Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence rate.The pathogenesis of temporal lobe epilepsy is complex and...Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence rate.The pathogenesis of temporal lobe epilepsy is complex and is not fully understood.Intracellular calcium dynamics have been implicated in temporal lobe epilepsy.However,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving mice.In this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy process.We found that calcium signals varied according to the grade of temporal lobe epilepsy episodes.In particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor seizures.Chemogenetic inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠepisodes.In addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly reduced.Intriguingly,it was possible to rescue the altered intracellular calcium dynamics.Via simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were improved.Our results indicate that the calcium dynamic between CA1 and M1 may reflect specific epileptic behaviors corresponding to different grades.Furthermore,the selective regulation of abnormal calcium signals in CA1 pyramidal neurons appears to effectively alleviate temporal lobe epilepsy,thereby providing a potential molecular mechanism for a new temporal lobe epilepsy diagnosis and treatment strategy.展开更多
Partial epilepsies, originating in a specific brain region, affect about 60% of adults with epilepsy. Temporal lobe epilepsy (TLE) is the most prevalent subtype within this category, often necessitating surgical inter...Partial epilepsies, originating in a specific brain region, affect about 60% of adults with epilepsy. Temporal lobe epilepsy (TLE) is the most prevalent subtype within this category, often necessitating surgical intervention due to its refractoriness to antiepileptic drugs (AEDs). Hippocampal sclerosis, a common underlying pathology, often exacerbates the severity by introducing cognitive and emotional challenges. This review delves deeper into the cognitive profile of TLE, along with the risk factors for cognitive disorders, depression, and anxiety in this population.展开更多
The performance of a newly designed tri-lobe industrial lobe pump of high capacity is simulated by using commercial CFD solver Ansys Fluent. A combination of user-defined-functions and meshing strategies is employed t...The performance of a newly designed tri-lobe industrial lobe pump of high capacity is simulated by using commercial CFD solver Ansys Fluent. A combination of user-defined-functions and meshing strategies is employed to capture the rotation of the lobes. The numerical model is validated by comparing the simulated results with the literature values. The processes of suction, displacement, compression and exhaust are accurately captured in the transient simulation. The fluid pressure value remains in the range of inlet pressure value till the processes of suction and displacement are over. The instantaneous process of compression is accurately captured in the simulation. The movement of a particular working chamber is traced along the gradual degree of lobe’s rotation. At five different degrees of lobe’s rotation, pressure contour plots are reported which clearly shows the pressure values inside the working chamber. Each pressure value inside the working chamber conforms to the particular process in which the working chamber is operating. Finally, the power requirement at the shaft of rotation is estimated from the simulated values. The estimated value of power requirement is 3.61 BHP FHP whereas the same calculated theoretically is 3 BHP FHP. The discrepancy is attributed to the assumption of symmetry of blower along the thickness.展开更多
The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud typ...The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1) More water clouds occur on the Atlantic side, and more ice clouds occur over continents.(2)The average spatial and seasonal distributions of cloud types show three patterns: high clouds and most cumuliform clouds are concentrated in low-latitude locations and peak in summer;altostratus and nimbostratus are concentrated over and around continents and are less abundant in summer;stratocumulus and stratus are concentrated near the inner Arctic and peak during spring and autumn.(3) Regional averaged interannual frequencies of ice clouds and altostratus clouds significantly decrease, while those of water clouds, altocumulus, and cumulus clouds increase significantly.(4) Significant features of the linear trends of cloud frequencies are mainly located over ocean areas.(5) The monthly water cloud frequency anomalies are positively correlated with air temperature in most of the troposphere, while those for ice clouds are negatively correlated.(6) The decrease in altostratus clouds is associated with the weakening of the Arctic front due to Arctic warming, while increased water vapor transport into the Arctic and higher atmospheric instability lead to more cumulus and altocumulus clouds.展开更多
BACKGROUND Hemichorea and other hyperkinetic movement disorders are uncommon present-ations of stroke and are usually secondary to deep infarctions affecting the basal ganglia and thalamus.Therefore,temporal ischemic ...BACKGROUND Hemichorea and other hyperkinetic movement disorders are uncommon present-ations of stroke and are usually secondary to deep infarctions affecting the basal ganglia and thalamus.Therefore,temporal ischemic lesions causing hemichorea are rare.We report the cases of two patients with acute ischemic temporal lobe infarct strokes that presented as hemichorea.CASE SUMMARY Patient 1:An 82-year-old woman presented with a 1-mo history of involuntary movement of the left extremity,which was consistent with hemichorea.Her diffusion-weighted imaging(DWI)revealed an acute ischemic stroke that predominantly affected the right temporal cortex,and magnetic resonance angiography of the head showed significant stenosis of the right middle cerebral artery(MCA).Treatment with 2.5 mg of olanzapine per day was initiated.When she was discharged from the hospital,her symptoms appeared to have improved compared with those previously observed.Twenty-seven days after the first admission,she was readmitted due to acute ischemic stroke.Computed tomogra-phy perfusion showed marked hypoperfusion in the right MCA territory.An emergency transfemoral cerebral angiogram was performed and showed severe stenosis in the M1 segment of the right MCA.After percutaneous transluminal angioplasty was successfully performed,abnormal movements or other neuro-logic problems did not occur.Patient 2:A 76-year-old man was admitted to our hospital for a 7-d history of right-upper-sided involuntary movements.DWI showed an acute patchy ischemic stroke in the left temporal lobe without basal ganglia involvement.Subsequent diffusion tensor imaging confirmed fewer white matter fiber tracts on the left side than on the opposite side.Treatment with 2.5 mg of olanzapine per day improved his condition,and he was discharged.CONCLUSION When acute hemichorea suddenly appears,temporal cortical ischemic stroke should be considered a possible diagnosis.In addition,hemichorea may be a sign of impending cerebral infarction with MCA stenosis.展开更多
Temporal lobe epilepsy is the most common form of focal epilepsy in adults,accounting for one third of all diagnosed epileptic patients,with seizures originating from or involving mesial temporal structures such as th...Temporal lobe epilepsy is the most common form of focal epilepsy in adults,accounting for one third of all diagnosed epileptic patients,with seizures originating from or involving mesial temporal structures such as the hippocampus,and many of these patients being refractory to treatment with anti-epileptic drugs.Temporal lobe epilepsy is the most common childhood neurological disorder and,compared with adults,the symptoms are greatly affected by age and brain development.Diagnosis of temporal lobe epilepsy relies on clinical examination,patient history,electroencephalographic recordings,and brain imaging.Misdiagnosis or delay in diagnosis is common.A molecular biomarker that could distinguish epilepsy from healthy subjects and other neurological conditions would allow for an earlier and more accurate diagnosis and appropriate treatment to be initiated.Among possible biomarkers of pathological changes as well as potential therapeutic targets in the epileptic brain are micro RNAs.Most of the recent studies had performed micro RNA profiling in body fluids such as blood plasma and blood serum and brain tissues such as temporal cortex tissue and hippocampal tissue.A large number of micro RNAs were dysregulated when compared to healthy controls and with some overlap between individual studies that could serve as potential biomarkers.For example,in adults with temporal lobe epilepsy,possible biomarkers are miR-199a-3p in blood plasma and miR-142-5p in blood plasma and blood serum.In adults with mesial temporal lobe epilepsy,possible biomarkers are miR-153 in blood plasma and miR-145-3p in blood serum.However,in many of the studies involving patients who receive one or several anti-epileptic drugs,the influence of these on micro RNA expression in body fluids and brain tissues is largely unknown.Further studies are warranted with children with temporal lobe epilepsy and consideration should be given to utilizing mouse or rat and non-human primate models of temporal lobe epilepsy.The animal models could be used to confirm micro RNA findings in human patients and to test the effects of targeting specific micro RNAs on disease progression and behavior.展开更多
Cognitive impairment is the most common complication in patients with temporal lobe epilepsy with hippocampal scle rosis.There is no effective treatment for cognitive impairment.Medial septum cholinergic neurons have ...Cognitive impairment is the most common complication in patients with temporal lobe epilepsy with hippocampal scle rosis.There is no effective treatment for cognitive impairment.Medial septum cholinergic neurons have been reported to be a potential target for controlling epileptic seizures in tempo ral lobe epile psy.However,their role in the cognitive impairment of temporal lobe epilepsy remains unclear.In this study,we found that patients with temporal lobe epile psy with hippocampal sclerosis had a low memory quotient and severe impairment in verbal memory,but had no impairment in nonverbal memory.The cognitive impairment was slightly correlated with reduced medial septum volume and medial septum-hippocampus tra cts measured by diffusion tensor imaging.In a mouse model of chronic temporal lobe epilepsy induced by kainic acid,the number of medial septum choline rgic neurons was reduced and acetylcholine release was reduced in the hippocampus.Furthermore,selective apoptosis of medial septum cholinergic neurons mimicked the cognitive deficits in epileptic mice,and activation of medial septum cholinergic neurons enhanced hippocampal acetylcholine release and restored cognitive function in both kainic acid-and kindling-induced epile psy models.These res ults suggest that activation of medial septum cholinergic neurons reduces cognitive deficits in temporal lobe epilepsy by increasing acetylcholine release via projections to the hippocampus.展开更多
At present,GNSS-Acoustic(GNSS-A)combined technology is widely used in positioning for seafloor geodetic stations.Based on Sound Velocity Profiles(SVPs)data,the equal gradient acoustic ray-tracing method is applied in ...At present,GNSS-Acoustic(GNSS-A)combined technology is widely used in positioning for seafloor geodetic stations.Based on Sound Velocity Profiles(SVPs)data,the equal gradient acoustic ray-tracing method is applied in high-precision position inversion.However,because of the discreteness of the SVPs used in the forementioned method,it ignores the continuous variation of sound velocity structure in time domain,which worsens the positioning accuracy.In this study,the time-domain variation of Sound Speed Structure(SSS)has been considered,and the cubic B-spline function is applied to characterize the perturbed sound velocity.Based on the ray-tracing theory,an inversion model of“stepwise iteration&progressive corrections”for both positioning and sound speed information is proposed,which conducts the gradual correction of seafloor geodetic station coordinates and disturbed sound velocity.The practical data was used to test the effectiveness of our method.The results show that the Root Mean Square(RMS)errors of the residual values of the traditional methods without sound velocity correction,based on quadratic polynomial correction and based on cubic B-spline function correction are 1.43 ms,0.44 ms and 0.21 ms,respectively.The inversion model with sound velocity correction can effectively eliminate the systematic error caused by the change of SSS,and significantly improve the positioning accuracy of the seafloor geodetic stations.展开更多
Super-resolution(SR)microscopy has dramatically enhanced our understanding of biological processes.However,scattering media in thick specimens severely limits the spatial resolution,often rendering the images unclear ...Super-resolution(SR)microscopy has dramatically enhanced our understanding of biological processes.However,scattering media in thick specimens severely limits the spatial resolution,often rendering the images unclear or indistinguishable.Additionally,live-cell imaging faces challenges in achieving high temporal resolution for fast-moving subcellular structures.Here,we present the principles of a synthetic wave microscopy(SWM)to extract three-dimensional information from thick unlabeled specimens,where photobleaching and phototoxicity are avoided.SWM exploits multiple-wave interferometry to reveal the specimen’s phase information in the area of interest,which is not affected by the scattering media in the optical path.SWM achieves~0.42λ/NA resolution at an imaging speed of up to 106 pixels/s.SWM proves better temporal resolution and sensitivity than the most conventional microscopes currently available while maintaining exceptional SR and anti-scattering capabilities.Penetrating through the scattering media is challenging for conventional imaging techniques.Remarkably,SWM retains its efficacy even in conditions of low signal-to-noise ratios.It facilitates the visualization of dynamic subcellular structures in live cells,encompassing tubular endoplasmic reticulum(ER),lipid droplets,mitochondria,and lysosomes.展开更多
Background: Improving the mechanical properties and angiogenesis of acellular scaffolds before transplantation is an important challenge facing the development of acellular liver grafts. The present study aimed to eva...Background: Improving the mechanical properties and angiogenesis of acellular scaffolds before transplantation is an important challenge facing the development of acellular liver grafts. The present study aimed to evaluate the cytotoxicity and angiogenesis of polyethylene glycol(PEG) crosslinked decellularized single liver lobe scaffolds(DLSs), and establish its suitability as a graft for long-term liver tissue engineering. Methods: Using mercaptoacrylate produced by the Michael addition reaction, DLSs were first modified using N-succinimidyl S-acetylthioacetate(SATA), followed by cross-linking with PEG as well as vascular endothelial growth factor(VEGF). The optimal concentration of agents and time of the individual steps were identified in this procedure through biomechanical testing and morphological analysis. Subsequently, human umbilical vein endothelial cells(HUVECs) were seeded on the PEG crosslinked scaffolds to detect the proliferation and viability of cells. The scaffolds were then transplanted into the subcutaneous tissue of Sprague-Dawley rats to evaluate angiogenesis. In addition, the average number of blood vessels was evaluated in the grafts with or without PEG at days 7, 14, and 21 after implantation. Results: The PEG crosslinked DLS maintained their three-dimensional structure and were more translucent after decellularization than native DLS, which presented a denser and more porous network structure. The results for Young’s modulus proved that the mechanical properties of 0.5 PEG crosslinked DLS were the best and close to that of native livers. The PEG-VEGF-DLS could better promote cell proliferation and differentiation of HUVECs compared with the groups without PEG cross-linking. Importantly, the average density of blood vessels was higher in the PEG-VEGF-DLS than that in other groups at days 7, 14, and 21 after implantation in vivo. Conclusions: The PEG crosslinked DLS with VEGF could improve the biomechanical properties of native DLS, and most importantly, their lack of cytotoxicity provides a new route to promote the proliferation of cells in vitro and angiogenesis in vivo in liver tissue engineering.展开更多
The human brain is known to be influenced by environmental stimuli(Feeney et al.,1982;Kaplan,1988).Therefore,research on the brain activation pattern by external stimuli has been an important topic in neuroscience(Kap...The human brain is known to be influenced by environmental stimuli(Feeney et al.,1982;Kaplan,1988).Therefore,research on the brain activation pattern by external stimuli has been an important topic in neuroscience(Kaplan,1988).Chewing gum has been known to have a positive effect on cognition,including alertness,attention,cognitive processing speed,展开更多
Background: Knowledge of temporal evolution of preeclampsia (PE) in its various aspects is essential in strategies to reduce maternal and perinatal morbidity and mortality. Preeclampsia is a public health problem due ...Background: Knowledge of temporal evolution of preeclampsia (PE) in its various aspects is essential in strategies to reduce maternal and perinatal morbidity and mortality. Preeclampsia is a public health problem due to maternal mortality associated with it worldwide (5.6%). Improving quality of its management is a major challenge in low-income countries where, despite progress made in this field, PE remains a major factor in maternal morbidity and mortality. Objective: To evaluate temporal evolution of frequency, risk factors and complications of PE at the University clinics of Kinshasa (UCK). Methods: Descriptive and cross-sectional study concerning minimum simple size of 119 pregnant women who consulted for antenatal care at the University clinics of Kinshasa from January 2012 to December 2022. Results will be reported as percentage proportion, mean and standard deviation. Comparison of proportion and means between groups will be made using Student’s t-test and Pearson’s chi-square test, respectively. The test will be statistically significant for a p value ≤ less than 0.05. Data will be collected and analysed anonymously and confidentially. Conclusion: This study will allow us to evaluate the effectiveness of different prevention and treatment modalities used over time in management of preeclampsia in our setting.展开更多
Purpose:Our study aims to compare speech understanding in noise and spectral-temporal resolution skills with regard to the degree of hearing loss,age,hearing aid use experience and gender of hearing aid users.Methods:...Purpose:Our study aims to compare speech understanding in noise and spectral-temporal resolution skills with regard to the degree of hearing loss,age,hearing aid use experience and gender of hearing aid users.Methods:Our study included sixty-eight hearing aid users aged between 40-70 years,with bilateral mild and moderate symmetrical sensorineural hearing loss.Random gap detection test,Turkish matrix test and spectral-temporally modulated ripple test were implemented on the participants with bilateral hearing aids.The test results acquired were compared statistically according to different variables and the correlations were examined.Results:No statistically significant differences were observed for speech-in-noise recognition,spectraltemporal resolution among older and younger adults in hearing aid users(p>0.05).There wasn’t found a statistically significant difference among test outcomes as regards different hearing loss degrees(p>0.05).Higher performances were obtained in terms of temporal resolution in male participants and participants with more hearing aid use experience(p<0.05).Significant correlations were obtained between the results of speech-in-noise recognition,temporal resolution and spectral resolution tests performed with hearing aids(p<0.05).Conclusion:Our study findings emphasized the importance of regular hearing aid use and it showed that some auditory skills can be improved with hearing aids.Observation of correlations among the speechin-noise recognition,temporal resolution and spectral resolution tests have revealed that these skills should be evaluated as a whole to maximize the patient’s communication abilities.展开更多
Protecting the ecological security of the Qinghai-Tibet Plateau(QTP)is of great importance for global ecology and climate.Over the past few decades,climate extremes have posed a significant challenge to the ecological...Protecting the ecological security of the Qinghai-Tibet Plateau(QTP)is of great importance for global ecology and climate.Over the past few decades,climate extremes have posed a significant challenge to the ecological environment of the QTP.However,there are few studies that explored the effects of climate extremes on ecological environment quality of the QTP,and few researchers have made quantitative analysis.Hereby,this paper proposed the Ecological Environmental Quality Index(EEQI)for analyzing the spatial and temporal variation of ecological environment quality on the QTP from 2000 to 2020,and explored the effects of climate extremes on EEQI based on Geographically and Temporally Weighted Regression(GTWR)model.The results showed that the ecological environment quality in QTP was poor in the west,but good in the east.Between 2000 and 2020,the area of EEQI variation was large(34.61%of the total area),but the intensity of EEQI variation was relatively low and occurred mainly by a slightly increasing level(EEQI change range of 0.05-0.1).The overall ecological environment quality of the QTP exhibited spatial and temporal fluctuations,which may be attributed to climate extremes.Significant spatial heterogeneity was observed in the effects of the climate extremes on ecological environment quality.Specifically,the effects of daily temperature range(DTR),number of frost days(FD0),maximum 5-day precipitation(RX5day),and moderate precipitation days(R10)on ecological environment quality were positive in most regions.Furthermore,there were significant temporal differences in the effects of consecutive dry days(CDD),consecutive wet days(CWD),R10,and FD0 on ecological environment quality.These differences may be attributed to variances in ecological environment quality,climate extremes,and vegetation types across different regions.In conclusion,the impact of climate extremes on ecological environment quality exhibits complex patterns.These findings will assist managers in identifying changes in the ecological environment quality of the QTP and addressing the effects of climate extremes.展开更多
Climate change has resulted in serious social-economic ramifications and extremely catastrophic weather events in the world, Tanzania and Zanzibar in particular, with adaptation being the only option to reduce impacts...Climate change has resulted in serious social-economic ramifications and extremely catastrophic weather events in the world, Tanzania and Zanzibar in particular, with adaptation being the only option to reduce impacts. The study focuses on the influence of climate change and variability on spatio-temporal rainfall and temperature variability and distribution in Zanzibar. The station observation datasets of rainfall, T<sub>max</sub> and T<sub>min</sub> acquired from Tanzania Meteorological Authority (TMA) and the Coordinated Regional Climate Downscaling Experiment program (CORDEX) projected datasets from the Regional climate model HIRHAM5 under driving model ICHEC-EC-EARH, for the three periods of 1991-2020 used as baseline (HS), 2021-2050 as near future (NF) and 2051-2080 far future (FF), under two representative concentration pathways (RCP) of 4.5 and 8.5, were used. The long-term observed T<sub>max</sub> and T<sub>min</sub> were used to produce time series for observing the nature and trends, while the observed rainfall data was used for understanding wet and dry periods, trends and slope (at p ≤ 0.05) using the Standardized Precipitation Index (SPI) and the Mann Kendall test (MK). Moreover, the Quantum Geographic Information System (QGIS) under the Inverse Distance Weighting (IDW) interpolation techniques were used for mapping the three decades of 1991-2000 (hereafter D1), 2001-2010 (hereafter D2) and 2011-2020 (hereafter D3) to analyze periodical spatial rainfall distribution in Zanzibar. As for the projected datasets the Climate Data Operator Commands (CDO), python scripts and Grid analysis and Display System (GrADS) soft-wares were used to process and display the results of the projected datasets of rainfall, T<sub>max</sub> and T<sub>min</sub> for the HS, NF and FF, respectively. The results show that the observed T<sub>max</sub> increased by the rates of 0.035℃ yr<sup>-</sup><sup>1</sup> and 0.0169℃ yr<sup>-</sup><sup>1</sup>, while the T<sub>min</sub> was increased by a rate of 0.064℃ yr<sup>-</sup><sup>1</sup> and 0.104℃ yr<sup>-</sup><sup>1</sup> for Unguja and Pemba, respectively. The temporal distribution of wetness and dryness indices showed a climate shift from near normal to moderate wet during 2005 at Zanzibar Airport, while normal to moderately dry conditions, were observed in Pemba at Matangatuani. The decadal rainfall variability and distributions revealed higher rainfall intensity with an increasing trend and good spatial distribution in D3 from March to May (MAM) and October to December (OND). The projected results for T<sub>max</sub> during MAM and OND depicted higher values ranging from 1.7℃ - 1.8℃ to 1.9℃ - 2.0℃ and 1.5℃ to 2.0℃ in FF compared to NF under both RCPs. Also, higher T<sub>min</sub> values of 1.12℃ - 1.16℃ was projected in FF for MAM and OND under both RCPs. Besides, the rainfall projection generally revealed increased rainfall intensity in the range of 0 - 25 mm for Pemba and declined rainfall in the range of 25 - 50 mm in Unguja under both RCPs in perspectives of both NF and FF. Conclusively the study has shown that the undergoing climate change has posed a significant impact on both rainfall and temperature spatial and temporal distributions in Zanzibar (Unguja and Pemba), with Unguja being projected to have higher rainfall deficits while increasing rainfall strengths in Pemba. Thus, the study calls for more studies and formulation of effective adaptation, strategies and resilience mechanisms to combat the projected climate change impacts especially in the agricultural sector, water and food security.展开更多
Water resources are one of the key factors restricting the development of arid areas,and cloud water resources is an important part of water resources.The arid region of central Asia is the core region of the current ...Water resources are one of the key factors restricting the development of arid areas,and cloud water resources is an important part of water resources.The arid region of central Asia is the core region of the current national green silk road construction,and is the largest arid region in the world.Based on cloud cover data of ECMWF,the current study analyzed temporal and spatial characteristics of cloud properties in arid regions of Central Asia between 1980 and 2019.Our findings show that:(1)From the point of view of spatial distribution,total cloudiness in arid regions of Central Asia was low in the south and high in the north.The distribution of high cloud frequency and medium cloud frequency was higher in the south and lower in the north,while low cloud frequency distribution was low in the south and high in the north.(2)In terms of time,the variation of cloud cover and cloud type frequency had obvious seasonal characteristics.From winter to spring,cloud cover increased,and the change of cloud type frequency increased.From spring to summer,cloud cover continued to increase and the change of cloud type frequency increased further.Cloud cover began to decrease from summer to autumn,and the change of cloud type frequency also decreased.(3)Generally,average total cloud cover decreased in most of central Asia,and high and medium cloud cover increased while low cloud cover decreased.This study provides a reference for the rational development of cloud resources in the region.展开更多
The preceding and succeeding precipitation(PSP)often act together with extreme precipitation(EP),in turn,causing floods,which is an objective component that is often overlooked with regard to summer flood hazards in t...The preceding and succeeding precipitation(PSP)often act together with extreme precipitation(EP),in turn,causing floods,which is an objective component that is often overlooked with regard to summer flood hazards in the arid region of Northwest China.In this study,event-based extreme precipitation(EEP)was defined as continuous precipitation that includes at least one day of EP.We analyzed the spatiotemporal variation characteristics of four EEP types(front EEP,late EEP,balanced EEP,and single day EEP)across the Loess Plateau(LP)based on data acquired from 87 meteorological stations from 1960 to 2019.Precipitation on the LP basically maintained a spatial pattern of"low in the northwest region and high in the southeast region",and EP over the last 10 a increased significantly.The cumulative precipitation percentage of single day EEP was 34%and was dominant for 60 a,while the cumulative precipitation percentage of front,late,and balanced EEP types associated with PSP accounted for 66%,which confirms to the connotation of EEP.The cumulative frequencies of front and late EEP types were 23%and 21%,respectively,while the cumulative frequency of balanced EEP had the lowest value at only 13%.Moreover,global warming could lead to more single day EEP across the LP,and continuous EEP could increase in the northwestern region and decrease in the eastern region in the future.The concept of process-oriented EP could facilitate further exploration of disaster-causing processes associated with different types of EP,and provide a theoretical basis for deriving precipitation disaster chains and construction of disaster cluster characteristics.展开更多
Temporal bone malignant tumors are characterized by atypical clinical symptoms,and easy recurrence and metastasis.They account for 0.2%of head and neck tumors,and the most common pathological type is squamous cell car...Temporal bone malignant tumors are characterized by atypical clinical symptoms,and easy recurrence and metastasis.They account for 0.2%of head and neck tumors,and the most common pathological type is squamous cell carcinoma.Patients with squamous cell carcinoma of the temporal bone are often at advanced stages when diagnosed,and lose the chance for surgery.Neoadjuvant immunotherapy has recently been approved as the first-line treatment for refractory recurrent/metastatic squamous cell carcinoma of the head and neck.However,it remains to be determined whether neoadjuvant immunotherapy can be used as the first-line treatment for temporal bone squamous cell carcinoma to reduce the tumor stage before surgery,or as a palliative treatment for patients with unresectable advanced stage carcinoma.The present study reviews the development of immunotherapy and its clinical application in head and neck squamous cell carcinoma,summarizes the treatment of temporal bone squamous cell carcinoma,and prospects the neoadjuvant immunotherapy as the first-line treatment for temporal bone squamous cell carcinoma.展开更多
Mandarin在(pinyin:zài)is the most frequently used character in representing spatial and temporal relationship.Current studies mostly focus on its lexical meaning and syntactic structure while cognitive features o...Mandarin在(pinyin:zài)is the most frequently used character in representing spatial and temporal relationship.Current studies mostly focus on its lexical meaning and syntactic structure while cognitive features of its grammatical categories have been neglected.This paper investigates into the categorization of zài by conducting a morphosyntactic test among College English majors in China.The results show that:prototypes are organizing the grammatical categories of zài at all levels in terms of intra-categorial gradience;the semantic construal of zài construction could significantly influence the accuracy of the grammatical categorization of zài;the syntactic structure can provide viable cue for the identification of grammatical categories of zài;spatiality,temporality and the status of existing are three essential semantic features encoded by zài,the concurrence of which leads to various degree of inter-categorial vagueness,indicating a conflict between the rigid grammatical classification and the indeterminate nature of the grammatical functions of zai,suggesting the necessity to reconsider the efficacy of applying indiscriminately the Anglo-Saxon grammar into the study of Chinese spatial-temporal constructions.展开更多
The CO_(2)effl ux of branches and leaves plays an important role in ecosystem carbon balance.Using a carbon fl ux system,the effl ux of Larix gmelinii var.principisrupprechtii(Dahurian larch)was investigated in 27 yea...The CO_(2)effl ux of branches and leaves plays an important role in ecosystem carbon balance.Using a carbon fl ux system,the effl ux of Larix gmelinii var.principisrupprechtii(Dahurian larch)was investigated in 27 years(immature),31 years(near-mature),and 47 years(mature)stands at diurnal,seasonal,and spatial scales(direction and height)as well as its connection with environmental factors from May to October 2020.Diurnal variation in effl ux was a single peak,and the maximum occurring between 14:00 and 16:00.Seasonal variation also exhibited a single peak,with the maximum in late July and the minimum in early October.From May to September,effl ux on the south side was the largest among the three stands,and mean values on the south side of 27 year-old,31 year-old,and 47 year-old trees were 0.50,0.97 and 1.05μmol·m^(–2)·s^(–1),respectively.The minimum occurred on the north side.Except for the maximum in July and September in the 27 year-old stand in the middle of the canopy,the maximum effl ux in the upper canopy,and the means in the 27 year-old,31 year-old,and 47 year-old stands were 0.49,0.96 and 1.04μmol·m^(-2)·s^(-1),respectively;the minimum occurred in the lower canopy.Temperatures and relative humidity infl uenced seasonal variations in effl ux.Seasonal variation in temperature sensitivity coeffi cient(Q 10)was opposite that of temperature,increasing with decreasing temperature.At the spatial scale,maximum Q 10 occurred in the mid canopy.With the effl ux and temperature data in diff erent locations,it is possible to better estimate effl ux variations in each stand.展开更多
基金supported by the National Natural Science Foundation of China,Nos.62027812(to HS),81771470(to HS),and 82101608(to YL)Tianjin Postgraduate Research and Innovation Project,No.2020YJSS122(to XD)。
文摘Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence rate.The pathogenesis of temporal lobe epilepsy is complex and is not fully understood.Intracellular calcium dynamics have been implicated in temporal lobe epilepsy.However,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving mice.In this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy process.We found that calcium signals varied according to the grade of temporal lobe epilepsy episodes.In particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor seizures.Chemogenetic inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠepisodes.In addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly reduced.Intriguingly,it was possible to rescue the altered intracellular calcium dynamics.Via simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were improved.Our results indicate that the calcium dynamic between CA1 and M1 may reflect specific epileptic behaviors corresponding to different grades.Furthermore,the selective regulation of abnormal calcium signals in CA1 pyramidal neurons appears to effectively alleviate temporal lobe epilepsy,thereby providing a potential molecular mechanism for a new temporal lobe epilepsy diagnosis and treatment strategy.
文摘Partial epilepsies, originating in a specific brain region, affect about 60% of adults with epilepsy. Temporal lobe epilepsy (TLE) is the most prevalent subtype within this category, often necessitating surgical intervention due to its refractoriness to antiepileptic drugs (AEDs). Hippocampal sclerosis, a common underlying pathology, often exacerbates the severity by introducing cognitive and emotional challenges. This review delves deeper into the cognitive profile of TLE, along with the risk factors for cognitive disorders, depression, and anxiety in this population.
文摘The performance of a newly designed tri-lobe industrial lobe pump of high capacity is simulated by using commercial CFD solver Ansys Fluent. A combination of user-defined-functions and meshing strategies is employed to capture the rotation of the lobes. The numerical model is validated by comparing the simulated results with the literature values. The processes of suction, displacement, compression and exhaust are accurately captured in the transient simulation. The fluid pressure value remains in the range of inlet pressure value till the processes of suction and displacement are over. The instantaneous process of compression is accurately captured in the simulation. The movement of a particular working chamber is traced along the gradual degree of lobe’s rotation. At five different degrees of lobe’s rotation, pressure contour plots are reported which clearly shows the pressure values inside the working chamber. Each pressure value inside the working chamber conforms to the particular process in which the working chamber is operating. Finally, the power requirement at the shaft of rotation is estimated from the simulated values. The estimated value of power requirement is 3.61 BHP FHP whereas the same calculated theoretically is 3 BHP FHP. The discrepancy is attributed to the assumption of symmetry of blower along the thickness.
基金supported in part by the National Natural Science Foundation of China (Grant No. 42105127)the Special Research Assistant Project of the Chinese Academy of Sciencesthe National Key Research and Development Plans of China (Grant Nos. 2019YFC1510304 and 2016YFE0201900-02)。
文摘The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 2017 is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1) More water clouds occur on the Atlantic side, and more ice clouds occur over continents.(2)The average spatial and seasonal distributions of cloud types show three patterns: high clouds and most cumuliform clouds are concentrated in low-latitude locations and peak in summer;altostratus and nimbostratus are concentrated over and around continents and are less abundant in summer;stratocumulus and stratus are concentrated near the inner Arctic and peak during spring and autumn.(3) Regional averaged interannual frequencies of ice clouds and altostratus clouds significantly decrease, while those of water clouds, altocumulus, and cumulus clouds increase significantly.(4) Significant features of the linear trends of cloud frequencies are mainly located over ocean areas.(5) The monthly water cloud frequency anomalies are positively correlated with air temperature in most of the troposphere, while those for ice clouds are negatively correlated.(6) The decrease in altostratus clouds is associated with the weakening of the Arctic front due to Arctic warming, while increased water vapor transport into the Arctic and higher atmospheric instability lead to more cumulus and altocumulus clouds.
文摘BACKGROUND Hemichorea and other hyperkinetic movement disorders are uncommon present-ations of stroke and are usually secondary to deep infarctions affecting the basal ganglia and thalamus.Therefore,temporal ischemic lesions causing hemichorea are rare.We report the cases of two patients with acute ischemic temporal lobe infarct strokes that presented as hemichorea.CASE SUMMARY Patient 1:An 82-year-old woman presented with a 1-mo history of involuntary movement of the left extremity,which was consistent with hemichorea.Her diffusion-weighted imaging(DWI)revealed an acute ischemic stroke that predominantly affected the right temporal cortex,and magnetic resonance angiography of the head showed significant stenosis of the right middle cerebral artery(MCA).Treatment with 2.5 mg of olanzapine per day was initiated.When she was discharged from the hospital,her symptoms appeared to have improved compared with those previously observed.Twenty-seven days after the first admission,she was readmitted due to acute ischemic stroke.Computed tomogra-phy perfusion showed marked hypoperfusion in the right MCA territory.An emergency transfemoral cerebral angiogram was performed and showed severe stenosis in the M1 segment of the right MCA.After percutaneous transluminal angioplasty was successfully performed,abnormal movements or other neuro-logic problems did not occur.Patient 2:A 76-year-old man was admitted to our hospital for a 7-d history of right-upper-sided involuntary movements.DWI showed an acute patchy ischemic stroke in the left temporal lobe without basal ganglia involvement.Subsequent diffusion tensor imaging confirmed fewer white matter fiber tracts on the left side than on the opposite side.Treatment with 2.5 mg of olanzapine per day improved his condition,and he was discharged.CONCLUSION When acute hemichorea suddenly appears,temporal cortical ischemic stroke should be considered a possible diagnosis.In addition,hemichorea may be a sign of impending cerebral infarction with MCA stenosis.
文摘Temporal lobe epilepsy is the most common form of focal epilepsy in adults,accounting for one third of all diagnosed epileptic patients,with seizures originating from or involving mesial temporal structures such as the hippocampus,and many of these patients being refractory to treatment with anti-epileptic drugs.Temporal lobe epilepsy is the most common childhood neurological disorder and,compared with adults,the symptoms are greatly affected by age and brain development.Diagnosis of temporal lobe epilepsy relies on clinical examination,patient history,electroencephalographic recordings,and brain imaging.Misdiagnosis or delay in diagnosis is common.A molecular biomarker that could distinguish epilepsy from healthy subjects and other neurological conditions would allow for an earlier and more accurate diagnosis and appropriate treatment to be initiated.Among possible biomarkers of pathological changes as well as potential therapeutic targets in the epileptic brain are micro RNAs.Most of the recent studies had performed micro RNA profiling in body fluids such as blood plasma and blood serum and brain tissues such as temporal cortex tissue and hippocampal tissue.A large number of micro RNAs were dysregulated when compared to healthy controls and with some overlap between individual studies that could serve as potential biomarkers.For example,in adults with temporal lobe epilepsy,possible biomarkers are miR-199a-3p in blood plasma and miR-142-5p in blood plasma and blood serum.In adults with mesial temporal lobe epilepsy,possible biomarkers are miR-153 in blood plasma and miR-145-3p in blood serum.However,in many of the studies involving patients who receive one or several anti-epileptic drugs,the influence of these on micro RNA expression in body fluids and brain tissues is largely unknown.Further studies are warranted with children with temporal lobe epilepsy and consideration should be given to utilizing mouse or rat and non-human primate models of temporal lobe epilepsy.The animal models could be used to confirm micro RNA findings in human patients and to test the effects of targeting specific micro RNAs on disease progression and behavior.
基金National Natural Science Foundation of China,Nos.82003 729 (to Ying W),82022071 (to YiW)Natural Science Foundation of Shandong Province of China,No.ZR2020QH357 (to Ying W)Public Welfare Technology Research Program of Zhejiang Province,No.LGF20H09001 1 (to JF)。
文摘Cognitive impairment is the most common complication in patients with temporal lobe epilepsy with hippocampal scle rosis.There is no effective treatment for cognitive impairment.Medial septum cholinergic neurons have been reported to be a potential target for controlling epileptic seizures in tempo ral lobe epile psy.However,their role in the cognitive impairment of temporal lobe epilepsy remains unclear.In this study,we found that patients with temporal lobe epile psy with hippocampal sclerosis had a low memory quotient and severe impairment in verbal memory,but had no impairment in nonverbal memory.The cognitive impairment was slightly correlated with reduced medial septum volume and medial septum-hippocampus tra cts measured by diffusion tensor imaging.In a mouse model of chronic temporal lobe epilepsy induced by kainic acid,the number of medial septum choline rgic neurons was reduced and acetylcholine release was reduced in the hippocampus.Furthermore,selective apoptosis of medial septum cholinergic neurons mimicked the cognitive deficits in epileptic mice,and activation of medial septum cholinergic neurons enhanced hippocampal acetylcholine release and restored cognitive function in both kainic acid-and kindling-induced epile psy models.These res ults suggest that activation of medial septum cholinergic neurons reduces cognitive deficits in temporal lobe epilepsy by increasing acetylcholine release via projections to the hippocampus.
基金National Natural Science Foundation of China(Nos.41931076,42174020)Laoshan Laboratory(No.LSKJ202205101)State Key Laboratory of Geo-Information Engineering(No.SKLGIE2020-M-1-1)。
文摘At present,GNSS-Acoustic(GNSS-A)combined technology is widely used in positioning for seafloor geodetic stations.Based on Sound Velocity Profiles(SVPs)data,the equal gradient acoustic ray-tracing method is applied in high-precision position inversion.However,because of the discreteness of the SVPs used in the forementioned method,it ignores the continuous variation of sound velocity structure in time domain,which worsens the positioning accuracy.In this study,the time-domain variation of Sound Speed Structure(SSS)has been considered,and the cubic B-spline function is applied to characterize the perturbed sound velocity.Based on the ray-tracing theory,an inversion model of“stepwise iteration&progressive corrections”for both positioning and sound speed information is proposed,which conducts the gradual correction of seafloor geodetic station coordinates and disturbed sound velocity.The practical data was used to test the effectiveness of our method.The results show that the Root Mean Square(RMS)errors of the residual values of the traditional methods without sound velocity correction,based on quadratic polynomial correction and based on cubic B-spline function correction are 1.43 ms,0.44 ms and 0.21 ms,respectively.The inversion model with sound velocity correction can effectively eliminate the systematic error caused by the change of SSS,and significantly improve the positioning accuracy of the seafloor geodetic stations.
基金support from CAS West Light Grant (xbzgzdsys-202206)National Key Research and Development Program of China (2021YFA1401003).
文摘Super-resolution(SR)microscopy has dramatically enhanced our understanding of biological processes.However,scattering media in thick specimens severely limits the spatial resolution,often rendering the images unclear or indistinguishable.Additionally,live-cell imaging faces challenges in achieving high temporal resolution for fast-moving subcellular structures.Here,we present the principles of a synthetic wave microscopy(SWM)to extract three-dimensional information from thick unlabeled specimens,where photobleaching and phototoxicity are avoided.SWM exploits multiple-wave interferometry to reveal the specimen’s phase information in the area of interest,which is not affected by the scattering media in the optical path.SWM achieves~0.42λ/NA resolution at an imaging speed of up to 106 pixels/s.SWM proves better temporal resolution and sensitivity than the most conventional microscopes currently available while maintaining exceptional SR and anti-scattering capabilities.Penetrating through the scattering media is challenging for conventional imaging techniques.Remarkably,SWM retains its efficacy even in conditions of low signal-to-noise ratios.It facilitates the visualization of dynamic subcellular structures in live cells,encompassing tubular endoplasmic reticulum(ER),lipid droplets,mitochondria,and lysosomes.
基金supported by grants from Natural Science Foundation of Zhejiang Province (LY20H180011)National Natural Science Foundation of China (81970653)Medical and Health Science and Technology project of Zhejiang (2016KYA061)
文摘Background: Improving the mechanical properties and angiogenesis of acellular scaffolds before transplantation is an important challenge facing the development of acellular liver grafts. The present study aimed to evaluate the cytotoxicity and angiogenesis of polyethylene glycol(PEG) crosslinked decellularized single liver lobe scaffolds(DLSs), and establish its suitability as a graft for long-term liver tissue engineering. Methods: Using mercaptoacrylate produced by the Michael addition reaction, DLSs were first modified using N-succinimidyl S-acetylthioacetate(SATA), followed by cross-linking with PEG as well as vascular endothelial growth factor(VEGF). The optimal concentration of agents and time of the individual steps were identified in this procedure through biomechanical testing and morphological analysis. Subsequently, human umbilical vein endothelial cells(HUVECs) were seeded on the PEG crosslinked scaffolds to detect the proliferation and viability of cells. The scaffolds were then transplanted into the subcutaneous tissue of Sprague-Dawley rats to evaluate angiogenesis. In addition, the average number of blood vessels was evaluated in the grafts with or without PEG at days 7, 14, and 21 after implantation. Results: The PEG crosslinked DLS maintained their three-dimensional structure and were more translucent after decellularization than native DLS, which presented a denser and more porous network structure. The results for Young’s modulus proved that the mechanical properties of 0.5 PEG crosslinked DLS were the best and close to that of native livers. The PEG-VEGF-DLS could better promote cell proliferation and differentiation of HUVECs compared with the groups without PEG cross-linking. Importantly, the average density of blood vessels was higher in the PEG-VEGF-DLS than that in other groups at days 7, 14, and 21 after implantation in vivo. Conclusions: The PEG crosslinked DLS with VEGF could improve the biomechanical properties of native DLS, and most importantly, their lack of cytotoxicity provides a new route to promote the proliferation of cells in vitro and angiogenesis in vivo in liver tissue engineering.
基金supported by the Medical Research Center Program(2015R1A5A2009124)through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning
文摘The human brain is known to be influenced by environmental stimuli(Feeney et al.,1982;Kaplan,1988).Therefore,research on the brain activation pattern by external stimuli has been an important topic in neuroscience(Kaplan,1988).Chewing gum has been known to have a positive effect on cognition,including alertness,attention,cognitive processing speed,
文摘Background: Knowledge of temporal evolution of preeclampsia (PE) in its various aspects is essential in strategies to reduce maternal and perinatal morbidity and mortality. Preeclampsia is a public health problem due to maternal mortality associated with it worldwide (5.6%). Improving quality of its management is a major challenge in low-income countries where, despite progress made in this field, PE remains a major factor in maternal morbidity and mortality. Objective: To evaluate temporal evolution of frequency, risk factors and complications of PE at the University clinics of Kinshasa (UCK). Methods: Descriptive and cross-sectional study concerning minimum simple size of 119 pregnant women who consulted for antenatal care at the University clinics of Kinshasa from January 2012 to December 2022. Results will be reported as percentage proportion, mean and standard deviation. Comparison of proportion and means between groups will be made using Student’s t-test and Pearson’s chi-square test, respectively. The test will be statistically significant for a p value ≤ less than 0.05. Data will be collected and analysed anonymously and confidentially. Conclusion: This study will allow us to evaluate the effectiveness of different prevention and treatment modalities used over time in management of preeclampsia in our setting.
文摘Purpose:Our study aims to compare speech understanding in noise and spectral-temporal resolution skills with regard to the degree of hearing loss,age,hearing aid use experience and gender of hearing aid users.Methods:Our study included sixty-eight hearing aid users aged between 40-70 years,with bilateral mild and moderate symmetrical sensorineural hearing loss.Random gap detection test,Turkish matrix test and spectral-temporally modulated ripple test were implemented on the participants with bilateral hearing aids.The test results acquired were compared statistically according to different variables and the correlations were examined.Results:No statistically significant differences were observed for speech-in-noise recognition,spectraltemporal resolution among older and younger adults in hearing aid users(p>0.05).There wasn’t found a statistically significant difference among test outcomes as regards different hearing loss degrees(p>0.05).Higher performances were obtained in terms of temporal resolution in male participants and participants with more hearing aid use experience(p<0.05).Significant correlations were obtained between the results of speech-in-noise recognition,temporal resolution and spectral resolution tests performed with hearing aids(p<0.05).Conclusion:Our study findings emphasized the importance of regular hearing aid use and it showed that some auditory skills can be improved with hearing aids.Observation of correlations among the speechin-noise recognition,temporal resolution and spectral resolution tests have revealed that these skills should be evaluated as a whole to maximize the patient’s communication abilities.
基金funded by the key R&D project of the Sichuan Provincial Department of Science and Technology,“Research and Application of Key Technologies for Agricultural Drought Monitoring in Tibet Based on Multi-source Remote Sensing Data”(2021YFQ0042)Tibet Autonomous Region Science and Technology Support Plan Project“Construction and Demonstration Application of Ecological Environment Monitoring Technology System in Tibet Based on Three-Dimensional Remote Sensing Observation Network”(XZ201901-GA-07)。
文摘Protecting the ecological security of the Qinghai-Tibet Plateau(QTP)is of great importance for global ecology and climate.Over the past few decades,climate extremes have posed a significant challenge to the ecological environment of the QTP.However,there are few studies that explored the effects of climate extremes on ecological environment quality of the QTP,and few researchers have made quantitative analysis.Hereby,this paper proposed the Ecological Environmental Quality Index(EEQI)for analyzing the spatial and temporal variation of ecological environment quality on the QTP from 2000 to 2020,and explored the effects of climate extremes on EEQI based on Geographically and Temporally Weighted Regression(GTWR)model.The results showed that the ecological environment quality in QTP was poor in the west,but good in the east.Between 2000 and 2020,the area of EEQI variation was large(34.61%of the total area),but the intensity of EEQI variation was relatively low and occurred mainly by a slightly increasing level(EEQI change range of 0.05-0.1).The overall ecological environment quality of the QTP exhibited spatial and temporal fluctuations,which may be attributed to climate extremes.Significant spatial heterogeneity was observed in the effects of the climate extremes on ecological environment quality.Specifically,the effects of daily temperature range(DTR),number of frost days(FD0),maximum 5-day precipitation(RX5day),and moderate precipitation days(R10)on ecological environment quality were positive in most regions.Furthermore,there were significant temporal differences in the effects of consecutive dry days(CDD),consecutive wet days(CWD),R10,and FD0 on ecological environment quality.These differences may be attributed to variances in ecological environment quality,climate extremes,and vegetation types across different regions.In conclusion,the impact of climate extremes on ecological environment quality exhibits complex patterns.These findings will assist managers in identifying changes in the ecological environment quality of the QTP and addressing the effects of climate extremes.
文摘Climate change has resulted in serious social-economic ramifications and extremely catastrophic weather events in the world, Tanzania and Zanzibar in particular, with adaptation being the only option to reduce impacts. The study focuses on the influence of climate change and variability on spatio-temporal rainfall and temperature variability and distribution in Zanzibar. The station observation datasets of rainfall, T<sub>max</sub> and T<sub>min</sub> acquired from Tanzania Meteorological Authority (TMA) and the Coordinated Regional Climate Downscaling Experiment program (CORDEX) projected datasets from the Regional climate model HIRHAM5 under driving model ICHEC-EC-EARH, for the three periods of 1991-2020 used as baseline (HS), 2021-2050 as near future (NF) and 2051-2080 far future (FF), under two representative concentration pathways (RCP) of 4.5 and 8.5, were used. The long-term observed T<sub>max</sub> and T<sub>min</sub> were used to produce time series for observing the nature and trends, while the observed rainfall data was used for understanding wet and dry periods, trends and slope (at p ≤ 0.05) using the Standardized Precipitation Index (SPI) and the Mann Kendall test (MK). Moreover, the Quantum Geographic Information System (QGIS) under the Inverse Distance Weighting (IDW) interpolation techniques were used for mapping the three decades of 1991-2000 (hereafter D1), 2001-2010 (hereafter D2) and 2011-2020 (hereafter D3) to analyze periodical spatial rainfall distribution in Zanzibar. As for the projected datasets the Climate Data Operator Commands (CDO), python scripts and Grid analysis and Display System (GrADS) soft-wares were used to process and display the results of the projected datasets of rainfall, T<sub>max</sub> and T<sub>min</sub> for the HS, NF and FF, respectively. The results show that the observed T<sub>max</sub> increased by the rates of 0.035℃ yr<sup>-</sup><sup>1</sup> and 0.0169℃ yr<sup>-</sup><sup>1</sup>, while the T<sub>min</sub> was increased by a rate of 0.064℃ yr<sup>-</sup><sup>1</sup> and 0.104℃ yr<sup>-</sup><sup>1</sup> for Unguja and Pemba, respectively. The temporal distribution of wetness and dryness indices showed a climate shift from near normal to moderate wet during 2005 at Zanzibar Airport, while normal to moderately dry conditions, were observed in Pemba at Matangatuani. The decadal rainfall variability and distributions revealed higher rainfall intensity with an increasing trend and good spatial distribution in D3 from March to May (MAM) and October to December (OND). The projected results for T<sub>max</sub> during MAM and OND depicted higher values ranging from 1.7℃ - 1.8℃ to 1.9℃ - 2.0℃ and 1.5℃ to 2.0℃ in FF compared to NF under both RCPs. Also, higher T<sub>min</sub> values of 1.12℃ - 1.16℃ was projected in FF for MAM and OND under both RCPs. Besides, the rainfall projection generally revealed increased rainfall intensity in the range of 0 - 25 mm for Pemba and declined rainfall in the range of 25 - 50 mm in Unguja under both RCPs in perspectives of both NF and FF. Conclusively the study has shown that the undergoing climate change has posed a significant impact on both rainfall and temperature spatial and temporal distributions in Zanzibar (Unguja and Pemba), with Unguja being projected to have higher rainfall deficits while increasing rainfall strengths in Pemba. Thus, the study calls for more studies and formulation of effective adaptation, strategies and resilience mechanisms to combat the projected climate change impacts especially in the agricultural sector, water and food security.
基金financially supported by the National Natural Science Foundation of China (41867030, 41971036)the National Natural Science Foundation innovation research group science foundation of China (41421061)
文摘Water resources are one of the key factors restricting the development of arid areas,and cloud water resources is an important part of water resources.The arid region of central Asia is the core region of the current national green silk road construction,and is the largest arid region in the world.Based on cloud cover data of ECMWF,the current study analyzed temporal and spatial characteristics of cloud properties in arid regions of Central Asia between 1980 and 2019.Our findings show that:(1)From the point of view of spatial distribution,total cloudiness in arid regions of Central Asia was low in the south and high in the north.The distribution of high cloud frequency and medium cloud frequency was higher in the south and lower in the north,while low cloud frequency distribution was low in the south and high in the north.(2)In terms of time,the variation of cloud cover and cloud type frequency had obvious seasonal characteristics.From winter to spring,cloud cover increased,and the change of cloud type frequency increased.From spring to summer,cloud cover continued to increase and the change of cloud type frequency increased further.Cloud cover began to decrease from summer to autumn,and the change of cloud type frequency also decreased.(3)Generally,average total cloud cover decreased in most of central Asia,and high and medium cloud cover increased while low cloud cover decreased.This study provides a reference for the rational development of cloud resources in the region.
基金This research was supported by the National Natural Science Foundation of China(52022081)the Technology Project Funded by Clean Energy and Ecological Water Conservancy Engineering Research Center of China(QNZX-2019-03).
文摘The preceding and succeeding precipitation(PSP)often act together with extreme precipitation(EP),in turn,causing floods,which is an objective component that is often overlooked with regard to summer flood hazards in the arid region of Northwest China.In this study,event-based extreme precipitation(EEP)was defined as continuous precipitation that includes at least one day of EP.We analyzed the spatiotemporal variation characteristics of four EEP types(front EEP,late EEP,balanced EEP,and single day EEP)across the Loess Plateau(LP)based on data acquired from 87 meteorological stations from 1960 to 2019.Precipitation on the LP basically maintained a spatial pattern of"low in the northwest region and high in the southeast region",and EP over the last 10 a increased significantly.The cumulative precipitation percentage of single day EEP was 34%and was dominant for 60 a,while the cumulative precipitation percentage of front,late,and balanced EEP types associated with PSP accounted for 66%,which confirms to the connotation of EEP.The cumulative frequencies of front and late EEP types were 23%and 21%,respectively,while the cumulative frequency of balanced EEP had the lowest value at only 13%.Moreover,global warming could lead to more single day EEP across the LP,and continuous EEP could increase in the northwestern region and decrease in the eastern region in the future.The concept of process-oriented EP could facilitate further exploration of disaster-causing processes associated with different types of EP,and provide a theoretical basis for deriving precipitation disaster chains and construction of disaster cluster characteristics.
基金supported by grants from The National Natural Science Foundation of China(No.81771003 and 82071508).
文摘Temporal bone malignant tumors are characterized by atypical clinical symptoms,and easy recurrence and metastasis.They account for 0.2%of head and neck tumors,and the most common pathological type is squamous cell carcinoma.Patients with squamous cell carcinoma of the temporal bone are often at advanced stages when diagnosed,and lose the chance for surgery.Neoadjuvant immunotherapy has recently been approved as the first-line treatment for refractory recurrent/metastatic squamous cell carcinoma of the head and neck.However,it remains to be determined whether neoadjuvant immunotherapy can be used as the first-line treatment for temporal bone squamous cell carcinoma to reduce the tumor stage before surgery,or as a palliative treatment for patients with unresectable advanced stage carcinoma.The present study reviews the development of immunotherapy and its clinical application in head and neck squamous cell carcinoma,summarizes the treatment of temporal bone squamous cell carcinoma,and prospects the neoadjuvant immunotherapy as the first-line treatment for temporal bone squamous cell carcinoma.
文摘Mandarin在(pinyin:zài)is the most frequently used character in representing spatial and temporal relationship.Current studies mostly focus on its lexical meaning and syntactic structure while cognitive features of its grammatical categories have been neglected.This paper investigates into the categorization of zài by conducting a morphosyntactic test among College English majors in China.The results show that:prototypes are organizing the grammatical categories of zài at all levels in terms of intra-categorial gradience;the semantic construal of zài construction could significantly influence the accuracy of the grammatical categorization of zài;the syntactic structure can provide viable cue for the identification of grammatical categories of zài;spatiality,temporality and the status of existing are three essential semantic features encoded by zài,the concurrence of which leads to various degree of inter-categorial vagueness,indicating a conflict between the rigid grammatical classification and the indeterminate nature of the grammatical functions of zai,suggesting the necessity to reconsider the efficacy of applying indiscriminately the Anglo-Saxon grammar into the study of Chinese spatial-temporal constructions.
基金supported by the National Natural Science Foundation of China(No.31870387),China Scholarship Council.
文摘The CO_(2)effl ux of branches and leaves plays an important role in ecosystem carbon balance.Using a carbon fl ux system,the effl ux of Larix gmelinii var.principisrupprechtii(Dahurian larch)was investigated in 27 years(immature),31 years(near-mature),and 47 years(mature)stands at diurnal,seasonal,and spatial scales(direction and height)as well as its connection with environmental factors from May to October 2020.Diurnal variation in effl ux was a single peak,and the maximum occurring between 14:00 and 16:00.Seasonal variation also exhibited a single peak,with the maximum in late July and the minimum in early October.From May to September,effl ux on the south side was the largest among the three stands,and mean values on the south side of 27 year-old,31 year-old,and 47 year-old trees were 0.50,0.97 and 1.05μmol·m^(–2)·s^(–1),respectively.The minimum occurred on the north side.Except for the maximum in July and September in the 27 year-old stand in the middle of the canopy,the maximum effl ux in the upper canopy,and the means in the 27 year-old,31 year-old,and 47 year-old stands were 0.49,0.96 and 1.04μmol·m^(-2)·s^(-1),respectively;the minimum occurred in the lower canopy.Temperatures and relative humidity infl uenced seasonal variations in effl ux.Seasonal variation in temperature sensitivity coeffi cient(Q 10)was opposite that of temperature,increasing with decreasing temperature.At the spatial scale,maximum Q 10 occurred in the mid canopy.With the effl ux and temperature data in diff erent locations,it is possible to better estimate effl ux variations in each stand.
