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SNAPC3 gene rs12093 polymorphism is significantly associated with ischemic stroke wind syndrome
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作者 Lian Gu Xian-Li Huang +3 位作者 Yan Yan Yi-Bing Yang Lue-Jun Tang Li Su 《Journal of Hainan Medical University》 2022年第2期28-33,共6页
Objective:To investigate whether The small nuclear RNA activating complex polypeptide 3(SNAPC3)gene rs12093 polymorphism is associated with ischemic stroke(IS)and Traditional Chinese Medicine(TCM)syndromes of IS.Metho... Objective:To investigate whether The small nuclear RNA activating complex polypeptide 3(SNAPC3)gene rs12093 polymorphism is associated with ischemic stroke(IS)and Traditional Chinese Medicine(TCM)syndromes of IS.Methods:This study enrolled 774 patients with ischemic stroke(IS)and 793 normal controls.Massarray technology was used for genotyping.And genetic association analysis was estimated by PLINK program.Results:①SNAPC3 gene rs12093 polymorphism was significantly associated with the risk of ischemic stroke wind syndrome of IS[OR=0.76,95%CI(0.58-0.99),P=0.047 in dominant model)].②After adjusting age and gender,SNAPC3 gene rs12093 polymorphism and the score of ischemic stroke wind syndrome(Padj=0.037 in additive model;Padj=0.009 in recessive model),the correlation is statistically significant.③After adjusting age and gender,platelet(PLT)(Padj=0.024 in addiction model;Padj=0.039 in dominant model)and thrombin time(TT)(Padj=0.042 in dominant model)were significantly associated with rs12093 polymorphism in patients with ischemic stroke wind syndrome.Conclusion:SNAPC3 gene rs12093 polymorphism may affect the occurrence of ischemic stroke wind syndrome. 展开更多
关键词 Ischemic stroke SNAPC3 gene Gene polymorphism TCM syndrome wind syndrome
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Jinye Baidu granule for wind-warmth lung-heat disease(heat in the lung-wei): protocol for a randomized, double-blind, parallel, controlled trial
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作者 Jiang Junjie Zhang Yin +6 位作者 Xie Yanming Li Yuan Sun Shuailing Zhang Yili Wang Shuo Zhu Yong Qi Wensheng 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2017年第5期621-628,共8页
OBJECTIVE: To observe the curative effect of Jinye Baidu granule in the treatment of fever and swollen and sore throat caused by wind-warmth lung-heat disease(heat in the lung-wei) to further identify the indications.... OBJECTIVE: To observe the curative effect of Jinye Baidu granule in the treatment of fever and swollen and sore throat caused by wind-warmth lung-heat disease(heat in the lung-wei) to further identify the indications.METHODS: This randomized, double-blind, parallel, controlled trial will include patients with acute upper respiratory infection and wind-warmth lung-heat disease(heat in the lung-wei). Patientswith serious bacterial infection(white blood cell count > 12 × 10~9, neutrophils > 80%) will be excluded. Patients will be divided into three categories(blocks) according to their condition: fever only, a swollen and sore throat, and combined fever plus a swollen and sore throat. Patients within each of the three blocks will be further divided into a treatment group and a control group via stratified blocked randomization. The treatment group will be treated with Jinye Baidu granule, and the control group will be treated with Fufang Shuanghua granule. The primary outcome measure will be body temperature recovery time for patients with fever, throat symptom score for patients with a swollen and sore throat, and body temperature recovery time and throat symptom score for patients with combined fever plus a swollen and sore throat. Routine blood testing, urine testing, liver function, kidney function and ECG data of all patients will be collected as safety indices before and after enrollment, and adverse events will be recorded during the whole trial course.CONCLUSION: This study protocol will include stratified block analysis according to patients' symptoms, and identify the accurate clinical indications of Jinye Baidu granule. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment. 展开更多
关键词 syndrome of wind heat invading lung and stomach Respiratory tract infections Randomized controlled trial Clinical protocols Jinye Baidu granule
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