When assessing the sliding stability of a concrete dam,the influence of large-scale asperities in the sliding plane is often ignored due to limitations of the analytical rigid body assessment methods provided by curre...When assessing the sliding stability of a concrete dam,the influence of large-scale asperities in the sliding plane is often ignored due to limitations of the analytical rigid body assessment methods provided by current dam assessment guidelines.However,these asperities can potentially improve the load capacity of a concrete dam in terms of sliding stability.Although their influence in a sliding plane has been thoroughly studied for direct shear,their influence under eccentric loading,as in the case of dams,is unknown.This paper presents the results of a parametric study that used finite element analysis(FEA)to investigate the influence of large-scale asperities on the load capacity of small buttress dams.By varying the inclination and location of an asperity located in the concrete-rock interface along with the strength of the rock foundation material,transitions between different failure modes and correlations between the load capacity and the varied parameters were observed.The results indicated that the inclination of the asperity had a significant impact on the failure mode.When the inclinationwas 30and greater,interlocking occurred between the dam and foundation and the governing failure modes were either rupture of the dam body or asperity.When the asperity inclination was significant enough to provide interlocking,the load capacity of the dam was impacted by the strength of the rock in the foundation through influencing the load capacity of the asperity.The location of the asperity along the concrete-rock interface did not affect the failure mode,except for when the asperity was located at the toe of the dam,but had an influence on the load capacity when the failure occurred by rupture of the buttress or by sliding.By accounting for a single large-scale asperity in the concrete-rock interface of the analysed dam,a horizontal load capacity increase of 30%e160%was obtained,depending on the inclination and location of the asperity and the strength of the foundation material.展开更多
China’s low-carbon development path will make significant contributions to achieving global sustainable development goals.Due to the diverse natural and economic conditions across different regions in China,there exi...China’s low-carbon development path will make significant contributions to achieving global sustainable development goals.Due to the diverse natural and economic conditions across different regions in China,there exists an imbalance in the distribution of car-bon emissions.Therefore,regional cooperation serves as an effective means to attain low-carbon development.This study examined the pattern of carbon emissions and proposed a potential joint emission reduction strategy by utilizing the industrial carbon emission intens-ity(ICEI)as a crucial factor.We utilized social network analysis and Local Indicators of Spatial Association(LISA)space-time trans-ition matrix to investigate the spatiotemporal connections and discrepancies of ICEI in the cities of the Pearl River Basin(PRB),China from 2010 to 2020.The primary drivers of the ICEI were determined through geographical detectors and multi-scale geographically weighted regression.The results were as follows:1)the overall ICEI in the Pearl River Basin is showing a downward trend,and there is a significant spatial imbalance.2)There are numerous network connections between cities regarding the ICEI,but the network structure is relatively fragile and unstable.3)Economically developed cities such as Guangzhou,Foshan,and Dongguan are in the center of the network while playing an intermediary role.4)Energy consumption,industrialization,per capita GDP,urbanization,science and techno-logy,and productivity are found to be the most influential variables in the spatial differentiation of ICEI,and their combination in-creased the explanatory power of the geographic variation of ICEI.Finally,through the analysis of differences and connections in urban carbon emissions under different economic levels and ICEI,the study suggests joint carbon reduction strategies,which are centered on carbon transfer,financial support,and technological assistance among cities.展开更多
Objective:To compare the efficacy of using“distal acupoints only”vs.“local acupoints mainly combined with distal acupoints”in cases of acute low back pain(ALBP).Methods: A total of 102 eligible patients aged 18–6...Objective:To compare the efficacy of using“distal acupoints only”vs.“local acupoints mainly combined with distal acupoints”in cases of acute low back pain(ALBP).Methods: A total of 102 eligible patients aged 18–65 years with ALBP lasting less than 6 weeks will be randomized in a 1:1 ratio to the distal acupoints only group(DPOG)and the local acupoints mainly combined with the distal acupoints group(LPMG).During a 4-week treatment period,patients in the DPOG will receive acupuncture at distal acupoints only(Houxi[SI 3]and Yaotongxue[EX-UE 7])twice a week,while those in the LPMG group will receive acupuncture at local acupoints(mainly Shenshu[BL 23]and Dachangshu[BL 25])combined with distal points(Weizhong[BL 40]).The patients in both groups will be evaluated at every session of treatment,and the follow-up will be performed for 3 months.The primary outcome measure will be the change in ALBP intensity,assessed using visual analogue scale scores before and after treatment.The secondary outcome measure will be the evaluation of functional disability using the Oswestry Disability Index.Discussion: This study compares the DPOG and LPMG to explore the feasibility of the DPOG in the treatment of ALBP.展开更多
The Internet of Things(IoT)is a smart networking infrastructure of physical devices,i.e.,things,that are embedded with sensors,actuators,software,and other technologies,to connect and share data with the respective se...The Internet of Things(IoT)is a smart networking infrastructure of physical devices,i.e.,things,that are embedded with sensors,actuators,software,and other technologies,to connect and share data with the respective server module.Although IoTs are cornerstones in different application domains,the device’s authenticity,i.e.,of server(s)and ordinary devices,is the most crucial issue and must be resolved on a priority basis.Therefore,various field-proven methodologies were presented to streamline the verification process of the communicating devices;however,location-aware authentication has not been reported as per our knowledge,which is a crucial metric,especially in scenarios where devices are mobile.This paper presents a lightweight and location-aware device-to-server authentication technique where the device’s membership with the nearest server is subjected to its location information along with other measures.Initially,Media Access Control(MAC)address and Advance Encryption Scheme(AES)along with a secret shared key,i.e.,λ_(i) of 128 bits,have been utilized by Trusted Authority(TA)to generate MaskIDs,which are used instead of the original ID,for every device,i.e.,server and member,and are shared in the offline phase.Secondly,TA shares a list of authentic devices,i.e.,server S_(j) and members C_(i),with every device in the IoT for the onward verification process,which is required to be executed before the initialization of the actual communication process.Additionally,every device should be located such that it lies within the coverage area of a server,and this location information is used in the authentication process.A thorough analytical analysis was carried out to check the susceptibility of the proposed and existing authentication approaches against well-known intruder attacks,i.e.,man-in-the-middle,masquerading,device,and server impersonations,etc.,especially in the IoT domain.Moreover,proposed authentication and existing state-of-the-art approaches have been simulated in the real environment of IoT to verify their performance,particularly in terms of various evaluation metrics,i.e.,processing,communication,and storage overheads.These results have verified the superiority of the proposed scheme against existing state-of-the-art approaches,preferably in terms of communication,storage,and processing costs.展开更多
BACKGROUND Chronic eczema significantly impacts daily life,social interactions,and quality of life;however,no curative treatment has been identified.AIM To determine the clinical efficacy of acupoint injection for chr...BACKGROUND Chronic eczema significantly impacts daily life,social interactions,and quality of life;however,no curative treatment has been identified.AIM To determine the clinical efficacy of acupoint injection for chronic eczema and its influence on peripheral blood T cells.METHODS Eighty patients with chronic eczema treated at our hospital between June 2022 and March 2023 were randomly assigned to a control group(n=40),which received conventional Western medicine treatment,or an observation group(n=40),which received routine Western medicine treatment plus acupoint injection of triamcinolone acetonide.Response and adverse reaction rates,as well as differences in the levels of serum cytokines IFN-γ,IL-2,IL-4,and IL-10 before and after treatment were investigated.RESULTS No difference in overall response rates were found between the observation and control groups(100%vs 90%,respectively;P>0.05);however,the observation group had a higher marked response rate than the control group(87.5%vs 52.5%;P<0.05).Both groups had decreased Eczema Area and Severity Index scores and increased pruritus after treatment(P<0.05),particularly in the observation group(P<0.05).The observation group had an adverse reaction rate of 2.5%(1/40),which did not differ significantly from that of the control group(P>0.05).The observation group exhibited higher post-treatment INF-γand IL-2 but lower IL-4 levels than the control group(P<0.05);however,no significant inter-group difference was observed in post-treatment IL-10 levels(P>0.05).CONCLUSION Acupoint injection of triamcinolone acetonide is safe and effective in treating chronic eczema.Its therapeutic mechanism is related to the regulation of peripheral blood T cell levels,inhibition of inflammatory reactions,and mitigation of immune imbalance.展开更多
To enhance the understanding of the geometry and characteristics of seismogenic faults in the Beijing-Tianjin-Hebei region,we relocated 14805 out of 16063 earthquakes(113°E-120°E,36°N-43°N)that occ...To enhance the understanding of the geometry and characteristics of seismogenic faults in the Beijing-Tianjin-Hebei region,we relocated 14805 out of 16063 earthquakes(113°E-120°E,36°N-43°N)that occurred between January 2008 and December 2020 using the double-difference tomography method.Based on the spatial variation in seismicity after relocation,the Beijing-Tianjin-Hebei region can be divided into three seismic zones:Xingtai-Wen'an,Zhangbei-Ninghexi,and Tangshan.(1)The Xingtai-Wen'an Seismic Zone has a northeastsouthwest strike.The depth profile of earthquakes perpendicular to the strike reveals three northeast-striking,southeast-dipping,high-angle deep faults(>10 km depth),including one below the shallow(<10 km depth)listric,northwest-dipping Xinghe fault in the Xingtai region.Two additional deep faults in the Wen'an region are suggested to be associated with the 2006 M 5.1 Wen'an Earthquake and the 1967 M 6.3 Dacheng earthquake;(2)The Zhangbei-Ninghexi Seismic Zone is oriented north-northwest.Multiple northeast-striking faults(10-20 km depth),inferred from the earthquake-intensive zones,exist beneath the shallow(<10 km depth)Xiandian Fault,Xiaotangshan Fault,Huailai-Zhuolu Basin North Fault,Yangyuan Basin Fault and Yanggao Basin North Fault;(3)In the Tangshan Seismic Zone,earthquakes are mainly concentrated near the northeast-striking Tangshan-Guye Fault,Lulong Fault,and northwest-striking Luanxian-Laoting Fault.An inferred north-south-oriented blind fault is present to the north of the Tangshan-Guye Fault.The 1976 M 7.8 Tangshan earthquake occurred at the junction of a shallow northwest-dipping fault and a deep southeast-dipping fault.This study emphasizes that earthquakes in the region are primarily associated with deep blind faults.Some deep blind faults have different geometries compared to shallow faults,suggesting a complex fault system in the region.Overall,this research provides valuable insights into the seismogenic faults in the Beijing–Tianjin–Hebei region.Further studies and monitoring of these faults are essential for earthquake mitigation efforts in this region.展开更多
Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c mice.It also ...Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c mice.It also conducted an initial examination of the underlying molecular mechanisms.Methods:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding treatment.After DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day 8.Mice in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut implantation.Severity was assessed using SCORAD on treatment days 1,10,and 20.On day 18,nine mice per group were euthanized,and the remaining on day 28.Histopathological changes were observed using hematoxylin-eosin and immunohistochemistry staining.TNF-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western blot.Results:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like mice.Significant decreases occurred in serum IL-4,IL-6,IL-13,and TNF-αlevels.Skin analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein levels.Conclusion:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.展开更多
Objective:To investigate the mechanism of JAK2/STAT3/SOCS1 signaling pathway in electroacupuncture of different acupoints on acute colitis rats.Methods:36 SPF SD rats were randomly divided into 6 groups,with 6 rats in...Objective:To investigate the mechanism of JAK2/STAT3/SOCS1 signaling pathway in electroacupuncture of different acupoints on acute colitis rats.Methods:36 SPF SD rats were randomly divided into 6 groups,with 6 rats in each group.The rat model of acute colitis was prepared by enema with glacial acetic acid solution.After the model was established,electroacupuncture was given to each acupoint group,with density wave,frequency 2Hz-50 Hz,intensity 2 mA,muscle tremor as the degree 20 min/time,1 time/day,for 3 consecutive days.Observe the general condition of rats;the pathological changes of colonic mucosa in rats were observed by HE method.The contents of serum interleukin-4(IL-4)and interleukin-8(IL-8)were detected by ELISA.Western blot and RT-PCR were used to detect the expression of JAK2,STAT3,SOCS1 protein and mRNA in rat colon tissue.Results:In contrast to the normal group,the overall condition of the model group was worse,the colonic mucosa was severely damaged,even necrotic,and the ulcer surface was obvious.The content of IL-4 in serum was obviously reduced,and the content of IL-8 was obviously go up(P<0.01).The protein content of JAK2,STAT3 and the expression of JAK2,STAT3 mRNA in colon tissue of rats were obviously go up,while the protein content of SOCS1 and the expression of SOCS1 mRNA were obviously reduced(P<0.01).In contrast to the model group,the general condition of rats in each acupoint group was significantly improved,the damage and necrosis of colonic mucosa and ulcer surface were obviously alleviated,the content of IL-4 in serum was obviously go up,and the content of IL-8 was significantly decreased(P<0.01).The protein content of JAK2,STAT3 and the expression of JAK2,STAT3 mRNA in colon tissue of rats were obviously reduced,while the protein content of SOCS1 and the expression of SOCS1 mRNA were obviously go up(P<0.05,P<0.01).Comparison of different acupoint groups,the colonic mucosal injury in the Zusanli group was significantly reduced,the content of serum IL-4 was significantly increased,and the content of IL-8 was significantly decreased(P<0.05,P<0.01).The protein content and mRNA expression of JAK2 and STAT3 in colon tissue were significantly down-regulated,while the protein content and mRNA expression of SOCS1 were significantly go up(P<0.05,P<0.01).Conclusion:Electroacupuncture at each acupoint can improve the damage of colonic mucosa and reduce the inflammatory response.The therapeutic effect of Zusanli(ST36)is better than that of Tianshu(ST25),Dachangshu(BL25)and Shangjuxu(ST37).The mechanism may be related to the regulation of JAK2/STAT3/SOCS1 signaling pathway related proteins and inflammatory cytokines IL-4 and IL-8.展开更多
Objective: To observe the therapeutic effect of combined traditional Chinese medicine (TCM) therapy with acupoint injection and herbal patch application on patients with ovulatory dysfunction associated with polycysti...Objective: To observe the therapeutic effect of combined traditional Chinese medicine (TCM) therapy with acupoint injection and herbal patch application on patients with ovulatory dysfunction associated with polycystic ovary syndrome (PCOS). Methods: A total of 80 PCOS patients who received treatment at the First Affiliated Hospital of Guangxi University of Chinese Medicine between October 2022 and March 2024 were enrolled in this study. They were randomly divided into a control group (n = 40) and an observation group (n = 40). The control group received conventional Western medical treatments, while the observation group was administered TCM combined with acupoint injection and herbal patch application. Pre- and post-treatment conditions were compared between the two groups. Results: After treatment, the overall effective rate was significantly higher in the observation group compared to the control group (P 0.05). Following treatment, both ovulation and pregnancy rates increased in both groups, but the increase was more evident in the observation group, showing a statistically significant difference (P < 0.01). Conclusion: For patients with oligoovulation or anovulation due to PCOS, the combined use of TCM, acupoint injection, and herbal patch application appears to be effective in improving systemic symptoms and achieving notable clinical outcomes.展开更多
Objective:To analyze the effect of combining transcutaneous electrical acupoint stimulation(TEAS)with rehabilitation training in patients with upper limb dysfunction after stroke(ULDAS).Methods:A total of 130 ULDAS pa...Objective:To analyze the effect of combining transcutaneous electrical acupoint stimulation(TEAS)with rehabilitation training in patients with upper limb dysfunction after stroke(ULDAS).Methods:A total of 130 ULDAS patients who were hospitalized and rehabilitated in Wuxi Xinwu District Rehabilitation Hospital from May 2021 to May 2023 were selected and randomly divided into Group A(65 cases,rehabilitation training)and Group B(65 cases,rehabilitation training+TEAS).The effects of the two groups were compared.Results:After treatment,the upper limb functional indexes of Group B were better than those of Group A(P<0.05).The rate of muscle tone grades 0-4 in Group B was higher than those of Group A(P<0.05).Conclusion:The function of upper limbs and muscle strength of ULDAS patients improved by combining TEAS with rehabilitation training.展开更多
Lightning-generated nitrogen oxides(LNO_(x))have a major influence on the atmosphere and global climate change.Therefore,it is of great importance to obtain a more accurate estimation of LNO_(x).The aim of this study ...Lightning-generated nitrogen oxides(LNO_(x))have a major influence on the atmosphere and global climate change.Therefore,it is of great importance to obtain a more accurate estimation of LNO_(x).The aim of this study is to provide a reference for the accurate estimation of the total LNO_(x) in the mainland of China based on cloud-to-ground lightning(CG)location data from 2014 to 2018.The energy of each CG flash was based on the number of return strokes per CG flash,the peak current of each return stroke,and the assumed CG breakdown voltage.The energy of intracloud lightning(IC)was based on the estimated frequencies of IC and the assumed energy of each IC flash.Combining the energy of lightning and the number of nitric oxide(NO)molecules produced by unit energy(ρno),the total LNO_(x) production in the mainland of China was determined.The LNO_(x) in the mainland of China estimated in this study is in the range(0.157-0.321)×10^(9) kg per year[Tg(N)yr-1],which is on the high end of other scholars’works.Negative cloud-to-ground lightning(NCG)flashes produce the most moles of NO_(x),while positive cloud-to-ground lightning(PCG)flashes produce the least total moles of NO_(x).The breakdown voltage of PCG is greater than that of IC or NCG,while the latter has a greater output of LNO_(x).展开更多
Plant-associated microbes represent a key determinant of plant fitness through acquiring nutrients,promoting growth,and resisting to abiotic and biotic stresses.However,an extensive characterization of the bacterial a...Plant-associated microbes represent a key determinant of plant fitness through acquiring nutrients,promoting growth,and resisting to abiotic and biotic stresses.However,an extensive characterization of the bacterial and fungal microbiomes present in different plant compartments of soybean in field conditions has remained elusive.In this study,we investigated the effects of four niches(roots,stems,leaves,and pods),four genotypes(Andou 203,Hedou 12,Sanning 16,and Zhonghuang 13),and three field locations(Jining,Suzhou,and Xuzhou)on the diversity and composition of bacterial and fungal communities in soybean using 16S and internal transcribed spacer rRNA amplicon sequencing,respectively.The soybean microbiome significantly differed across organs.Host genotypes explained more variation in stem bacterial community composition and leaf fungal community composition.Field location significantly affected the composition of bacterial communities in all compartments and the effects were stronger in the root and stem than in the leaf and pod,whereas field location explained more variation in stem and leaf fungal community composition than in the root and pod.The relative abundances of potential soybean fungal pathogens also differed among host organs and genotypes,reflecting the niches of these microbes in the host and probably their compatibility to the host genotypes.Systematic profiling of the microbiome composition and diversity will aid the development of plant protection technologies to benefit soybean health.展开更多
Using observational data from multiple satellites,we studied seasonal variations of the shape and location of the Luzon cold eddy(LCE)northwest of Luzon Island.The shape and location of the LCE have obvious seasonal v...Using observational data from multiple satellites,we studied seasonal variations of the shape and location of the Luzon cold eddy(LCE)northwest of Luzon Island.The shape and location of the LCE have obvious seasonal variations.The LCE occurs,develops,and disappears from December to April of the next year.During this period,the shape of the LCE changed from a flat ellipse to a circular ellipse,and the change in shape can be reflected by the increase of the ellipticity of the LCE from 0.16 to 0.82.The latitude of center location of the LCE changes from 17.4°N to 19°N,and the change in latitude can reach 1.6°.Further study showed that seasonal variation of the northeast monsoon intensity leads to the change in the shape and location of the LCE.The seasonal variation of the LCE shape can significantly alter the spatial distribution of the thermal front and chlorophyll a northwest of the Luzon Island by geostrophic advection.展开更多
Using foxtail millet (Setaria italica (L.) Beauv.) male-sterile line 1066A as female parent and Yugu 1 primary trisomic series (1 - 7) and tetrasomics 8, 9 as male parents, chromosome location of gene for male-sterili...Using foxtail millet (Setaria italica (L.) Beauv.) male-sterile line 1066A as female parent and Yugu 1 primary trisomic series (1 - 7) and tetrasomics 8, 9 as male parents, chromosome location of gene for male-sterility and yellow seedling in line 1066A was studied by primary trisomic analysis. The plants of F-1 generation of trisomics 2 - 9 were obtained by crossing with a great many plants of 1066A. F-1 generation of trisomics was similar to their male parent in morphologic characters, the color of their seedling was green, and pollen was partially fertile. The segregation ratio of fertility to sterility is 3:1 in F-2 generation of trisomics 2, 3, 4, 5, 7, 8 and 9; and 14:1 only in F-2 generation of trisomic 6 (chi(0.05)(2) = 0.012). The segregation ratio of green seedling to yellow seedling is 12:1 only in F-2 generation of trisomic 7 (chi(0.05)(2) = 0.31), but in other cases, this ratio is 3:1. The results indicated that the male-sterility gene was located on chromosome 6, and the gene for yellow seedling was monogenic recessive and located on chromosome 7. The rate of trisomics transmission by pollen was tested, trisomics 8 and 9 were the highest in rates of trisomics transmission and followed by trisomics 6 and 4.展开更多
On August 6,2023,a magnitude MW5.5 earthquake struck Pingyuan County,Dezhou City,Shandong Province,China.This event was significant as no large earthquakes had been recorded in the region for over a century,and no act...On August 6,2023,a magnitude MW5.5 earthquake struck Pingyuan County,Dezhou City,Shandong Province,China.This event was significant as no large earthquakes had been recorded in the region for over a century,and no active fault had been previously identified.This study collects 1309 P-wave arrival times and 866 S-wave arrival times from 74 seismic stations less than 200 km to the epicenter to constrain the spatial distribution of the mainshock and its 125 early aftershocks by the double difference earthquake relocation method,and selects 864 P-waveforms from 288 stations located within 800 km of the epicenter to constrain the focal mechanism solution of the mainshock through centroid moment tensor inversion.The relocation and the inversion indicate,the Pingyuan MW5.5 earthquake was caused by a rupture on a buried fault,likely an extensive segment of the Gaotang fault.This buried fault exhibited a dip of approximately 75°to the northwest,with a strike of 222°,similar to the Gaotang fault.The rupture initiated at the depth of 18.6 km and propagated upward and northeastward.However,the ground surface was not broken.The total duration of the rupture was~6.0 s,releasing the scalar moment of 2.5895×1017 N·m,equivalent to MW5.54.The moment rate reached the maximum only 1.4 seconds after the rupture initiation,and the 90%scalar moment was released in the first 4.6 s.In the first 1.4 seconds of the rupture process,the rupture velocity was estimated to be 2.6 km/s,slower than the local S-wave velocity.As the rupture neared its end,the rupture velocity decreased significantly.This study provides valuable insights into the seismic characteristics of the Pingyuan MW5.5 earthquake,shedding light on the previously unidentified buried fault responsible for the seismic activity in the region.Understanding the behavior of such faults is crucial for assessing seismic hazards and enhancing earthquake preparedness in the future.展开更多
Rural settlement is the basic spatial unit for compact communities in rural area. Scientific exploration of spatial-temporal differentiation and its influencing factors is the premise of spatial layout rationalization...Rural settlement is the basic spatial unit for compact communities in rural area. Scientific exploration of spatial-temporal differentiation and its influencing factors is the premise of spatial layout rationalization. Based on land use data of Liangshan Yi Autonomous Prefecture(hereinafter referred to as Liangshan Prefecture) in Sichuan Province, China from 1980 to 2020, compactness index, fractal dimension, imbalance index, location entropy and the optimal parameters-based geographical detector(OPGD) model are used to analyze the spatial-temporal evolution of the morphological characteristics of rural settlements, and to explore the influence of natural geographical factors, socioeconomic factors, and policy factors on the spatial differentiation of rural settlements. The results show that:(1) From 1980 to 2020, the rural settlements area in Liangshan Prefecture increased by 15.96 km^(2). In space, the rural settlements are generally distributed in a local aggregation, dense in the middle and sparse around the periphery. In 2015, the spatial density and expansion index of rural settlements reached the peak.(2) From 1980 to 2020, the compactness index decreased from 0.7636 to 0.7496, the fractal dimension increased from 1.0283 to 1.0314, and the fragmentation index decreased from 0.1183 to 0.1047. The spatial morphological structure of rural settlements tended to be loose, the shape contour tended to be complex, the degree of fragmentation decreased, and the spatial distribution was significantly imbalanced.(3) The results of OPGD detection in 2015 show that the influence of each factor is slope(0.2371) > traffic accessibility(0.2098) > population(0.1403) > regional GDP(0.1325) > elevation(0.0987) > poverty alleviation(0). The results of OPGD detection in 2020 show that the influence of each factor is slope(0.2339) > traffic accessibility(0.2198) > population(0.1432) > regional GDP(0.1219) > poverty alleviation(0.0992) > elevation(0.093). Natural geographical factors(slope and elevation) are the basic factors affecting the spatial distribution of rural settlements, and rural settlements are widely distributed in the river valley plain and the second half mountain area. Socioeconomic factors(traffic accessibility, population, and regional GDP) have a greater impact on the spatial distribution of rural settlements, which is an important factor affecting the spatial distribution of rural settlements. Policy factors such as poverty alleviation relocation have an indispensable impact on the spatial distribution of rural settlements. The research results can provide decisionmaking basis for the spatial arrangement of rural settlements in Liangshan Prefecture, and optimize the implementation of rural revitalization policies.展开更多
Based on the EAST equilibrium,the effects of boron(B)and neon(Ne)injected at different locations on the target heat load,and the distributions of B and Ne particles were investigated by transport code SOLPS-ITER.It wa...Based on the EAST equilibrium,the effects of boron(B)and neon(Ne)injected at different locations on the target heat load,and the distributions of B and Ne particles were investigated by transport code SOLPS-ITER.It was found that the B injection was more sensitive to the injection location for heat flux control than impurity Ne.The high electron and ion densities near the inner target in the discharge with impurity B injected from over X-point(R1)led to plasma detachment only at the inner target,and the localized B ions in the cases with injection from outer target location(R2)and upstream location(R3)led to far-SOL detachment at the outer target,but not at the inner target.In contrast,for Ne,the spatial distributions of Ne ions and electrons were found to be similar in all the cases at the three injection locations,and the detached plasma was achieved at the inner target and the electron temperature was reduced at the outer target.For locations R2 and R3,impurity B showed a more pronounced effect on the heat flux at the far-SOL of the outer target.Further analysis indicated that Ne atoms came mainly from the recycling sources,whereas B atoms came mainly from injection,and that their distinct atomic distributions resulted from the difference in the ionization threshold and ionization mean free path.In addition,the radiation proportion of B in the divertor region was larger than that of Ne when the total radiation power was similar,which suggests that B has less influence on the core region.展开更多
Deterministic, probabilistic and composite-grading methods are used to get the possible locations of strong earth-quakes in the future in Norwest Beijing and its vicinity based on the quantitative data and their accur...Deterministic, probabilistic and composite-grading methods are used to get the possible locations of strong earth-quakes in the future in Norwest Beijing and its vicinity based on the quantitative data and their accuracy about active tectonics in the research area and by ordering, some questions in the results are also discussed. It shows that the most dangerous fault segments for strong earthquakes in the future include: segments B and A of the southern boundary fault of the Yangyuan basin, the southern boundary fault of the Xuanhua basin, the east segment of the southern Huaian fault and the east segment of the northern YanggaoTianzhen fault. The most dangerous area is YangyuanShenjing basin, the second one is TianzhenHuaianXuanhua basin and the third dangerous areas are WanquanZhangjiakou and northeast of Yuxian to southwest of Fanshan.展开更多
Objective:To investigate whether acupoint penetration acupuncture(APA)could regulate chondrocyte autophagy and apoptosis via the PI3K/Akt-mTOR signaling pathway to reduce cartilage degeneration in knee osteoarthritis(...Objective:To investigate whether acupoint penetration acupuncture(APA)could regulate chondrocyte autophagy and apoptosis via the PI3K/Akt-mTOR signaling pathway to reduce cartilage degeneration in knee osteoarthritis(KOA)rats.Methods: KOA was induced in rats via intra-articular injection of sodium iodoacetate resolution.Forty male Sprague-Dawley rats were randomly assigned to blank control,model,APA,electro-acupuncture(EA),and sham model groups(n=8)and those in the APA and EA groups received their respective therapies.Following completion of the treatment course,histological examinations of cartilage and muscle were conducted.Levels of apoptosis-and autophagy-related factors,including Bax,Bcl-2,mTOR,ULK-1,and Beclin-1 protein,and mRNAs were assessed.Additionally,β-endorphin(β-EP)concentrations in the brain and serum were measured.Results: Histological analysis revealed that APA alleviated cartilage and muscle damage compared with the model group.APA inhibited cartilage degeneration by modulating the expression of apoptosis-and autophagy-related proteins and mRNA,thus preventing chondrocyte apoptosis.In the APA group,Bax and mTOR protein levels were significantly lower than those in the model group(both P=.024).Conversely,the Bcl-2 expression level was significantly higher than that in the EA group(P=.035).Additionally,ULK-1 expression was significantly lower than that in the EA group(P=.045).The mRNA level of Bax was significantly higher than that in the blank control group(P<.001).However,Beclin-1 levels were significantly higher than those in both the model and EA groups(both P<.001).ELISA results showed a significant decrease in the concentration ofβ-EP in the brains of the rats in the APA group compared with those in the model group(P=.032).Conclusions: APA reduced osteoarthritis-related pain and alleviated cartilage damage by upregulating chondrocyte autophagy and down-regulating apoptosis via signaling pathways involving PI3K/Akt-mTOR in KOA rats.展开更多
Acoustic emission(AE)source localization is a fundamental element of rock fracture damage imaging.To improve the efficiency and accuracy of AE source localization,this paper proposes a joint method comprising a three-...Acoustic emission(AE)source localization is a fundamental element of rock fracture damage imaging.To improve the efficiency and accuracy of AE source localization,this paper proposes a joint method comprising a three-dimensional(3D)AE source localization simplex method and grid search scanning.Using the concept of the geometry of simplexes,tetrahedral iterations were first conducted to narrow down the suspected source region.This is followed by a process of meshing the region and node searching to scan for optimal solutions,until the source location is determined.The resulting algorithm was tested using the artificial excitation source localization and uniaxial compression tests,after which the localization results were compared with the simplex and exhaustive methods.The results revealed that the localization obtained using the proposed method is more stable and can be effectively avoided compared with the simplex localization method.Furthermore,compared with the global scanning method,the proposed method is more efficient,with an average time of 10%–20%of the global scanning localization algorithm.Thus,the proposed algorithm is of great significance for laboratory research focused on locating rupture damages sustained by large-sized rock masses or test blocks.展开更多
基金the Research Council of Norway(Grant No.244029)the project‘Stable dams’,FORMAS(Grant No.2019e01236)+1 种基金the project‘Improved safety assessment of concrete dams’,and SVC(Grant No.VKU32019)the project‘Safe dams’,that supported the development of the research presented in this article.
文摘When assessing the sliding stability of a concrete dam,the influence of large-scale asperities in the sliding plane is often ignored due to limitations of the analytical rigid body assessment methods provided by current dam assessment guidelines.However,these asperities can potentially improve the load capacity of a concrete dam in terms of sliding stability.Although their influence in a sliding plane has been thoroughly studied for direct shear,their influence under eccentric loading,as in the case of dams,is unknown.This paper presents the results of a parametric study that used finite element analysis(FEA)to investigate the influence of large-scale asperities on the load capacity of small buttress dams.By varying the inclination and location of an asperity located in the concrete-rock interface along with the strength of the rock foundation material,transitions between different failure modes and correlations between the load capacity and the varied parameters were observed.The results indicated that the inclination of the asperity had a significant impact on the failure mode.When the inclinationwas 30and greater,interlocking occurred between the dam and foundation and the governing failure modes were either rupture of the dam body or asperity.When the asperity inclination was significant enough to provide interlocking,the load capacity of the dam was impacted by the strength of the rock in the foundation through influencing the load capacity of the asperity.The location of the asperity along the concrete-rock interface did not affect the failure mode,except for when the asperity was located at the toe of the dam,but had an influence on the load capacity when the failure occurred by rupture of the buttress or by sliding.By accounting for a single large-scale asperity in the concrete-rock interface of the analysed dam,a horizontal load capacity increase of 30%e160%was obtained,depending on the inclination and location of the asperity and the strength of the foundation material.
基金Under the auspices of the Philosophy and Social Science Planning Project of Guizhou,China(No.21GZZD59)。
文摘China’s low-carbon development path will make significant contributions to achieving global sustainable development goals.Due to the diverse natural and economic conditions across different regions in China,there exists an imbalance in the distribution of car-bon emissions.Therefore,regional cooperation serves as an effective means to attain low-carbon development.This study examined the pattern of carbon emissions and proposed a potential joint emission reduction strategy by utilizing the industrial carbon emission intens-ity(ICEI)as a crucial factor.We utilized social network analysis and Local Indicators of Spatial Association(LISA)space-time trans-ition matrix to investigate the spatiotemporal connections and discrepancies of ICEI in the cities of the Pearl River Basin(PRB),China from 2010 to 2020.The primary drivers of the ICEI were determined through geographical detectors and multi-scale geographically weighted regression.The results were as follows:1)the overall ICEI in the Pearl River Basin is showing a downward trend,and there is a significant spatial imbalance.2)There are numerous network connections between cities regarding the ICEI,but the network structure is relatively fragile and unstable.3)Economically developed cities such as Guangzhou,Foshan,and Dongguan are in the center of the network while playing an intermediary role.4)Energy consumption,industrialization,per capita GDP,urbanization,science and techno-logy,and productivity are found to be the most influential variables in the spatial differentiation of ICEI,and their combination in-creased the explanatory power of the geographic variation of ICEI.Finally,through the analysis of differences and connections in urban carbon emissions under different economic levels and ICEI,the study suggests joint carbon reduction strategies,which are centered on carbon transfer,financial support,and technological assistance among cities.
基金funded by Chinese Medicine Research Practical Training Program of Hong Kong Hospital Authority Chinese Medicine Department(Hong Kong,China),fourth batch.
文摘Objective:To compare the efficacy of using“distal acupoints only”vs.“local acupoints mainly combined with distal acupoints”in cases of acute low back pain(ALBP).Methods: A total of 102 eligible patients aged 18–65 years with ALBP lasting less than 6 weeks will be randomized in a 1:1 ratio to the distal acupoints only group(DPOG)and the local acupoints mainly combined with the distal acupoints group(LPMG).During a 4-week treatment period,patients in the DPOG will receive acupuncture at distal acupoints only(Houxi[SI 3]and Yaotongxue[EX-UE 7])twice a week,while those in the LPMG group will receive acupuncture at local acupoints(mainly Shenshu[BL 23]and Dachangshu[BL 25])combined with distal points(Weizhong[BL 40]).The patients in both groups will be evaluated at every session of treatment,and the follow-up will be performed for 3 months.The primary outcome measure will be the change in ALBP intensity,assessed using visual analogue scale scores before and after treatment.The secondary outcome measure will be the evaluation of functional disability using the Oswestry Disability Index.Discussion: This study compares the DPOG and LPMG to explore the feasibility of the DPOG in the treatment of ALBP.
文摘The Internet of Things(IoT)is a smart networking infrastructure of physical devices,i.e.,things,that are embedded with sensors,actuators,software,and other technologies,to connect and share data with the respective server module.Although IoTs are cornerstones in different application domains,the device’s authenticity,i.e.,of server(s)and ordinary devices,is the most crucial issue and must be resolved on a priority basis.Therefore,various field-proven methodologies were presented to streamline the verification process of the communicating devices;however,location-aware authentication has not been reported as per our knowledge,which is a crucial metric,especially in scenarios where devices are mobile.This paper presents a lightweight and location-aware device-to-server authentication technique where the device’s membership with the nearest server is subjected to its location information along with other measures.Initially,Media Access Control(MAC)address and Advance Encryption Scheme(AES)along with a secret shared key,i.e.,λ_(i) of 128 bits,have been utilized by Trusted Authority(TA)to generate MaskIDs,which are used instead of the original ID,for every device,i.e.,server and member,and are shared in the offline phase.Secondly,TA shares a list of authentic devices,i.e.,server S_(j) and members C_(i),with every device in the IoT for the onward verification process,which is required to be executed before the initialization of the actual communication process.Additionally,every device should be located such that it lies within the coverage area of a server,and this location information is used in the authentication process.A thorough analytical analysis was carried out to check the susceptibility of the proposed and existing authentication approaches against well-known intruder attacks,i.e.,man-in-the-middle,masquerading,device,and server impersonations,etc.,especially in the IoT domain.Moreover,proposed authentication and existing state-of-the-art approaches have been simulated in the real environment of IoT to verify their performance,particularly in terms of various evaluation metrics,i.e.,processing,communication,and storage overheads.These results have verified the superiority of the proposed scheme against existing state-of-the-art approaches,preferably in terms of communication,storage,and processing costs.
基金Supported by Jinshan District Medical and Health Science and Technology Innovation Funding Project,No.2021-3-07.
文摘BACKGROUND Chronic eczema significantly impacts daily life,social interactions,and quality of life;however,no curative treatment has been identified.AIM To determine the clinical efficacy of acupoint injection for chronic eczema and its influence on peripheral blood T cells.METHODS Eighty patients with chronic eczema treated at our hospital between June 2022 and March 2023 were randomly assigned to a control group(n=40),which received conventional Western medicine treatment,or an observation group(n=40),which received routine Western medicine treatment plus acupoint injection of triamcinolone acetonide.Response and adverse reaction rates,as well as differences in the levels of serum cytokines IFN-γ,IL-2,IL-4,and IL-10 before and after treatment were investigated.RESULTS No difference in overall response rates were found between the observation and control groups(100%vs 90%,respectively;P>0.05);however,the observation group had a higher marked response rate than the control group(87.5%vs 52.5%;P<0.05).Both groups had decreased Eczema Area and Severity Index scores and increased pruritus after treatment(P<0.05),particularly in the observation group(P<0.05).The observation group had an adverse reaction rate of 2.5%(1/40),which did not differ significantly from that of the control group(P>0.05).The observation group exhibited higher post-treatment INF-γand IL-2 but lower IL-4 levels than the control group(P<0.05);however,no significant inter-group difference was observed in post-treatment IL-10 levels(P>0.05).CONCLUSION Acupoint injection of triamcinolone acetonide is safe and effective in treating chronic eczema.Its therapeutic mechanism is related to the regulation of peripheral blood T cell levels,inhibition of inflammatory reactions,and mitigation of immune imbalance.
基金supported by the Natural Science Foundation of China(U2034207)the Natural Science Foundation of Hebei Province(E2021210099)the Technical Development Project of Shuohuang Railway Development Co.,Ltd.(GJNY-20-230).
文摘To enhance the understanding of the geometry and characteristics of seismogenic faults in the Beijing-Tianjin-Hebei region,we relocated 14805 out of 16063 earthquakes(113°E-120°E,36°N-43°N)that occurred between January 2008 and December 2020 using the double-difference tomography method.Based on the spatial variation in seismicity after relocation,the Beijing-Tianjin-Hebei region can be divided into three seismic zones:Xingtai-Wen'an,Zhangbei-Ninghexi,and Tangshan.(1)The Xingtai-Wen'an Seismic Zone has a northeastsouthwest strike.The depth profile of earthquakes perpendicular to the strike reveals three northeast-striking,southeast-dipping,high-angle deep faults(>10 km depth),including one below the shallow(<10 km depth)listric,northwest-dipping Xinghe fault in the Xingtai region.Two additional deep faults in the Wen'an region are suggested to be associated with the 2006 M 5.1 Wen'an Earthquake and the 1967 M 6.3 Dacheng earthquake;(2)The Zhangbei-Ninghexi Seismic Zone is oriented north-northwest.Multiple northeast-striking faults(10-20 km depth),inferred from the earthquake-intensive zones,exist beneath the shallow(<10 km depth)Xiandian Fault,Xiaotangshan Fault,Huailai-Zhuolu Basin North Fault,Yangyuan Basin Fault and Yanggao Basin North Fault;(3)In the Tangshan Seismic Zone,earthquakes are mainly concentrated near the northeast-striking Tangshan-Guye Fault,Lulong Fault,and northwest-striking Luanxian-Laoting Fault.An inferred north-south-oriented blind fault is present to the north of the Tangshan-Guye Fault.The 1976 M 7.8 Tangshan earthquake occurred at the junction of a shallow northwest-dipping fault and a deep southeast-dipping fault.This study emphasizes that earthquakes in the region are primarily associated with deep blind faults.Some deep blind faults have different geometries compared to shallow faults,suggesting a complex fault system in the region.Overall,this research provides valuable insights into the seismogenic faults in the Beijing–Tianjin–Hebei region.Further studies and monitoring of these faults are essential for earthquake mitigation efforts in this region.
基金supported by grants from the National Natural Science Foundation of China(Grant No.82260940)the Yunnan Provincial(Traditional Chinese Medicine)Clinical Dermatology Center,12th Five-year Key Construction Discipline of State Administration of Traditional Chinese Medicine“Dai Pharmacy”+1 种基金Open Project of Yunnan Key Laboratory of Dai and Yi Medicines(No.30971101100)Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission&Ministry of Education,Yunnan Minzu University.
文摘Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c mice.It also conducted an initial examination of the underlying molecular mechanisms.Methods:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding treatment.After DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day 8.Mice in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut implantation.Severity was assessed using SCORAD on treatment days 1,10,and 20.On day 18,nine mice per group were euthanized,and the remaining on day 28.Histopathological changes were observed using hematoxylin-eosin and immunohistochemistry staining.TNF-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western blot.Results:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like mice.Significant decreases occurred in serum IL-4,IL-6,IL-13,and TNF-αlevels.Skin analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein levels.Conclusion:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.
基金Natural Science Foundation of Shanxi Province(No.201801D121358)"Basic Research Special Project"of Shanxi University of Tradit Chin Med Science and Technology Innovation Ability Cultivation Program(No.2021PY-JC-13)。
文摘Objective:To investigate the mechanism of JAK2/STAT3/SOCS1 signaling pathway in electroacupuncture of different acupoints on acute colitis rats.Methods:36 SPF SD rats were randomly divided into 6 groups,with 6 rats in each group.The rat model of acute colitis was prepared by enema with glacial acetic acid solution.After the model was established,electroacupuncture was given to each acupoint group,with density wave,frequency 2Hz-50 Hz,intensity 2 mA,muscle tremor as the degree 20 min/time,1 time/day,for 3 consecutive days.Observe the general condition of rats;the pathological changes of colonic mucosa in rats were observed by HE method.The contents of serum interleukin-4(IL-4)and interleukin-8(IL-8)were detected by ELISA.Western blot and RT-PCR were used to detect the expression of JAK2,STAT3,SOCS1 protein and mRNA in rat colon tissue.Results:In contrast to the normal group,the overall condition of the model group was worse,the colonic mucosa was severely damaged,even necrotic,and the ulcer surface was obvious.The content of IL-4 in serum was obviously reduced,and the content of IL-8 was obviously go up(P<0.01).The protein content of JAK2,STAT3 and the expression of JAK2,STAT3 mRNA in colon tissue of rats were obviously go up,while the protein content of SOCS1 and the expression of SOCS1 mRNA were obviously reduced(P<0.01).In contrast to the model group,the general condition of rats in each acupoint group was significantly improved,the damage and necrosis of colonic mucosa and ulcer surface were obviously alleviated,the content of IL-4 in serum was obviously go up,and the content of IL-8 was significantly decreased(P<0.01).The protein content of JAK2,STAT3 and the expression of JAK2,STAT3 mRNA in colon tissue of rats were obviously reduced,while the protein content of SOCS1 and the expression of SOCS1 mRNA were obviously go up(P<0.05,P<0.01).Comparison of different acupoint groups,the colonic mucosal injury in the Zusanli group was significantly reduced,the content of serum IL-4 was significantly increased,and the content of IL-8 was significantly decreased(P<0.05,P<0.01).The protein content and mRNA expression of JAK2 and STAT3 in colon tissue were significantly down-regulated,while the protein content and mRNA expression of SOCS1 were significantly go up(P<0.05,P<0.01).Conclusion:Electroacupuncture at each acupoint can improve the damage of colonic mucosa and reduce the inflammatory response.The therapeutic effect of Zusanli(ST36)is better than that of Tianshu(ST25),Dachangshu(BL25)and Shangjuxu(ST37).The mechanism may be related to the regulation of JAK2/STAT3/SOCS1 signaling pathway related proteins and inflammatory cytokines IL-4 and IL-8.
文摘Objective: To observe the therapeutic effect of combined traditional Chinese medicine (TCM) therapy with acupoint injection and herbal patch application on patients with ovulatory dysfunction associated with polycystic ovary syndrome (PCOS). Methods: A total of 80 PCOS patients who received treatment at the First Affiliated Hospital of Guangxi University of Chinese Medicine between October 2022 and March 2024 were enrolled in this study. They were randomly divided into a control group (n = 40) and an observation group (n = 40). The control group received conventional Western medical treatments, while the observation group was administered TCM combined with acupoint injection and herbal patch application. Pre- and post-treatment conditions were compared between the two groups. Results: After treatment, the overall effective rate was significantly higher in the observation group compared to the control group (P 0.05). Following treatment, both ovulation and pregnancy rates increased in both groups, but the increase was more evident in the observation group, showing a statistically significant difference (P < 0.01). Conclusion: For patients with oligoovulation or anovulation due to PCOS, the combined use of TCM, acupoint injection, and herbal patch application appears to be effective in improving systemic symptoms and achieving notable clinical outcomes.
文摘Objective:To analyze the effect of combining transcutaneous electrical acupoint stimulation(TEAS)with rehabilitation training in patients with upper limb dysfunction after stroke(ULDAS).Methods:A total of 130 ULDAS patients who were hospitalized and rehabilitated in Wuxi Xinwu District Rehabilitation Hospital from May 2021 to May 2023 were selected and randomly divided into Group A(65 cases,rehabilitation training)and Group B(65 cases,rehabilitation training+TEAS).The effects of the two groups were compared.Results:After treatment,the upper limb functional indexes of Group B were better than those of Group A(P<0.05).The rate of muscle tone grades 0-4 in Group B was higher than those of Group A(P<0.05).Conclusion:The function of upper limbs and muscle strength of ULDAS patients improved by combining TEAS with rehabilitation training.
基金supported by the National Natural Science Foundation of China (Grant Nos. 91537209 and 91644224)
文摘Lightning-generated nitrogen oxides(LNO_(x))have a major influence on the atmosphere and global climate change.Therefore,it is of great importance to obtain a more accurate estimation of LNO_(x).The aim of this study is to provide a reference for the accurate estimation of the total LNO_(x) in the mainland of China based on cloud-to-ground lightning(CG)location data from 2014 to 2018.The energy of each CG flash was based on the number of return strokes per CG flash,the peak current of each return stroke,and the assumed CG breakdown voltage.The energy of intracloud lightning(IC)was based on the estimated frequencies of IC and the assumed energy of each IC flash.Combining the energy of lightning and the number of nitric oxide(NO)molecules produced by unit energy(ρno),the total LNO_(x) production in the mainland of China was determined.The LNO_(x) in the mainland of China estimated in this study is in the range(0.157-0.321)×10^(9) kg per year[Tg(N)yr-1],which is on the high end of other scholars’works.Negative cloud-to-ground lightning(NCG)flashes produce the most moles of NO_(x),while positive cloud-to-ground lightning(PCG)flashes produce the least total moles of NO_(x).The breakdown voltage of PCG is greater than that of IC or NCG,while the latter has a greater output of LNO_(x).
基金supported by grants from the earmarked fund for China Agriculture Research System(CARS004-PS14)the National Key R&D Program of China(2018YFD0201000)the Special Fund for Agroscientific Research in the Public Interest,China(201303018)。
文摘Plant-associated microbes represent a key determinant of plant fitness through acquiring nutrients,promoting growth,and resisting to abiotic and biotic stresses.However,an extensive characterization of the bacterial and fungal microbiomes present in different plant compartments of soybean in field conditions has remained elusive.In this study,we investigated the effects of four niches(roots,stems,leaves,and pods),four genotypes(Andou 203,Hedou 12,Sanning 16,and Zhonghuang 13),and three field locations(Jining,Suzhou,and Xuzhou)on the diversity and composition of bacterial and fungal communities in soybean using 16S and internal transcribed spacer rRNA amplicon sequencing,respectively.The soybean microbiome significantly differed across organs.Host genotypes explained more variation in stem bacterial community composition and leaf fungal community composition.Field location significantly affected the composition of bacterial communities in all compartments and the effects were stronger in the root and stem than in the leaf and pod,whereas field location explained more variation in stem and leaf fungal community composition than in the root and pod.The relative abundances of potential soybean fungal pathogens also differed among host organs and genotypes,reflecting the niches of these microbes in the host and probably their compatibility to the host genotypes.Systematic profiling of the microbiome composition and diversity will aid the development of plant protection technologies to benefit soybean health.
基金The 2022 Research Program of Sanya Yazhou Bay Science and Technology City under contract No.SKJC-2022-01-001the Project of Sanya Yazhou Bay Science and Technology City under contract No.SCKJ-JYRC-2022-47+4 种基金the National Natural Science Foundation of China under contract No.41806019the Natural Science Foundation of Hainan Province under contract No.121MS062the National Natural Science Foundation of China under contract Nos 42006008 and 41876031the National Key Research and Development Plan of China under contract No.2016YFC1401603the Research Startup Funding from Hainan Institute of Zhejiang University under contract No.HZY20210801。
文摘Using observational data from multiple satellites,we studied seasonal variations of the shape and location of the Luzon cold eddy(LCE)northwest of Luzon Island.The shape and location of the LCE have obvious seasonal variations.The LCE occurs,develops,and disappears from December to April of the next year.During this period,the shape of the LCE changed from a flat ellipse to a circular ellipse,and the change in shape can be reflected by the increase of the ellipticity of the LCE from 0.16 to 0.82.The latitude of center location of the LCE changes from 17.4°N to 19°N,and the change in latitude can reach 1.6°.Further study showed that seasonal variation of the northeast monsoon intensity leads to the change in the shape and location of the LCE.The seasonal variation of the LCE shape can significantly alter the spatial distribution of the thermal front and chlorophyll a northwest of the Luzon Island by geostrophic advection.
文摘Using foxtail millet (Setaria italica (L.) Beauv.) male-sterile line 1066A as female parent and Yugu 1 primary trisomic series (1 - 7) and tetrasomics 8, 9 as male parents, chromosome location of gene for male-sterility and yellow seedling in line 1066A was studied by primary trisomic analysis. The plants of F-1 generation of trisomics 2 - 9 were obtained by crossing with a great many plants of 1066A. F-1 generation of trisomics was similar to their male parent in morphologic characters, the color of their seedling was green, and pollen was partially fertile. The segregation ratio of fertility to sterility is 3:1 in F-2 generation of trisomics 2, 3, 4, 5, 7, 8 and 9; and 14:1 only in F-2 generation of trisomic 6 (chi(0.05)(2) = 0.012). The segregation ratio of green seedling to yellow seedling is 12:1 only in F-2 generation of trisomic 7 (chi(0.05)(2) = 0.31), but in other cases, this ratio is 3:1. The results indicated that the male-sterility gene was located on chromosome 6, and the gene for yellow seedling was monogenic recessive and located on chromosome 7. The rate of trisomics transmission by pollen was tested, trisomics 8 and 9 were the highest in rates of trisomics transmission and followed by trisomics 6 and 4.
基金support from the National Natural Science Foundation of China(Nos.42104043,42374081,and U2039208)the Fundamental Research Funds for the Institute of Geophysics,China Earthquake Administration(No.DQJB22R35).
文摘On August 6,2023,a magnitude MW5.5 earthquake struck Pingyuan County,Dezhou City,Shandong Province,China.This event was significant as no large earthquakes had been recorded in the region for over a century,and no active fault had been previously identified.This study collects 1309 P-wave arrival times and 866 S-wave arrival times from 74 seismic stations less than 200 km to the epicenter to constrain the spatial distribution of the mainshock and its 125 early aftershocks by the double difference earthquake relocation method,and selects 864 P-waveforms from 288 stations located within 800 km of the epicenter to constrain the focal mechanism solution of the mainshock through centroid moment tensor inversion.The relocation and the inversion indicate,the Pingyuan MW5.5 earthquake was caused by a rupture on a buried fault,likely an extensive segment of the Gaotang fault.This buried fault exhibited a dip of approximately 75°to the northwest,with a strike of 222°,similar to the Gaotang fault.The rupture initiated at the depth of 18.6 km and propagated upward and northeastward.However,the ground surface was not broken.The total duration of the rupture was~6.0 s,releasing the scalar moment of 2.5895×1017 N·m,equivalent to MW5.54.The moment rate reached the maximum only 1.4 seconds after the rupture initiation,and the 90%scalar moment was released in the first 4.6 s.In the first 1.4 seconds of the rupture process,the rupture velocity was estimated to be 2.6 km/s,slower than the local S-wave velocity.As the rupture neared its end,the rupture velocity decreased significantly.This study provides valuable insights into the seismic characteristics of the Pingyuan MW5.5 earthquake,shedding light on the previously unidentified buried fault responsible for the seismic activity in the region.Understanding the behavior of such faults is crucial for assessing seismic hazards and enhancing earthquake preparedness in the future.
基金funded by the National Natural Science Foundation of China (Grant Nos. 41971015)Doctoral research program of China West Normal University (Grant Nos.19E067)。
文摘Rural settlement is the basic spatial unit for compact communities in rural area. Scientific exploration of spatial-temporal differentiation and its influencing factors is the premise of spatial layout rationalization. Based on land use data of Liangshan Yi Autonomous Prefecture(hereinafter referred to as Liangshan Prefecture) in Sichuan Province, China from 1980 to 2020, compactness index, fractal dimension, imbalance index, location entropy and the optimal parameters-based geographical detector(OPGD) model are used to analyze the spatial-temporal evolution of the morphological characteristics of rural settlements, and to explore the influence of natural geographical factors, socioeconomic factors, and policy factors on the spatial differentiation of rural settlements. The results show that:(1) From 1980 to 2020, the rural settlements area in Liangshan Prefecture increased by 15.96 km^(2). In space, the rural settlements are generally distributed in a local aggregation, dense in the middle and sparse around the periphery. In 2015, the spatial density and expansion index of rural settlements reached the peak.(2) From 1980 to 2020, the compactness index decreased from 0.7636 to 0.7496, the fractal dimension increased from 1.0283 to 1.0314, and the fragmentation index decreased from 0.1183 to 0.1047. The spatial morphological structure of rural settlements tended to be loose, the shape contour tended to be complex, the degree of fragmentation decreased, and the spatial distribution was significantly imbalanced.(3) The results of OPGD detection in 2015 show that the influence of each factor is slope(0.2371) > traffic accessibility(0.2098) > population(0.1403) > regional GDP(0.1325) > elevation(0.0987) > poverty alleviation(0). The results of OPGD detection in 2020 show that the influence of each factor is slope(0.2339) > traffic accessibility(0.2198) > population(0.1432) > regional GDP(0.1219) > poverty alleviation(0.0992) > elevation(0.093). Natural geographical factors(slope and elevation) are the basic factors affecting the spatial distribution of rural settlements, and rural settlements are widely distributed in the river valley plain and the second half mountain area. Socioeconomic factors(traffic accessibility, population, and regional GDP) have a greater impact on the spatial distribution of rural settlements, which is an important factor affecting the spatial distribution of rural settlements. Policy factors such as poverty alleviation relocation have an indispensable impact on the spatial distribution of rural settlements. The research results can provide decisionmaking basis for the spatial arrangement of rural settlements in Liangshan Prefecture, and optimize the implementation of rural revitalization policies.
基金Project supported by the National Key R&D Program of China(Grant No.2019YFE03030004)the National Natural Science Foundation of China(Grant No.12275040)+1 种基金the Users with Excellence Program of Hefei Science Center CAS(Grant No.2020HSC-UE010)This research is also sponsored in part by the U.S.Department of Energy under contract DEAC02-09CH11466.
文摘Based on the EAST equilibrium,the effects of boron(B)and neon(Ne)injected at different locations on the target heat load,and the distributions of B and Ne particles were investigated by transport code SOLPS-ITER.It was found that the B injection was more sensitive to the injection location for heat flux control than impurity Ne.The high electron and ion densities near the inner target in the discharge with impurity B injected from over X-point(R1)led to plasma detachment only at the inner target,and the localized B ions in the cases with injection from outer target location(R2)and upstream location(R3)led to far-SOL detachment at the outer target,but not at the inner target.In contrast,for Ne,the spatial distributions of Ne ions and electrons were found to be similar in all the cases at the three injection locations,and the detached plasma was achieved at the inner target and the electron temperature was reduced at the outer target.For locations R2 and R3,impurity B showed a more pronounced effect on the heat flux at the far-SOL of the outer target.Further analysis indicated that Ne atoms came mainly from the recycling sources,whereas B atoms came mainly from injection,and that their distinct atomic distributions resulted from the difference in the ionization threshold and ionization mean free path.In addition,the radiation proportion of B in the divertor region was larger than that of Ne when the total radiation power was similar,which suggests that B has less influence on the core region.
基金National major basic-theory planning project Mechanism and Prediction of Strong Earthquake (95130105) and the Key Project from China Seismological Bureau (95040803).
文摘Deterministic, probabilistic and composite-grading methods are used to get the possible locations of strong earth-quakes in the future in Norwest Beijing and its vicinity based on the quantitative data and their accuracy about active tectonics in the research area and by ordering, some questions in the results are also discussed. It shows that the most dangerous fault segments for strong earthquakes in the future include: segments B and A of the southern boundary fault of the Yangyuan basin, the southern boundary fault of the Xuanhua basin, the east segment of the southern Huaian fault and the east segment of the northern YanggaoTianzhen fault. The most dangerous area is YangyuanShenjing basin, the second one is TianzhenHuaianXuanhua basin and the third dangerous areas are WanquanZhangjiakou and northeast of Yuxian to southwest of Fanshan.
基金supported by the Startup Fund Project for Doctor Research,the First Affiliated Hospital of Henan University of Chinese Medicine in 2020(KY-B0354-14).
文摘Objective:To investigate whether acupoint penetration acupuncture(APA)could regulate chondrocyte autophagy and apoptosis via the PI3K/Akt-mTOR signaling pathway to reduce cartilage degeneration in knee osteoarthritis(KOA)rats.Methods: KOA was induced in rats via intra-articular injection of sodium iodoacetate resolution.Forty male Sprague-Dawley rats were randomly assigned to blank control,model,APA,electro-acupuncture(EA),and sham model groups(n=8)and those in the APA and EA groups received their respective therapies.Following completion of the treatment course,histological examinations of cartilage and muscle were conducted.Levels of apoptosis-and autophagy-related factors,including Bax,Bcl-2,mTOR,ULK-1,and Beclin-1 protein,and mRNAs were assessed.Additionally,β-endorphin(β-EP)concentrations in the brain and serum were measured.Results: Histological analysis revealed that APA alleviated cartilage and muscle damage compared with the model group.APA inhibited cartilage degeneration by modulating the expression of apoptosis-and autophagy-related proteins and mRNA,thus preventing chondrocyte apoptosis.In the APA group,Bax and mTOR protein levels were significantly lower than those in the model group(both P=.024).Conversely,the Bcl-2 expression level was significantly higher than that in the EA group(P=.035).Additionally,ULK-1 expression was significantly lower than that in the EA group(P=.045).The mRNA level of Bax was significantly higher than that in the blank control group(P<.001).However,Beclin-1 levels were significantly higher than those in both the model and EA groups(both P<.001).ELISA results showed a significant decrease in the concentration ofβ-EP in the brains of the rats in the APA group compared with those in the model group(P=.032).Conclusions: APA reduced osteoarthritis-related pain and alleviated cartilage damage by upregulating chondrocyte autophagy and down-regulating apoptosis via signaling pathways involving PI3K/Akt-mTOR in KOA rats.
基金supported by the Natural Science Foundation of Henan Province(No.222300420596)China Railway Science and Technology Innovation Program Funded Project(CZ02-Special-03)Science and Technology Innovation Project funded by China Railway Tunnel Group(Tunnel Research 2021-03)。
文摘Acoustic emission(AE)source localization is a fundamental element of rock fracture damage imaging.To improve the efficiency and accuracy of AE source localization,this paper proposes a joint method comprising a three-dimensional(3D)AE source localization simplex method and grid search scanning.Using the concept of the geometry of simplexes,tetrahedral iterations were first conducted to narrow down the suspected source region.This is followed by a process of meshing the region and node searching to scan for optimal solutions,until the source location is determined.The resulting algorithm was tested using the artificial excitation source localization and uniaxial compression tests,after which the localization results were compared with the simplex and exhaustive methods.The results revealed that the localization obtained using the proposed method is more stable and can be effectively avoided compared with the simplex localization method.Furthermore,compared with the global scanning method,the proposed method is more efficient,with an average time of 10%–20%of the global scanning localization algorithm.Thus,the proposed algorithm is of great significance for laboratory research focused on locating rupture damages sustained by large-sized rock masses or test blocks.
