AIM To assess the diagnostic value of a laparoscopic finding of a hepatic subcapsular spider-like telangiectasis(HSST) sign in biliary atresia.METHODS A retrospective study was conducted first and then a validation se...AIM To assess the diagnostic value of a laparoscopic finding of a hepatic subcapsular spider-like telangiectasis(HSST) sign in biliary atresia.METHODS A retrospective study was conducted first and then a validation set was used to investigate the value of an HSST sign in predicting biliary atresia(BA). In the retrospective study, laparoscopic images of the liver surface were reviewed in 126 patients with infantile cholestasis(72 BA patients and 54 non-BA cholestasis patients) and a control group of 38 patients with nonhepatic conditions. Analysis was first made by two observers separately and finally, a consensus conclusion was achieved. Then, the diagnostic value of the HSST sign was validated in an independent cohort including 45 BA and 45 non-BA patients.RESULTS In the retrospective investigation, an amplified HSST sign was found in all BA patients, while we were unable to detect the HSST sign in 98.1% of the 54 non-BA patients. There was no HSST sign in any of the control subjects. In the first review, the sensitivity and specificity from one reviewer were 100% and 98.1%, respectively, and the results from the other reviewer were both 100%. The consensus sensitivity and specificity were 100% and 98.1%, respectively. The HSST sign was defined as being composed of several enlarged tortuous spider-like vascular plexuses with two to eight branches distributed on all over the liver surface, which presented as either a concentrated type or a dispersed type. In the independent validation group, the sensitivity, specificity, positive predictive value and negative predictive value of the HSST sign were 100%, 97.8%, 97.8% and 100%, respectively.CONCLUSION The HSST sign is characteristic in BA, and laparoscopic exploration for the HSST sign is valuable in the diagnosis of BA.展开更多
BACKGROUND Coats disease is an idiopathic exudative outer retinopathy caused by abnormalretinal vascular development.AIM To evaluate the long-term outcomes of intravitreal conbercept injection with laserphotocoagulati...BACKGROUND Coats disease is an idiopathic exudative outer retinopathy caused by abnormalretinal vascular development.AIM To evaluate the long-term outcomes of intravitreal conbercept injection with laserphotocoagulation as a treatment for Coats disease in adults.METHODS This retrospective case series study included patients diagnosed with Coatsdisease and treated with intravitreal conbercept injection and 532-nm laserphotocoagulation at the Ophthalmology Department of Shenzhen People’sHospital between January 2016 and January 2017. Best-corrected visual acuity(BCVA) measurements, noncontact tonometry, ophthalmoscopy, fundusphotography, fundus fluorescein angiography and optical coherence tomographywere performed before treatment and at 1 wk, 1 mo, 3 mo, 6 mo, 9 mo, 12 mo, 24mo and 36 mo after therapy. Best-corrected visual acuity was measured using theearly treatment of diabetic retinopathy study chart.RESULTS The study included eight eyes of 8 patients (7 men) aged 36.10 ± 6.65 years. Theaverage BCVA of the affected eye before treatment was 51.17 ± 15.15 letters(range, 28–70 letters), and the average central macular thickness was 303.30 ±107.87 μm (range, 221–673 μm). Four eyes were injected once, three were injectedtwice, and one was injected three times. Average follow-up duration was 37.33 ±2.26 mo. Average BCVA of the affected eye was 51.17 ± 15.15 letters before treatment and was increased by 13.50 ± 3.20, 16.25 ± 7.73, 18.25 ± 8.96, 18.03 ± 5.27,18.63 ± 3.35, 19.75 ± 6.96, 18.05 ± 5.36 and 17.88 ± 3.45 letters at 1 wk, 1 mo, 3 mo, 6mo, 9 mo, 12 mo, 24 mo and 36 mo after treatment, respectively (P < 0.01). Thepatients showed varying degrees of subretinal fluid resorption after treatment.None of the patients had serious complications such as increased intraocularpressure, development/progression of cataracts, endophthalmitis or retinaldetachment.CONCLUSION Intravitreal injection of conbercept combined with 532-nm laser photocoagulationmay be a feasible treatment for Coats disease in adult patients.展开更多
目的:评价强脉冲光(Int ense Pul sed Li ghtI,PL)和可变脉宽倍频Nd:YAG激光(Vari abl e-pul se iW dt h Nd:YAG Laser,VPW532)联合应用治疗面部毛细血管扩张症(Tel angi ect asi s)的临床疗效和安全性。方法:纳入2001年7月～2004年4月...目的:评价强脉冲光(Int ense Pul sed Li ghtI,PL)和可变脉宽倍频Nd:YAG激光(Vari abl e-pul se iW dt h Nd:YAG Laser,VPW532)联合应用治疗面部毛细血管扩张症(Tel angi ect asi s)的临床疗效和安全性。方法:纳入2001年7月～2004年4月采用IPL及VPW532激光治疗面部毛细血管扩张症的患者656例,术后随访观察疗效和不良反应。结果:所有患者经过治疗后,有效率98.9%,治愈率91.9%;不良反应发生率为37.5%,无严重并发症出现。结论:两者联合应用治疗面部毛细血管扩张症是一种疗效确切、安全的治疗策略。展开更多
基金Supported by the Public Welfare Research Special Fund of the National Health and Family Planning of China,No.201402007
文摘AIM To assess the diagnostic value of a laparoscopic finding of a hepatic subcapsular spider-like telangiectasis(HSST) sign in biliary atresia.METHODS A retrospective study was conducted first and then a validation set was used to investigate the value of an HSST sign in predicting biliary atresia(BA). In the retrospective study, laparoscopic images of the liver surface were reviewed in 126 patients with infantile cholestasis(72 BA patients and 54 non-BA cholestasis patients) and a control group of 38 patients with nonhepatic conditions. Analysis was first made by two observers separately and finally, a consensus conclusion was achieved. Then, the diagnostic value of the HSST sign was validated in an independent cohort including 45 BA and 45 non-BA patients.RESULTS In the retrospective investigation, an amplified HSST sign was found in all BA patients, while we were unable to detect the HSST sign in 98.1% of the 54 non-BA patients. There was no HSST sign in any of the control subjects. In the first review, the sensitivity and specificity from one reviewer were 100% and 98.1%, respectively, and the results from the other reviewer were both 100%. The consensus sensitivity and specificity were 100% and 98.1%, respectively. The HSST sign was defined as being composed of several enlarged tortuous spider-like vascular plexuses with two to eight branches distributed on all over the liver surface, which presented as either a concentrated type or a dispersed type. In the independent validation group, the sensitivity, specificity, positive predictive value and negative predictive value of the HSST sign were 100%, 97.8%, 97.8% and 100%, respectively.CONCLUSION The HSST sign is characteristic in BA, and laparoscopic exploration for the HSST sign is valuable in the diagnosis of BA.
基金Supported by the Shenzhen Municipal Health and Family Planning System Research Project,No.SZFZ2017085.
文摘BACKGROUND Coats disease is an idiopathic exudative outer retinopathy caused by abnormalretinal vascular development.AIM To evaluate the long-term outcomes of intravitreal conbercept injection with laserphotocoagulation as a treatment for Coats disease in adults.METHODS This retrospective case series study included patients diagnosed with Coatsdisease and treated with intravitreal conbercept injection and 532-nm laserphotocoagulation at the Ophthalmology Department of Shenzhen People’sHospital between January 2016 and January 2017. Best-corrected visual acuity(BCVA) measurements, noncontact tonometry, ophthalmoscopy, fundusphotography, fundus fluorescein angiography and optical coherence tomographywere performed before treatment and at 1 wk, 1 mo, 3 mo, 6 mo, 9 mo, 12 mo, 24mo and 36 mo after therapy. Best-corrected visual acuity was measured using theearly treatment of diabetic retinopathy study chart.RESULTS The study included eight eyes of 8 patients (7 men) aged 36.10 ± 6.65 years. Theaverage BCVA of the affected eye before treatment was 51.17 ± 15.15 letters(range, 28–70 letters), and the average central macular thickness was 303.30 ±107.87 μm (range, 221–673 μm). Four eyes were injected once, three were injectedtwice, and one was injected three times. Average follow-up duration was 37.33 ±2.26 mo. Average BCVA of the affected eye was 51.17 ± 15.15 letters before treatment and was increased by 13.50 ± 3.20, 16.25 ± 7.73, 18.25 ± 8.96, 18.03 ± 5.27,18.63 ± 3.35, 19.75 ± 6.96, 18.05 ± 5.36 and 17.88 ± 3.45 letters at 1 wk, 1 mo, 3 mo, 6mo, 9 mo, 12 mo, 24 mo and 36 mo after treatment, respectively (P < 0.01). Thepatients showed varying degrees of subretinal fluid resorption after treatment.None of the patients had serious complications such as increased intraocularpressure, development/progression of cataracts, endophthalmitis or retinaldetachment.CONCLUSION Intravitreal injection of conbercept combined with 532-nm laser photocoagulationmay be a feasible treatment for Coats disease in adult patients.
文摘目的:评价强脉冲光(Int ense Pul sed Li ghtI,PL)和可变脉宽倍频Nd:YAG激光(Vari abl e-pul se iW dt h Nd:YAG Laser,VPW532)联合应用治疗面部毛细血管扩张症(Tel angi ect asi s)的临床疗效和安全性。方法:纳入2001年7月～2004年4月采用IPL及VPW532激光治疗面部毛细血管扩张症的患者656例,术后随访观察疗效和不良反应。结果:所有患者经过治疗后,有效率98.9%,治愈率91.9%;不良反应发生率为37.5%,无严重并发症出现。结论:两者联合应用治疗面部毛细血管扩张症是一种疗效确切、安全的治疗策略。
