Cutaneous leishmaniasis is regarded as a re-emerging disease due to its increase in spread and rate of transmission over the past decade due to a proportionate increase in global human movements.This study was therefo...Cutaneous leishmaniasis is regarded as a re-emerging disease due to its increase in spread and rate of transmission over the past decade due to a proportionate increase in global human movements.This study was therefore carried out to review epidemiology,laboratory diagnosis and treatment with in-depth discussion on some of the rare clinical presentations of the disease capable of influencing its control.The study was based on literature review on clinical and laboratory features of cutaneous leishmaniasis from original research articles,review articles, short communications,letters to editor and case reports on the disease for the past 10 years(April 2000 to April 2010).The results were analysed using simple descriptive methods.The rarest presentations of leishmaniasis encountered were peritibial ulcerations,hard painful nipple in a male,swollen upper lip,dermatofibro sarcoma protuberans,sternal proliferative growth,turban tumour,post operative granuloma,chalazion-like 0.00%,and cutaneous sterile pyogranuloma with asymmetrical alopecia 0.00%each.Others include infected sebaceous cysts 0.45%,syphilis 0.19%,yaws 0.13%,thrombotic ulcerations 0.40%,mycetoma 0.90%,sarcoidosis 0.67%,painless nasal solitary nodule 0.00%,tuberculous lymphadenopathy 0.25%and unilateral erythema nodosum 0.28%.Physicians practicing in cutaneous leishmaniasis endemic,but most especially in the non-endemic areas should bear in mind that the disease may not be that rare in the context of the present global village phenomenon:and that,the next case could just be that of cutaneous leishmaniasis,the clinical picture of the patient notwithstanding.展开更多
[Objectives]To analyze the current research situation,hotspots and trends of curcumin and diabetes in recent 10 years.[Methods]Web of Science database was set as data source,the annual number of papers,the distributio...[Objectives]To analyze the current research situation,hotspots and trends of curcumin and diabetes in recent 10 years.[Methods]Web of Science database was set as data source,the annual number of papers,the distribution of authors,the distribution of country/institution,the distribution of journals,the distribution of key words in the literature about curcumin and diabetes from January 1,2010 to March 31,2021 were quantitatively and visually analyzed with the aid of visualization software Bibliometrix.[Results]A total of 475 articles were included,and the annual number of papers was on the rise;the top three high-yielding countries were China(120 papers),India(65 papers),and the United States(58 papers).In terms of international cooperation,China and the United States had the most cooperation(27 papers);the top three high-yielding institutions were Wenzhou Medical University(42 papers),Mashhad University of Medical Sciences(41 papers)and Tehran University of Medical Sciences(30 papers);the most frequently cited authors were Wang Y(19 times),Li X(13 times),Li Y(12 times),Liang G(12 times)and Zhang Y(12 times);the top three journals in number of papers were Diabetology&Metabolic Syndrome(8 papers),PLoS One(8 papers),and European Journal of Pharmacology(7 papers),and the h index was 7,8,and 6,respectively;the most frequently cited journals were Diabetes(496 times),Journal of Biological Chemistry(486 times),PLoS One(347 times),Diabetes Care(284 times),and European Journal of Pharmacology(229 times);the most frequent key words mainly included oxidative stress,curcumin,insulin-resistance and expression;the hotspots were insulin resistance and NF-κB,mainly focusing on in vitro experiments.[Conclusions]The curcumin has good therapeutic potential in improving insulin resistance,inhibiting inflammation and oxidative stress,etc.The results are expected provide a reference and basis for scientific researchers to understand the current situation of curcumin and diabetes research and carry out the further research.展开更多
Objective: To analyze the literature status and research hotspots of Science Citation Index(SCI)-related ostomy in the world and to provide references for scientific research and clinical work in the stoma care field....Objective: To analyze the literature status and research hotspots of Science Citation Index(SCI)-related ostomy in the world and to provide references for scientific research and clinical work in the stoma care field.Methods: Based on the Web of Science core database and its own analysis function, HistCite analysis software and Excel were used to study the published research about ostomy patients.Results: A total of 1,262 articles were published between 1910 and 2016 with the authors from 48 countries and regions, 1,347 research institutions, published in 321 journals, with 4,048 first authors and coauthors; globally, there was a trend of slow growth in the number of authors every year. The study in the USA was absolutely in the lead position, and Canada and Turkey were more active.China's circulation volume was the 15 th in the world. The periodical that published most often was the Journal of Wound Ostomy and Continence Nursing. The most interdisciplinary surgical studies were surgery and nursing, where these should be considered important. The most prolific author in the field was "Grant", and the highest cited article was entitled as "Living with a stoma: a review of the literature".Conclusions: The related research of global stoma is constantly developing. The research hotspot is nursing before and after stoma surgery. China and the USA are leading countries in research. They should follow the recent trend to improve the depth and breadth of the research in the field.展开更多
AIM: To systematically review the association between complement factors I(CFI) polymorphisms and age-related macular degeneration(AMD) and to explore whether CFI polymorphisms are associated with AMD.·METHODS: M...AIM: To systematically review the association between complement factors I(CFI) polymorphisms and age-related macular degeneration(AMD) and to explore whether CFI polymorphisms are associated with AMD.·METHODS: Meta-analysis of articles published from1995 to January 2015 of articles involved with AMD and polymorphisms of the CFI gene. Eligible data were pooled in a Meta-analysis, analyzing using STATA software(version 12.0), Review Manager(version 5.2) and different models based on the heterogeneity of effect sizes. Egger's test, Begg's rank correlation methods were used to evaluate for publication bias.·RESULTS: Thirteen articles were eligible, describing two loci polymorphisms of the CFI gene(of which 12 articles focus on rs10033900 T >C and 3 articles focus on rs2285714 C >T). For rs10033900 T >C, the results of our study revealed that having a mutant allele C, TC, CC and TC +CC was associated with a decreased risk of AMD in all population groups studied(C versus T models, OR=0.84,95% CI: 0.72-0.99, P =0.04; TC versus TT models OR =0.89, 95% CI: 0.88-0.99, P =0.04;CC versus TT models,OR =0.76, 95% CI: 0.60-0.98, P =0.03; TC +CC versus TT models, OR =0.81, 95% CI:0.65-0.99, P =0.04). We found that C allele were related to lower AMD risk in the Caucasian population by subgroup analysis, but there was no association with AMD under the allele andgenotypes comparison in Asian studies. For rs2285714C>T, the TC, TT genotypes contributed to a higher risk of AMD, compared with the CC carriers and CT+CC(OR=1.34,95%CI: 1.09-1.63, P =0.004; OR=1.50, 95% CI: 1.25-1.80,P <0.0001).·CONCLUSION: This Meta-analysis suggests that CFI rs10033900 T >C and rs2285714 C >T polymorphisms may contribute to AMD.展开更多
The literary review presented in the following paper aims to analyze the tracking tools used in different countries during the period of the COVID-19 pandemic. Tracking apps that have been adopted in many countries to...The literary review presented in the following paper aims to analyze the tracking tools used in different countries during the period of the COVID-19 pandemic. Tracking apps that have been adopted in many countries to collect data in a homogeneous and immediate way have made up for the difficulty of collecting data and standardizing evaluation criteria. However, the regulation on the protection of personal data in the health sector and the adoption of the new General Data Protection Regulation in European countries has placed a strong limitation on their use. This has not been the case in non-European countries, where monitoring methodologies have become widespread. The textual analysis presented is based on co-occurrence and multiple correspondence analysis to show the contact tracing methods adopted in different countries in the pandemic period by relating them to the issue of privacy. It also analyzed the possibility of applying Blockchain technology in applications for tracking contagions from COVID-19 and managing health data to provide a high level of security and transparency, including through anonymization, thus increasing user trust in using the apps.展开更多
BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack specificity.Thus,it is easy to misdiagnose HEA as other tumors of the liver,especially in the pre...BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack specificity.Thus,it is easy to misdiagnose HEA as other tumors of the liver,especially in the presence of liver diseases such as hepatitis cirrhosis.This article reviewed the diagnosis and treatment of a patient with HEA and alcoholic cirrhosis,and analyzed the literature,in order to improve the understanding of this disease.CASE SUMMARY A 67-year-old male patient with a history of alcoholic cirrhosis was admitted due to the discovery of a space-occupying lesion in the liver.Based on the patient’s history,laboratory examinations,and imaging examinations,a malignant liver tumor was considered and laparoscopic partial hepatectomy was performed.Postoperative pathology showed HEA.During outpatient follow-up,the patient showed no sign of recurrence.CONCLUSION HEA is difficult to make a definite diagnosis before surgery.HEA has the poten-tial for malignant degeneration.If conditions permit,surgical treatment is recom-mended.展开更多
Gears are pivotal in mechanical drives,and gear contact analysis is a typically difficult problem to solve.Emerging isogeometric analysis(IGA)methods have developed new ideas to solve this problem.In this paper,a thre...Gears are pivotal in mechanical drives,and gear contact analysis is a typically difficult problem to solve.Emerging isogeometric analysis(IGA)methods have developed new ideas to solve this problem.In this paper,a threedimensional body parametric gear model of IGA is established,and a theoretical formula is derived to realize single-tooth contact analysis.Results were benchmarked against those obtained from commercial software utilizing the finite element analysis(FEA)method to validate the accuracy of our approach.Our findings indicate that the IGA-based contact algorithmsuccessfullymet theHertz contact test.When juxtaposed with the FEA approach,the IGAmethod demonstrated fewer node degrees of freedomand reduced computational units,all whilemaintaining comparable accuracy.Notably,the IGA method appeared to exhibit consistency in analysis accuracy irrespective of computational unit density,and also significantlymitigated non-physical oscillations in contact stress across the tooth width.This underscores the prowess of IGA in contact analysis.In conclusion,IGA emerges as a potent tool for addressing contact analysis challenges and holds significant promise for 3D gear modeling,simulation,and optimization of various mechanical components.展开更多
The supercritical CO_(2)cOoled Lithium-Lead(COOL)blanket has been designed as one advanced blanket candidate for the Chinese Fusion Engineering Test Reactor(CFETR).This work focuses on the electromagnetic(EM)loads(Max...The supercritical CO_(2)cOoled Lithium-Lead(COOL)blanket has been designed as one advanced blanket candidate for the Chinese Fusion Engineering Test Reactor(CFETR).This work focuses on the electromagnetic(EM)loads(Maxwell force and Lorentz force)acting on the COOL blanket,which are important mechanical loads in further structural analysis of the COOL blanket.A 3D electromagnetic analysis is performed using the ANSYS finite element method to obtain EM loads on the COOL blanket in this study.At first,the magnetic scalar potential(MSP)method is used to obtain the magnetic field and the Maxwell force on the COOL blanket.Then,the magnetic vector potential(MVP)method is performed during a plasma disruption event to get the eddy current distribution.At last,a multi-step method is adopted for the calculation of the Lorentz force and the torque.The maximum Lorentz forces of inboard and outboard blanket structural components are 5624 kN and 2360 kN respectively.展开更多
DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation ...DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis.展开更多
Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellul...Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellular space, are key enzymes participating in sucrose allocation in higher plants. Previous studies have shown that CWINs play an essential role in bulblet initiation process in bulbous crops, but the underlying molecular mechanism remains unclear. Here, a CWIN gene of Lilium brownii var. giganteum(Lbg) was identified and amplified from genomic DNA. Quantitative RT-PCR assays revealed that the expression level of LbgCWIN1 was highly upregulated exactly when the endogenous starch degraded in non-sucrose medium during in vitro bulblet initiation in Lbg. Phylogenetic relationship, motif, and domain analysis of LbgCWIN1 protein and CWINs in other plant species showed that all sequences of these CWIN proteins were highly conserved. The promoter sequence of LbgCWIN1 possessed a number of alpha-amylase-, phytohormone-, light-and stress-responsive cis-elements. Meanwhile, β-glucuronidase(GUS) assay showed that the 459 bp upstream fragment from the translational start site displayed maximal promoter activity. These results revealed that LbgCWIN1 might function in the process of in vitro bulblet initiation and be in the response to degradation of endogenous starch.展开更多
Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To expl...Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To explore the risk and protective factors of suicidal behaviours(ie,suicidal ideation,plans and attempts)in early adolescence in China using a social-ecological perspective.Methods Using data from the cross-sectional project‘Healthy and Risky Behaviours Among Middle School Students in Anhui Province,China',stratified random cluster sampling was used to select 5724 middle school students who had completed self-report questionnaires in November 2020.Network analysis was employed to examine the correlates of suicidal ideation,plans and attempts at four levels,namely individual(sex,academic performance,serious physical llness/disability,history of self-harm,depression,impulsivity,sleep problems,resilience),family(family economic status,relationship with mother,relationship with father,family violence,childhood abuse,parental mental illness),school(relationship with teachers,relationship with classmates,school-bullying victimisation and perpetration)and social(social support,satisfaction with society).Results In total,37.9%,19.0%and 5.5%of the students reported suicidal ideation,plans and attempts in the past 6 months,respectively.The estimated network revealed that suicidal ideation,plans and attempts were collectively associated with a history of self-harm,sleep problems,childhood abuse,school bullying and victimisation.Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse.Notably,the network also showed unique correlates of suicidal ideation(sex,weight=0.60;impulsivity,weight=0.24;family violence,weight=0.17;relationship with teachers,weight=-0.03;school-bullying perpetration,weight=0.22),suicidal plans(social support,weight=-0.15)and suicidal attempts(relationship with mother,weight=-0.10;parental mental llness,weight=0.61).Conclusions This study identified the correlates of suicidal ideation,plans and attempts,and provided practical implications for suicide prevention for young adolescents in China.Firstly,this study highlighted the importance of joint interventions across multiple departments.Secondly,the common risk factors of suicidal ideation,plans and attempts were elucidated.Thirdly,this study proposed target interventions to address the unique influencing factors of suicidal ideation,plans and attempts.展开更多
To the editor:Non-suicidal self-injury(NSSI)is defined as direct,repetitive self-injury to bodily tissues without suicidal intent. The estimated prevalence of NsSI among adolescents is 17.2%worldwide with a comparable...To the editor:Non-suicidal self-injury(NSSI)is defined as direct,repetitive self-injury to bodily tissues without suicidal intent. The estimated prevalence of NsSI among adolescents is 17.2%worldwide with a comparable rate observed in China. As a behavioural addiction, NSSI poses a significant suicide risk,and is emerging as a major mental health problem among adolescents.To unravel this puzzle,the four-function model(FFM)distinguishes between interpersonal and intrapersonal functions,as well as positive and negative reinforcement functions,proving relatively comprehensive among various theoretical models.展开更多
Effects of performing an R-factor analysis of observed variables based on population models comprising R- and Q-factors were investigated. Although R-factor analysis of data based on a population model comprising R- a...Effects of performing an R-factor analysis of observed variables based on population models comprising R- and Q-factors were investigated. Although R-factor analysis of data based on a population model comprising R- and Q-factors is possible, this may lead to model error. Accordingly, loading estimates resulting from R-factor analysis of sample data drawn from a population based on a combination of R- and Q-factors will be biased. It was shown in a simulation study that a large amount of Q-factor variance induces an increase in the variation of R-factor loading estimates beyond the chance level. Tests of the multivariate kurtosis of observed variables are proposed as an indicator of possible Q-factor variance in observed variables as a prerequisite for R-factor analysis.展开更多
We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with Principal Component Analysis(PCA). AISI 316L stainless steel sheets were use...We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with Principal Component Analysis(PCA). AISI 316L stainless steel sheets were used to develop double wall angle pyramid with aid of tungsten carbide tool. GRA coupled with PCA was used to plan the experiment conditions. Control factors such as Tool Diameter(TD), Step Depth(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Spindle Speed(SS) on Top Wall Angle(TWA) and Top Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workpiece. As the step depth, feed rate and spindle speed increase,TWASR decreases with increasing tool diameter. As the step depth increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the proposed hybrid method was suitable for optimizing the factors and response.展开更多
A weed is a plant that thrives in areas of human disturbance, such as gardens, fields, pastures, waysides, and waste places where it is not intentionally cultivated. Dispersal affects community dynamics and vegetation...A weed is a plant that thrives in areas of human disturbance, such as gardens, fields, pastures, waysides, and waste places where it is not intentionally cultivated. Dispersal affects community dynamics and vegetation response to global change. The process of seed disposal is influenced by wind, which plays a crucial role in determining the distance and probability of seed dispersal. Existing models of seed dispersal consider wind direction but fail to incorporate wind intensity. In this paper, a novel seed disposal model was proposed in this paper, incorporating wind intensity based on relevant references. According to various climatic conditions, including temperate, arid, and tropical regions, three specific regions were selected to establish a wind dispersal model that accurately reflects the density function distribution of dispersal distance. Additionally, dandelions growth is influenced by a multitude of factors, encompassing temperature, humidity, climate, and various environmental variables that necessitate meticulous consideration. Based on Factor Analysis model, which completely considers temperature, precipitation, solar radiation, wind, and land carrying capacity, a conclusion is presented, indicating that the growth of seeds is primarily influenced by plant attributes and climate conditions, with the former exerting a relatively stronger impact. Subsequently, the remaining two plants were chosen based on seed weight, yielding consistent conclusion.展开更多
The rotor is the most important component of rotating machinery,and the vibration produced by its mass unbalance has a serious influence on the secure and steady operation of the machine,so an effective online suppres...The rotor is the most important component of rotating machinery,and the vibration produced by its mass unbalance has a serious influence on the secure and steady operation of the machine,so an effective online suppression technology is urgently needed.A new hydraulic unbalanced bionic self-recovery system is introduced,imitating the way of manually repairing faulty equipment.To accomplish the effect of actuator mass redistribution,the technology employs pressurized air to drive the quantitative transfer of liquid in the reservoir cavity at opposite positions.It can complete the online adjustment of the equipment's balancing state and suppress the unbalanced vibration of equipment in real time,which gives the equipment the ability to maintain an autonomous health state and improve equipment performance.The composition and working principle of the system are introduced in detail,and the key performance parameters,such as the minimum running speed and the balancing liquid transfer speed,are analyzed theoretically.The fluid-solid coupling model of the actuator was established,and the two-phase flow from inside the hydraulic unbalanced bionic self-recovery actuator was simulated under multiple working conditions and the performance parameters were quantitatively analyzed.A balancing simulation test bed was built,and its effectiveness was verified by performance parameter tests and unbalanced bionic self-recovery experiments.The experimental results show that the mass distribution adjustment of the balancing disk can be achieved using different viscosity balancing liquid,and the response of liquid viscosity 10 cSt is faster than that of liquid viscosity 100 cSt in the process of balancing liquid transfer,and the time is reduced by more than 75%;the system can reduce the simulated rotor amplitude from 18.3μm to 10.6μm online in real time,which provides technical support for the subsequent development of a new generation of bionic intelligent equipment.展开更多
AIM:To gain insights into the global research hotspots and trends of myopia.METHODS:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically...AIM:To gain insights into the global research hotspots and trends of myopia.METHODS:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics software.RESULTS:A total of 444 institutions in 87 countries published 4124 articles.Between 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related journals.Citations from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research frontiers.CONCLUSION:Myopia has become a hot research field.China and Chinese institutions have the strongest academic influence in the field from 2013 to 2022.The main driver of myopic research is still medical or ophthalmologists.This study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s health.At present,a unified theoretical system is still needed.Accurate surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive errors.In addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.展开更多
The Ki67 index (KI) is a standard clinical marker for tumor proliferation;however, its application is hindered by intratumoral heterogeneity. In this study, we used digital image analysis to comprehensively analyze Ki...The Ki67 index (KI) is a standard clinical marker for tumor proliferation;however, its application is hindered by intratumoral heterogeneity. In this study, we used digital image analysis to comprehensively analyze Ki67 heterogeneity and distribution patterns in breast carcinoma. Using Smart Pathology software, we digitized and analyzed 42 excised breast carcinoma Ki67 slides. Boxplots, histograms, and heat maps were generated to illustrate the KI distribution. We found that 30% of cases (13/42) exhibited discrepancies between global and hotspot KI when using a 14% KI threshold for classification. Patients with higher global or hotspot KI values displayed greater heterogenicity. Ki67 distribution patterns were categorized as randomly distributed (52%, 22/42), peripheral (43%, 18/42), and centered (5%, 2/42). Our sampling simulator indicated analyzing more than 10 high-power fields was typically required to accurately estimate global KI, with sampling size being correlated with heterogeneity. In conclusion, using digital image analysis in whole-slide images allows for comprehensive Ki67 profile assessment, shedding light on heterogeneity and distribution patterns. This spatial information can facilitate KI surveys of breast cancer and other malignancies.展开更多
As part of the drive to improve coffee and cocoa production in Ivory Coast, studies are carried out to identify soils that are favourable for these crops. It is therefore necessary to orientate soil investigations bas...As part of the drive to improve coffee and cocoa production in Ivory Coast, studies are carried out to identify soils that are favourable for these crops. It is therefore necessary to orientate soil investigations based on reliable criteria that best discriminate soil cover. With this in mind, this study is being carried out to help improve survey methods by mapping soil landscapes. It uses GIS and weighted multicriteria analysis. To do this, satellite images were processed and the geological map of the square degrees of M’Bahiakro and Daloa was reclassified. The results show that relief is the main factor in soil landscape differentiation, with respective weights of 0.58 and 0.67 for the forest and pre-forest zones. In contrast, the weight of geological formation in soil landscape differentiation remains low (0.05 for the forest zone and 0.07 for the pre-forest zone). The criteria used on the base of aggregation sum methods have made it possible to formulate soil landscape mapping prediction functions according to agro-ecological environments in the humid intertropical zone. This is essential for the orientation of soil survey work. Nevertheless, other comparative methods, such as the coding mapping method, could provide elements for discussion to validate the models.展开更多
文摘Cutaneous leishmaniasis is regarded as a re-emerging disease due to its increase in spread and rate of transmission over the past decade due to a proportionate increase in global human movements.This study was therefore carried out to review epidemiology,laboratory diagnosis and treatment with in-depth discussion on some of the rare clinical presentations of the disease capable of influencing its control.The study was based on literature review on clinical and laboratory features of cutaneous leishmaniasis from original research articles,review articles, short communications,letters to editor and case reports on the disease for the past 10 years(April 2000 to April 2010).The results were analysed using simple descriptive methods.The rarest presentations of leishmaniasis encountered were peritibial ulcerations,hard painful nipple in a male,swollen upper lip,dermatofibro sarcoma protuberans,sternal proliferative growth,turban tumour,post operative granuloma,chalazion-like 0.00%,and cutaneous sterile pyogranuloma with asymmetrical alopecia 0.00%each.Others include infected sebaceous cysts 0.45%,syphilis 0.19%,yaws 0.13%,thrombotic ulcerations 0.40%,mycetoma 0.90%,sarcoidosis 0.67%,painless nasal solitary nodule 0.00%,tuberculous lymphadenopathy 0.25%and unilateral erythema nodosum 0.28%.Physicians practicing in cutaneous leishmaniasis endemic,but most especially in the non-endemic areas should bear in mind that the disease may not be that rare in the context of the present global village phenomenon:and that,the next case could just be that of cutaneous leishmaniasis,the clinical picture of the patient notwithstanding.
基金In-hospital Training Project of National Natural Science Foundation of China(04.03.19.153).
文摘[Objectives]To analyze the current research situation,hotspots and trends of curcumin and diabetes in recent 10 years.[Methods]Web of Science database was set as data source,the annual number of papers,the distribution of authors,the distribution of country/institution,the distribution of journals,the distribution of key words in the literature about curcumin and diabetes from January 1,2010 to March 31,2021 were quantitatively and visually analyzed with the aid of visualization software Bibliometrix.[Results]A total of 475 articles were included,and the annual number of papers was on the rise;the top three high-yielding countries were China(120 papers),India(65 papers),and the United States(58 papers).In terms of international cooperation,China and the United States had the most cooperation(27 papers);the top three high-yielding institutions were Wenzhou Medical University(42 papers),Mashhad University of Medical Sciences(41 papers)and Tehran University of Medical Sciences(30 papers);the most frequently cited authors were Wang Y(19 times),Li X(13 times),Li Y(12 times),Liang G(12 times)and Zhang Y(12 times);the top three journals in number of papers were Diabetology&Metabolic Syndrome(8 papers),PLoS One(8 papers),and European Journal of Pharmacology(7 papers),and the h index was 7,8,and 6,respectively;the most frequently cited journals were Diabetes(496 times),Journal of Biological Chemistry(486 times),PLoS One(347 times),Diabetes Care(284 times),and European Journal of Pharmacology(229 times);the most frequent key words mainly included oxidative stress,curcumin,insulin-resistance and expression;the hotspots were insulin resistance and NF-κB,mainly focusing on in vitro experiments.[Conclusions]The curcumin has good therapeutic potential in improving insulin resistance,inhibiting inflammation and oxidative stress,etc.The results are expected provide a reference and basis for scientific researchers to understand the current situation of curcumin and diabetes research and carry out the further research.
基金supported by the Humanities and Social Science Research Program of the Ministry of Education(No.15YJAZH105)
文摘Objective: To analyze the literature status and research hotspots of Science Citation Index(SCI)-related ostomy in the world and to provide references for scientific research and clinical work in the stoma care field.Methods: Based on the Web of Science core database and its own analysis function, HistCite analysis software and Excel were used to study the published research about ostomy patients.Results: A total of 1,262 articles were published between 1910 and 2016 with the authors from 48 countries and regions, 1,347 research institutions, published in 321 journals, with 4,048 first authors and coauthors; globally, there was a trend of slow growth in the number of authors every year. The study in the USA was absolutely in the lead position, and Canada and Turkey were more active.China's circulation volume was the 15 th in the world. The periodical that published most often was the Journal of Wound Ostomy and Continence Nursing. The most interdisciplinary surgical studies were surgery and nursing, where these should be considered important. The most prolific author in the field was "Grant", and the highest cited article was entitled as "Living with a stoma: a review of the literature".Conclusions: The related research of global stoma is constantly developing. The research hotspot is nursing before and after stoma surgery. China and the USA are leading countries in research. They should follow the recent trend to improve the depth and breadth of the research in the field.
基金Supported by the Scientific Research Project of Traditional Chinese Medicine of Health and Family Planning Commission of Chongqing (ZY20150243)
文摘AIM: To systematically review the association between complement factors I(CFI) polymorphisms and age-related macular degeneration(AMD) and to explore whether CFI polymorphisms are associated with AMD.·METHODS: Meta-analysis of articles published from1995 to January 2015 of articles involved with AMD and polymorphisms of the CFI gene. Eligible data were pooled in a Meta-analysis, analyzing using STATA software(version 12.0), Review Manager(version 5.2) and different models based on the heterogeneity of effect sizes. Egger's test, Begg's rank correlation methods were used to evaluate for publication bias.·RESULTS: Thirteen articles were eligible, describing two loci polymorphisms of the CFI gene(of which 12 articles focus on rs10033900 T >C and 3 articles focus on rs2285714 C >T). For rs10033900 T >C, the results of our study revealed that having a mutant allele C, TC, CC and TC +CC was associated with a decreased risk of AMD in all population groups studied(C versus T models, OR=0.84,95% CI: 0.72-0.99, P =0.04; TC versus TT models OR =0.89, 95% CI: 0.88-0.99, P =0.04;CC versus TT models,OR =0.76, 95% CI: 0.60-0.98, P =0.03; TC +CC versus TT models, OR =0.81, 95% CI:0.65-0.99, P =0.04). We found that C allele were related to lower AMD risk in the Caucasian population by subgroup analysis, but there was no association with AMD under the allele andgenotypes comparison in Asian studies. For rs2285714C>T, the TC, TT genotypes contributed to a higher risk of AMD, compared with the CC carriers and CT+CC(OR=1.34,95%CI: 1.09-1.63, P =0.004; OR=1.50, 95% CI: 1.25-1.80,P <0.0001).·CONCLUSION: This Meta-analysis suggests that CFI rs10033900 T >C and rs2285714 C >T polymorphisms may contribute to AMD.
文摘The literary review presented in the following paper aims to analyze the tracking tools used in different countries during the period of the COVID-19 pandemic. Tracking apps that have been adopted in many countries to collect data in a homogeneous and immediate way have made up for the difficulty of collecting data and standardizing evaluation criteria. However, the regulation on the protection of personal data in the health sector and the adoption of the new General Data Protection Regulation in European countries has placed a strong limitation on their use. This has not been the case in non-European countries, where monitoring methodologies have become widespread. The textual analysis presented is based on co-occurrence and multiple correspondence analysis to show the contact tracing methods adopted in different countries in the pandemic period by relating them to the issue of privacy. It also analyzed the possibility of applying Blockchain technology in applications for tracking contagions from COVID-19 and managing health data to provide a high level of security and transparency, including through anonymization, thus increasing user trust in using the apps.
基金Supported by Natural Science Foundation of Zhejiang Province,No.LY19H030004and The Lishui City Key Research and Ddevelopment Project,No.2022ZDYF08。
文摘BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack specificity.Thus,it is easy to misdiagnose HEA as other tumors of the liver,especially in the presence of liver diseases such as hepatitis cirrhosis.This article reviewed the diagnosis and treatment of a patient with HEA and alcoholic cirrhosis,and analyzed the literature,in order to improve the understanding of this disease.CASE SUMMARY A 67-year-old male patient with a history of alcoholic cirrhosis was admitted due to the discovery of a space-occupying lesion in the liver.Based on the patient’s history,laboratory examinations,and imaging examinations,a malignant liver tumor was considered and laparoscopic partial hepatectomy was performed.Postoperative pathology showed HEA.During outpatient follow-up,the patient showed no sign of recurrence.CONCLUSION HEA is difficult to make a definite diagnosis before surgery.HEA has the poten-tial for malignant degeneration.If conditions permit,surgical treatment is recom-mended.
基金support provided by the National Nature Science Foundation of China (Grant Nos.52075340,51875360)Project of Science and Technology Commission of Shanghai Municipality (No.19060502300).
文摘Gears are pivotal in mechanical drives,and gear contact analysis is a typically difficult problem to solve.Emerging isogeometric analysis(IGA)methods have developed new ideas to solve this problem.In this paper,a threedimensional body parametric gear model of IGA is established,and a theoretical formula is derived to realize single-tooth contact analysis.Results were benchmarked against those obtained from commercial software utilizing the finite element analysis(FEA)method to validate the accuracy of our approach.Our findings indicate that the IGA-based contact algorithmsuccessfullymet theHertz contact test.When juxtaposed with the FEA approach,the IGAmethod demonstrated fewer node degrees of freedomand reduced computational units,all whilemaintaining comparable accuracy.Notably,the IGA method appeared to exhibit consistency in analysis accuracy irrespective of computational unit density,and also significantlymitigated non-physical oscillations in contact stress across the tooth width.This underscores the prowess of IGA in contact analysis.In conclusion,IGA emerges as a potent tool for addressing contact analysis challenges and holds significant promise for 3D gear modeling,simulation,and optimization of various mechanical components.
基金supported by the Comprehensive Research Facility for Fusion Technology(CRAFT)Program of China(No.2018-000052-73-01-001228)National Natural Science Foundation of China(No.12205330)。
文摘The supercritical CO_(2)cOoled Lithium-Lead(COOL)blanket has been designed as one advanced blanket candidate for the Chinese Fusion Engineering Test Reactor(CFETR).This work focuses on the electromagnetic(EM)loads(Maxwell force and Lorentz force)acting on the COOL blanket,which are important mechanical loads in further structural analysis of the COOL blanket.A 3D electromagnetic analysis is performed using the ANSYS finite element method to obtain EM loads on the COOL blanket in this study.At first,the magnetic scalar potential(MSP)method is used to obtain the magnetic field and the Maxwell force on the COOL blanket.Then,the magnetic vector potential(MVP)method is performed during a plasma disruption event to get the eddy current distribution.At last,a multi-step method is adopted for the calculation of the Lorentz force and the torque.The maximum Lorentz forces of inboard and outboard blanket structural components are 5624 kN and 2360 kN respectively.
基金support from the National Key R&D Program of China(Grant No.2018YFE0118700)the National Natural Science Foundation of China(NSFC Grant No.62174119)+1 种基金the 111 Project(Grant No.B07014)the Foundation for Talent Scientists of Nanchang Institute for Microtechnology of Tianjin University.
文摘DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis.
基金financially supported by the National Natural Science Foundation of China (Grant Nos.32101571,32002071)the Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding (Grant No.2021C02071-6)。
文摘Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellular space, are key enzymes participating in sucrose allocation in higher plants. Previous studies have shown that CWINs play an essential role in bulblet initiation process in bulbous crops, but the underlying molecular mechanism remains unclear. Here, a CWIN gene of Lilium brownii var. giganteum(Lbg) was identified and amplified from genomic DNA. Quantitative RT-PCR assays revealed that the expression level of LbgCWIN1 was highly upregulated exactly when the endogenous starch degraded in non-sucrose medium during in vitro bulblet initiation in Lbg. Phylogenetic relationship, motif, and domain analysis of LbgCWIN1 protein and CWINs in other plant species showed that all sequences of these CWIN proteins were highly conserved. The promoter sequence of LbgCWIN1 possessed a number of alpha-amylase-, phytohormone-, light-and stress-responsive cis-elements. Meanwhile, β-glucuronidase(GUS) assay showed that the 459 bp upstream fragment from the translational start site displayed maximal promoter activity. These results revealed that LbgCWIN1 might function in the process of in vitro bulblet initiation and be in the response to degradation of endogenous starch.
文摘Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To explore the risk and protective factors of suicidal behaviours(ie,suicidal ideation,plans and attempts)in early adolescence in China using a social-ecological perspective.Methods Using data from the cross-sectional project‘Healthy and Risky Behaviours Among Middle School Students in Anhui Province,China',stratified random cluster sampling was used to select 5724 middle school students who had completed self-report questionnaires in November 2020.Network analysis was employed to examine the correlates of suicidal ideation,plans and attempts at four levels,namely individual(sex,academic performance,serious physical llness/disability,history of self-harm,depression,impulsivity,sleep problems,resilience),family(family economic status,relationship with mother,relationship with father,family violence,childhood abuse,parental mental illness),school(relationship with teachers,relationship with classmates,school-bullying victimisation and perpetration)and social(social support,satisfaction with society).Results In total,37.9%,19.0%and 5.5%of the students reported suicidal ideation,plans and attempts in the past 6 months,respectively.The estimated network revealed that suicidal ideation,plans and attempts were collectively associated with a history of self-harm,sleep problems,childhood abuse,school bullying and victimisation.Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse.Notably,the network also showed unique correlates of suicidal ideation(sex,weight=0.60;impulsivity,weight=0.24;family violence,weight=0.17;relationship with teachers,weight=-0.03;school-bullying perpetration,weight=0.22),suicidal plans(social support,weight=-0.15)and suicidal attempts(relationship with mother,weight=-0.10;parental mental llness,weight=0.61).Conclusions This study identified the correlates of suicidal ideation,plans and attempts,and provided practical implications for suicide prevention for young adolescents in China.Firstly,this study highlighted the importance of joint interventions across multiple departments.Secondly,the common risk factors of suicidal ideation,plans and attempts were elucidated.Thirdly,this study proposed target interventions to address the unique influencing factors of suicidal ideation,plans and attempts.
文摘To the editor:Non-suicidal self-injury(NSSI)is defined as direct,repetitive self-injury to bodily tissues without suicidal intent. The estimated prevalence of NsSI among adolescents is 17.2%worldwide with a comparable rate observed in China. As a behavioural addiction, NSSI poses a significant suicide risk,and is emerging as a major mental health problem among adolescents.To unravel this puzzle,the four-function model(FFM)distinguishes between interpersonal and intrapersonal functions,as well as positive and negative reinforcement functions,proving relatively comprehensive among various theoretical models.
文摘Effects of performing an R-factor analysis of observed variables based on population models comprising R- and Q-factors were investigated. Although R-factor analysis of data based on a population model comprising R- and Q-factors is possible, this may lead to model error. Accordingly, loading estimates resulting from R-factor analysis of sample data drawn from a population based on a combination of R- and Q-factors will be biased. It was shown in a simulation study that a large amount of Q-factor variance induces an increase in the variation of R-factor loading estimates beyond the chance level. Tests of the multivariate kurtosis of observed variables are proposed as an indicator of possible Q-factor variance in observed variables as a prerequisite for R-factor analysis.
文摘We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with Principal Component Analysis(PCA). AISI 316L stainless steel sheets were used to develop double wall angle pyramid with aid of tungsten carbide tool. GRA coupled with PCA was used to plan the experiment conditions. Control factors such as Tool Diameter(TD), Step Depth(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Spindle Speed(SS) on Top Wall Angle(TWA) and Top Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workpiece. As the step depth, feed rate and spindle speed increase,TWASR decreases with increasing tool diameter. As the step depth increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the proposed hybrid method was suitable for optimizing the factors and response.
文摘A weed is a plant that thrives in areas of human disturbance, such as gardens, fields, pastures, waysides, and waste places where it is not intentionally cultivated. Dispersal affects community dynamics and vegetation response to global change. The process of seed disposal is influenced by wind, which plays a crucial role in determining the distance and probability of seed dispersal. Existing models of seed dispersal consider wind direction but fail to incorporate wind intensity. In this paper, a novel seed disposal model was proposed in this paper, incorporating wind intensity based on relevant references. According to various climatic conditions, including temperate, arid, and tropical regions, three specific regions were selected to establish a wind dispersal model that accurately reflects the density function distribution of dispersal distance. Additionally, dandelions growth is influenced by a multitude of factors, encompassing temperature, humidity, climate, and various environmental variables that necessitate meticulous consideration. Based on Factor Analysis model, which completely considers temperature, precipitation, solar radiation, wind, and land carrying capacity, a conclusion is presented, indicating that the growth of seeds is primarily influenced by plant attributes and climate conditions, with the former exerting a relatively stronger impact. Subsequently, the remaining two plants were chosen based on seed weight, yielding consistent conclusion.
基金the financial support through Beijing Natural Science Foundation(Grant No.3212010)National Natural Science Foundation of China(Grant No.51875031).
文摘The rotor is the most important component of rotating machinery,and the vibration produced by its mass unbalance has a serious influence on the secure and steady operation of the machine,so an effective online suppression technology is urgently needed.A new hydraulic unbalanced bionic self-recovery system is introduced,imitating the way of manually repairing faulty equipment.To accomplish the effect of actuator mass redistribution,the technology employs pressurized air to drive the quantitative transfer of liquid in the reservoir cavity at opposite positions.It can complete the online adjustment of the equipment's balancing state and suppress the unbalanced vibration of equipment in real time,which gives the equipment the ability to maintain an autonomous health state and improve equipment performance.The composition and working principle of the system are introduced in detail,and the key performance parameters,such as the minimum running speed and the balancing liquid transfer speed,are analyzed theoretically.The fluid-solid coupling model of the actuator was established,and the two-phase flow from inside the hydraulic unbalanced bionic self-recovery actuator was simulated under multiple working conditions and the performance parameters were quantitatively analyzed.A balancing simulation test bed was built,and its effectiveness was verified by performance parameter tests and unbalanced bionic self-recovery experiments.The experimental results show that the mass distribution adjustment of the balancing disk can be achieved using different viscosity balancing liquid,and the response of liquid viscosity 10 cSt is faster than that of liquid viscosity 100 cSt in the process of balancing liquid transfer,and the time is reduced by more than 75%;the system can reduce the simulated rotor amplitude from 18.3μm to 10.6μm online in real time,which provides technical support for the subsequent development of a new generation of bionic intelligent equipment.
基金Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(No.SZGSP014)Sanming Project of Medicine in Shenzhen(No.SZSM202311012)Shenzhen Science and Technology Planning Project(No.KCXFZ20211020163813019).
文摘AIM:To gain insights into the global research hotspots and trends of myopia.METHODS:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics software.RESULTS:A total of 444 institutions in 87 countries published 4124 articles.Between 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related journals.Citations from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research frontiers.CONCLUSION:Myopia has become a hot research field.China and Chinese institutions have the strongest academic influence in the field from 2013 to 2022.The main driver of myopic research is still medical or ophthalmologists.This study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s health.At present,a unified theoretical system is still needed.Accurate surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive errors.In addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.
文摘The Ki67 index (KI) is a standard clinical marker for tumor proliferation;however, its application is hindered by intratumoral heterogeneity. In this study, we used digital image analysis to comprehensively analyze Ki67 heterogeneity and distribution patterns in breast carcinoma. Using Smart Pathology software, we digitized and analyzed 42 excised breast carcinoma Ki67 slides. Boxplots, histograms, and heat maps were generated to illustrate the KI distribution. We found that 30% of cases (13/42) exhibited discrepancies between global and hotspot KI when using a 14% KI threshold for classification. Patients with higher global or hotspot KI values displayed greater heterogenicity. Ki67 distribution patterns were categorized as randomly distributed (52%, 22/42), peripheral (43%, 18/42), and centered (5%, 2/42). Our sampling simulator indicated analyzing more than 10 high-power fields was typically required to accurately estimate global KI, with sampling size being correlated with heterogeneity. In conclusion, using digital image analysis in whole-slide images allows for comprehensive Ki67 profile assessment, shedding light on heterogeneity and distribution patterns. This spatial information can facilitate KI surveys of breast cancer and other malignancies.
文摘As part of the drive to improve coffee and cocoa production in Ivory Coast, studies are carried out to identify soils that are favourable for these crops. It is therefore necessary to orientate soil investigations based on reliable criteria that best discriminate soil cover. With this in mind, this study is being carried out to help improve survey methods by mapping soil landscapes. It uses GIS and weighted multicriteria analysis. To do this, satellite images were processed and the geological map of the square degrees of M’Bahiakro and Daloa was reclassified. The results show that relief is the main factor in soil landscape differentiation, with respective weights of 0.58 and 0.67 for the forest and pre-forest zones. In contrast, the weight of geological formation in soil landscape differentiation remains low (0.05 for the forest zone and 0.07 for the pre-forest zone). The criteria used on the base of aggregation sum methods have made it possible to formulate soil landscape mapping prediction functions according to agro-ecological environments in the humid intertropical zone. This is essential for the orientation of soil survey work. Nevertheless, other comparative methods, such as the coding mapping method, could provide elements for discussion to validate the models.
