AIM:To assess the effect of experimentally induced anisometropia on binocularity in normal adults with glassesfree three-dimensional(3D)technique.METHODS:Totally 54 healthy medical students with normal binocularity in...AIM:To assess the effect of experimentally induced anisometropia on binocularity in normal adults with glassesfree three-dimensional(3D)technique.METHODS:Totally 54 healthy medical students with normal binocularity in the cross-sectional study were enrolled.Anisometropia was induced by placing trail lenses over the right eye,in 0.5 D steps including lenses of-0.5,-1,-1.5,-2,-2.5 D(hyperopic anisometropia)and lenses of+0.5,+1,+1.5,+2,+2.5 D(myopic anisometropia).The glasses-free 3D technique was used to evaluated not only fine stereopsis,but also coarse stereopsis,dynamic stereopsis,foveal suppression,and peripheral suppression in these subjects.One-way analysis of variance was used to compare quantitative data such as fine stereopsis,coarse stereopsis.Pearson’s Chi-square test was performed to compare categorical data such as dynamic stereopsis,foveal suppression and peripheral suppression.RESULTS:The subjects showed a statistically significant decline in fine stereopsis,coarse stereopsis,and dynamic stereopsis with increasing levels of anisometropia(P<0.001).Binocularity was af fected when induced anisometropia was more than 1 D(P<0.05).Foveal suppression and peripheral suppression were evident and increased in proportion to anisometropia(P<0.001).CONCLUSION:The relatively low degrees of anisometropia may have a potentially significant effect on high-grade binocular interaction.The mechanisms underlying the defect of binocularity seem to involve not only foveal suppression,but also peripheral suppression.展开更多
AIM:To investigate the differences in retinal refraction difference values(RDVs)of adult patients with myopic anisometropia compared with those without myopic anisometropia,and to investigate the relationship between ...AIM:To investigate the differences in retinal refraction difference values(RDVs)of adult patients with myopic anisometropia compared with those without myopic anisometropia,and to investigate the relationship between ocular biometric measurements and relative peripheral refraction.METHODS:This clinical observation study included 130 patients with myopia(-0.25 to-10.00 D)between October 2022 and January 2023 aged between 18 and 40y.The patients were divided into anisometropia(n=63;difference in binocular anisometropia≥1.00 D)and non-anisometropia(n=67;difference in binocular anisometropia<1.00 D)groups accordingly.Ocular biometric measurements were performed by optical biometrics and corneal topography to assess the steep keratometry(Ks),flap keratometry(Kf),axial length(AL),corneal astigmatism(CYL;Ks-Kf),surface regularity index(SRI),surface asymmetry index(SAI),and central corneal thickness(CCT).The RDV was measured at five retinal areas from the fovea to 53 degrees(RDV-0-10,RDV-10-20,RDV-20-30,RDV-30-40,and RDV-40-53),the total RDV(TRDV)of 53 degrees,and four regions,including RDV-superior,RDV-inferior,RDV-temporal,and RDV-nasal.An analysis of Spearman correlation was carried out to examine the correlation between RDV and the spherical equivalent(SE)and ocular biological parameters.RESULTS:Within RDV-20-53,both groups showed relative hyperopic defocus,and the increase in RDV corresponds to the increase in eccentricity.In the myopic anisometropia group,the TRDV,RDV-20-53,RDV-superior,and more myopic eyes had significantly higher RDVtemporal values than less myopic eyes.(P<0.05).In the non-anisometropia group,there was no significant difference in the RDV between the more and less myopic eyes at different eccentricities(P>0.05).There was a negative correlation between SE and TRDV(r=-0.205,P=0.001),RDV-20-53(r=-0.281,-0.183,-0.176,P<0.05),RDV-superior(r=-0.251,P<0.001),and RDV-temporal(r=-0.230,P<0.001),a negative correlation between CYL and RDV-10-30(r=-0.147,-0.180,P<0.05),and a negative correlation between SRI and RDV-0-20(r=-0.190,-0.170,P<0.05).AL had a positive correlation with RDV-20-30(r=0.164,P=0.008)and RDV-temporal(r=0.160,P=0.010).CONCLUSION:More myopic eyes in patients with myopic anisometropia show more peripheral hyperopic defocus.Diopter and corneal morphology may affect peripheral retinal defocus.展开更多
AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult my...AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult myopia anisometropia based on the nomogram.METHODS:It’s a prospective cohort study.Patients with anisometropic myopia of refractive difference≥2.0 diopters(D)who underwent SMILE between September 2020 and March 2021 were enrolled.Clinical features and visual function were assessed preoperatively and at 1wk,1,3,and 6mo after the operation.The examination included tests for uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),refractive errors,effectiveness index(preoperative CDVA/postoperative UDVA),safety index(postoperative CDVA/preoperative CDVA),nomogram and stereoscopic function.Paired t-test,Wilcoxon signed-rank test and repeated-measures analyses of variance were used for continuous variables,and Pearson Chi-squared test was used for categorical variables.RESULTS:The study involved 45 consecutive patients(average age:25.0±6.9y;82 out of 90 eyes underwent SMILE,while 8 eyes were not operated).The average preoperative spherical equivalent(SE)was-4.74±0.22 D.Six months after surgery,the effectiveness index was 1.05±0.12,and the safety index was 1.09±0.11.Seventy eyes(85.4%)exhibited SE correction error within±0.5 D.The percentage of eyes with Titmus stereoscopic function equal to or less than 200”significantly increased from 55.6%preoperatively to 88.9%postoperatively(P<0.05).There was statistically significant difference between higher myopia eyes and contralateral eyes in average nomogram value/spherical refraction ratio.CONCLUSION:SMILE is safe,effective and predictable in correcting myopic anisometropia,and it improves stereoscopic visual function of anisometropia patients.The precise and individualized design of the nomogram is a vital element to ensure the balance of both eyes after SMILE.展开更多
AIM:To investigate the significance of ultrasound elastography for evaluating stiffness of the human lens nucleus in patients with anisometropia.METHODS:A total of 14 patients(28 eyes)with anisometropia were enrolled....AIM:To investigate the significance of ultrasound elastography for evaluating stiffness of the human lens nucleus in patients with anisometropia.METHODS:A total of 14 patients(28 eyes)with anisometropia were enrolled.The difference in refractive status between two eyes≥-4.0 diopters(D)and the difference in axial length(AL)of the eyes was≥3 mm.There were 5 males and 9 females with an average age of 62±3.3 y.The test data of the long AL eye of each patient was included in group A(14 eyes),and test data of the eye with relative short AL was included in group B.Lens nuclear stiffness was measured with free-hand qualitative elastography by independent operators.Strain gray scale and color-coded elastography maps were recorded.In each case,three consecutive measurements were performed and strain ratio was used for statistical analysis.Photograph and sectional view of the lens were analyzed and archived by anterior segment image.RESULTS:In the long AL group,the strain rate in the nucleus of the lens was 0.16%±0.08%;in the short AL group,the strain rate in the nucleus of the lens was 0.54%±0.16%.Independent sample t-test analyses showed that the long AL group lens had a significantly smaller nuclear strain rate than the relatively short AL group,P<0.05.CONCLUSION:The relationship between human lens stiffness and different AL is demonstrated by ultrasound elastography.The long AL is associated with lower strain ratio and less resilience of the lens.展开更多
Dear Editor,We read with great interest article titled"Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia"by Chen et al[1].The authors have analysed subjects with pre...Dear Editor,We read with great interest article titled"Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia"by Chen et al[1].The authors have analysed subjects with previously untreated anisometropic amblyopia and found a significant correlation between high degree of anisometropia and deep amblyopia,worse contrast sensitivity,fusion and stereopsis functions.We commend the authors in addressing a very important problem and agree with the authors in the notation that children with anisometropia are usually detected later owing to lack of noticeable physical abnormalities.展开更多
Objectives: The study aimed to compare stereopsis, aniseikonia, and associated symptoms in bilateral pseudophakia with and without anisometropia. Methods: Patients with senile cataracts, previously scheduled for phaco...Objectives: The study aimed to compare stereopsis, aniseikonia, and associated symptoms in bilateral pseudophakia with and without anisometropia. Methods: Patients with senile cataracts, previously scheduled for phacoemulsification with an IOL implant in both eyes were included in this cross-sectional study. Patients were divided into two groups: control group (n = 69) with an interocular post-surgical refraction difference in Spherical Equivalent (SE) <sup>?</sup>;Stereotest. Ten symptoms related to aniseikonia were evaluated with a questionnaire. Statistical evaluation of data included models of univariate, multivariate, and regression analyses. Results: Cataract surgery-induced aniseikonia was 0.64% ± 1.41% in control group and 0.62% ± 1.76% in anisometropia group with an insignificant difference (p = 0.766). Measured stereoacuity was 1.95 ± 0.17 log10 seconds of arc in the control group and 2.12 ± 0.22 log10 seconds of arc in the anisometropia group with a significant difference (p Conclusions: The study showed that stereopsis, aniseikonia, and associated symptoms did not stand for a substantial problem for visual comfort of bilateral pseu- dophakia with anisometropia less than 3D.展开更多
Objective: The current study aimed to assess the association between the type of anisometropia and its effects on monocular and binocular best-corrected vision acuity (BCVA), aniseikonia, and stereopsis in the absence...Objective: The current study aimed to assess the association between the type of anisometropia and its effects on monocular and binocular best-corrected vision acuity (BCVA), aniseikonia, and stereopsis in the absence of strabismus. Methods: In total, 162 individuals with anisometropia and healthy eyes and without a previous history of amblyopia therapy and eye surgery were included in the analysis. According to spherical and cylindrical components and spherical equivalent, they were divided into the spherical hyperopic anisometropia (SHA, n = 31), spherical myopic anisometropia (SMA, n = 45), astigmatic or cylindrical hyperopic anisometropia (CHA, n = 22), and astigmatic or cylindrical myopic anisometropia (CMA, n = 64) groups. Patients without anisometropia (NA, n = 188) were classified under the control group. The effects of anisometropia on monocular and binocular BCVA, aniseikonia, and stereoacuity were examined. Results: The NA group had a significantly lower LogMAR of BCVA of the right eye (RE), left eye (LE), worse eye than the SHA, SMA, CMA, and CHA groups. Moreover, the SMA group had significantly lower LogMAR of BCVA than the CHA group (p Conclusion: Worse visual levels of the RE, LE, worse eye, BCVA difference, and lower stereopsis were evidenced in each type of anisometropia defined in this study. Cylindrical hyperopic anisometropia (CHA) resulted in a statically significant worsening VA level and stereopsis than cylindrical myopic (CMA) or spherical myopic anisometropia.展开更多
目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正...目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正视力(BCVA)、一阶光栅锐度和(或)二阶纹理敏感度,并分析不同程度弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。结果:弱视组与正常对照组一阶光栅锐度(11.58±6.10 vs 20.27±3.47,P<0.001)、二阶纹理敏感度(0.33±0.16 vs 0.12±0.04,P<0.001)均有明显差异,且轻中度弱视患者与重度弱视患者一阶光栅锐度(12.10±6.23 vs 8.13±3.70,P<0.001)和二阶纹理敏感度(0.32±0.16 vs 0.37±0.17,P<0.05)均有明显差异。结论:单眼屈光参差性弱视患者大脑皮层一阶视觉通路和二阶视觉通路均存在不同程度的损伤,重度弱视患者较轻中度弱视患者损伤更为严重。展开更多
Background:This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal b...Background:This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia.Methods:The sample comprised 44 participants with anisometropic myopia,aged 9 to 18 years,with normal bestcorrected visual acuity.All participants underwent a series of examinations,including spherical equivalent refraction(SER)and axial length(AL),measured by a Lenstar optical biometer and optical coherence tomography angiography(OCTA)scanner.OCT measured the choroidal thickness,vascular density,and flow voids of the choriocapillaris,and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL.The choroidal thickness was measured at the fovea and 0.5,1.0,1.5,2.0,2.5,and 3.0 mm nasally,temporally,inferiorly,and superiorly to the fovea.The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle,and the 0.6-2.5 mm diameter circle in the nasal,temporal,inferior,and superior regions.Repeated-measured ANOVAs were used to analyze the interocular differences.Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness,the choriocapillaris vascular density and flow voids,the SER and AL.Results:The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes(P≤0.001),and the flow voids in the more myopic eyes were more than less myopic eyes(P=0.002).There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes(P=0.525).However,when anisometropia was more than 1.50 D,the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes(P=0.026).The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center,superior,and inferior regions but not in the nasal or temporal regions.The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL.Conclusions:The choroidal thickness is thinner in the more myopic eyes.The flow void is increased,and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D.展开更多
Amblyopia is the most common cause of vision loss in children and can persist into adulthood in the absence of effective intervention.Previous clinical and neuroimaging studies have suggested that the neural mechanism...Amblyopia is the most common cause of vision loss in children and can persist into adulthood in the absence of effective intervention.Previous clinical and neuroimaging studies have suggested that the neural mechanisms underlying strabismic amblyopia and anisometropic amblyopia may be different.Therefore,we performed a systematic review of magnetic resonance imaging studies investigating brain alterations in patients with these two subtypes of amblyopia;this study is registered with PROSPERO(registration ID:CRD42022349191).We searched three online databases(PubMed,EMBASE,and Web of Science) from inception to April 1,2022;39 studies with 633 patients(324patients with anisometropic amblyo pia and 309 patients with strabismic amblyopia) and 580 healthy controls met the inclusion criteria(e.g.,case-control designed,pee r-reviewed articles) and were included in this review.These studies highlighted that both strabismic amblyopia and anisometropic amblyopia patients showed reduced activation and distorted topological cortical activated maps in the striate and extrastriate co rtices during tas k-based functional magnetic resonance imaging with spatial-frequency stimulus and retinotopic representations,respectively;these may have arisen from abnormal visual experiences.Compensations for amblyopia that are reflected in enhanced spontaneous brain function have been reported in the early visual cortices in the resting state,as well as reduced functional connectivity in the dorsal pathway and structural connections in the ventral pathway in both anisometro pic amblyopia and strabismic amblyopia patients.The shared dysfunction of anisometro pic amblyopia and strabismic amblyopia patients,relative to controls,is also chara cterized by reduced spontaneous brain activity in the oculomotor co rtex,mainly involving the frontal and parietal eye fields and the cerebellu m;this may underlie the neural mechanisms of fixation instability and anomalous saccades in amblyopia.With regards to specific alterations of the two forms of amblyo pia,anisometropic amblyo pia patients suffer more microstructural impairments in the precortical pathway than strabismic amblyopia patients,as reflected by diffusion tensor imaging,and more significant dysfunction and structural loss in the ventral pathway.Strabismic amblyopia patients experience more attenuation of activation in the extrastriate co rtex than in the striate cortex when compared to anisometropic amblyopia patients.Finally,brain structural magnetic resonance imaging alterations tend to be lateralized in the adult anisometropic amblyopia patients,and the patterns of brain alterations are more limited in amblyopic adults than in childre n.In conclusion,magnetic resonance imaging studies provide important insights into the brain alterations underlying the pathophysiology of amblyopia and demonstrate common and specific alte rations in anisometropic amblyo pia and strabismic amblyopia patients;these alterations may improve our understanding of the neural mechanisms underlying amblyopia.展开更多
基金Supported by Sichuan Science and Technology Program (No.23NSFSC0856)。
文摘AIM:To assess the effect of experimentally induced anisometropia on binocularity in normal adults with glassesfree three-dimensional(3D)technique.METHODS:Totally 54 healthy medical students with normal binocularity in the cross-sectional study were enrolled.Anisometropia was induced by placing trail lenses over the right eye,in 0.5 D steps including lenses of-0.5,-1,-1.5,-2,-2.5 D(hyperopic anisometropia)and lenses of+0.5,+1,+1.5,+2,+2.5 D(myopic anisometropia).The glasses-free 3D technique was used to evaluated not only fine stereopsis,but also coarse stereopsis,dynamic stereopsis,foveal suppression,and peripheral suppression in these subjects.One-way analysis of variance was used to compare quantitative data such as fine stereopsis,coarse stereopsis.Pearson’s Chi-square test was performed to compare categorical data such as dynamic stereopsis,foveal suppression and peripheral suppression.RESULTS:The subjects showed a statistically significant decline in fine stereopsis,coarse stereopsis,and dynamic stereopsis with increasing levels of anisometropia(P<0.001).Binocularity was af fected when induced anisometropia was more than 1 D(P<0.05).Foveal suppression and peripheral suppression were evident and increased in proportion to anisometropia(P<0.001).CONCLUSION:The relatively low degrees of anisometropia may have a potentially significant effect on high-grade binocular interaction.The mechanisms underlying the defect of binocularity seem to involve not only foveal suppression,but also peripheral suppression.
文摘AIM:To investigate the differences in retinal refraction difference values(RDVs)of adult patients with myopic anisometropia compared with those without myopic anisometropia,and to investigate the relationship between ocular biometric measurements and relative peripheral refraction.METHODS:This clinical observation study included 130 patients with myopia(-0.25 to-10.00 D)between October 2022 and January 2023 aged between 18 and 40y.The patients were divided into anisometropia(n=63;difference in binocular anisometropia≥1.00 D)and non-anisometropia(n=67;difference in binocular anisometropia<1.00 D)groups accordingly.Ocular biometric measurements were performed by optical biometrics and corneal topography to assess the steep keratometry(Ks),flap keratometry(Kf),axial length(AL),corneal astigmatism(CYL;Ks-Kf),surface regularity index(SRI),surface asymmetry index(SAI),and central corneal thickness(CCT).The RDV was measured at five retinal areas from the fovea to 53 degrees(RDV-0-10,RDV-10-20,RDV-20-30,RDV-30-40,and RDV-40-53),the total RDV(TRDV)of 53 degrees,and four regions,including RDV-superior,RDV-inferior,RDV-temporal,and RDV-nasal.An analysis of Spearman correlation was carried out to examine the correlation between RDV and the spherical equivalent(SE)and ocular biological parameters.RESULTS:Within RDV-20-53,both groups showed relative hyperopic defocus,and the increase in RDV corresponds to the increase in eccentricity.In the myopic anisometropia group,the TRDV,RDV-20-53,RDV-superior,and more myopic eyes had significantly higher RDVtemporal values than less myopic eyes.(P<0.05).In the non-anisometropia group,there was no significant difference in the RDV between the more and less myopic eyes at different eccentricities(P>0.05).There was a negative correlation between SE and TRDV(r=-0.205,P=0.001),RDV-20-53(r=-0.281,-0.183,-0.176,P<0.05),RDV-superior(r=-0.251,P<0.001),and RDV-temporal(r=-0.230,P<0.001),a negative correlation between CYL and RDV-10-30(r=-0.147,-0.180,P<0.05),and a negative correlation between SRI and RDV-0-20(r=-0.190,-0.170,P<0.05).AL had a positive correlation with RDV-20-30(r=0.164,P=0.008)and RDV-temporal(r=0.160,P=0.010).CONCLUSION:More myopic eyes in patients with myopic anisometropia show more peripheral hyperopic defocus.Diopter and corneal morphology may affect peripheral retinal defocus.
基金Supported by the National Natural Science Foundation of China(No.81970832No.81870650)+2 种基金the Key Project of the Chongqing Health Commission(No.2018MSXM003No.2018GDRC008)Natural Science Foundation of Chongqing Science and Technology Bureau(No.cstc2021jcyj-msxmX0967).
文摘AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult myopia anisometropia based on the nomogram.METHODS:It’s a prospective cohort study.Patients with anisometropic myopia of refractive difference≥2.0 diopters(D)who underwent SMILE between September 2020 and March 2021 were enrolled.Clinical features and visual function were assessed preoperatively and at 1wk,1,3,and 6mo after the operation.The examination included tests for uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),refractive errors,effectiveness index(preoperative CDVA/postoperative UDVA),safety index(postoperative CDVA/preoperative CDVA),nomogram and stereoscopic function.Paired t-test,Wilcoxon signed-rank test and repeated-measures analyses of variance were used for continuous variables,and Pearson Chi-squared test was used for categorical variables.RESULTS:The study involved 45 consecutive patients(average age:25.0±6.9y;82 out of 90 eyes underwent SMILE,while 8 eyes were not operated).The average preoperative spherical equivalent(SE)was-4.74±0.22 D.Six months after surgery,the effectiveness index was 1.05±0.12,and the safety index was 1.09±0.11.Seventy eyes(85.4%)exhibited SE correction error within±0.5 D.The percentage of eyes with Titmus stereoscopic function equal to or less than 200”significantly increased from 55.6%preoperatively to 88.9%postoperatively(P<0.05).There was statistically significant difference between higher myopia eyes and contralateral eyes in average nomogram value/spherical refraction ratio.CONCLUSION:SMILE is safe,effective and predictable in correcting myopic anisometropia,and it improves stereoscopic visual function of anisometropia patients.The precise and individualized design of the nomogram is a vital element to ensure the balance of both eyes after SMILE.
基金Supported by the National Natural Science Foundation of China(No.81600720,No.81370997)Shaanxi Nature Science Foundation Project(No.2017JQ8012).
文摘AIM:To investigate the significance of ultrasound elastography for evaluating stiffness of the human lens nucleus in patients with anisometropia.METHODS:A total of 14 patients(28 eyes)with anisometropia were enrolled.The difference in refractive status between two eyes≥-4.0 diopters(D)and the difference in axial length(AL)of the eyes was≥3 mm.There were 5 males and 9 females with an average age of 62±3.3 y.The test data of the long AL eye of each patient was included in group A(14 eyes),and test data of the eye with relative short AL was included in group B.Lens nuclear stiffness was measured with free-hand qualitative elastography by independent operators.Strain gray scale and color-coded elastography maps were recorded.In each case,three consecutive measurements were performed and strain ratio was used for statistical analysis.Photograph and sectional view of the lens were analyzed and archived by anterior segment image.RESULTS:In the long AL group,the strain rate in the nucleus of the lens was 0.16%±0.08%;in the short AL group,the strain rate in the nucleus of the lens was 0.54%±0.16%.Independent sample t-test analyses showed that the long AL group lens had a significantly smaller nuclear strain rate than the relatively short AL group,P<0.05.CONCLUSION:The relationship between human lens stiffness and different AL is demonstrated by ultrasound elastography.The long AL is associated with lower strain ratio and less resilience of the lens.
文摘Dear Editor,We read with great interest article titled"Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia"by Chen et al[1].The authors have analysed subjects with previously untreated anisometropic amblyopia and found a significant correlation between high degree of anisometropia and deep amblyopia,worse contrast sensitivity,fusion and stereopsis functions.We commend the authors in addressing a very important problem and agree with the authors in the notation that children with anisometropia are usually detected later owing to lack of noticeable physical abnormalities.
文摘Objectives: The study aimed to compare stereopsis, aniseikonia, and associated symptoms in bilateral pseudophakia with and without anisometropia. Methods: Patients with senile cataracts, previously scheduled for phacoemulsification with an IOL implant in both eyes were included in this cross-sectional study. Patients were divided into two groups: control group (n = 69) with an interocular post-surgical refraction difference in Spherical Equivalent (SE) <sup>?</sup>;Stereotest. Ten symptoms related to aniseikonia were evaluated with a questionnaire. Statistical evaluation of data included models of univariate, multivariate, and regression analyses. Results: Cataract surgery-induced aniseikonia was 0.64% ± 1.41% in control group and 0.62% ± 1.76% in anisometropia group with an insignificant difference (p = 0.766). Measured stereoacuity was 1.95 ± 0.17 log10 seconds of arc in the control group and 2.12 ± 0.22 log10 seconds of arc in the anisometropia group with a significant difference (p Conclusions: The study showed that stereopsis, aniseikonia, and associated symptoms did not stand for a substantial problem for visual comfort of bilateral pseu- dophakia with anisometropia less than 3D.
文摘Objective: The current study aimed to assess the association between the type of anisometropia and its effects on monocular and binocular best-corrected vision acuity (BCVA), aniseikonia, and stereopsis in the absence of strabismus. Methods: In total, 162 individuals with anisometropia and healthy eyes and without a previous history of amblyopia therapy and eye surgery were included in the analysis. According to spherical and cylindrical components and spherical equivalent, they were divided into the spherical hyperopic anisometropia (SHA, n = 31), spherical myopic anisometropia (SMA, n = 45), astigmatic or cylindrical hyperopic anisometropia (CHA, n = 22), and astigmatic or cylindrical myopic anisometropia (CMA, n = 64) groups. Patients without anisometropia (NA, n = 188) were classified under the control group. The effects of anisometropia on monocular and binocular BCVA, aniseikonia, and stereoacuity were examined. Results: The NA group had a significantly lower LogMAR of BCVA of the right eye (RE), left eye (LE), worse eye than the SHA, SMA, CMA, and CHA groups. Moreover, the SMA group had significantly lower LogMAR of BCVA than the CHA group (p Conclusion: Worse visual levels of the RE, LE, worse eye, BCVA difference, and lower stereopsis were evidenced in each type of anisometropia defined in this study. Cylindrical hyperopic anisometropia (CHA) resulted in a statically significant worsening VA level and stereopsis than cylindrical myopic (CMA) or spherical myopic anisometropia.
文摘目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正视力(BCVA)、一阶光栅锐度和(或)二阶纹理敏感度,并分析不同程度弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。结果:弱视组与正常对照组一阶光栅锐度(11.58±6.10 vs 20.27±3.47,P<0.001)、二阶纹理敏感度(0.33±0.16 vs 0.12±0.04,P<0.001)均有明显差异,且轻中度弱视患者与重度弱视患者一阶光栅锐度(12.10±6.23 vs 8.13±3.70,P<0.001)和二阶纹理敏感度(0.32±0.16 vs 0.37±0.17,P<0.05)均有明显差异。结论:单眼屈光参差性弱视患者大脑皮层一阶视觉通路和二阶视觉通路均存在不同程度的损伤,重度弱视患者较轻中度弱视患者损伤更为严重。
基金supported by the Health Technology Plan Project of Zhejiang Province(2018KY542 and 2021KY808)the Key Research and Development Program of Zhejiang Province(2021C03102).
文摘Background:This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia.Methods:The sample comprised 44 participants with anisometropic myopia,aged 9 to 18 years,with normal bestcorrected visual acuity.All participants underwent a series of examinations,including spherical equivalent refraction(SER)and axial length(AL),measured by a Lenstar optical biometer and optical coherence tomography angiography(OCTA)scanner.OCT measured the choroidal thickness,vascular density,and flow voids of the choriocapillaris,and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL.The choroidal thickness was measured at the fovea and 0.5,1.0,1.5,2.0,2.5,and 3.0 mm nasally,temporally,inferiorly,and superiorly to the fovea.The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle,and the 0.6-2.5 mm diameter circle in the nasal,temporal,inferior,and superior regions.Repeated-measured ANOVAs were used to analyze the interocular differences.Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness,the choriocapillaris vascular density and flow voids,the SER and AL.Results:The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes(P≤0.001),and the flow voids in the more myopic eyes were more than less myopic eyes(P=0.002).There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes(P=0.525).However,when anisometropia was more than 1.50 D,the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes(P=0.026).The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center,superior,and inferior regions but not in the nasal or temporal regions.The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL.Conclusions:The choroidal thickness is thinner in the more myopic eyes.The flow void is increased,and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D.
文摘Amblyopia is the most common cause of vision loss in children and can persist into adulthood in the absence of effective intervention.Previous clinical and neuroimaging studies have suggested that the neural mechanisms underlying strabismic amblyopia and anisometropic amblyopia may be different.Therefore,we performed a systematic review of magnetic resonance imaging studies investigating brain alterations in patients with these two subtypes of amblyopia;this study is registered with PROSPERO(registration ID:CRD42022349191).We searched three online databases(PubMed,EMBASE,and Web of Science) from inception to April 1,2022;39 studies with 633 patients(324patients with anisometropic amblyo pia and 309 patients with strabismic amblyopia) and 580 healthy controls met the inclusion criteria(e.g.,case-control designed,pee r-reviewed articles) and were included in this review.These studies highlighted that both strabismic amblyopia and anisometropic amblyopia patients showed reduced activation and distorted topological cortical activated maps in the striate and extrastriate co rtices during tas k-based functional magnetic resonance imaging with spatial-frequency stimulus and retinotopic representations,respectively;these may have arisen from abnormal visual experiences.Compensations for amblyopia that are reflected in enhanced spontaneous brain function have been reported in the early visual cortices in the resting state,as well as reduced functional connectivity in the dorsal pathway and structural connections in the ventral pathway in both anisometro pic amblyopia and strabismic amblyopia patients.The shared dysfunction of anisometro pic amblyopia and strabismic amblyopia patients,relative to controls,is also chara cterized by reduced spontaneous brain activity in the oculomotor co rtex,mainly involving the frontal and parietal eye fields and the cerebellu m;this may underlie the neural mechanisms of fixation instability and anomalous saccades in amblyopia.With regards to specific alterations of the two forms of amblyo pia,anisometropic amblyo pia patients suffer more microstructural impairments in the precortical pathway than strabismic amblyopia patients,as reflected by diffusion tensor imaging,and more significant dysfunction and structural loss in the ventral pathway.Strabismic amblyopia patients experience more attenuation of activation in the extrastriate co rtex than in the striate cortex when compared to anisometropic amblyopia patients.Finally,brain structural magnetic resonance imaging alterations tend to be lateralized in the adult anisometropic amblyopia patients,and the patterns of brain alterations are more limited in amblyopic adults than in childre n.In conclusion,magnetic resonance imaging studies provide important insights into the brain alterations underlying the pathophysiology of amblyopia and demonstrate common and specific alte rations in anisometropic amblyo pia and strabismic amblyopia patients;these alterations may improve our understanding of the neural mechanisms underlying amblyopia.
