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The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case
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作者 Chen Han Zhixin Zhang +8 位作者 Zhiyang Feng Chuanjia Zhai Xuejiao Li Yulian Shi Xiang Li Miao Li Ying Wang Gan Luo Xiaoyan Gao 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第3期416-426,共11页
The comprehensive detection and identification of active ingredients in complex matrices is a crucial challenge.Liquid chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analyt... The comprehensive detection and identification of active ingredients in complex matrices is a crucial challenge.Liquid chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex matrices.However,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 spectra.Lycibarbarspermidines are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low content.To comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this study.First,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine derivatives.Second,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target compounds.Third,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of identification.Finally,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly improved.Based on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally characterized.The integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds. 展开更多
关键词 Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines
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Acellular dermal matrices in reconstructive surgery;history,current implications and future perspectives for surgeons
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作者 Ömer F Dilek Kamuran Z Sevim Osman N Dilek 《World Journal of Clinical Cases》 SCIE 2024年第35期6791-6807,共17页
Large-scale defects of body in the reconstructive surgical practice,and the help-lessness of their repair with autologous tissues,have been an important factor in the development of artificial biological products for ... Large-scale defects of body in the reconstructive surgical practice,and the help-lessness of their repair with autologous tissues,have been an important factor in the development of artificial biological products for the temporary,definitive,or staged repair of these defects.A major advance in the field of plastic and other reconstructive surgery in this regard has been the introduction and successful use of acellular dermal matrices(ADMs).In recent years,not only the type of tissue from which ADMs are produced,product range,diversity and areas of use have increased,but their use in reconstructive fields,especially in post oncologic breast surgery,has become highly regarded and this has favored ADMs to be a potential cornerstone in specific and well-defined surgical fields in future.It is essential that reconstructive surgeons become familiar with some of the ADM’s as well as the advantages and limitations to their use.This review not only provides basic science and clinical evidence of the current use of ADMs in wide range of surgical fields but also targets to keep them as an important backdrop in the arma-mentarium of reconstructive surgeons.Brief considerations of possible future directions for ADMs are also conducted in the end. 展开更多
关键词 Acellular dermal matrices BREAST DECELLULARIZATION Reconstruction Surgery Tissue defect
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Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss
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作者 Moon Sung Kang Yeuni Yu +5 位作者 Rowoon Park Hye Jin Heo Seok Hyun Lee Suck Won Hong Yun Hak Kim Dong‑Wook Han 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第4期269-292,共24页
Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient bioactivities.To overcome these limitations,tissue-engineered scaffolds have emerged as ... Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient bioactivities.To overcome these limitations,tissue-engineered scaffolds have emerged as a promising alternative.In this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue regeneration.The PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and hydrophilicity.In vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 myoblasts.Moreover,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML injury.Mechanistic insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT pathway.Additionally,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast maturation.These findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery. 展开更多
关键词 Ti_(3)C_(2)T_(x)MXene nanoparticle Ternary nanofibrous matrices Myogenesis Regeneration of volumetric muscle loss Next generation sequencing
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MINIMIZATION PROBLEM FOR SYMMETRIC ORTHOGONAL ANTI-SYMMETRIC MATRICES 被引量:1
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作者 Yuan Lei Anping Liao Lei Zhang 《Journal of Computational Mathematics》 SCIE EI CSCD 2007年第2期211-220,共10页
By applying the generalized singular value decomposition and the canonical correlation decomposition simultaneously, we derive an analytical expression of the optimal approximate solution ^-X, which is both a least-sq... By applying the generalized singular value decomposition and the canonical correlation decomposition simultaneously, we derive an analytical expression of the optimal approximate solution ^-X, which is both a least-squares symmetric orthogonal anti-symmetric solu- tion of the matrix equation A^TXA = B and a best approximation to a given matrix X^*. Moreover, a numerical algorithm for finding this optimal approximate solution is described in detail, and a numerical example is presented to show the validity of our algorithm. 展开更多
关键词 Symmetric orthogonal anti-symmetric matrix Generalized singular value decomposition Canonical correlation decomposition
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Least-square Solutions of Inverse Problems for Anti-symmetric and Skew-symmetric Matrices
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作者 周硕 吴柏生 《Northeastern Mathematical Journal》 CSCD 2007年第3期189-199,共11页
The least-square solutions of inverse problem for anti-symmetric and skew-symmetric matrices are studied. In addition, the problem of using anti-symmetric and skew-symmetric matrices to construct the optimal approxima... The least-square solutions of inverse problem for anti-symmetric and skew-symmetric matrices are studied. In addition, the problem of using anti-symmetric and skew-symmetric matrices to construct the optimal approximation to a given matrix is discussed, the necessary and sufficient conditions for the problem are derived, and the expression of the solution is provided. A numerical example is given to show the effectiveness of the proposed method. 展开更多
关键词 anti-symmetric and skew-symmetric matrix matrix norm optimal approximation canonical correlation decomposition
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Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods
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作者 Yi-Xin Zhang Yuan Zhang +5 位作者 Yu Bian Ya-jie Liu Ai Ren Yu Zhou Du Shi Xue-Song Feng 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2023年第5期442-462,共21页
Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are... Benzodiazepines(BDZs)are used in clinics for anxiolysis,anticonvulsants,sedative hypnosis,and muscle relaxation.They have high consumptions worldwide because of their easy availability and potential addiction.They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault.The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging.Efficient pretreatment methods followed by accurate and sensitive detections are necessary.Herein,pretreatment methods for the extraction,enrichment,and preconcentration of BDZs as well as the strategies for their screening,identification,and quantitation developed in the past five years have been reviewed.Moreover,recent advances in various methods are summarized.Characteristics and advantages of each method are encompassed.Future directions of the pretreatment and detection methods for BDZs are also reviewed. 展开更多
关键词 BENZODIAZEPINE Biological matrices Detectionmethods Samplepreparation
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Separable Symmetric Tensors and Separable Anti-symmetric Tensors
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作者 Changqing Xu Kaijie Xu 《Communications on Applied Mathematics and Computation》 EI 2023年第4期1509-1523,共15页
In this paper,we first initialize the S-product of tensors to unify the outer product,contractive product,and the inner product of tensors.Then,we introduce the separable symmetry tensors and separable anti-symmetry t... In this paper,we first initialize the S-product of tensors to unify the outer product,contractive product,and the inner product of tensors.Then,we introduce the separable symmetry tensors and separable anti-symmetry tensors,which are defined,respectively,as the sum and the algebraic sum of rank-one tensors generated by the tensor product of some vectors.We offer a class of tensors to achieve the upper bound for rank(A)≤6 for all tensors of size 3×3×3.We also show that each 3×3×3 anti-symmetric tensor is separable. 展开更多
关键词 S-product Invertible tensor Separable symmetric tensor Separable anti-symmetric tensor
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Materials Selection of Thermoplastic Matrices of Natural Fibre Composites for Cyclist Helmet Using an Integration of DMAIC Approach in Six Sigma Method Together with Grey Relational Analysis Approach
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作者 N.A.Maidin S.M.Sapuan +1 位作者 M.T.Mastura M.Y.M.Zuhri 《Journal of Renewable Materials》 SCIE EI 2023年第5期2381-2397,共17页
Natural fibre reinforced polymer composite(NFRPC)materials are gaining popularity in the modern world due to their eco-friendliness,lightweight nature,life-cycle superiority,biodegradability,low cost,and noble mechani... Natural fibre reinforced polymer composite(NFRPC)materials are gaining popularity in the modern world due to their eco-friendliness,lightweight nature,life-cycle superiority,biodegradability,low cost,and noble mechanical properties.Due to the wide variety of materials available that have comparable attributes and satisfy the requirements of the product design specification,material selection has become a crucial component of design for engineers.This paper discusses the study’s findings in choosing the suitable thermoplastic matrices of Natural Fibre Composites for Cyclist Helmet utilising the DMAIC,and GRA approaches.The results are based on integrating two decision methods implemented utilising two distinct decision-making approaches:qualitative and quantitative.This study suggested thermoplastic polyethylene as a particularly ideal matrix in composite cyclist helmets during the selection process for the best thermoplastic matrices material using the 6σtechnique,with the decision based on the highest performance,the lightest weight,and the most environmentally friendly criteria.The DMAIC and GRA approach significantly influenced the material selection process by offering different tools for each phase.In the future study,selection technique may have been more exhaustive if more information from other factors had been added. 展开更多
关键词 Material selection DMAIC Six Sigma grey relational analysis thermoplastic matrices natural fibre polymerreinforced composites
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Criteria Condition for Generalized Diagonally Dominant Matrices 被引量:3
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作者 田素霞 《Chinese Quarterly Journal of Mathematics》 CSCD 2001年第1期102-106,共5页
In this paper, we provide some new necessary and sufficient conditions for generalized diagonally dominant matrices and also obtain some criteria for nongeneralized dominant matrices.
关键词 generalized diagonally dominant matrices Positive diagonal matrix criteria condition
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The Monotonicity Problems for Generalized Inverses of Matrices in H (n, ≥) 被引量:1
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作者 庄瓦金 《Chinese Quarterly Journal of Mathematics》 CSCD 1992年第3期18-23,共6页
On the basis of the paoers[3—7],this paper study the monotonicity problems for the positive semidefinite generalized inverses of the positive semidefinite self-conjugate matrices of quaternions in the Lowner partial ... On the basis of the paoers[3—7],this paper study the monotonicity problems for the positive semidefinite generalized inverses of the positive semidefinite self-conjugate matrices of quaternions in the Lowner partial order,give the explicit formulations of the monotonicity solution sets A{1;≥,T_1;≤B^(1)}and B{1;≥,T_2≥A^(1)}for the(1)-inverse,and two results of the monotonicity charac teriaztion for the(1,2)-inverse. 展开更多
关键词 positive semidefinite self-Conjugate matrices of quaternions generalized inverses Lwner partial order MONOTONICITY
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BEST APPROXIMATION BY NORMAL MATRICES WITH SPECTRAL CONSTRAINTS
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作者 戴华 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 1998年第2期88-92,共5页
The problem of best approximating, a given square complex matrix in the Frobenius norm by normal matrices under a given spectral restriction is considered. The ne cessary and sufficient condition for the solvability ... The problem of best approximating, a given square complex matrix in the Frobenius norm by normal matrices under a given spectral restriction is considered. The ne cessary and sufficient condition for the solvability of the problem is given. A numerical algorithm for solving the problem is provided and a numerical example is presented. 展开更多
关键词 normal matrices best approximation EIGENVALUES inverse problems spectral constraint
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Formulation and evaluation the bioadhesive properties of drug delivery system based on PEGylated mucin matrices 被引量:3
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作者 Momohmumuni Audu Adikwu Michael Umale Ibezim Emmanuel Chinnedu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第6期461-464,共4页
Objective:To formulate and evaluate the application of PEGylated mucin in oral bioadhesive drug(OBD) delivery system.Methods:The bioadhesive strength of different formulation ratios of polyethylene glycol(PEG) and muc... Objective:To formulate and evaluate the application of PEGylated mucin in oral bioadhesive drug(OBD) delivery system.Methods:The bioadhesive strength of different formulation ratios of polyethylene glycol(PEG) and mucin was evaluated by tensiometry.Co polymer matrices containing mucin and PEG(PEGylated mucin) in the following ratios of 1:1(A),2:1(B),1:2(C), 0:1(D) and 1:0(E) were prepared by co-precipitation.Microparticles were prepared from the matrices using a size reduction technique.Five different samples were prepared using direct mixtures in the appropriate solvenfs having mucin and PEG ratios of 1:1,2:1,1:2,0:1, 1:0 and labeled as(A-E).The matrices were evaluated for their flow properties and the in vitro bioadhesion characteristics of the samples were examined.Results:The range of flow rates of the matrices was 1.35-2.23 g/sec.The angle of repose was in the range of 37.3-39.9 degree.The bulk and tapped densities were within the ranges of 0.41- 0.49.The Hausner’s quotient(HQ) were 1.12, 1.24,1.14,1.25 and 1.2 for matrix batches A-E respectively,The bioadhesive strength of polymer matrices appeared to be directly related to amount of mucin.The order of bioadhesive strength is 2:1】1:1】1:0】1:2】0:1 of PEG:mucin in both simulated intestine fluid(SEP) and simulated gastrointestinal fluid(SGF).The physical properties of the micrometrics properties of the matrices were within the accepted values.Conclusions:OBD preparation containing PEGylated mucin can be prepared by direct compression and be used in drug delivery to the oral cavity. 展开更多
关键词 PEGylated MUCUS Delivery matrices
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Generalized Drazin spectrum of operator matrices 被引量:4
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作者 ZHANG Shi-fang ZHONG Huai-jie LIN Li-qiong 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2014年第2期162-170,共9页
Let A ∈ B(X) and B ∈ B(Y), Me be an operator on Banach space X + Y given by Mc =(A C 0 B)A generalized Drazin spectrum defined by σgD(T) = {λ∈C : T-λI is not generalized Drazin invertible} is considere... Let A ∈ B(X) and B ∈ B(Y), Me be an operator on Banach space X + Y given by Mc =(A C 0 B)A generalized Drazin spectrum defined by σgD(T) = {λ∈C : T-λI is not generalized Drazin invertible} is considered in this paper. It is shown that 展开更多
关键词 operator matrices generalized Drazin spectrum filling-in-hole problem.
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Sparse recovery in probability via l_q-minimization with Weibull random matrices for 0 < q ≤ 1 被引量:3
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作者 GAO Yi PENG Ji-gen YUE Shi-gang 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2018年第1期1-24,共24页
Although Gaussian random matrices play an important role of measurement matrices in compressed sensing, one hopes that there exist other random matrices which can also be used to serve as the measurement matrices. Hen... Although Gaussian random matrices play an important role of measurement matrices in compressed sensing, one hopes that there exist other random matrices which can also be used to serve as the measurement matrices. Hence, Weibull random matrices induce extensive interest. In this paper, we first propose the lrobust null space property that can weaken the D-RIP, and show that Weibull random matrices satisfy the lrobust null space property with high probability. Besides, we prove that Weibull random matrices also possess the lquotient property with high probability. Finally, with the combination of the above mentioned properties,we give two important approximation characteristics of the solutions to the l-minimization with Weibull random matrices, one is on the stability estimate when the measurement noise e ∈ R~n needs a priori ‖e‖≤ε, the other is on the robustness estimate without needing to estimate the bound of ‖e‖. The results indicate that the performance of Weibull random matrices is similar to that of Gaussian random matrices in sparse recovery. 展开更多
关键词 compressed sensing l_q-minimization Weibull matrices null space property quotient property
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Synchronization of complex switched delay dynamical networks with simultaneously diagonalizable coupling matrices 被引量:4
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作者 Tao LIU Jun ZHAO 《控制理论与应用(英文版)》 EI 2008年第4期351-356,共6页
This paper studies local exponential synchronization of complex delayed networks with switching topology via switched system stability theory. First, by a common unitary matrix, the problem of synchronization is trans... This paper studies local exponential synchronization of complex delayed networks with switching topology via switched system stability theory. First, by a common unitary matrix, the problem of synchronization is transformed into the stability analysis of some linear switched delay systems. Then, when all subnetworks are synchronizable, a delay-dependent sufficient condition is given in terms of linear matrix inequalities (LMIs) which guarantees the solvability of the synchronization problem under an average dwell time scheme. We extend this result to the case that not all subnetworks are synchronizable. It is shown that in addition to average dwell time, if the ratio of the total activation time of synchronizable and non-synchronizable subnetworks satisfy an extra condition, then the problem is also solvable. Two numerical examples of delayed dynamical networks with switching topology are given, which demonstrate the effectiveness of obtained results. 展开更多
关键词 Exponential synchronization Complex dynamical network Switching topology Switched systems Av-erage dwell time Coupling delays Simultaneously diagonalizable matrices
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Inverse Eigenvalue Problem for Generalized Arrow-Like Matrices 被引量:3
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作者 Zhibin Li Cong Bu Hui Wang 《Applied Mathematics》 2011年第12期1443-1445,共3页
This paper researches the following inverse eigenvalue problem for arrow-like matrices. Give two characteristic pairs, get a generalized arrow-like matrix, let the two characteristic pairs are the characteristic pairs... This paper researches the following inverse eigenvalue problem for arrow-like matrices. Give two characteristic pairs, get a generalized arrow-like matrix, let the two characteristic pairs are the characteristic pairs of this generalized arrow-like matrix. The expression and an algorithm of the solution of the problem is given, and a numerical example is provided. 展开更多
关键词 Generalized Arrow-Like matrices CHARACTERISTIC Value INVERSE Problem UNIQUE
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Development of damage probability matrices based on Greek earthquake damage data 被引量:3
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作者 Anastasia K. Eleftheriadou Athanasios I. Karabinis 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2011年第1期129-141,共13页
A comprehensive study is presented for empirical seismic vulnerability assessment of typical structural types, representative of the building stock of Southern Europe, based on a large set of damage statistics. The ob... A comprehensive study is presented for empirical seismic vulnerability assessment of typical structural types, representative of the building stock of Southern Europe, based on a large set of damage statistics. The observational database was obtained from post-earthquake surveys carried out in the area struck by the September 7, 1999 Athens earthquake. After analysis of the collected observational data, a unified damage database has been created which comprises 180,945 damaged buildings from/after the near-field area of the earthquake. The damaged buildings are classified in specific structural types, according to the materials, seismic codes and construction techniques in Southern Europe. The seismic demand is described in terms of both the regional macroseismic intensity and the ratio αg/ao, where αg is the maximum peak ground acceleration (PGA) of the earthquake event and ao is the unique value PGA that characterizes each municipality shown on the Greek hazard map. The relative and cumulative frequencies of the different damage states for each structural type and each intensity level are computed in terms of damage ratio. Damage probability matrices (DPMs) and vulnerability curves are obtained for specific structural types. A comparison analysis is fulfilled between the produced and the existing vulnerability models. 展开更多
关键词 seismic vulnerability observational earthquake damage damage probability matrices (DPMs) vulnerability curves post-earthquake surveys Athens earthquake existing buildings
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Construction of protograph LDPC codes with circular generator matrices 被引量:5
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作者 Kaiyao Wang Yang Xiao Kiseon Kim 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第5期840-847,共8页
The application of protograph low density parity check (LDPC) codes involves the encoding complexity problem. Since the generator matrices are dense, and if the positions of "1" s are irregularity, the encoder nee... The application of protograph low density parity check (LDPC) codes involves the encoding complexity problem. Since the generator matrices are dense, and if the positions of "1" s are irregularity, the encoder needs to store every "1" of the generator matrices by using huge chip area. In order to solve this problem, we need to design the protograph LDPC codes with circular generator matrices. A theorem concerning the circulating property of generator matrices of nonsingular protograph LDPC codes is proposed. The circulating property of generator matrix of nonsingular protograph LDPC codes can be obtained from the corresponding quasi-cyclic parity check matrix. This paper gives a scheme of constructing protograph LDPC codes with circulating generator matrices, and it reveals that the fast encoding algorithm of protograph LDPC codes has lower encoding complexity under the condition of the proposed theorem. Simulation results in ad- ditive white Gaussian noise (AWGN) channels show that the bit error rate (BER) performance of the designed codes based on the proposed theorem is much better than that of GB20600 LDPC codes and Tanner LDPC codes. 展开更多
关键词 protograph low density parity check (LDPC) codes cyclic matrices fast encoding algorithm bit error rate (BER) performance.
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Compressed data separation via dual frames based split-analysis with Weibull matrices 被引量:2
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作者 CAI Yun LI Song 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2013年第4期427-437,共11页
In this paper, we consider data separation problem, where the original signal is composed of two distinct subcomponents, via dual frames based Split-analysis approach. We show that the two distinct subcomponents, whic... In this paper, we consider data separation problem, where the original signal is composed of two distinct subcomponents, via dual frames based Split-analysis approach. We show that the two distinct subcomponents, which are sparse in two diff erent general frames respectively, can be exactly recovered with high probability, when the measurement matrix is a Weibull random matrix (not Gaussian) and the two frames satisfy a mutual coherence property. Our result may be significant for analysing Split-analysis model for data separation. 展开更多
关键词 Compressed sensing data separation dual frames split-analysis Weibull random matrices
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Real-time origin-destination matrices estimation for urban rail transit network based on structural state-space model 被引量:1
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作者 姚向明 赵鹏 禹丹丹 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第11期4498-4506,共9页
The major objective of this work was to establish a structural state-space model to estimate the dynamic origin-destination(O-D) matrices for urban rail transit network, using in- and out-flows at each station from au... The major objective of this work was to establish a structural state-space model to estimate the dynamic origin-destination(O-D) matrices for urban rail transit network, using in- and out-flows at each station from automatic fare collection(AFC) system as the real time observed passenger flow counts. For lacking of measurable passenger flow information, the proposed model employs priori O-D matrices and travel time distribution from historical travel records in AFC system to establish the dynamic system equations. An arriving rate based on travel time distribution is defined to identify the dynamic interrelations between time-varying O-D flows and observed flows, which greatly decreases the computational complexity and improve the model's applicability for large-scale network. This methodology is tested in a real transit network from Beijing subway network in China through comparing the predicted matrices with the true matrices. Case study results indicate that the proposed model is effective and applicative for estimating dynamic O-D matrices for large-scale rail transit network. 展开更多
关键词 DYNAMIC origin-destination matrices ESTIMATION sta
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