Photodynamictherapy (PDT) using a photo sensitizing agent and several light sources has been shown to have nonspecific and noninvasive effects on superficial cancers. Phthalocyanine (Pc) derivatives as novel photosens...Photodynamictherapy (PDT) using a photo sensitizing agent and several light sources has been shown to have nonspecific and noninvasive effects on superficial cancers. Phthalocyanine (Pc) derivatives as novel photosensitizers, trifluoroethoxy-coatedzinc Pcconjugated with β-cyclodextrin (βCD-4TFEO-Pc) was synthesized and its photodynamic effect in vitro and in vivo was evaluated. βCD-4TFEO-Pc alone was completely non-cytotoxic even at high concentrations, and showed excellentphotodynamic effects in B16-F10 and HT-1080 celllines. The in vivo antitumor effect of βCD-4TFEO-Pc against B16-F10 cells transplanted on to the chorioallantoic membranes of chickembryos was 52.7%, but that of laserirradiation alone and photosensitizer alone was 2 (50 mW). These data suggest that βCD-4TFEO-Pc is a useful photosensitizer for the treatment of superficial cancers. If a high-power LED with optimal wavelength is developed, excellent treatment of superficial cancers could be achieved by applying βCD-4TFEO-Pc for PDT.展开更多
A zinc phthalocyanine containing (17-crown-5) ether subunits has been synthesized.UV-visible absorption and fluorescence emission spectra and associated photophysical parameters have been determined. In addition to th...A zinc phthalocyanine containing (17-crown-5) ether subunits has been synthesized.UV-visible absorption and fluorescence emission spectra and associated photophysical parameters have been determined. In addition to the fluorescence at 710 nm from S1. a strong upper excited state emission around 424 nm has been detected. X-ray structural analysis showed that the crown ether unit is conformationally deformed and oblate like that accounted for the unusual spectroscopic展开更多
The singlet and triplet excited-state refraction cross-sections of dimethyl sulfoxide (DMSO) solutions of ten zinc phthalocyanine derivatives with mono-or tetra-peripheral substituents at 532 nm were obtained by simul...The singlet and triplet excited-state refraction cross-sections of dimethyl sulfoxide (DMSO) solutions of ten zinc phthalocyanine derivatives with mono-or tetra-peripheral substituents at 532 nm were obtained by simultaneous fitting of closed-aperture Z scans with both nanosecond and picosecond pulse widths. Self-focusing of both nanosecond and picosecond laser pulses was observed in all complexes at 532-nm wavelength. The complexes with tetra-substituents at the ?-position exhibit relatively larger refraction cross-sections than the other complexes. The wavelength dependence of the singlet refraction cross-section of a representative complex was observed to be non-monotonic in the range of 470 - 550 nm.展开更多
We demonstrate that the electroluminescent performances of organic light-emitting diodes are significantly improved by employing a zinc phthalocyanine(ZnPc)-based composite hole transport layer(c-HTL). The optimum ris...We demonstrate that the electroluminescent performances of organic light-emitting diodes are significantly improved by employing a zinc phthalocyanine(ZnPc)-based composite hole transport layer(c-HTL). The optimum ris-(8-hydroxyquinoline)aluminum(Alq3)-based organic light-emitting diode with a c-HTL exhibits a lower turn-on voltage of 2.8 V, a higher maximum current efficiency of 3.40 cd/A and a higher maximum power efficiency of 1.91 lm/W, which are superior to those of the conventional device(turn-on voltage of 3.8 V, maximum current efficiency of 2.60 cd/A, and maximum power efficiency of 1.21 lm/W). We systematically studied the effects of different kinds of N'-diphenyl-N,N'-bis(1-naphthyl)(1,1'-biphenyl)-4,4'diamine(NPB):ZnPc c-HTL. Meanwhile, we also investigate their mechanisms different from that in the case of using ZnPc as buffer layer. The specific analysis is based on the absorption spectra of the hole transporting material and current density–voltage characteristics of the corresponding hole-only devices.展开更多
文摘Photodynamictherapy (PDT) using a photo sensitizing agent and several light sources has been shown to have nonspecific and noninvasive effects on superficial cancers. Phthalocyanine (Pc) derivatives as novel photosensitizers, trifluoroethoxy-coatedzinc Pcconjugated with β-cyclodextrin (βCD-4TFEO-Pc) was synthesized and its photodynamic effect in vitro and in vivo was evaluated. βCD-4TFEO-Pc alone was completely non-cytotoxic even at high concentrations, and showed excellentphotodynamic effects in B16-F10 and HT-1080 celllines. The in vivo antitumor effect of βCD-4TFEO-Pc against B16-F10 cells transplanted on to the chorioallantoic membranes of chickembryos was 52.7%, but that of laserirradiation alone and photosensitizer alone was 2 (50 mW). These data suggest that βCD-4TFEO-Pc is a useful photosensitizer for the treatment of superficial cancers. If a high-power LED with optimal wavelength is developed, excellent treatment of superficial cancers could be achieved by applying βCD-4TFEO-Pc for PDT.
文摘A zinc phthalocyanine containing (17-crown-5) ether subunits has been synthesized.UV-visible absorption and fluorescence emission spectra and associated photophysical parameters have been determined. In addition to the fluorescence at 710 nm from S1. a strong upper excited state emission around 424 nm has been detected. X-ray structural analysis showed that the crown ether unit is conformationally deformed and oblate like that accounted for the unusual spectroscopic
文摘The singlet and triplet excited-state refraction cross-sections of dimethyl sulfoxide (DMSO) solutions of ten zinc phthalocyanine derivatives with mono-or tetra-peripheral substituents at 532 nm were obtained by simultaneous fitting of closed-aperture Z scans with both nanosecond and picosecond pulse widths. Self-focusing of both nanosecond and picosecond laser pulses was observed in all complexes at 532-nm wavelength. The complexes with tetra-substituents at the ?-position exhibit relatively larger refraction cross-sections than the other complexes. The wavelength dependence of the singlet refraction cross-section of a representative complex was observed to be non-monotonic in the range of 470 - 550 nm.
基金Project supported by the National Key Basic Research and Development Program of China(Grant No.2010CB327701)the National Natural Science Foundation of China(Grant No.61275033)
文摘We demonstrate that the electroluminescent performances of organic light-emitting diodes are significantly improved by employing a zinc phthalocyanine(ZnPc)-based composite hole transport layer(c-HTL). The optimum ris-(8-hydroxyquinoline)aluminum(Alq3)-based organic light-emitting diode with a c-HTL exhibits a lower turn-on voltage of 2.8 V, a higher maximum current efficiency of 3.40 cd/A and a higher maximum power efficiency of 1.91 lm/W, which are superior to those of the conventional device(turn-on voltage of 3.8 V, maximum current efficiency of 2.60 cd/A, and maximum power efficiency of 1.21 lm/W). We systematically studied the effects of different kinds of N'-diphenyl-N,N'-bis(1-naphthyl)(1,1'-biphenyl)-4,4'diamine(NPB):ZnPc c-HTL. Meanwhile, we also investigate their mechanisms different from that in the case of using ZnPc as buffer layer. The specific analysis is based on the absorption spectra of the hole transporting material and current density–voltage characteristics of the corresponding hole-only devices.
