This paper developed a comprehensive evaluation system that was able to quantify the levels of high-quality development across the cities within the Chengdu-Chongqing economic circle,and investigate the impact that di...This paper developed a comprehensive evaluation system that was able to quantify the levels of high-quality development across the cities within the Chengdu-Chongqing economic circle,and investigate the impact that digital finance had on the cities’high-quality development and the underlying mechanisms through which it achieved this.This comprehensive evaluation system was constructed using statistical data from these cities for the period 2014 to 2020 while also taking China’s high-quality development philosophy into account.The key findings revealed that:(a)Digital finance was able to significantly promote high-quality development in the Chengdu-Chongqing economic circle;(b)Digital finance had a significant positive effect in promoting innovative,coordinated,green,open,and shared development;(c)Digital finance was able to stimulate the high-quality development in the Chengdu-Chongqing economic circle by boosting entrepreneurial dynamism;(d)Digital finance had a significant impact on the high-quality development of the axis areas,while its impact was less discernible in non-axis areas.The insights from this research offer a deeper understanding of the factors that drive high-quality development,the role digital finance plays,and the mechanisms through which digital finance is able to propel high-quality development at the city cluster scale.展开更多
Coordinative development across various systems,particularly the economic,social,cultural,and human resources subsystems,is a key aspect of urban sustainability and has a direct impact on the quality of urbanization.T...Coordinative development across various systems,particularly the economic,social,cultural,and human resources subsystems,is a key aspect of urban sustainability and has a direct impact on the quality of urbanization.The Hangzhou Metropolitan Circle,comprising Hangzhou City,Huzhou City,Jiaxing City,and Shaoxing City,was the first metropolitan circle approved by the National Development and Reform Commission(NDRC)as a demonstration of economic transformation in China.To evaluate the coupling coordination degree of the four cities and analyze the coordinative development in three systems(including digital economy,regional innovation,and talent employment),we collected panel data during 2015–2022 from these four cities.The development level of the three systems was evaluated by the standard deviation method and comprehensive development index.The results are as follows:(1)the level of coupling coordinated development of the three systems in the Hangzhou Metropolitan Circle was relatively low;(2)the coupling coordination degree of the four cities in the Hangzhou Metropolitan Circle showed significant regional differences,among which Hangzhou City was in the leading position,and Huzhou,Jiaxing,and Shaoxing cities made steady but slow progress in the coupling development of the three systems;and(3)the development of digital economy and talent employment needs to be strengthened.This study contributes to the coordinative development of Hangzhou Metropolitan Circle by innovatively focusing on the coupling coordination relationship among digital economy,regional innovation,and talent employment,which also meets the industrial layout of Hangzhou Metropolitan Circle.In this way,the optimal allocation and sustainable development of digital economy,regional innovation,and talent employment in the Hangzhou Metropolitan Circle can be achieved.展开更多
Building a 15-minute radius livelihood service circle from the needs of residents is a topdown process of optimizing urban layout and promoting high-quality development implemented by the government.In September 2022,...Building a 15-minute radius livelihood service circle from the needs of residents is a topdown process of optimizing urban layout and promoting high-quality development implemented by the government.In September 2022,Xicheng District of Beijing served as a national pilot of the 15-minute radius livelihood service circle.Based on the data of POI,urban walking network and building outline,this paper studies the coverage of commercial service facilities in the 15-minute radius livelihood service circle of Chunshu Street by using kernel density analysis and urban network analysis tools.The research shows that the commercial facilities are concentrated in Zhuangsheng Square and Dazhalan commercial district.There are large gaps in housekeeping and couriers logistics facilities,which need to be further improved.展开更多
Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs ...Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs Institute (JBI) evidence-based health care model, the best evidence of airway management in adult critically ill patients was obtained and applied to the clinic. Results: The total implementation rate of airway management measures in adult critically ill patients increased from 23.62% before the implementation of quality control circle to 88.82%, and the pulmonary infection rate in critically ill patients decreased from 42.31% to 21.74%, with statistical significance between the two groups (P 0.05). Conclusion: Evidence-based quality control circle activities can standardize the practice standards of airway management in critically ill patients, reduce the occurrence of patients’ airway related complications, and improve clinical outcomes.展开更多
The important role of atherosclerosis in pathophysiology of Alzheimer's Disease has become evident.Mechanisms such as hyperlipidemia,inflammation,abdominal obesity and insulin resistance are important yet they may...The important role of atherosclerosis in pathophysiology of Alzheimer's Disease has become evident.Mechanisms such as hyperlipidemia,inflammation,abdominal obesity and insulin resistance are important yet they may not fully explain the specific involvement of the Circle of Willis in these pathologies.The Circle of Wills is a complex geometrical structure which has several areas with different curvature as well as various branching angles of vessels composing the circle.The hemodynamics in this region should take into account the Dean number which indicates the influence of curvature on the resistance to blood flow.Thus,areas with various curvature and angles may have different hemodynamics and there are certain areas in the Circle of Willis that are more likely to develop atherosclerotic changes.Therefore,this could suggest the novel pathophysiological pathway resulting from the geometric peculiarities of the Circle of Willis.One of the directions of future research is to examine whether specific areas of the Circle of Willis are more likely to develop atherosclerotic changes compared to other ones.Selective areas of the Circle of Willis affected by atherosclerotic changes could indicate the primary role of atherosclerosis promoting Alzheimer's disease although other pathophysiological mechanisms suggesting the opposite direction should be also examined in prospective studies.展开更多
目的探讨单侧颈动脉重度狭窄患者,在行颈动脉血流重建前后,Willis环的不同代偿能力对脑血流灌注的差异性。方法选择2018年6月至2022年6月航天中心医院神经科就诊的单侧颈动脉狭窄程度70%~99%患者65例,根据在数字减影血管造影术下压颈试...目的探讨单侧颈动脉重度狭窄患者,在行颈动脉血流重建前后,Willis环的不同代偿能力对脑血流灌注的差异性。方法选择2018年6月至2022年6月航天中心医院神经科就诊的单侧颈动脉狭窄程度70%~99%患者65例,根据在数字减影血管造影术下压颈试验证实经Willis环代偿能力依据改良脑梗死溶栓分级(mTICI)分为代偿良好组33例(mTICI≥2b)和代偿不良组32例(mTICI≤2a)。代偿良好组和代偿不良组术前颈动脉狭窄率<90%患者分别为20例和19例,代偿良好组和代偿不良组术前颈动脉狭窄率≥90%患者分别为13例和13例。所有患者均行狭窄处支架置入手术,术前、术后均完善CT灌注成像检测相对脑血流量(rCBF)、相对脑血容量(rCBV)、相对平均通过时间(rMTT)、相对达峰时间(rTTP)。结果代偿不良组术前rCBF略低于代偿良好组,差异无统计学意义(P>0.05)。代偿不良组术前rCBV、rMTT、rTTP明显高于代偿良好组,差异有统计学意义(1.04±0.03 vs 1.02±0.02,1.19±0.12 vs 1.06±0.07,1.28±0.16 vs 1.10±0.09,P<0.01);2组术后rCBV、rCBF、rMTT、rTTP比较,差异无统计学意义(P>0.05)。代偿不良组颈动脉狭窄率<90%患者术前rCBV、rMTT、rTTP明显高于代偿良好组,差异有统计学意义(P<0.01)。代偿不良组颈动脉狭窄率≥90%患者术前rCBV、rMTT、rTTP明显高于代偿良好组,rCBF明显低于代偿良好组,差异有统计学意义(P<0.01)。结论Willis环能够改变颈动脉重度狭窄患者的脑血流分布,而且颈动脉狭窄越重,Willis环的代偿功能体现的越明显,在进行颈动脉狭窄血流重建时,要充分考虑和评估Willis环的代偿功能。展开更多
The cerebral arterial circle (circle of Willis) plays an important role in the redistribution of the blood flow between the anterior and posterior territories and maintains the plasticity of the cerebral blood circula...The cerebral arterial circle (circle of Willis) plays an important role in the redistribution of the blood flow between the anterior and posterior territories and maintains the plasticity of the cerebral blood circulation. The anatomical variability of the vascular circle often alters the cerebral hemodynamics and determines the outcomes of acute and chronic cerebrovascular disease. The heritability and prevalence of certain variants of the circle of Willis in different ethnic and racial groups are frequently disputed by authors. Our cross-sectional retrospective study aims to compare the patterns of the cerebral arterial circle in 64 Caucasian cadavers with 64 Arabic living individuals, by methods of anatomic dissection and magnetic resonance angiography, respectively. The typical structure of the circle of Willis was revealed in 8.3% of the Caucasian study group, and in 22.2% of the Arabic one. The anterior part of the circle of Willis was incomplete in 6 out of 64 of the Caucasian specimens, where the anterior communicating artery was hypoplastic (6.3%) or absent (3.1%). The posterior part of the circle of Willis had hypoplastic or absent posterior communicating artery on one side in 20, and on both sides in 12 out of 64 Caucasian specimens. In the Arabic cohort, the posterior part of the circle of Willis was incomplete in 17 out of 64 specimens, with absence of the posterior communicating artery unilaterally (in 11 cases) or bilaterally (in 6 cases). The present study reveals that the configuration of the cerebral arterial circle and distribution of the blood flow between the anterior and posterior territories have certain differences in the Caucasian study group versus the Arabic one.展开更多
Coupled phase oscillators are adopted as powerful platforms in studying synchrony behaviors emerged in various systems with rhythmic dynamics. Much attention has been focused on coupled time-continuous oscillators des...Coupled phase oscillators are adopted as powerful platforms in studying synchrony behaviors emerged in various systems with rhythmic dynamics. Much attention has been focused on coupled time-continuous oscillators described by differential equations. In this paper, we study the synchronization dynamics of networks of coupled circle maps as the discrete version of the Kuramoto model. Despite of its simplicity in mathematical form, it is found that discreteness may induce many interesting synchronization behaviors. Multiple synchronization and desynchronization transitions of both phases and frequencies are found with varying the coupling among circle-map oscillators. The mechanisms of these transitions are interpreted in terms of the mean-field approach, where collective bifurcation cascades are revealed for coupled circle-map oscillators.展开更多
The anterior system of the polygon of Willis plays an anastomotic role between the carotid territories and communicates with the posterior system. It ensures adequate cerebral blood flow in the event of internal occlu...The anterior system of the polygon of Willis plays an anastomotic role between the carotid territories and communicates with the posterior system. It ensures adequate cerebral blood flow in the event of internal occlusion. Its ability to redistribute blood flow depends on its morphology, the presence and size of the vessels that constitute it and their variants, knowledge of which is essential. The morphology of the carotid system is not constant and a number of variants are well recognized with greater hemodynamic importance. In this context, we undertook this work which aims to seek the anatomical variants of the anterior part of the PW;to determine the diameters of the vessels of the latter and to correlate these results with epidemiological data. We carried out a retrospective, descriptive and analytical study over a period of 4 months at Fann University Hospital, targeting patients who had undergone brain MRI with a 3D TOF sequence whatever the indication. Patients with lesions of cerebrovascular pathologies such as ischemia, hemorrhage, aneurysm, arteriovenous malformations or presenting a limited analysis examination due to the presence of kinetic or other artifact, were not included. Demographic data and anatomical variants were studied as well as the measurements of any continuous arterial segment greater than 0.8 mm in diameter. Those less than 0.8 mm in diameter were considered hypoplastic. The C3 segment of the internal carotid arteries, the A1 segment of the anterior cerebral arteries, the anterior communicating artery, constituted our main measurement sites. The sex ratio was 1.06, the mean age of the patients was 43 years ± 17.9 with extremes of 11 and 85 years. The anterior configuration of the polygon was complete in 57.5% representing 50% of men and 65.5% of women, in 56% of subjects under 40 years old and 58% in subjects over 40 years old. We noted a predominance of type a in 47% of patients followed by type g found in 35% of patients. The morphology of the anterior system of the Willis polygon is a function of its variants, some of which have greater hemodynamic importance than others. Its knowledge is essential for the management of cerebrovascular diseases.展开更多
Objective:To evaluate the efficacy of a novel coated stent in the treatment of intracranial pseudoaneurysm.Methods:MEDLINE,EMBASE,and PubMed databases were searched for literature published between 1990 and April 2022...Objective:To evaluate the efficacy of a novel coated stent in the treatment of intracranial pseudoaneurysm.Methods:MEDLINE,EMBASE,and PubMed databases were searched for literature published between 1990 and April 2022 according to PRISMA guidelines.All studies with≥10 patients reporting successful implantation of Willis covered stent,therapeutic effect,complications,and postoperative follow-up were included.The combined incidence and corresponding 95%confidence intervals were assessed using a generalized linear mixed method and random effects model.Results:Five studies(116 patients with pseudoaneurysms)were included.The experimental groups in the selected studies showed a combined technical success rate of 81.03%(OR=18.31,95%CI=9.39-35.69,I^(2)=79%,P<0.001).Clinical follow-up showed that the complete cure rate was as high as 94.4%after the follow-up(OR=106.81,95%CI=39.08-291.88,I^(2)=0%,P=0.71).Conclusions:Willis covered stent is feasible,safe,and effective in the treatment of intracranial pseudoaneurysm.展开更多
Squaring the circle is one of the oldest challenges in mathematical geometry. In 1882, it was proven that π was transcendental, and the task of squaring the circle was considered impossible. Demonstrating that squari...Squaring the circle is one of the oldest challenges in mathematical geometry. In 1882, it was proven that π was transcendental, and the task of squaring the circle was considered impossible. Demonstrating that squaring the circle was not possible took place before discovering quantum mechanics. The purpose of this paper is to show that it is actually possible to square the circle when taking into account the Heisenberg uncertainty principle. The conclusion is clear: it is possible to square the circle when taking into account the Heisenberg uncertainty principle.展开更多
Blood blister-like aneurysms(BBAs)are fragile and difficult to treat.However,the optimal treatment has yet to be determined.Pipeline embolization devices and Willis covered stent implementation are still controversial...Blood blister-like aneurysms(BBAs)are fragile and difficult to treat.However,the optimal treatment has yet to be determined.Pipeline embolization devices and Willis covered stent implementation are still controversial strategies for treating BBA.Herein,we report a case of recurrent BBA successfully treated with a Willis covered stent.A long-term follow-up angiography after the procedure indicated complete occlusion of the aneurysm.This case demonstrates the safety and efficacy of applying the Wills cover stent in the treatment of recurrent BBA after Pipeline implantation.展开更多
文摘This paper developed a comprehensive evaluation system that was able to quantify the levels of high-quality development across the cities within the Chengdu-Chongqing economic circle,and investigate the impact that digital finance had on the cities’high-quality development and the underlying mechanisms through which it achieved this.This comprehensive evaluation system was constructed using statistical data from these cities for the period 2014 to 2020 while also taking China’s high-quality development philosophy into account.The key findings revealed that:(a)Digital finance was able to significantly promote high-quality development in the Chengdu-Chongqing economic circle;(b)Digital finance had a significant positive effect in promoting innovative,coordinated,green,open,and shared development;(c)Digital finance was able to stimulate the high-quality development in the Chengdu-Chongqing economic circle by boosting entrepreneurial dynamism;(d)Digital finance had a significant impact on the high-quality development of the axis areas,while its impact was less discernible in non-axis areas.The insights from this research offer a deeper understanding of the factors that drive high-quality development,the role digital finance plays,and the mechanisms through which digital finance is able to propel high-quality development at the city cluster scale.
基金supported by the Ningbo Polytechnic Industry-Education Integration Research Project(NZ23CJ05Z)the Ningbo Municipal Philosophy and Social Science Project(G2023-2-Z11)the Soft Science Project of Zhejiang Science and Technology Department,China(2024C35096).
文摘Coordinative development across various systems,particularly the economic,social,cultural,and human resources subsystems,is a key aspect of urban sustainability and has a direct impact on the quality of urbanization.The Hangzhou Metropolitan Circle,comprising Hangzhou City,Huzhou City,Jiaxing City,and Shaoxing City,was the first metropolitan circle approved by the National Development and Reform Commission(NDRC)as a demonstration of economic transformation in China.To evaluate the coupling coordination degree of the four cities and analyze the coordinative development in three systems(including digital economy,regional innovation,and talent employment),we collected panel data during 2015–2022 from these four cities.The development level of the three systems was evaluated by the standard deviation method and comprehensive development index.The results are as follows:(1)the level of coupling coordinated development of the three systems in the Hangzhou Metropolitan Circle was relatively low;(2)the coupling coordination degree of the four cities in the Hangzhou Metropolitan Circle showed significant regional differences,among which Hangzhou City was in the leading position,and Huzhou,Jiaxing,and Shaoxing cities made steady but slow progress in the coupling development of the three systems;and(3)the development of digital economy and talent employment needs to be strengthened.This study contributes to the coordinative development of Hangzhou Metropolitan Circle by innovatively focusing on the coupling coordination relationship among digital economy,regional innovation,and talent employment,which also meets the industrial layout of Hangzhou Metropolitan Circle.In this way,the optimal allocation and sustainable development of digital economy,regional innovation,and talent employment in the Hangzhou Metropolitan Circle can be achieved.
文摘Building a 15-minute radius livelihood service circle from the needs of residents is a topdown process of optimizing urban layout and promoting high-quality development implemented by the government.In September 2022,Xicheng District of Beijing served as a national pilot of the 15-minute radius livelihood service circle.Based on the data of POI,urban walking network and building outline,this paper studies the coverage of commercial service facilities in the 15-minute radius livelihood service circle of Chunshu Street by using kernel density analysis and urban network analysis tools.The research shows that the commercial facilities are concentrated in Zhuangsheng Square and Dazhalan commercial district.There are large gaps in housekeeping and couriers logistics facilities,which need to be further improved.
文摘Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs Institute (JBI) evidence-based health care model, the best evidence of airway management in adult critically ill patients was obtained and applied to the clinic. Results: The total implementation rate of airway management measures in adult critically ill patients increased from 23.62% before the implementation of quality control circle to 88.82%, and the pulmonary infection rate in critically ill patients decreased from 42.31% to 21.74%, with statistical significance between the two groups (P 0.05). Conclusion: Evidence-based quality control circle activities can standardize the practice standards of airway management in critically ill patients, reduce the occurrence of patients’ airway related complications, and improve clinical outcomes.
文摘The important role of atherosclerosis in pathophysiology of Alzheimer's Disease has become evident.Mechanisms such as hyperlipidemia,inflammation,abdominal obesity and insulin resistance are important yet they may not fully explain the specific involvement of the Circle of Willis in these pathologies.The Circle of Wills is a complex geometrical structure which has several areas with different curvature as well as various branching angles of vessels composing the circle.The hemodynamics in this region should take into account the Dean number which indicates the influence of curvature on the resistance to blood flow.Thus,areas with various curvature and angles may have different hemodynamics and there are certain areas in the Circle of Willis that are more likely to develop atherosclerotic changes.Therefore,this could suggest the novel pathophysiological pathway resulting from the geometric peculiarities of the Circle of Willis.One of the directions of future research is to examine whether specific areas of the Circle of Willis are more likely to develop atherosclerotic changes compared to other ones.Selective areas of the Circle of Willis affected by atherosclerotic changes could indicate the primary role of atherosclerosis promoting Alzheimer's disease although other pathophysiological mechanisms suggesting the opposite direction should be also examined in prospective studies.
文摘目的探讨单侧颈动脉重度狭窄患者,在行颈动脉血流重建前后,Willis环的不同代偿能力对脑血流灌注的差异性。方法选择2018年6月至2022年6月航天中心医院神经科就诊的单侧颈动脉狭窄程度70%~99%患者65例,根据在数字减影血管造影术下压颈试验证实经Willis环代偿能力依据改良脑梗死溶栓分级(mTICI)分为代偿良好组33例(mTICI≥2b)和代偿不良组32例(mTICI≤2a)。代偿良好组和代偿不良组术前颈动脉狭窄率<90%患者分别为20例和19例,代偿良好组和代偿不良组术前颈动脉狭窄率≥90%患者分别为13例和13例。所有患者均行狭窄处支架置入手术,术前、术后均完善CT灌注成像检测相对脑血流量(rCBF)、相对脑血容量(rCBV)、相对平均通过时间(rMTT)、相对达峰时间(rTTP)。结果代偿不良组术前rCBF略低于代偿良好组,差异无统计学意义(P>0.05)。代偿不良组术前rCBV、rMTT、rTTP明显高于代偿良好组,差异有统计学意义(1.04±0.03 vs 1.02±0.02,1.19±0.12 vs 1.06±0.07,1.28±0.16 vs 1.10±0.09,P<0.01);2组术后rCBV、rCBF、rMTT、rTTP比较,差异无统计学意义(P>0.05)。代偿不良组颈动脉狭窄率<90%患者术前rCBV、rMTT、rTTP明显高于代偿良好组,差异有统计学意义(P<0.01)。代偿不良组颈动脉狭窄率≥90%患者术前rCBV、rMTT、rTTP明显高于代偿良好组,rCBF明显低于代偿良好组,差异有统计学意义(P<0.01)。结论Willis环能够改变颈动脉重度狭窄患者的脑血流分布,而且颈动脉狭窄越重,Willis环的代偿功能体现的越明显,在进行颈动脉狭窄血流重建时,要充分考虑和评估Willis环的代偿功能。
文摘The cerebral arterial circle (circle of Willis) plays an important role in the redistribution of the blood flow between the anterior and posterior territories and maintains the plasticity of the cerebral blood circulation. The anatomical variability of the vascular circle often alters the cerebral hemodynamics and determines the outcomes of acute and chronic cerebrovascular disease. The heritability and prevalence of certain variants of the circle of Willis in different ethnic and racial groups are frequently disputed by authors. Our cross-sectional retrospective study aims to compare the patterns of the cerebral arterial circle in 64 Caucasian cadavers with 64 Arabic living individuals, by methods of anatomic dissection and magnetic resonance angiography, respectively. The typical structure of the circle of Willis was revealed in 8.3% of the Caucasian study group, and in 22.2% of the Arabic one. The anterior part of the circle of Willis was incomplete in 6 out of 64 of the Caucasian specimens, where the anterior communicating artery was hypoplastic (6.3%) or absent (3.1%). The posterior part of the circle of Willis had hypoplastic or absent posterior communicating artery on one side in 20, and on both sides in 12 out of 64 Caucasian specimens. In the Arabic cohort, the posterior part of the circle of Willis was incomplete in 17 out of 64 specimens, with absence of the posterior communicating artery unilaterally (in 11 cases) or bilaterally (in 6 cases). The present study reveals that the configuration of the cerebral arterial circle and distribution of the blood flow between the anterior and posterior territories have certain differences in the Caucasian study group versus the Arabic one.
文摘目的使用颅颈一体化的高分辨率磁共振血管成像(magnetic resonance angiography,MRA)检查,对前循环缺血性脑卒中患者的Willis环完整性、颅颈动脉粥样硬化斑块特征进行分析,探寻与复发性卒中独立相关的影像特征。材料与方法回顾性分析前循环缺血性脑卒中患者87例,均在症状出现14 d内接受高分辨率磁共振血管壁成像检查,并根据临床及影像资料将其分为卒中初发组和复发组。记录斑块总数、颅颈动脉斑块特征及Willis环完整性。比较初发组、复发组之间及Willis环完整组、不完整组之间的颅颈动脉斑块特征。采用多因素logistic回归分析评估与前循环缺血性脑卒中复发相关的独立危险因素。结果共纳入87例患者。初发组54例,复发组33例。两组间性别(P=0.223)、年龄(P=0.779)差异无均统计学意义。与初发组相比,复发组的颅内斑块强化(P=0.010)、颅内动脉狭窄程度(P=0.002)、斑块总数(P<0.001)、颅内斑块强化合并颅外斑块(P=0.006)、颅内(或颅外)动脉狭窄>50%合并颅外(或颅内)斑块(P=0.001)及Willis环后循环症状侧不完整(P<0.001)与复发性卒中显著相关。与Willis环前循环完整组相比,Willis环前循环不完整组颅内斑块强化(P=0.012)更多见。多因素logistic回归分析显示:斑块总数[比值比(odds ratio,OR)=2.14,95%置信区间(confidence interval,CI):1.182~3.869,P=0.012]和Willis环后循环症状侧不完整(OR=4.58,95%CI:1.496~14.041,P=0.008)为前循环缺血性脑卒中复发的独立危险因素。logistic回归模型的整体预测效能最佳[曲线下面积(area under the curve,AUC)=0.811,95%CI:0.711~0.910]。结论斑块总数和Willis环后循环症状侧不完整与前循环缺血性脑卒中复发独立相关。颅颈一体化的高分辨率磁共振血管壁成像检查可为前循环缺血性脑卒中复发预测模型的构建提供新指标。
基金Project supported by the National Natural Science Foundation of China (Grant No. 11875135)。
文摘Coupled phase oscillators are adopted as powerful platforms in studying synchrony behaviors emerged in various systems with rhythmic dynamics. Much attention has been focused on coupled time-continuous oscillators described by differential equations. In this paper, we study the synchronization dynamics of networks of coupled circle maps as the discrete version of the Kuramoto model. Despite of its simplicity in mathematical form, it is found that discreteness may induce many interesting synchronization behaviors. Multiple synchronization and desynchronization transitions of both phases and frequencies are found with varying the coupling among circle-map oscillators. The mechanisms of these transitions are interpreted in terms of the mean-field approach, where collective bifurcation cascades are revealed for coupled circle-map oscillators.
文摘The anterior system of the polygon of Willis plays an anastomotic role between the carotid territories and communicates with the posterior system. It ensures adequate cerebral blood flow in the event of internal occlusion. Its ability to redistribute blood flow depends on its morphology, the presence and size of the vessels that constitute it and their variants, knowledge of which is essential. The morphology of the carotid system is not constant and a number of variants are well recognized with greater hemodynamic importance. In this context, we undertook this work which aims to seek the anatomical variants of the anterior part of the PW;to determine the diameters of the vessels of the latter and to correlate these results with epidemiological data. We carried out a retrospective, descriptive and analytical study over a period of 4 months at Fann University Hospital, targeting patients who had undergone brain MRI with a 3D TOF sequence whatever the indication. Patients with lesions of cerebrovascular pathologies such as ischemia, hemorrhage, aneurysm, arteriovenous malformations or presenting a limited analysis examination due to the presence of kinetic or other artifact, were not included. Demographic data and anatomical variants were studied as well as the measurements of any continuous arterial segment greater than 0.8 mm in diameter. Those less than 0.8 mm in diameter were considered hypoplastic. The C3 segment of the internal carotid arteries, the A1 segment of the anterior cerebral arteries, the anterior communicating artery, constituted our main measurement sites. The sex ratio was 1.06, the mean age of the patients was 43 years ± 17.9 with extremes of 11 and 85 years. The anterior configuration of the polygon was complete in 57.5% representing 50% of men and 65.5% of women, in 56% of subjects under 40 years old and 58% in subjects over 40 years old. We noted a predominance of type a in 47% of patients followed by type g found in 35% of patients. The morphology of the anterior system of the Willis polygon is a function of its variants, some of which have greater hemodynamic importance than others. Its knowledge is essential for the management of cerebrovascular diseases.
基金supported by China Natural Science Funding(No.81902937)Hubei University of Science and Technology ENT special project(No.2020WG06)+1 种基金Hubei University of Science and Technology ENT special project(No.2)and Hubei province Key R&D plan(2022BCE011)and(No.2020XZ30)for SDWHubei University of Science and Technology the Second Affiliated Hospital Scientific project(No.2020LCZ001)and ENT special project(No.2021WG10).
文摘Objective:To evaluate the efficacy of a novel coated stent in the treatment of intracranial pseudoaneurysm.Methods:MEDLINE,EMBASE,and PubMed databases were searched for literature published between 1990 and April 2022 according to PRISMA guidelines.All studies with≥10 patients reporting successful implantation of Willis covered stent,therapeutic effect,complications,and postoperative follow-up were included.The combined incidence and corresponding 95%confidence intervals were assessed using a generalized linear mixed method and random effects model.Results:Five studies(116 patients with pseudoaneurysms)were included.The experimental groups in the selected studies showed a combined technical success rate of 81.03%(OR=18.31,95%CI=9.39-35.69,I^(2)=79%,P<0.001).Clinical follow-up showed that the complete cure rate was as high as 94.4%after the follow-up(OR=106.81,95%CI=39.08-291.88,I^(2)=0%,P=0.71).Conclusions:Willis covered stent is feasible,safe,and effective in the treatment of intracranial pseudoaneurysm.
文摘Squaring the circle is one of the oldest challenges in mathematical geometry. In 1882, it was proven that π was transcendental, and the task of squaring the circle was considered impossible. Demonstrating that squaring the circle was not possible took place before discovering quantum mechanics. The purpose of this paper is to show that it is actually possible to square the circle when taking into account the Heisenberg uncertainty principle. The conclusion is clear: it is possible to square the circle when taking into account the Heisenberg uncertainty principle.
文摘Blood blister-like aneurysms(BBAs)are fragile and difficult to treat.However,the optimal treatment has yet to be determined.Pipeline embolization devices and Willis covered stent implementation are still controversial strategies for treating BBA.Herein,we report a case of recurrent BBA successfully treated with a Willis covered stent.A long-term follow-up angiography after the procedure indicated complete occlusion of the aneurysm.This case demonstrates the safety and efficacy of applying the Wills cover stent in the treatment of recurrent BBA after Pipeline implantation.
