a 50 g dose of MDCQD(prepared as a hydrogel)was applied through topical delivery at the site of abodminal pain or Tianshu(S 25)using LFUS for 30 min,twice daily for 5 consecutive days.The overall outcomes were the remission of intestinal obstruction,improvement on abdominal pain,abdominal distention,nausea and vomiting scores.Indicators of safety evaluation included liver and renal function as well as blood coagulation indicators.Results:Among 50 patients,5 patients(10%)showed complete remission of intestinal obstruction and 21 patients(42%)showed improvement of intestinal obstruction.The overall remission rate of bowel obstruction was 52%.The results of the symptom score,based on the severity and frequency of the episode,were as follows:26 patients(52%)showed improvment on symptom scores,20 patients(40%)did not respond to treatment,and 4 patients(8%)discontinued treatment due to intolerance.No serious adverse effects or abnormal changes on liver and renal functions or blood coagulation were observed.Conclusion:Topical delivery of MDCQD at 100 g/day using LFUS can improve the treatment response in patients with refractory metastatic MBO. 展开更多
关键词 METASTATIC malignant bowel obstruction Da-Cheng-Qi DECOCTION topical delivery low-frequency ultrasound sonophoresis objective performance criteria
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